Clinical trials: Fibrosis; Skin
Adhesion
LEAFix Adhesion in Healthy Volunteers
This study compares the adhesiveness of the 3M material to be used in the final design.
- Trial name
- NCT05415059
- Testing
- Covatech Stoma bag material
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Rheumatoid Arthritis, Interstitial Lung Disease
Interstitial Lung Disease in Early Rheumatoid Arthritis
The purpose of this study is to determine how interstitial lung disease can be predicted over time in early rheumatoid arthritis.
- Trial name
- ILD-Early RA (NCT03977415)
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- National Jewish Health
Lupus Nephritis (LN)
The Role of Transforming Growth Factor- Beta (TGF- β) Expression in Renal Biopsy of Lupus Nephritis Patients
To investigate the possible role of TGF-β expression in renal biopsy and it's relation with fibrosis, activity and chronicity indices
- Trial name
- NCT07823556
- Testing
- renal biopsy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Keloid
A Study Using Fractional Carbon Dioxide and Long Pulsed Neodymium-yttrium Aluminum Garnet Lasers in Treatment of Keloids
clinical comparative study comparing the effectiveness of fractional CO2, long pulsed Nd YAG and their combination in collagen remodeling in keloid clinically, biochemically and histopathologically
- Trial name
- NCT03460431
- Testing
- fractional CO2 laser 10,600nm, Nd YAG laser1064 nm
- Volunteers
- 30 people
- Sponsor
- Cairo University
Hematoma, Subdural, Chronic, Hematoma, Subdural, Intracranial
Covers to Improve Esthetic Outcome After Surgery for Chronic Subdural Hematoma
The clinical-functional result after frontal and parietal burr-hole trepanation for the treatment of chronic subdural hematoma (cSDH) is effective with regards to control of the hematoma and regression of symptoms (headache…
- Conditions
- Hematoma, Subdural, Chronic, Hematoma, Subdural, Intracranial, Haematoma;Subdural;Traumatic
- Trial name
- CORRECT-SCAR (NCT03755349)
- Testing
- Placement of burr-hole covers, No placement of burr-hole covers
- Where
- Switzerland
- Volunteers
- 83 people
- Sponsor
- University of Zurich
Keloid, Stem Cell
The Effect of Intralesian Injection of Umbilical Cord Mesenchymal Stem Cells, Its Conditioned Medium, and Triamcinolone Acetonide on Type 1:3 Collagen Ratio and Interleukin-10 Levels in Keloid: A Randomised Controlled Trial
The objective of this study is to observe the potency of umbilical cord-derived mesenchymal stem cells (UC-MSC) and umbilical cord-derived conditioned medium (UC-CM), or triamcinolone acetonide (TA) in keloid therapy, measured by…
- Trial name
- NCT05939817
- Testing
- umbilical cord-derived mesenchymal stem cells (UC-MSC), umbilical cord-derived mesenchymal stem cells conditioned medium (UC-CM), Triamcinolone Acetonide (TA)
- Where
- Indonesia
- Volunteers
- 24 people
- Sponsor
- Rumah Sakit Pusat Angkatan Darat Gatot Soebroto
Scars
Cutaneous Scarring of Scalpel Versus Cautery
Cutaneous scarring after elective surgery is a concern for surgeons of all types, perhaps even more so to plastic surgeons. Cautery is often used on the "cut" setting to make or extend incisions; however very few studies have…
- Trial name
- NCT00803140
- Testing
- Cautery vs Active Control Arm (Scalpel)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Scott and White Hospital & Clinic
ANCA Associated Vasculitis, Extramembranous Glomerulopathy
Epithelial Dysmetabolism and Renal Fibrosis in ANCA Vasculitis
The project is to explore in humans the hypothesis of the link between the alteration of tubulo-interstitial metabolism and the rate of deterioration of renal function by comparing various nephropathies.
- Conditions
- ANCA Associated Vasculitis, Extramembranous Glomerulopathy, Nephrotic Syndrome, Minimal Change, Interstitial Nephritis
- Trial name
- PROTECT-Fi (NCT07010250)
- Where
- France
- Volunteers
- 146 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma, Atrial Fibrillation
The Living With a Long-Term Condition Study
Psychological distress (anxiety and depression) is common in and experienced differently by people living with long-term health conditions (LTCs).
- Conditions
- Asthma, Atrial Fibrillation, Cancer, Cerebrovascular Disorders
- Trial name
- LTC (NCT06072287)
- Testing
- Living with LTC Questionnaire
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- King's College London
Keloid
Exploratory Study of the Efficacy and Safety of Juvista 250ng When Administered Following Excision of Ear Lobe Keloids
This trial will explore the efficacy and safety of 250ng Juvista per Linear cm, administered by intradermal injection following the excision of ear lobe keloids.
- Trial name
- NCT00836147
- Testing
- Avotermin (Juvista)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Renovo
Scar Keloid
Intralesional Triamcinolone Acetonide and Its Combination With 5-fluorouracil in Keloids and Hypertrophic Scars
Summary: Keloids and hypertrophic scars are benign fibrous growth, differing mainly by overgrowth beyond the initial defect in keloid whereas hypertrophic scar is confined to initial lesion and tends to regress over the years.
