Clinical trials: Fibrosis Lung
Cystic Fibrosis in Children
Exercise With or Without Electrical Stimulation in Cystic Fibrosis (Part I): Effects on Physical Fitness
This study aims to assess the effects of programmed exercise with or without electrical stimulation in the cardiorespiratory fitness, strength, functional capacity and agility in a group of young patients with Cystic Fibrosis: A…
- Trial name
- ECOMIRIN (NCT04153669)
- Testing
- Exercise-NMES, Exercise-No NMES
- Where
- Spain
- Volunteers
- 27 people
- Sponsor
- Universidad Europea de Madrid
Idiopathic Pulmonary Fibrosis
Microaspiration in Pulmonary Fibrosis
Hypothesis 1: Microaspiration, as diagnosed by bronchoalveolar lavage (BAL) pepsin, is common in patients with IPF. Hypothesis 2a: Baseline clinical variables and co-morbid conditions are risk factors for microaspiration in…
- Trial name
- ROMI (NCT01150591)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Thyroid Pathology, Head and Neck Cancer (H&N)
FAPI PET Imaging - An Exploratory Study
This study is testing a new imaging tracer called [18F]FAPI-74 with PET scans. Researchers want to find out how well this tracer shows certain diseases in the body, including several types of cancer and some non-cancer conditions…
- Conditions
- Thyroid Pathology, Head and Neck Cancer (H&N), Sinonasal Tract Tumor, Sarcoidosis
- Trial name
- FAPIPET (NCT07705074)
- Testing
- [18F]FAPI-74 PET/CT
- Where
- 5 sites in Switzerland
- Volunteers
- 770 people
- Sponsor
- Martin Huellner
Idiopathic Pulmonary Fibrosis
Investigating Trends in Quality of Life in Patients With Idiopathic Pulmonary Fibrosis (IPF) Under Treatment With Nintedanib
Multi-center, non-interventional, prospective cohort study aiming to enroll 240 Idiopathic Pulmonary Fibrosis patients receiving treatment with nintedanib in a consecutive manner from 10-12 reference centers across Greece.
- Trial name
- QUALIFY IPF (NCT03710824)
- Testing
- Nintedanib
- Where
- 10 sites in Greece
- Volunteers
- 180 people
- Sponsor
- Boehringer Ingelheim
Chronic Radiation Dermatitis
Pilot Study of the Effect of Laser on Reversing Chronic Radiation Injury
Radiotherapy, an essential modality in cancer treatment, frequently induces a fibrotic process in the skin which can lead to increased risk of malignancy, poor wound healing, pain and limitation of movement, and permanent loss of…
- Trial name
- NCT01910818
- Testing
- Fractional CO2 laser treatment, No treatment
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cystic Fibrosis, Lungtransplantation
Upper and Lower Airway Colonization in Cystic Fibrosis Patients After Lung Transplantation
A hot topic in lung transplantation is the treatment of persisting sinus disease/colonization in CF patients to prevent descending graft colonization and chronic allograft dysfunction.
- Conditions
- Cystic Fibrosis, Lungtransplantation, Paranasal Sinus Diseases
- Trial name
- NCT02591524
- Testing
- Bronchoalveolar and Nasal Lavage
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Hannover Medical School
Cystic Fibrosis
Evaluation of Sit-to-stand Test in Patients With Cystic Fibrosis and Matched Controls.
Introduction: In recent years, since the discovery of the cystic fibrosis (CF) transmembrane conductance regulator gene in human skeletal muscle, there appears to be growing interest in the measurement of muscle function in CF.
- Trial name
- STS-CF (NCT03524859)
- Where
- Spain
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Idiopathic Pulmonary Fibrosis, Lung Disease
Gleevec Idiopathic Pulmonary Fibrosis (IPF) Study
The purpose of the study is to evaluate the safety and efficacy of Gleevec (imatinib mesylate) in the treatment of idiopathic pulmonary fibrosis (IPF).
- Conditions
- Idiopathic Pulmonary Fibrosis, Lung Disease, Pulmonary Fibrosis
- Trial name
- NCT00131274
- Testing
- Imatinib Mesylate (Gleevec)
- Volunteers
- 120 people
- Sponsor
- Daniels, Craig E., M.D.
Methicillin-Resistant Staphylococcus Aureus, Cystic Fibrosis
Initial and Chronic Methicillin Resistant Staphylococcus Aureus (MRSA) Infection in Cystic Fibrosis (CF)
This study aims to examine features of MRSA that are associated with chronic MRSA infection and bacterial persistence despite IV antibiotic therapy.
- Trial name
- TRI-STAR (NCT02684422)
- Testing
- Intervention N/A. Observational study
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- University of North Carolina, Chapel Hill
Cystic Fibrosis
Outcomes in CF Patients Accessing Their Registry Health Records
A multifactorial, parallel group, randomised control study in cystic fibrosis (CF) patients aged 13-30 years over an 18 month period.
