Clinical trials: First Pregnancy
Voluntary Termination of Pregnancy
Preoperative Ultrasound Evaluation of Gastric Contents in Voluntary Termination of Pregnancy During the First Trimester
This is an observational, prospective, monocentric, diagnostic study aiming to evaluate the diagnostic properties of the presence of nausea-vomiting in predicting the existence of gastric contents in preoperative surgical…
- Trial name
- ECHONAV (NCT06210308)
- Testing
- Data collection from gastric ultrasound
- Where
- France
- Volunteers
- 304 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Premature; Infant
Comparing of High Flow Nasal Cannula Versus Cpap for Initial Respiratory Stabilisation of Very Premature Infants
Non-invasive continuous positive airway pressure (CPAP) stabilizes premature newborns, but its optimal pressure is unknown. High-flow nasal cannula (HFNC) is an alternative that minimizes trigeminal stimulation but lacks precise…
- Trial name
- SIMPLSAFE3 (NCT06543589)
- Testing
- High-flow-nasal-cannula
- Volunteers
- 443 people
- Sponsor
- Charles University, Czech Republic
Recurrent Miscarriage
Habitual Abortion Study: Oral Dydrogesterone Treatment During Pregnancy in Women With Recurrent Miscarriage
The purpose of this clinical study is to demonstrate the shift from inflammatory cytokines to non-inflammatory cytokines in women suffering from habitual abortion treated with dydrogesterone (Duphaston).
- Trial name
- NCT00193674
- Testing
- Dydrogesterone
- Where
- 3 sites in Austria, Poland
- Volunteers
- 71 people
- Sponsor
- Abbott Products
Metastatic Renal Cell Carcinoma, Good or Only One Adverse Prognostic Factor Intermediate Risk Per IMDC Score
Treatment Pause Versus Treatment Continuation in IMDC Good or Intermediate Risk With Only One Adverse Prognostic Factor in mRCC Patients With an Objective Response at 12 Months of Treatment With PD1/ PDL1 ICIs + VEGFR-Tyrosine Kinase Inhibitors
The purpose of this study is to demonstrate the non-inferiority of treatment pause versus treatment continuation in good or intermediate risk with only one adverse prognostic factor as per IMDC mRCC patients with a confirmed…
- Trial name
- SPICI (NCT05219318)
- Testing
- Combination PD-1/PD-L1 ICI + VEGFR-TKI, Treatment pause
- Where
- 26 sites in France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Bordeaux
Premature Birth
Vermont Intervention: Effect on Joint Attention Skills Between Parents and Moderate/Late Preterm Infants in the First Year of Life
The purpose of this study is to investigate if the effects of the Vermont intervention, implemented by nurses in a Neonatal Intensive Care Unit (NICU), can influence social interaction and joint attention skills between parents…
- Trial name
- NCT00245843
- Testing
- Mother Infant Transaction Program (MITP)
- Where
- Norway
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Ullevaal University Hospital
Pregnancy Related
Women's Refusal to Participate in a Randomized Trial Involving First-trimester Screening for Pre-eclampsia: Factors Associated With Refusal and Reasons for Acceptance and Refusal
The main objective is to assess whether there are factors associated with women's refusal to participate in a randomized clinical trial involving first-trimester screening for pre-eclampsia.
- Trial name
- RANSPRE-refus (NCT06322771)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 472 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preeclampsia
A Study to Evaluate the Use of Placenta Protein 13 (PP13) in the First Trimester of Pregnancy as a Diagnostic Aiding Tool in the Assessment of the Risk for Developing Preeclampsia in Women With Low and Unknown Risk
The purpose of this study is to evaluate whether it is possible to detect changes in the concentration of PP13 in the blood of pregnant women who may go on to develop the complication of preeclampsia later on in the pregnancy…
- Trial name
- NCT00572793
- Where
- United States
- Volunteers
- 431 people, healthy volunteers welcome
- Sponsor
- Carl Weiner, MD
Relapse, Advanced Malignant Neoplasm
A Phase 1 Clinical Trial of AUR106 in Patients With Relapsed Advanced Malignancies
A Phase I, Open Label, Dose-Escalation, First in Human (FIH) Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics and Efficacy of AUR106 in Patients with Select Relapsed Advanced Malignancies (JIVAN).
- Conditions
- Relapse, Advanced Malignant Neoplasm, Non Small Cell Lung Cancer, Gastric Cancer
- Trial name
- JIVAN (NCT05861947)
- Testing
- AUR106
- Where
- 6 sites in India
- Volunteers
- 21 people
- Sponsor
- Aurigene Discovery Technologies Limited
Chronic Kidney Disease (CKD) Stage 5, Kidney Dysfunction Requiring Dialysis (KDRD)
Incremental Hemodialysis for Veterans in the First Year of Dialysis (IncHVets)
In this pragmatic clinical trial, which will dovetail with Veterans' routine outpatient dialysis clinic visits in six VA medical centers, the investigators will study 252 Veterans with kidney disease who need to start dialysis…
- Conditions
- Chronic Kidney Disease (CKD) Stage 5, Kidney Dysfunction Requiring Dialysis (KDRD), Dialysis Dependency
- Trial name
- INCHVETS (NCT05465044)
- Testing
- Twice-weekly hemodialysis with incremental crossover to thrice-weekly schedule, Thrice-Weekly Hemodialysis
- Where
- 8 sites in United States
- Volunteers
- 252 people
- Sponsor
- VA Office of Research and Development
Solid Tumor, Adult, Breast Cancer
PROCLAIM-CX-2009: A Trial to Find Safe and Active Doses of an Investigational Drug CX-2009 for Patients With Selected Solid Tumors
The purpose of this first-in-human study of CX-2009 is to characterize the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and antitumor activity of CX-2009 in adult subjects with metastatic or locally advanced…
- Conditions
- Solid Tumor, Adult, Breast Cancer, Non Small Cell Lung Cancer, Head and Neck Cancer
- Trial name
- NCT03149549
- Testing
- CX-2009
- Where
- 26 sites in United States, Netherlands and 2 more
- Volunteers
- 99 people
- Sponsor
- CytomX Therapeutics
Ovarian Cancer
Gemcitabine in Ovarian Cancer
The primary endpoint of this study is to assess the objective tumor response rate in patients with advanced epithelial ovarian cancer receiving combination of Gemcitabine at a dose 1250 mg/m2 (Day 1 and 8) with Cisplatin 75 mg/m2…
- Trial name
- NCT00191334
- Testing
- gemcitabine, cisplatin
- Where
- 5 sites in Russia
- Volunteers
- 50 people
- Sponsor
- Eli Lilly and Company
Ovarian Cancer
Evaluation of Safety, Tolerability, Pharmacokinetics, Food Effect and Interaction With Midazolam in Healthy Volunteers After Oral Single and Multiple Ascending Dosing of KAND145
The goal of this study is to learn more about the study candidate drug, KAND145, when given to healthy volunteers. The study will consist of two parts.
- Trial name
- NCT06063343
- Testing
- KAND145
- Where
- Finland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Novakand Pharma AB
Rupture of Membranes Prior to Onset of Labor, Induction of Labor
Intravenous Dexamethasone for Inducing Labor in Women With Term Pregnancy and Pre-Labour Rupture of Membranes
This clinical trial aims to determine whether giving intravenous dexamethasone can shorten the time it takes for women to deliver after labor induction in term pregnancies with pre-labour rupture of membranes (PROM).
- Conditions
- Rupture of Membranes Prior to Onset of Labor, Induction of Labor, Dexamethasone
- Trial name
- NCT07503184
- Testing
- Dexamethasone, Prostaglandin E1, Normal Saline
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Nishtar Medical University
Endometrial Cancer, Recurrent Endometrial Carcinoma
First-line Carboplatin and Paclitaxel in Combination With Pembrolizumab, Followed by Maintenance Pembrolizumab With or Without Nesuparib, in Patients With Newly Diagnosed Advanced or Recurrent MMR-proficient (pMMR) Endometrial Cancer
The goal of this study is listed below. Part A (Safety Run-in Phase) : To determine feasibility of pembrolizumab and nesuparib combination as maintenance therapy in patients with MMR-proficient advanced and recurrent endometrial…
- Conditions
- Endometrial Cancer, Recurrent Endometrial Carcinoma, Endometrial Carcinoma, Gynecologycal Cancer
- Trial name
- PENELOPE (NCT06502743)
- Testing
- Nesuparib, Pembrolizumab
- Where
- 6 sites in South Korea
- Volunteers
- 92 people
- Sponsor
- Yonsei University
Gingivitis, Pregnancy
Oral Hygiene and Maternity Outcomes Multicenter Study (OHMOM)
This study will track changes in oral health in pregnant women. Subjects will be assigned to either regular oral care or advanced oral care and be given oral care products to use until they deliver.
- Trial name
- OHMOM (NCT01549587)
- Testing
- 0.243% sodium fluoride, toothbrush, dental floss
- Where
- 2 sites in United States
- Volunteers
- 746 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Vaginal Delivery
Outcomes of Delivery in Primigravida
Primigravida women are a high-priority population due to their increased risk of obstetric interventions and adverse outcomes compared to multiparous women.
- Trial name
- NCT07075848
- Testing
- vaginal delivery
- Volunteers
- 200 people
- Sponsor
- Assiut University
Ovarian Neoplasms
TAX + Carboplatin or Cisplatin 1st Line Post-Surgery Ovarian
Evaluate response rate of Docetaxel in combination with Carboplatin or Cisplatin as first line chemotherapy in epithelial ovarian cancer.
- Trial name
- NCT00539669
- Testing
- Docetaxel
- Where
- South Korea
- Volunteers
- 47 people
- Sponsor
- Sanofi
Cancer
A Phase I, Open-Label, First-Time-In-Human Study of the Oral AKT Inhibitor GSK2141795
This study is a first time in human, Phase I, open-label, dose-escalation study of the oral AKT inhibitor GSK2141795 in subjects with solid tumors or lymphomas.
- Trial name
- NCT00920257
- Testing
- GSK2141795
- Where
- 7 sites in United States, Canada
- Volunteers
- 77 people
- Sponsor
- GlaxoSmithKline
Renal Cell Carcinoma
A Prospective Study on Sunitinib as First Line Therapy for Advanced/Metastatic Renal Cell Carcinoma in Asian Population
This is a multi-national, phase II, single arm study to explore the safety/efficacy and potential biomarkers on sunitinib 2/1 schedule for Asian patients with advanced renal cell carcinoma.
- Trial name
- NCT02626754
- Testing
- Sunitinib malate
- Where
- 7 sites in Taiwan
- Volunteers
- 13 people
- Sponsor
- vghtpe user
Pregnancy Related
Effects of Antenatal Exercises on Maternal Birth Outcomes
The study is aimed to determine the effects of pelvic floor stretching Vs strengthening on maternal birth outcomes and postpartum urogenital distress in primigravida.
- Trial name
- NCT05936866
- Testing
- Pelvic floor stretching, Pelvic floor strengthening
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
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