Clinical trials: First Trimester Abortion
Abortion Early
Dry vs Wet Misoprostol for Cervical Dilation in First Trimester Abortion
This study aims to verify whether the moisture of 400 µg of misoprostol pre uterine evacuation increases the dilatation of uterine cervix compared to dry misoprostol
- Trial name
- MisoWet (NCT02522078)
- Testing
- dry misoprostol, wet misoprostol
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Abortion, Spontaneous, Abortion in First Trimester
Effect of Paracervical Block Volume on Pain Control for Dilation and Curettage.o
The investigators are conducting a study on pain control for dilation and curettage (D\&C). Participants are eligible to enroll if they are a planning to have a D\&C in a participating clinic.
- Conditions
- Abortion, Spontaneous, Abortion in First Trimester, Pain Uterus, Abortion Early
- Trial name
- NCT03636451
- Testing
- 40cc buffered 0.5% lidocaine with 2 units of vasopressin paracervical block, 20cc 1% lidocaine with 2 units of vasopressin paracervical block
- Where
- 2 sites in United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Abortion in First Trimester
The Use of Letrozole or Mifepristone for Pretreatment of Medical Termination of Pregnancy
Medical termination of pregnancy (mTOP) generally involves using either a combined regimen consisting of mifepristone and misoprostol, or a misoprostol-only regimen.
- Trial name
- NCT05341817
- Testing
- Letrozole, Mifepristone
- Where
- Singapore
- Volunteers
- 144 people
- Sponsor
- KK Women's and Children's Hospital
Miscarriage, Missed Abortion
Letrozole Pretreatment With Misoprostol fInduction of Abortion In First-Trimester Missed Miscarriage
This study compares the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of first trimester pregnancy.
- Trial name
- NCT03628625
- Testing
- Letrozole 2.5mg, Misoprostol
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Missed Abortion
Comparative Study Between Combined Vaginal Misoprostol
"Comparative study between Combined Vaginal Misoprostol with Isosorbide-5-Mononitrate
- Trial name
- comparative (NCT04981457)
- Testing
- Misoprostol and iso sorbide mononitrates
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Missed Abortion
Buccal Versus Vaginal Misoprostol in Surgical Termination of the First Trimester Missed Abortion in Erbil
The purpose of this study is to determine the effectiveness of buccal misoprostol and comparing this with vaginal route of the same drug.
- Trial name
- NCT00892229
- Testing
- Misoprostol (given buccally), Misoprostol (given vaginally)
- Where
- Iraq
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hawler Medical University
Induced Abortion
Is Oxytocin Given During Surgical Procedure for Abortion Before 12 Weeks of Pregnancy Useful?
This is a randomized, single-blind study using oxytocin 5U i.v. during surgical abortion in one arm of the study, and no medication in the other arm of the study.
- Trial name
- oxystudien (NCT00540748)
- Testing
- oxytocin
- Where
- Norway
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Asker & Baerum Hospital
Miscarriage
Serum Kisspeptin: a Predictive Marker of Miscarriage or Not?
This is a prospective observational study. Eligible women undergo ART treatment in our centre will be recruited for the study and each woman will only be included in the study once. Informed written consent will be obtained.
- Trial name
- NCT03940495
- Where
- China
- Volunteers
- 182 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
First-trimester Pregnancy
Abortions at Strasbourg University Hospitals
The number of abortions in France and Strasbourg has been stable for several years. In 2017, 1847 were performed in the Gynecology-Obstetrics Department for 6146 deliveries (23% of all pregnancies).
- Trial name
- NCT04101175
- Testing
- Evaluation of the procedure of abortion
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- University Hospital, Strasbourg, France
Miscarriage
Management of Women With an Incomplete Miscarriage
Miscarriage is defined as the spontaneous loss of a pregnancy before 24 weeks' gestation, that is, before the fetal viability. The clinical signs of miscarriage are usually vaginal bleeding associated abdominal pain and cramping…
- Trial name
- NCT03148561
- Testing
- Misoprostol
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Assiut University
First Trimester Abortion
Early Pregnancy Ultrasound Measurements and Prediction of First Trimester Pregnancy Loss.
Ultrasound measurements of fetus during first trimester may be an indicator of first trimester pregnancy loss. Investigators took 4 measurements of the fetus on 2 intervals during first trimester to confirm this hypothesis.
