Clinical trials: Fissure in Ano
Anal Fissure Chronic
Comparison of Botulinum Toxin Injection and Lateral Internal Sphincterotomy in Chronic Anal Fissure Management
This study aims to compare two commonly used treatments for chronic anal fissure: botulinum toxin injection and lateral internal sphincterotomy.
- Trial name
- BOT-LIS-CAF (NCT07568314)
- Testing
- Botulinum Toxin Type A (BOTOX) Injection, Lateral Internal Sphincterotomy
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Islamabad Medical and Dental College
Anal Fissure
An Open Label Multi-Dose Study to Examine the Effect of Coated Nifedipine Suppository on Anal Fissure Pain and Healing
This is an open label study. The study will consist of 2 treatment group: coated Nifedipine suppository containing 12 mg of Nifedipine applied twice daily (group 1) and coated Nifedipine suppository containing 12 mg of Nifedipine…
- Trial name
- NCT02023047
- Testing
- Nifedipine 12 mg coated suppositories
- Where
- 4 sites in Israel
- Volunteers
- 33 people
- Sponsor
- RDD Pharma Ltd
Fissure in Ano
Use of Fototherapy in the Treatment of Fissure in Ano
The eligible population consisted of individuals with anal fissure awaiting surgical intervention. Individuals aged 18 years or older were included, diagnosed with anal fissure and who voluntarily agreed to participate in the…
- Trial name
- NCT05993793
- Testing
- Fototherapy
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Centro de Atenção ao Assoalho Pélvico
Chronic Anal Fissure
RELIEF Study: Resolving Fissures With Lateral Internal Sphincterotomy
The goal of this observational study is to learn how a common surgery called lateral internal sphincterotomy (LIS) affects people with chronic anal fissures, a painful tear near the anus.
- Trial name
- RELIEF (NCT06984601)
- Testing
- Lateral Internal Sphincterotomy (LIS)
- Volunteers
- 300 people
- Sponsor
- Turkish Society of Colon and Rectal Surgery
Anal Fissure Chronic
Pulsed Electromagnetic Field on Chronic Anal Fissure Healing
The purpose of this study is to find the effect of Pulsed Electromagnetic Field on chronic Anal fissure healing. Included both male and female aged 30-60 suffering from Anal fissure symptoms.
- Trial name
- PEMF (NCT07729709)
- Testing
- PEMS, Lidocaine and general advice, Lidocaine cream and general advice
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Galala University
Anal Fissure, Anal Fistula
Ultrasound Guided Caudal Block for Benign Anal Surgery
Interventional study that evaluate analgesia and side effects of Ultrasound guided Caudal block preoperatively in benign canal anal surgery
- Conditions
- Anal Fissure, Anal Fistula, Hemorrhoids, Pain, Postoperative
- Trial name
- NCT03345511
- Testing
- Ultrasound Guided Caudal Block
- Where
- Colombia
- Volunteers
- 23 people
- Sponsor
- Universidad de Antioquia
Pain
Application of Vitamin E on Anal Fissure
Patients were randomized into 2 groups: Vitamin E: Vitamin E ointment will be applied during 8 weeks Nitroglycerin: Nitroglycerin ointment will be applied during 8 weeks Healing rate of chronic anal fissure in patients receiving…
- Trial name
- NCT03787030
- Testing
- Vitamin E Acetate ointment, Glyceryl trinitrate ointment
- Where
- Spain
- Volunteers
- 160 people
- Sponsor
- Hospital General Universitario Elche
Hemorrhoids, Anal Fissure
Topical vs Oral Metronidazole After Benign Anorectal Surgery
While some investigators found oral metronidazole to be effective in reducing pain after hemorrhoidectomy, other researchers did not find a significant analgesic effect of systemic metronidazole.
- Conditions
- Hemorrhoids, Anal Fissure, Anal Fistula
- Trial name
- NCT05038605
- Testing
- Topical metronidazole, oral metronidazole
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Mansoura University
Fistula-in-ano, Rectal Polyp
Trial on Use of Coloshield in Transanal and Anal Surgery
In various transanal and anal procedures it is desirable to clean the operating field from stool contamination. Thus mechanical bowel preparation is not well tolerated by patients. Enema does not provide sufficient effect.
- Conditions
- Fistula-in-ano, Rectal Polyp, Rectal Adenoma, Hemorrhoids
- Trial name
- NCT02579330
- Testing
- Coloshield, Control
- Where
- Switzerland
- Volunteers
- 22 people
- Sponsor
- Daniel Steinemann, MD
Puerperal Infection, Fever
Diet and Lifestyle Intervention Study in Postpartum Women in China
Previous studies have shown "Doing the month", a traditional practice for postpartum women in China and other Asian countries, may be associated with higher prevalence of postpartum problems.
- Conditions
- Puerperal Infection, Fever, Constipation, Hemorrhoids
- Trial name
- NCT01039051
- Testing
- Diet and Lifestyle Intervention in Chinese Postpartum Women
- Where
- 3 sites in China
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Chronic Anal Fissure
Perianal Versus Endoanal Application of Glyceryl Trinitrate 0.4% Ointment for Chronic Anal Fissure
Perianal topical nitroglycerin has been widely used as a means for avoiding surgery in patients with anal fissure. However, nitroglycerin has not been universally accepted for this application because of inconsistency of efficacy…
- Trial name
- NCT01132391
- Testing
- Rectogesic® (glyceryl trinitrate 0.4% ointment)
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital General Universitario Elche
Anal Fissure
Efficacy Study of Dysport® in the Treatment of Anal Fissure.
To evaluate the effect on healing rates of two different prognostic factors in patients treated with Dysport® for anal fissure: duration of fissure and dose of study drug
- Trial name
- NCT00210444
- Testing
- Botulinum toxin type A
- Where
- 7 sites in Czechia, Poland and 2 more
- Volunteers
- 168 people
- Sponsor
- Ipsen
Hemorrhoids, Fissure in Ano
Measurement of Stress During Anesthesia With "Pain Detector" on Patients Receiving Atropine
24 patients randomly divided into two groups, one of the groups receiving atropine in addition to the planned anaesthesia. Skin conductance parameters to be compared between the two groups.
- Trial name
- NCT00328900
- Testing
- Administration of 0,7 mg of atropine, Measurement of skin conductance with Pain detector
- Where
- Norway
- Volunteers
- 24 people
- Sponsor
- Rikshospitalet University Hospital