Clinical trials: First-episode Psychosis
Schizophrenia, Psychotic Disorders
CAFE Comparison of Atypicals in First Episode of Psychosis
The purpose of this study is to compare the effectiveness, tolerability, and efficacy of the currently available atypical antipsychotic drugs olanzapine (2.5-20 mg/day), quetiapine (100-800 mg/day) and risperidone (0.5-4 mg/day)…
- Conditions
- Schizophrenia, Psychotic Disorders, Mental Health, Mental Disorders
- Trial name
- NCT00034892
- Testing
- Olanzapine, risperidone
- Where
- 26 sites in United States, Canada
- Sponsor
- AstraZeneca
First-episode Psychosis
Biomarkers Predictive of Thymic Evolution and Therapeutic Response at 2 Years in Patients With a First Psychotic Episode
Psychosis is a severe, common, and disabling psychological disorder. An epidemiological study conducted in England reported an incidence of 34 new cases per 100,000 person-years, with a peak between 16 and 19 years of age.
- Trial name
- PEPAMARKER (NCT05384392)
- Testing
- Recorded interview, Clinical scales, Blood sample
- Where
- 5 sites in France
- Volunteers
- 217 people
- Sponsor
- University Hospital, Brest
Cognitive Impairment, Psychosis
Action-based Cognitive Remediation for First Episode Psychosis
Cognitive impairments are a core and enduring feature of first-episode psychosis and schizophrenia, and are associated with significant functional impairment.
- Trial name
- NCT03814122
- Testing
- Action-based cognitive remediation, Waitlist Control Group
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- University of Manitoba
Schizophrenia, First Episode Psychosis
Using Digital Media Advertising to Reduce the Duration of Untreated Psychosis
There is compelling evidence that longer duration of untreated psychosis independently predicts negative outcomes. The proposal aims to explore whether targeted and proactive online outreach through search engine advertisements…
- Trial name
- NCT03975400
- Testing
- search engine advertisement campaign
- Where
- 2 sites in United States
- Volunteers
- 698 people
- Sponsor
- Northwell Health
Schizophrenia and Disorders With Psychotic Features, Affective Disorders, Psychotic
Anomalous Self-Experience in First Episode Psychosis - A Six-Year Follow-Up Study
The objective of this study is to explore the longitudinal course of self-disturbances (SD) in schizophrenia. The main aim of the study is to investigate, in a 6-7-year follow-up of a representative sample of patients with…
- Conditions
- Schizophrenia and Disorders With Psychotic Features, Affective Disorders, Psychotic, Self Concept
- Trial name
- NCT02321943
- Where
- Norway
- Volunteers
- 56 people
- Sponsor
- Sykehuset Innlandet HF
First-episode Psychosis
HIIT in Patients With a First-episode Psychosis
This study aims to estimate the effect of a 3-month High Intensity Interval Training on antipsychotic-induced weight gain in patients with a first episode of psychosis, as well as to determine whether these effects are maintained…
- Trial name
- NCT04792476
- Testing
- High Intensity Interval Training
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Intervención Temprana en Psicosis de Cantabria (ITPCan)
Schizophrenia, Schizophrenia Relapse
10-year Follow-up of Clinical Outcome After Antipsychotic Treatment Discontinuation in Psychosis Individuals
This open-label, non-randomized, prospective study will evaluate the risk of symptoms recurrence during the ten years after antipsychotic discontinuation in a sample of functionally recovered first-episode patients with…
- Conditions
- Schizophrenia, Schizophrenia Relapse, Schizophrenia Spectrum and Other Psychotic Disorders
- Trial name
- ADARFEP_10Y (NCT03090490)
- Testing
- Antipsychotic treatment discontinuation, Maintenance treatment discontinuation
- Where
- Spain
- Volunteers
- 68 people
- Sponsor
- Fundación Marques de Valdecilla
Schizophrenia
Pan European Collaboration on Antipsychotic Naive Schizophrenia (PECANS)
The investigators want to relate disturbances in first-episode schizophrenic patients in (dopaminergic) D2 receptors, brain structure, brain function, and information processing to each other and to psychopathology.
- Trial name
- PECANS (NCT01154829)
- Testing
- amisulpride, aripiprazole
- Where
- Denmark
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Psychosis
Cognitive Behavior Therapy (CBT) Informed Mobile-Application for First Episode Psychosis
Onset of First Episode Psychosis (FEP) is at a young age and is a critical period influencing the long-term course of the disorder.
- Trial name
- TechCare (NCT05567575)
- Testing
- Cognitive Behavioral Therapy,
- Where
- 2 sites in Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Living and Learning
Schizophrenia
Relapse Prevention in First Episode Schizophrenia: a 5 Year Trial
Objective: to evaluate the effectiveness of specialised and sustained intervention with or without parent groups during the initial phase of schizophrenia or related disorders on relapse prevention Methods: A three conditions…
- Trial name
- NCT01936220
- Testing
- Continuity of specialized care, Parent groups combined with Continuity of Specialized care, Discontinuity of care, non specialised care
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Schizophrenia, Schizophreniform Disorder
A German Multicenter Study on Toxoplasma Gondii in First-episode Schizophrenia
Environmental risk factors for the development of schizophrenia include infections during the perinatal period or later in life with Toxoplasma gondii (TG) being one of the candidate agents.
- Conditions
- Schizophrenia, Schizophreniform Disorder, Schizoaffective Disorder
- Trial name
- NCT00686400
- Testing
- TAU = treatment as usual
- Where
- 3 sites in Germany
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Clinical High Risk, Early Psychosis
Digital Strategies to Advance Help-Seeking Aim 1 and 2
This proposal aims to establish a Digital Laboratory focused on advancing help-seeking and expediting treatment initiation in youth ages 12-29 who are at Clinical High-Risk (CHR) for developing psychosis.
- Conditions
- Clinical High Risk, Early Psychosis, First Episode Psychosis
- Trial name
- NCT06774430
- Where
- United States
- Volunteers
- 25,000 people
- Sponsor
- Columbia University
Schizophrenia
The Danish Region Midt Schizophrenia Cohort
The objective of this study is to recruit patients at the first diagnosis with a schizophrenia spectrum disorder (SSD) and ultra-high risk patients (UHR), defined as patients with drug abuse and psychotic symptoms indicating a…
- Trial name
- RMS (NCT06431009)
- Testing
- Treatment-as-usual
- Where
- 5 sites in Denmark
- Volunteers
- 350 people
- Sponsor
- University of Aarhus
Schizophrenia
Treating Psychotic Symptoms of Young Individuals Presenting a First Episode of Schizophrenia: Comparison of Two State-of-the-Art Interventions
To verify the efficacy of a group cognitive-behavioral therapy approach to lessening psychotic symptoms of individuals with a first episode of psychosis, and to compare its effects to a known skills training approach and a…
- Trial name
- NCT00358709
- Testing
- Cognitive-Behavioral therapy and Symptom Management
- Where
- Canada
- Volunteers
- 129 people
- Sponsor
- University of British Columbia
Schizophrenia
Assertive Community Treatment (ACT) in Schizophrenia Spectrum Disorders
The study examined the 12-month effectiveness of continuous therapeutic assertive community treatment (ACT) as part of integrated care (IC) compared to standard care (SC) in a catchment area comparison design in patients with…
- Trial name
- ACCESS (NCT01081418)
- Testing
- Assertive Community Treatment (ACT)
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Auditory Perception
Auditory Localization in Schizophrenia
Auditory sound localization is the ability to identify the position of a sound source in space. It is defined into 3 dimensions: by its position in azimuth, elevation and distance.
- Trial name
- LOCIZ (NCT06974513)
- Testing
- cognitive experiments' session
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Schizophrenia, First-Episode
Optimization of Acute Treatment in First Episode Schizophrenia
The study is a multicenter, double-blind, randomized, parallel-group study with first episode schizophrenic patients. During a treatment phase of 8 weeks the patients are treated with Risperidone or Haloperidol.
- Trial name
- NCT00157378
- Testing
- Risperidone, Haloperidol
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Delusional Disorder, Brief Psychotic Disorder
FEEL-GOOD: A Multicenter Trial of a Mindfulness-Based Group Therapy in Young Adults With Early Psychosis
FEEL-GOOD is a prospective multi-site single-blinded randomized controlled trial in young inpatients with acute early psychosis. Participants are randomized 1:1 to FEEL-GOOD plus treatment as usual (TAU) or TAU alone.
- Conditions
- Delusional Disorder, Brief Psychotic Disorder, Schizophreniform Disorder, Schizophrenia / Schizoaffective Disorder
- Trial name
- FEEL-GOOD (NCT07645443)
- Testing
- FEEL GOOD, Treatment as Usual (TAU)
- Where
- 8 sites in Germany
- Volunteers
- 252 people
- Sponsor
- Stephanie Mehl
First Episode Psychosis (FEP), At Risk Mental State (ARMS)
Reducing the Duration of Untreated Psychosis in the United States
The goal of this project is to investigate whether a systematic screening approach for individuals with first episode psychosis (FEP) can substantially reduce Duration of Untreated Psychosis (DUP).
- Trial name
- NCT03369730
- Where
- 3 sites in United States
- Volunteers
- 94 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Psychotic Disorders, Schizophreniform Disorders
Clinical Trial of Integrated Treatment Versus Standard Treatment in First Episode Psychosis
The purpose of the study was to evaluate the effects of integrated treatment for patients with a first episode of psychotic illness.
- Conditions
- Psychotic Disorders, Schizophreniform Disorders, Schizoaffective Disorder, Psychosis, Brief Reactive
- Trial name
- NCT00157313
- Testing
- Integrated treatment, family involvement, Social skills training
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- Bispebjerg Hospital