- Trial name
- NCT06540092
- Testing
- ultrasound
- Where
- Egypt
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Abortion, First Trimester
Acceptability and Feasibility of Medical Abortion Using Mifepristone and Buccal Misoprostol
This study examined the acceptability and feasibility of introducing a mifepristone-misoprostol regimen of medical abortion into abortion services in two private clinics in Puerto Rico; 2 clinics in Baku, Azerbaijan; 3 clinics in…
- Trial name
- NCT00386282
- Testing
- mifepristone-misoprostol treatment
- Where
- 11 sites in Armenia, Azerbaijan and 2 more
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Miscarriage in First Trimester
Misoprostol 400 µg Versus 200 µg for Cervical Ripening in 1st Trimester Miscarriage
Local current protocol for cervical ripening in 1st trimester miscarriage recommends 400 µg of misoprostol intravaginally 3 hours before uterine evacuation. This regime has been recommended by some international guidelines .
- Trial name
- MISO200 (NCT02957305)
- Testing
- Misoprostol 400mcg Tab, Misoprostol 200mcg Tab
- Where
- Brazil
- Volunteers
- 211 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Abortion, Induced
Different Routes of Misoprostol Prior to First Trimester Surgical Abortion
A randomized clinical trial to assess the effectiveness of same-day cervical preparation with oral, buccal or vaginal Misoprostol, given 2-4 hours prior first trimester curettage.
- Trial name
- NCT02480543
- Testing
- Misoprostol (cytotec)
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Recurrent Spontaneous Abortion
Difference Between Mean Gestational Sac Diameter and Crown-rump Length as a Marker of First-trimester Pregnancy Outcome in Patients With Recurrent Spontaneous Abortion
Objective: To determine the effect and predictive value of the difference between the mean gestational diameter (mGSD) sac and crown-rump length (CRL) of the first trimester on the pregnancy outcomes of patients with recurrent…
- Trial name
- mGSD-CRL& RSA (NCT06081556)
- Testing
- ultrasonic testing
- Where
- China
- Volunteers
- 256 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Abortion, Induced, Pain
Paracervical Versus Intracervical Lidocaine
The aim of this study is to estimate the efficacy of intracervical versus paracervical block on pain experienced during first trimester suction curettage without the use of preoperative cervical ripening.
- Trial name
- NCT00816751
- Testing
- Paracervical block, Intracervical, Buffered Lidocaine, vasopressin, sodium bicarbonate
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Pregnancy
Randomized Double-blind Controlled Trial of Use of Dydrogesterone in Threatened Miscarriage
The aim of this study is to determine whether the dydrogesterone therapy is associated with reduction in miscarriage in women with first trimester threatened miscarriage.
- Trial name
- NCT02128685
- Testing
- Dydrogesterone
- Where
- 3 sites in Hong Kong
- Volunteers
- 406 people
- Sponsor
- The University of Hong Kong
Missed Abortion
Letrozole Pretreatment With Misoprostol Induction of Abortion In First-Trimester Missed Miscarriage
This study compares the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of first-trimester pregnancy among women with one or more previous cesarean deliveries.
- Trial name
- NCT04215835
- Testing
- letrozole then misoprostol
- Volunteers
- 200 people
- Sponsor
- Cairo University
Abortion, First Trimester
Acceptability and Feasibility of a Simplified Medical Abortion Regimen in Georgia
This study examined the acceptability and feasibility of using a simplified regimen of medical abortion in the eastern and western regions of the country of Georgia.
- Trial name
- NCT02398838
- Testing
- Home administration of 200 mg mifepristone, Home or clinic administration of 400 mcg buccal misoprostol
- Where
- 4 sites in Georgia
- Volunteers
- 622 people
- Sponsor
- Gynuity Health Projects
Contraception
Study of Immediate Start of Progestin Contraceptives in Medical Abortion
This study will compare immediate to post-abortion start of two progestin-based contraceptives (DMPA and etonorgestrel implants) among women having first trimester medical abortion who wish to use that method for post-abortion…
- Trial name
- Quickstart (NCT01902485)
- Testing
- Timing of Contraceptive Initiation in Medical Abortion
- Where
- 8 sites in United States, Mexico
- Volunteers
- 937 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects