Clinical trials: Filariasis
Mansonella Perstans Infection, Mp Microfilaremia
Doxycycline to Treat Mansonella Perstans Infection in Patients With and Without Lymphatic Filariasis
This study will examine: 1) the safety and effectiveness of the drug doxycycline in reducing the number of Mansonella perstans (Mp) worms in the blood of infected patients, and 2) the effects of doxycycline followed by…
- Trial name
- NCT00340691
- Testing
- Doxycycline
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Mycobacterium Infections, Tuberculosis
Effect of Filarial Infection on Immune Responses in Latent Tuberculosis
Background: Lymphatic filariasis is an infection that is caused by small, thread-like worms. It is spread by mosquitoes, and causes fever, chills, and headaches.
- Conditions
- Mycobacterium Infections, Tuberculosis, Filariasis, Latent Tuberculosis
- Trial name
- NCT01547884
- Where
- 2 sites in United States, India
- Volunteers
- 4,268 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Loiasis With Positive Blood Microfilaremia
Assessment and Treatment of Loiasis With Positive Microfilaremia
Loiasis is a vector-borne filariasis endemic in the forested areas in Central Africa whose incidence and morbi-mortality are poorly understood.
- Trial name
- LoPoMi (NCT06194149)
- Volunteers
- 200 people
- Sponsor
- University Hospital, Angers
Helminthiasis, Filariasis
Field Studies on the Feasibility of Interrupting the Transmission of Soil-transmitted Helminths (STH)
Over 1.5 billion people are infected with soil-transmitted helminths (STH). Global STH guidelines recommend MDA (mass drug administration) of albendazole or mebendazole to targeted populations, including pre-school age children…
- Trial name
- NCT03014167
- Testing
- Albendazole
- Where
- 3 sites in Benin, India and 1 more
- Volunteers
- 357,716 people, healthy volunteers welcome
- Sponsor
- University of Washington
Osteoarthritis, Knee, Knee Arthritis
Evaluation and Characterisation of Microplastics and Nanoplastics in Joint Synovial Liquid
The research study aims to evaluate the synovial fluid to highlight the presence of possible micropolymers (micro/nanoplastics) in order to better understand the pathophysiology of joint degenerative processes.
- Conditions
- Osteoarthritis, Knee, Knee Arthritis, Gout Arthritis, Microcrystal Disease
- Trial name
- NCT05678049
- Testing
- Synovial fluid analysis
- Volunteers
- 50 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Loiasis
A 3- to 5-day Clinical Trial of Levamisole in Loiasis Infected Subjects
The aim of the study is to evaluate the safety and efficacy of a 3- and 5-day course of levamisole (2.5 mg/kg) in management of loiasis microfilaremia.
- Trial name
- STOP-FiLAR (NCT06252961)
- Testing
- Levamisole 3 days, Levamisole 5 days
- Where
- 2 sites in Republic of the Congo
- Volunteers
- 99 people
- Sponsor
- Programme National de Lutte contre l'Onchocercose, Republic of the Congo
Onchocercal Subcutaneous Nodule, Onchocerciasis
Safety and Efficacy of Novel Combination Regimens for Treatment of Onchocerciasis
This study will investigate the safety and effectiveness of combination regimens in persons with onchocerciasis when it is administered after pre-treatment with ivermectin to clear or greatly reduce microfilariae from the skin…
- Conditions
- Onchocercal Subcutaneous Nodule, Onchocerciasis, Onchocerciasis, Ocular, Onchocerca Infection
- Trial name
- NCT06070116
- Testing
- Ivermectin w/ Albendazole, Ivermectin + Diethylcarbamazine + Albendazole, Moxidectin + Albendazole
- Where
- Liberia
- Volunteers
- 300 people
- Sponsor
- Washington University School of Medicine
Lymphatic Filariasis, Yaws
PK PD Study of IDA and Azithromycin for NTDs ( ComboNTDs )
This is a Pharmacokinetic and Pharmacodynamic study evaluating the safety of co-administering Azithromycin alongside the new IDA (Ivermectin, Diethylcarbamazine, Albendazole) combination treatment for LF.
- Conditions
- Lymphatic Filariasis, Yaws, Trauma
- Trial name
- NCT03664063
- Testing
- Azithromycin, Albendazole, Ivermectin
- Where
- Papua New Guinea
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Lihir Medical Centre
Malaria, Lymphatic Filariasis
Repeat Ivermectin Mass Drug Administrations for Control of Malaria: a Pilot Safety and Efficacy Study
The purpose of this study is to determine whether repeated ivermectin mass drug administrations to Burkinabé villagers, performed in three week intervals over the rainy-season, is well-tolerated and safe, and also effective in…
- Trial name
- RIMDAMAL (NCT02509481)
- Testing
- Ivermectin, Albendazole
- Where
- 2 sites in United States, Burkina Faso
- Volunteers
- 2,712 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Filariasis
PK, Safety and Tolerability of Single and Multiple Doses of Oxfendazole Tablets
The study evaluates the pharmacokinetics (PK), safety and tolerability of oxfendazole, after administration as a tablet formulation in healthy male and female participants.
- Trial name
- HELP-OFZ (NCT04920292)
- Testing
- Oxfendazole
- Where
- Tanzania
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Swiss Tropical & Public Health Institute
Onchocerciasis
A Pharmacokinetic and Safety Study of Moxidectin to Identify an Optimal Dose for Treatment of Children 4 to 11 Years
The primary purpose of this study is to determine a dose of moxidectin for children 4 to 11 years that is equivalent to an 8 mg dose administered for treatment of onchocerciasis in people 12 years and over.
- Trial name
- NCT03962062
- Testing
- Moxidectin
- Where
- Ghana
- Volunteers
- 36 people
- Sponsor
- Medicines Development for Global Health
Ivermectin, Onchocerciasis
Ivermectin Treatment in Patients With Onchocerciasis-associated Epilepsy
Many studies have reported an association between epilepsy, including Nodding Syndrome (NS), and onchocerciasis (river blindness).
- Conditions
- Ivermectin, Onchocerciasis, Epilepsy
- Trial name
- OAETREAT (NCT03052998)
- Testing
- Ivermectin
- Where
- Democratic Republic of the Congo
- Volunteers
- 91 people
- Sponsor
- Robert Colebunders
Onchocerciasis
Emodepside Phase II Trial for Treatment of Onchocerciasis
The trial evaluates safety, tolerability, pharmacodynamics, pharmacokinetics, dose-response, and efficacy of emodepside tablets, administrated as a range of dose regimens, in adults infected with Onchocerca Volvulus.
- Trial name
- NCT05180461
- Testing
- emodepside, ivermectin
- Where
- 3 sites in Democratic Republic of the Congo, Ghana
- Volunteers
- 578 people
- Sponsor
- Drugs for Neglected Diseases
Malaria, Filarial Infection
Immune Response Regulation in People Infected Concurrently With Malarial and Filarial Parasites
This study, conducted by NIH and the University of Bamako in Mali, Africa, will study the effect of concurrent infections with malaria and filariasis on patients' immune response.
- Trial name
- NCT00341666
- Where
- Mali
- Volunteers
- 360 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Schistosomiasis
Effect of Concomitant Mansonella Perstans Microfilaremia on Immune Responses Following Single Dose Praziquantel in People With Schistosomiasis
Background: Schistosomiasis is a chronic infection. It is caused by parasitic worms called Schistosoma haematobium (Sh) that are spread by snails that live in rivers. It can lead to liver problems or bladder cancer.
- Trial name
- NCT02734186
- Testing
- Praziquantel
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)