Clinical trials: First Trimester Abortion
Medical; Abortion, Fetus
Comparison of Rate of Complete Abortion Between Letrozole Plus Misoprostol vs Misoprostol Alone
Comparison of rate of complete abortion between Letrozole plus Misoprostol versus Misoprostol alone in first trimester pregnancy
- Trial name
- NCT05940233
- Testing
- Letrozole
- Where
- Thailand
- Volunteers
- 70 people
- Sponsor
- Queen Savang Vadhana Memorial Hospital, Thailand
Spontaneous Abortion in First Trimester
Comparing Buccal and Vaginal Misoprostol in Management of Early Pregnancy Loss
First trimester miscarriages are common. When the failed pregnancy does not pass spontaneously on its own, it is called a missed abortion.
- Trial name
- NCT02141555
- Testing
- Vaginal Misoprostol, Buccal Misoprostol
- Where
- 2 sites in United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Miscarriage
Misoprostol for Management of Women With an Incomplete Miscarriage
Miscarriage is defined as the spontaneous loss of a pregnancy before 24 weeks gestation, that is, before fetal viability. The clinical signs of miscarriage are usually vaginal bleeding associated with abdominal pain and cramping.
- Trial name
- NCT05088720
- Testing
- misoprostol 800 µg, misoprostol 400 µg
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Aswan University Hospital
IUCD Complication
Isonicotinic Acid Hydrazide (INH) Pretreatment With Misoprostol Versus Misoprostol Alone in Missed Abortion
The primary endpoint was the success rate of adjuvant isonicotinic acid hydrazide (INH) and misoprostol versus misoprostol alone for medical termination of first-trimester pregnancy.
- Trial name
- NCT04500002
- Testing
- Isonicotinic Acid Hydrazide, Misoprostol
- Where
- Egypt
- Volunteers
- 240 people
- Sponsor
- Aswan University Hospital
Abortion in First Trimester
Transcutaneous Electrical Nerve Stimulation (TENS) for Pain Control During First Trimester Abortion
High-frequency, high-intensity transcutaneous electrical nerve-stimulation (TENS) is an inexpensive and non-invasive pain control approach.
- Trial name
- NCT03187002
- Testing
- Transcutaneous electrical nerve stimulation (TENS), Moderate IV Sedation
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Stanford University
Abortion Early, Abortion in First Trimester
Delivery of Audiovisual Information on Early Medical Abortion
The majority of abortions in the United Kingdom (UK) are performed before 9 weeks (63 days) gestation using a method known as Early Medical Abortion (EMA).
- Trial name
- EMAVID (NCT03417362)
- Testing
- Animation
- Where
- 3 sites in France, Sweden and 1 more
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- NHS Lothian
Pain
Hydrocodone For Pain Control in First Trimester Surgical Abortion
The purpose of this study is to determine whether preoperatively administered hydrocodone/acetaminophen (HC/APAP) reduces pain during a first trimester surgical abortion.
- Trial name
- NCT01330459
- Testing
- Hydrocodone/acetaminophen, Ibuprofen, Lorazepam
- Where
- 2 sites in United States
- Volunteers
- 121 people
- Sponsor
- Elizabeth Micks
First Trimester Abortion
A Randomized Controlled Trial of Three Antibiotic Regimens for First Trimester Abortions
This study, a double blinded randomized controlled trial, is being done to compare side effects of commonly used antibiotic regimens prior to same day abortion procedures.
- Trial name
- NCT02756403
- Testing
- Azithromycin, Doxycycline, Metronidazole
- Where
- 2 sites in United States
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Medstar Health Research Institute
Pregnancy Loss, Early
Patient Satisfaction With the Management of a Stopped Pregnancy in the First Trimester
The clinical practice recommendations highlight the fact that the patient's choice concerning the management of her aborted pregnancy in the first trimester should be privileged, after clear and appropriate information on the…
- Trial name
- MYFEFACY (NCT05049980)
- Testing
- Medical treatment with Mifégyne® and MisoOne®, Endo-uterine aspiration
- Where
- France
- Volunteers
- 52 people
- Sponsor
- University Hospital, Toulouse
Retained Products of Conception Post Abortion
Oral Contraceptive Pills Versus Expectant Management for Retained Pregnancy Products
We speculate that the use of combined oral contraceptives may be a possible solution to promote the management of retained pregnancy products versus expectant management.
- Trial name
- NCT03230825
- Testing
- Oral contraceptive, Expectant management
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Threatened Abortion in First Trimester
Progesterone in Threatened Abortion
The main objective of this study will be to assess the efficacy of natural progesterone at a daily dose of 25 mg/bid in the maintenance of early pregnancy in women with symptoms of threatened abortion.
- Trial name
- NCT02950935
- Testing
- Progesterone
- Where
- 4 sites in Italy
- Volunteers
- 4 people
- Sponsor
- IBSA Institut Biochimique SA
Pregnancy Termination in First Trimester
Patient Preferences in Anesthesia for Abortion Care
This study will use semi-structured interviews with participants in a prospective cohort study to explore women's experiences of pain and preferences in pain management during first trimester surgical abortion to create a more…
- Trial name
- PAC (NCT03030443)
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Abortion Threatened
Biochemical Versus Ultrasound Findings as Predictors of Fetal Loss in Cases of First Trimester Threatened Miscarriage
Threatened miscarriage occurs in about one-fifth of pregnancies with an estimated miscarriage rate of 3-16% after successful demonstration of fetal cardiac activity.
- Trial name
- NCT03797508
- Testing
- ultrasound
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Ain Shams University
Miscarriage
Comparison Between Letrozole and Mifepristone in Medical Termination of First Trimester Miscarriages
Prospective interventional study where participants with non-viable pregnancy at 1st trimester will be randomized into two arms, one group will receive conventional treatment with oral mifepristone followed by misoprostol…
- Trial name
- NCT05304273
- Testing
- Mifepristone, Letrozole
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Calcutta National Medical College and Hospital
Abortion, Therapeutic
A Randomized Study of Cervical Priming With Misoprostol Prior to Elective First Trimester Pregnancy Termination
The purpose of this study is to determine whether misoprostol administered prior to elective first trimester pregnancy has an effect on pain and ease of procedure and complications.
- Trial name
- NCT00310921
- Testing
- Misoprostol
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Abortion in First Trimester, Abortion Early
A Patient Decision Aid for Method of Early Abortion: a Randomized Control Trial
Introduction: There are two options for women seeking early pregnancy termination in Canada; either surgical or medication abortion.
- Conditions
- Abortion in First Trimester, Abortion Early, Decision Aid, Clinical Decision-making
- Trial name
- NCT05182008
- Testing
- Decision aid, Usual care
- Where
- Canada
- Volunteers
- 365 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Cervical Preparation
Mifepristone vs Misoprostol
The Investigator team hypothesizes that in a randomized trial comparing mifepristone-alone or misoprostol-alone for cervical preparation for procedural abortions at 12 to 16 weeks in hospital-based care, the proportion of…
- Trial name
- NCT06502158
- Testing
- Mifepristone, Misoprostol
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Abortion, First Trimester, Pain Management
Virtual Reality as a Method for Pain and Anxiety Control During First Trimester Procedural Abortion
The goal of this clinical trial is to learn whether use of a virtual reality (VR) headset showing a meditative nature video will help reduce pain and anxiety during a first trimester procedural abortion.
- Conditions
- Abortion, First Trimester, Pain Management, Pain After Surgery, Satisfaction
- Trial name
- CALM-VR (NCT07288047)
- Testing
- VR headset, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- Study Investigator
Voluntary Termination of Pregnancy
Preoperative Ultrasound Evaluation of Gastric Contents in Voluntary Termination of Pregnancy During the First Trimester
This is an observational, prospective, monocentric, diagnostic study aiming to evaluate the diagnostic properties of the presence of nausea-vomiting in predicting the existence of gastric contents in preoperative surgical…
- Trial name
- ECHONAV (NCT06210308)
- Testing
- Data collection from gastric ultrasound
- Where
- France
- Volunteers
- 304 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Abortion in First Trimester, Pain, Procedural
Ketamine Versus Fentanyl for Surgical Abortions
Ketamine is commonly used for procedural sedation and analgesia. It is widely used for trauma cases in the emergency department and is considered a superior agent in the outpatient setting due to its lack of respiratory and…
- Conditions
- Abortion in First Trimester, Pain, Procedural, Opioid Use
- Trial name
- NCT04871425
- Testing
- Ketamine, Fentanyl
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Washington