- Trial name
- NCT04812626
- Testing
- 5-Fluorouracil
- Where
- Nepal
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- B.P. Koirala Institute of Health Sciences
Primary Biliary Cholangitis, Primary Sclerosing Cholangitis
The Effect of Bezafibrate on Cholestatic Itch
Randomized double blind placebo controlled trial to evaluate the antipruritic effect of bezafibrate in patients with moderate to severe cholestatic itch.
- Conditions
- Primary Biliary Cholangitis, Primary Sclerosing Cholangitis, Secondary Sclerosing Cholangitis
- Trial name
- FITCH (NCT02701166)
- Testing
- Bezafibrate
- Where
- 9 sites in Netherlands, Spain
- Volunteers
- 84 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Keloid
Case-control Study on Matrix Metalloproteinase Levels in Tissue in Patients With Keloid Scar
Purpose: To compare the levels of matrix metalloproteinase-1 (MMP-1), MMP-8, MMP-13 and tissue inhibitor of metalloproteinases (TIMPs) in keloid skin tissue with normal skin in the same patient and with normal discarded skin…
- Trial name
- NCT01125137
- Testing
- Removal of Keloid
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Fibrosis, Breast Cancer
Evaluation of the Medical Benefit of Spa Therapy on Fibrosis After Radiotherapy for Breast Cancer or UADT (Upper Aerodigestive Tract) Cancer
FIBROTHERME is a comparative, controlled, randomized, multicenter and simple blinded (investigator) trial. The aim of this study is to evaluate the medical benefit in terms of quality of life on the dermatological sequelae of…
- Conditions
- Fibrosis, Breast Cancer, Head and Neck Cancer
- Trial name
- FIBROTHERME (NCT05874492)
- Testing
- Thermal cure with a primary dermatological indication
- Where
- 13 sites in France, Luxembourg
- Volunteers
- 110 people
- Sponsor
- Association Francaise pour la Recherche Thermale
Port Wine Stain, Nevus of Ota
Optical Clearing of the Skin in Conjunction With Laser Treatments
The research hypothesis is that topical application of a mixture of pre-polymers of polypropylene glycol and polyethylene glycol (an optical clearing agent) will reduce skin light scattering, increasing the amount of light…
- Conditions
- Port Wine Stain, Nevus of Ota, Tattoos, Scars
- Trial name
- NCT00580736
- Testing
- Optical Clearing
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of California, Irvine
Keloid, Wound Heal
Comparing the Effect of siSPARC Microneedle Patch Versus siSPARC+siLR4A Microneedle Patch on Post-surgical Scars
This randomized, double-blind controlled study aims to compare the effect on appearance of post- surgical scars between daily application of siSPARC microneedle patch versus siSPARC + siLR4A microneedle patches.
- Conditions
- Keloid, Wound Heal, Wound
- Trial name
- NCT06138964
- Testing
- siSPARC + siLR4A microneedle patches, siSPARC microneedle patch
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Skin Centre
Hypertrophic Scar
Intra-lesional ACE Inhibitor for Treatment of Hypertrophic Scars
Hypertrophic scarring is a difficult and debilitating condition where one develops excessive scarring after full thickness injury to the skin. This is very common in full thickness burn injury.
- Trial name
- NCT05259137
- Testing
- Intralesional enalaprilat injection
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Bariatric Surgery, Abdominoplasty
Effect of a Preoperative Oral Collagen-Based Formulation on Dermal Collagen Content, Wound Outcomes, and Scar Quality
This single-center, randomized, placebo-controlled trial evaluated whether approximately 8 weeks of preoperative supplementation with a 10-g daily collagen-based oral formulation affected dermal collagen content and postoperative…
- Conditions
- Bariatric Surgery, Abdominoplasty, Collagen Synthesis, Skin Physiology
- Trial name
- COLLAGEN (NCT06787924)
- Testing
- Collagen hydrolyzed peptides, Starch
- Where
- Egypt
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Melanoma, Quality of Life
Quality of Life and Surgical Late Effects of Melanoma Treatment
Health-related Quality of life in Danish stage IB-III cutaneous melanoma patients.
- Conditions
- Melanoma, Quality of Life, Lymphedema, Depression
- Trial name
- NCT02352623
- Testing
- DXA scan, Clinical examination
- Where
- Denmark
- Volunteers
- 435 people
- Sponsor
- Herlev Hospital
Keloid
A Study for Safety and Efficacy Evaluation of Various Doses of STP705 in Reducing Keloid Recurrence
Phase 2, randomized, double-blind, multiple arm, controlled study to evaluate safety \& efficacy of various doses of STP705 in reducing post Keloidectomy keloid recurrence.
- Trial name
- NCT04844840
- Testing
- STP705
- Where
- 3 sites in United States
- Volunteers
- 29 people
- Sponsor
- Sirnaomics