Clinical trials: Fissure in Ano
Anal Fissure, Microbial Colonization
Microbiota in Chronic Anal Fissure and Its Association With Prognosis
In this study, we will try to answer the following questions: 1. What are the salient features of the microbiota in chronic anal fissure? 2. Are these features associated with prognosis and response to therapy? 3.
- Trial name
- NCT05405634
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lasse Krogsbøll
Fissure in Ano
The Use of Platelet-rich Plasma in the Treatment of Chronic Anal Fissure
use of platelet rich plasma had good effect in treating chronic wounds. healing of perianal fissure could be prolonged and associated with pain.
- Trial name
- NCT05837403
- Testing
- Platelet rich plasma injection, Nitroglycerin ointment
- Where
- Iraq
- Volunteers
- 460 people
- Sponsor
- Al-Kindy College of Medicine
Pharmacokinetics, Healthy Subjects
Pharmacokinetics Trial of Isosorbide Mononitrate 0.5% Gel for Intra Anal Application in Healthy Subjects
This is a Phase I trial to evaluate pharmacokinetics and safety of Isosorbide Mononitrate gel for intra anal administration in healthy subjects.
- Trial name
- NCT04729088
- Testing
- Isosorbide mononitrate
- Volunteers
- healthy volunteers welcome
- Sponsor
- Biolab Sanus Farmaceutica
Chronic Anal Fissure
Postero-lateral Internal Sphincterotomy vs Botulinum Toxin Injection in the Treatment of Chronic Anal Fissure
We hypothesized that optimization of the dose of the Botulinum toxin injection (BT) and standardization of the technique of lateral internal sphincterotomy to posterolateral internal sphincterotomy (PIAS) could, in turn, report a…
- Trial name
- NCT03920449
- Testing
- Botulinum Toxins, Posterolateral internal sphincterotomy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Chronic Anal Fissures
Efficacy and Safety Study With Diltiazem Hydrochloride Cream to Treat Anal Fissures
The purpose of this study is to determine if the study drug, VEN307 (diltiazem hydrochloride cream) is safe and to see if it will help with treatment of pain associated with anal fissures.
- Trial name
- NCT01690221
- Testing
- VEN 307
- Where
- 103 sites in United States
- Volunteers
- 434 people
- Sponsor
- Ventrus Biosciences, Inc
Focus: Anal Incontinence After Lateral Sphincterotomy for Chronic Anal Fissure
Ultrasound Guided Lateral Sphincterotomy: Long Term Results
Ultrasound guided placement of the knife intersphincteric increases accuracy and safety during sphincterotomy. Secondly 3-D ultrasound visualizes that the internal anal sphincter is divided.
- Trial name
- NCT02020915
- Testing
- lateral sphincterotomy, ultrasound guided lateral sphincterotomy
- Where
- Denmark
- Volunteers
- 28 people
- Sponsor
- Hvidovre University Hospital
Chronic Anal Fissure
Percutaneous Tibial Nerve Stimulation - an Alternative Treatment Option for Chronic Therapy Resistant Anal Fissure
At a tertiary referral centre, 10 patients (4 male and 6 female; mean age 49.8 years) were given neuromodulation via the posterior tibial nerve to the sacral nerve for 30 min on 10 consecutive days.
- Trial name
- NCT03554421
- Testing
- Percutaneous tibial nerve stimulation
- Volunteers
- 10 people
- Sponsor
- Region Skane
Chronic Anal Fissure
High Dose Multiple Site Injection of Botox Versus Lateral Sphincterotomy in Chronic Analfissure
comparison between the effect of lateral sphincterotomy against high dose botox injection in chronic anal fissure the outcome was healing time, recurrence continence relapse pain pruritus
- Trial name
- professor (NCT04166175)
- Testing
- botox injection in intersphincteric space, lateral internal sphincterotomy
- Where
- Egypt
- Volunteers
- 96 people
- Sponsor
- Zagazig University
Biological Therapy for Chronic Anal Fissure, Treatment by Biological Factors - Activated Macrophages
Treatment of Anal Fissure by Activated Human Macrophages
Chronic anal fissure is a linear tear in the distal anal canal. Most chronic fissures require intervention to heal. Surgical sphincterotomy is currently performed.
- Conditions
- Biological Therapy for Chronic Anal Fissure, Treatment by Biological Factors - Activated Macrophages, Interventional Study
- Trial name
- NCT00507364
- Testing
- Local injection of activated macrophages to anal fissure
- Where
- Israel
- Sponsor
- Hadassah Medical Organization
Hemorrhoids, Fissure in Ano
Pre-Emptive Analgesia in Ano-Rectal Surgery
The perianal region is the region around the anus. Administering a pain medication before a surgery starts is called preemptive analgesia.
- Conditions
- Hemorrhoids, Fissure in Ano, Rectal Fistula, Anal Condyloma
- Trial name
- PEAARS (NCT02402543)
- Testing
- Gabapentin, Ketamine, Acetaminophen
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of Vermont
Hemorrhoids, Anal Fissure and Fistula
Pudendal Nerve Block With Bupivacaine Alone and Bupivacaine With Methylene Blue for Postoperative Analgesia
Study Description: The goal of this clinical trial is to compare the duration of postoperative pain relief achieved with two different approaches to pudendal nerve block in patients undergoing elective perianal surgery.