- Trial name
- CFView (NCT03434886)
- Testing
- CFView, CF educational videos
- Volunteers
- 282 people
- Sponsor
- Cystic Fibrosis Registry of Ireland
Cystic Fibrosis
Structure and Function of Salivary Proteins
This study seeks to provide point-of-care clinical diagnostic systems for the diagnosis of current disease status using saliva as a sample specimen.
- Trial name
- NCT00916682
- Where
- United States
- Volunteers
- 273 people
- Sponsor
- Boston Children's Hospital
Idiopathic Pulmonary Fibrosis
Assess the Safety, Tolerability and Pharmacokinetics of AZD5055 Following Single and Multiple Ascending Doses in Healthy Participants
This is a phase I, First-in-Human study in healthy participants, performed at a single study center, consisting of 2 parts: Part 1 is a single ascending dose (SAD) study and Part 2 is a multiple ascending dose (MAD) study.
- Trial name
- NCT05134727
- Testing
- AZD5055
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Idiopathic Pulmonary Fibrosis
Macitentan Use in an Idiopathic Pulmonary Fibrosis Clinical Study
The AC-055B201/MUSIC study is a Phase II study, comparing one dose of ACT-064922 (macitentan) 10 mg with placebo in patients with idiopathic pulmonary fibrosis (IPF).
- Trial name
- MUSIC (NCT00903331)
- Testing
- ACT-064992 (macitentan)
- Where
- 53 sites in United States, Australia and 10 more
- Volunteers
- 178 people
- Sponsor
- Actelion
Dementia, Chronic Disease
Project to Improve Communication About Serious Illness--Hospital Study: Comparative Effectiveness Trial (Trial 2)
The objective of this protocol is to test the effectiveness of a Jumpstart intervention on patient-centered outcomes for patients with chronic illness by ensuring that they receive care that is concordant with their goals over…
- Conditions
- Dementia, Chronic Disease, Neoplasm Metastasis, Lung Neoplasms
- Trial name
- PICSI-H (NCT04283994)
- Testing
- Survey-based Patient/Clinician Jumpstart, EHR-based Clinician Jumpstart
- Where
- 3 sites in United States
- Volunteers
- 756 people
- Sponsor
- University of Washington
Cystic Fibrosis, Pancreatic Insufficiency
GLP-1 Agonist Therapy in Cystic Fibrosis-Related Glucose Intolerance
Diabetes is a major co-morbidity in pancreatic insufficient cystic fibrosis (PI-CF) and associated with worse outcomes. While reduced β-cell mass contributes to the insulin secretory defects that characterizes cystic…
- Conditions
- Cystic Fibrosis, Pancreatic Insufficiency, Abnormal Glucose Tolerance, Diabetes
- Trial name
- NCT04731272
- Testing
- Dulaglutide 0.75Mg/0.5Ml Inj Pen
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Pennsylvania
Cystic Fibrosis
Impact of Triple Combination CFTR Therapy on Sinus Disease.
The study's main goal is to observe how effective elexacaftor-tezacaftor-ivacaftor is for improving the symptoms and signs of CF-related sinus disease.
- Trial name
- NCT04056702
- Testing
- Elexacaftor-tezacaftor-ivacaftor exposure
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Jennifer Taylor-Cousar
Biliary Atresia, Alagille Syndrome
FibroScan™ in Pediatric Cholestatic Liver Disease (FORCE)
Noninvasive monitoring of liver fibrosis is an unmet need within the clinical management of pediatric chronic liver disease. While liver biopsy is often used in the initial diagnostic evaluation, subsequent biopsies are rarely…
- Conditions
- Biliary Atresia, Alagille Syndrome, Alpha1 Anti-Trypsin Deficiency, Portal Hypertension
- Trial name
- FORCE (NCT02922751)
- Testing
- Liver Stiffness Measurement (LSM)
- Where
- 13 sites in United States, Canada
- Volunteers
- 552 people
- Sponsor
- Arbor Research Collaborative for Health
Pulmonary Fibrosis
Study Evaluating the Safety and Efficacy of Etanercept in Patients With Idiopathic Pulmonary Fibrosis
The objective of the study is to evaluate the safety and efficacy of etanercept in comparison with placebo in a double-blind, parallel, randomized fashion in subjects with idiopathic pulmonary fibrosis (IPF) who failed previous…
- Trial name
- NCT00063869
- Testing
- Etanercept
- Volunteers
- 88 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Cystic Fibrosis
Tele-Coaching Intervention to Improve Treatment Adherence in Cystic Fibrosis
This is a prospective, multicenter pilot study to investigate the feasibility and preliminary effectiveness of a tailored tele-coaching intervention to enhance medical adherence in patients with CF.
- Trial name
- NCT03921229
- Testing
- Tele-coaching
- Where
- 6 sites in United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Idiopathic Pulmonary Fibrosis, Small Airways Disease
Small Airways Disease Functional Assessment in Idiopathic Pulmonary Fibrosis (SWIFT-IPF)
Idiopathic Pulmonary Fibrosis (IPF) is a chronic, fibrosing, and progressive lung disease of unknown cause, whose incidence increases proportionally from the age of 60. It is characterized by a poor prognosis.
- Trial name
- SWIFT-IPF (NCT07312305)
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Milan