Clinical trials: Fistula-in-ano
Anal Fistula
INVESTIGATION OF THE EFFICACY OF FISTULA OBLITERATION BY STEAM ABLATION IN PERİANAL FISTULAS
Perianal fistula(PF) is one of the most frequent disease in anorectal disease.The incidence of PF is 8,6 -10 / 100 000 . The first surgical treatment is defined by Hippocrates in PF .This surgical treatment which found by…
- Trial name
- STEAM (NCT04811105)
- Testing
- steam ablation
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Anal Fistula
Endoscopic Treatment of Complex Anal Fistulas
This is a randomised controlled trial to evaluate the outcome of treatment of complex perianal fistula by Video-assisted anal fistula treatment (VAAFT) compared to fistulectomy and sphincter reconstruction as standard surgical…
- Trial name
- VAAFT (NCT02585167)
- Testing
- operation, VAAFT
- Where
- Denmark
- Volunteers
- 47 people
- Sponsor
- University of Southern Denmark
Crohn's Disease
Phase 3 Study of Human TH-SC01 Cell Injection for Treating Perianal Fistulas in Patients With Crohn's Disease
The purpose of this study is to evaluate the efficacy of human TH-SC01 cell injection for the treatment of perianal fistulas in Crohn's Disease over 24 weeks.
- Trial name
- NCT06925594
- Testing
- Human TH-SC01 cell injection, Saline solution
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Jiangsu Topcel-KH Pharmaceutical Co., Ltd.
Crohn's Fistula
Darvadstrocel for Crohn's Fistula in the Realworld
Background Perianal fistula may affect 15-50% of patients with Crohn's disease (CD). Treatment is complex, requiring a multidisciplinary approach.
- Trial name
- NCT05742100
- Testing
- Darvadstrocel
- Where
- Spain
- Volunteers
- 73 people
- Sponsor
- Dolores Herreros Marcos
Hemorrhoids, Fissure in Ano
Multi-Drug Analgesia vs. Standard Solution for Anal Surgery
The primary aim is to test the magnitude and duration of analgesia provided by single dose multi-drug analgesia administered for perianal block, and compare with standard solution (Marcaine \& Lidocaine in 1:1 mixture - Total 60…
- Conditions
- Hemorrhoids, Fissure in Ano, Fistula;Rectal
- Trial name
- NCT03105674
- Testing
- Multi-drug local anesthetics (Combination), Standard local anesthetics (Combination)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Columbia University
Anal Fistula
Ligation of Inter-sphincteric Fistula Tract for Management of Anal Fistula
After abscess formation, an anal fistula is a common consequence, with crypto-glandular infection being the most commonly accepted causative cause.
- Trial name
- NCT05314205
- Testing
- ligation of inter-sphincteric fistula tract
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Al-Azhar University
High Perianal Fistula
Comparative Study: Fistula Rerouting vs. LIFT for High Perianal Fistula
The goal of this clinical trial is to compare two different surgery methods for treating a complex type of anal fistula. This condition is an abnormal tunnel connecting the inside of the anus to the skin nearby.
- Trial name
- NCT07399353
- Testing
- Fistula Rerouting Technique, Ligation of Intersphincteric Fistula Tract
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Fistula in Ano
Fistula-in-ano in Infants and Children
In this prospective, randomized trail, duration of non-cutting seton placement in patients with fistula-in-ano is evaluated.
- Trial name
- NCT05666609
- Testing
- placement of non-cutting seton (silicone)
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Friedrich-Alexander-Universität Erlangen-Nürnberg
Crohn's Diseases, Active Anal Fistula
Efficacy and Safety of Upatinib in the Treatment of Active Anal Fistulas in Crohn's Disease
Anal fistula is the most common perianal lesion of Crohn's disease (CD), and the incidence of anal fistula in eastern CD population is significantly higher than that in Western population.
- Conditions
- Crohn's Diseases, Active Anal Fistula, Upadacitinib
- Trial name
- NCT06902987
- Testing
- Upadacitinib
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Anal Fistula, Crohn Disease
Stem Cells Treatment of Complex Crohn's Anal Fistula
A pilot study to investigate the safety and feasibility of stem cells treatment of complex anal fistula in patients with Crohn's disease.
- Trial name
- fistula (NCT03466515)
- Testing
- stem cells injection
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- University of Southern Denmark
Perianal Crohn Disease, Perianal Fistula
The Impact of Perianal Disease on Patient's Sex Life
Perianal diseases, such as perianal abcesses, anal fistulae and perianal Crohn's disease, are often associated with significant physical symptoms, including pain and chronic drainage.
- Conditions
- Perianal Crohn Disease, Perianal Fistula, Fistula in Ano, Perianal Abscess
- Trial name
- SEXTON (NCT07519850)
- Testing
- Patient Reported Outcome Assessment (Questionnaires)
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- AHEPA University Hospital
Anal Fistula
Imaging Template for Reporting Anal Fistula
Magnetic resonance imaging (MRI) is the most used diagnostic tool for pre-operative assessment of anal fistula. However, there is lack of standardization in reporting this investigation.
- Trial name
- ITRAF (NCT04541238)
- Testing
- MRI
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Treviso Regional Hospital
Anal Fistula, Minimal Invasive Surgery
Treatment of Anal Fistulas With Obsidian RFT®
The study conducted a retrospective analysis from January 2018 to December 2022 on patients who received anal fistula closure with Obsidian RTF® at the Department of General Surgery, Medical University of Vienna.
- Conditions
- Anal Fistula, Minimal Invasive Surgery, Platelet-rich Fibrin Foam
- Trial name
- NCT06136325
- Testing
- Obsidian RFP anal fistula surgery
- Where
- Austria
- Volunteers
- 18 people
- Sponsor
- Medical University of Vienna
Hemorrhoids, Anal Fissure
Effects of Sodium Pentaborat Based Gel on Perianal Benign Diseases
New produced and patented sodium pantaborat based gel will be use for treatment of benign perianal diseases (hemooroidal disease, anal fissura anda perianal fistula)
- Conditions
- Hemorrhoids, Anal Fissure, Perianal Fistula
- Trial name
- NCT03780998
- Testing
- Life7
- Volunteers
- 250 people
- Sponsor
- SB Istanbul Education and Research Hospital
Hemorrhoid, Peri Anal Fistula
Discharge Conditions of Spinal Anesthesia With Heavy Prilocaine-Fentanyl and Heavy Bupivacaine-Fentanyl
In this prospective randomized study the investigators aimed to investigate difference of the duration of spinal anesthesia, discharge times and efficacy between low dose heavy Prilocaine-Fentanyl and heavy Bupivacaine-Fentanyl…
- Trial name
- NCT01880775
- Testing
- Prilocaine, Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Diskapi Teaching and Research Hospital
Anorectal Fistula
Effect of Short Term Versus Long Term Treatment With Seton Prior to LIFT Surgery for Complex Anal Fistula
The aim of this study is to compare short term (3 week) with long term (6 months) treatment with seton prior to LIFT surgery. The main end-points are recurrence rates and complication rates after surgery.
- Trial name
- NCT01913249
- Testing
- LIFT
- Where
- Norway
- Sponsor
- Sykehuset Innlandet HF
Chronic Anal Fissure, Hemorrhoidal Disease
Female Sexual Function After Surgery for Benign Perianal Diseases
Benign perianal diseases such as chronic anal fissure, hemorrhoidal disease, and cryptoglandular anal fistula may negatively affect female sexual function through pain, bleeding, discharge, discomfort, and impairment in quality…
- Conditions
- Chronic Anal Fissure, Hemorrhoidal Disease, Cryptoglandular Anal Fistula
- Trial name
- PERISEX (NCT07666035)
- Testing
- Surgical Treatment for Benign Perianal Diseases
- Volunteers
- 120 people
- Sponsor
- Gazi University
Perianal Fistula, Fissure in Ano
Perianal Nerval Block in Proctological Interventions
The aim of this study is to evaluate whether a local perianal block performed during a proctological intervention can reduce the postoperative pain.
- Conditions
- Perianal Fistula, Fissure in Ano, Hemorrhoids
- Trial name
- NCT03405922
- Testing
- 40 mL Ropivacain 0.5%
- Where
- Switzerland
- Volunteers
- 166 people
- Sponsor
- University Hospital, Basel, Switzerland
Anal Fistula Surgery, Anal Fistula
Recurrence and Anal Fistula Patient Reported Outcomes Trial
Perianal fistulas are a chronic anorectal condition associated with significant morbidity, including pain, persistent discharge, infection, and impaired continence, all of which can substantially affect patients' quality of life.
- Conditions
- Anal Fistula Surgery, Anal Fistula, Perianal Fistula
- Trial name
- RAPPORT (NCT07477496)
- Testing
- Perianal fistula surgical repair
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- National and Kapodistrian University of Athens
Anal Fistula
3D Endoanal Ultrasound and Anal Fistula
The study aims to evaluate the use of 3D endoanal ultrasound in preoperative management of anal fistula disease.
- Trial name
- UFU (NCT03937752)
- Testing
- 3D endodanal ultrasound
- Where
- Sweden
- Volunteers
- 95 people
- Sponsor
- Region Skane