- Conditions
- Hemorrhoids, Anal Fissure and Fistula, Perianal Abscess, Perianal Fistula
- Trial name
- NCT05990569
- Testing
- Ultrasound guided Pudendal nerve block
- Where
- Nepal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nepal Mediciti Hospital
Anal Fissure
Sungurtekin Technique vs. Closed Lateral Internal Sphincterotomy Technique
BACKGROUND: Currently, the lateral internal sphincterotomy is the treatment of choice for a chronic anal fissure. However, the length of the internal sphincter incision varies, due to lack of standardization.
- Trial name
- NCT04428697
- Testing
- Sungurtekin Technique
- Volunteers
- 200 people
- Sponsor
- Pamukkale University
Chronic Anal Fissure
Topical Nitroglycerin Versus Lateral Internal Sphincterotomy for Chronic Anal Fissure
Chronic anal fissure is a tear in the lining of the anal canal that can cause pain during and after defecation. This randomized controlled trial will compare topical 0.2% nitroglycerin ointment with lateral internal…
- Trial name
- NCT07884916
- Testing
- Topical 0.2% Glyceryl Trinitrate (Nitroglycerin) Ointment, Lateral Internal Sphincterotomy
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
Chronic Anal Fissure
Diltiazem Hydrochloride Cream for Anal Fissure
A Phase III, multicentre, randomised, double blind, placebo-controlled study in subjects having anal fissure (AF) with AF-related pain.
- Trial name
- NCT01217515
- Testing
- Diltiazem hydrochloride 4% cream, Diltiazem hydrochloride 2% cream
- Where
- 27 sites in Bulgaria, Germany and 4 more
- Volunteers
- 465 people
- Sponsor
- S.L.A. Pharma AG
Anal Fissure
PK, PD and Safety Comparative Trial of Isosorbide Mononitrate Gel in Healthy Participants and With Anal Fissure
This is a Phase I trial to evaluate Pharmacokinetics, Pharmacodynamics and Safety of Isosorbide Mononitrate gel for usage in participants with anal fissure and healthy volunteers.
- Trial name
- NCT02667535
- Testing
- Isosorbide Mononitrate
- Volunteers
- healthy volunteers welcome
- Sponsor
- Biolab Sanus Farmaceutica
Anal Fissures Treatment and Oligoantigenic Diet
Oligo-antigenic Diet in the Treatment of Chronic Anal Fissures.
Patients with chronic constipation due to food hypersensitivity (FH) had an elevated anal sphincter resting pressure. No studies have investigated a possible role of FH in anal fissures (AF).
- Trial name
- NCT01637857
- Testing
- oligoantigenic diet
- Where
- Italy
- Volunteers
- 161 people
- Sponsor
- University of Palermo
Fissure;Anal, Fistula;Rectal
Efficacy and Safety of CLIFE1 Gel in Benign Anorectal Surgery
Double-blinded multicenter randomized clinical trial to evaluate the efficacy and safety of CLIFE2 (lidocaine, referred as treatment A) respect CLIFE1 (lidocaine plus diclofenac, referred as treatment B) in benign anorectal…
- Conditions
- Fissure;Anal, Fistula;Rectal, Hemorrhoids
- Trial name
- NCT02961855
- Testing
- anesthesics plus antiinflammatory, CLIFE1, local anesthesics, CLIFE2
- Volunteers
- 120 people
- Sponsor
- Hospital de Viladecans
Chronic Anal Fissure
E-CEL UVEC Treatment for Anal Fissures
This clinical trial is being conducted by investigators who are colorectal surgeons. Eligible study participants will receive the experimental treatment E-CEL UVEC cells by direct injection into the anal fissure.
- Trial name
- NCT06456073
- Testing
- E-CEL UVEC cells (AB-207)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Anal Fissure
Pharmacokinetic,Safety and Exploratory Efficacy of RECTIV® in Adolescents With Chronic Anal Fissure
RECTIV® is an ointment containing 0.4% nitroglycerin (NTG) for the treatment of moderate to severe pain associated with chronic anal fissure approved in June 2011 by the US Food and Drug Administration (FDA) for adults.
- Trial name
- NCT01920074
- Testing
- Nitroglycerin Ointment 0.4%
- Where
- 6 sites in United States
- Sponsor
- Forest Laboratories
Perianal Fistula, Fissure in Ano
Perianal Nerval Block in Proctological Interventions
The aim of this study is to evaluate whether a local perianal block performed during a proctological intervention can reduce the postoperative pain.
- Conditions
- Perianal Fistula, Fissure in Ano, Hemorrhoids
- Trial name
- NCT03405922
- Testing
- 40 mL Ropivacain 0.5%
- Where
- Switzerland
- Volunteers
- 166 people
- Sponsor
- University Hospital, Basel, Switzerland