Clinical trials: Fistula-in-ano
Anal Fistula, Fistula in Ano
Laser Closure of Anal Fistula (FiLaC)
Laser closure of the perianal fistula is the minimally invasive and low complication rate procedure which is a life-saving way for complex fistulas, preserving anal sphincter injury.
- Conditions
- Anal Fistula, Fistula in Ano, Sphincter Ani Incontinence
- Trial name
- NCT04161469
- Testing
- Laser closure of the anal fistula tract (FiLaC), Internal orifice closure
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Surp Pırgiç Armenian Hospital
High Complex Anal Fistula
Decompression and Drainage Seton in the Treatment of High Complex Anal Fistula
This study aimed to compare the efficacy of the decompression and drainage seton (DADS) and cutting seton (CS) in the treatment of high complex anal fistula.
- Trial name
- NCT05087407
- Testing
- Decomprssion and drainage seton, Cutting seton
- Where
- China
- Volunteers
- 120 people
- Sponsor
- China-Japan Friendship Hospital
Complex Anal Fistula
Success Rate, Continence, and Quality of Life With a Bioprosthetic Plug for Treating Complex Anal Fistula
Anal abscess-fistula disease is of common occurrence and has a significant impact on the quality of life of affected individuals.
- Trial name
- NCT01612195
- Testing
- Anal fistula plug
- Where
- Switzerland
- Volunteers
- 46 people
- Sponsor
- University Hospital, Basel, Switzerland
Anal Fistula, Rectal Fistula
Mechanical Bowel Preparation Prior To Sphincter-Sparing Surgery For Complex Anal Fistulae
The goal of this clinical trial is to learn whether bowel preparation with Plenvu before surgery improves healing of complex anal fistula in adults aged 18 to 64 years with a fistula of cryptoglandular origin or associated with…
- Conditions
- Anal Fistula, Rectal Fistula, Crohn Disease
- Trial name
- PLEN-SPARE (NCT07897539)
- Testing
- Mechanical bowel preparation
- Where
- Sweden
- Volunteers
- 116 people
- Sponsor
- Region Skane
Anal Fistula
Treatment of Perianal Fistulas by Endorectal Advancement Flap Associated With Adipose Tissue Injection
The study aims to evaluate effectiveness of the association of endorectal advancement flap technique with local injection of autologous and micro-fragmented adipose tissue, obtained with the Lipogems® system, in patients with…
- Trial name
- Fistula_CM1 (NCT04750499)
- Testing
- Adipose tissue injection associated with endorectal advancement flap.
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Hospital Clinic of Barcelona
Anal Fistula
Anal Fistula and Microdialysis - What is Yet to Learn?
Anal Fistula can be a challenging condition to treat. Microdialysis has never before been used to examine the inner environment of anal fistula. This is now going to be performed.
- Trial name
- NCT04178707
- Testing
- OnZurf Probe, Senzime AB, Uppsala, Sweden
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- University Hospital, Umeå
Perianal Fistula, Adipose Tissue
Adipose Derived Mesenchymal Stem Cell Characteristics in Anal Fistulas
This study investigated the cellular and molecular characteristics of AT-MSCs obtained from autologous AT therapy in patients with high transphincteric perianal fistulas of crytoglandular origin.
- Conditions
- Perianal Fistula, Adipose Tissue, Tissue Transplantation
- Trial name
- NCT04834609
- Testing
- Injection of autologous adipose tissue in anal fistula
- Volunteers
- 27 people
- Sponsor
- University of Aarhus
Anal Fistula
Treatment of Ano-perineal Fistulas Resistant to Surgical Treatment with a Gel and Plug of Wharton's Jelly
The purpose of this open, multicenter pilot trial is to evaluate the tolerance of the combination of a gel and a plug made of Wharton's jelly in the treatment of ano-perineal fistulas resistant to surgical treatment.
- Trial name
- NCT05638139
- Testing
- SygeLIX-F + SygeLIX-G
- Where
- 2 sites in France
- Volunteers
- 9 people
- Sponsor
- TBF Genie Tissulaire
Fistula in Ano, Rectal Fistula
Laser Assisted Treatment of Fistula In Ano
Randomised Controlled Trial comparing Laser assisted closure of transsphincteric fistula to the rectal advancement flap.
- Trial name
- LATFIA (NCT05390151)
- Testing
- Laser treatment of anal fistula, RAF
- Where
- 5 sites in Belgium
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Anal Fistula
RCT on LIFT Versus Modified Parks Technique Versus Two-Stage Seton
LIFT is a sphincter-saving procedure that is based on the concept of secure closure of the internal opening and concomitant removal of infected cryptoglandular tissue in the intersphincteric plane.
- Trial name
- NCT04377542
- Testing
- LIFT, Parks, Seton
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Mansoura University
Perianal Fistula, Transsphincteric Anal Fistula
Treatment of Lower Transsphincteric Perianal Fistula: Fistulotomy With Marsupialization vs Open Wound
This study will compare the results of marsupialization versus open wound after fistulotomy in low transsphincteric perianal fistulas.
- Trial name
- NCT04722965
- Testing
- Fistulotomy with marsupialization, Fistulotomy with open wound
- Where
- Spain
- Volunteers
- healthy volunteers welcome
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Anal Fistula
Study of GORE® BIO-A® Fistula Plug for Use in Anal Fistula Repair
Primary outcome variable is healing at the final follow up visit.
- Trial name
- NCT01290666
- Testing
- Fistula Plug
- Volunteers
- 93 people
- Sponsor
- W.L.Gore & Associates
Anal Fistula
"Feasibility and Safety of the Calcium Alginate Hydrogel Sealant for the Treatment of Cryptoglandular Fistula-in-ano: Phase I/IIa Clinical Trial"
Background: Complex perianal fistulas pose a challenge to surgeons since the fistulous tract must be eliminated without impairing continence.
- Trial name
- NCT04740086
- Testing
- Calcium alginate hydrogel
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Anal Fistula
Endoscopic Treatment of Complex Anal Fistulas
This is a randomised controlled trial to evaluate the outcome of treatment of complex perianal fistula by Video-assisted anal fistula treatment (VAAFT) compared to fistulectomy and sphincter reconstruction as standard surgical…
- Trial name
- VAAFT (NCT02585167)
- Testing
- operation, VAAFT
- Where
- Denmark
- Volunteers
- 47 people
- Sponsor
- University of Southern Denmark
Anal Fistula, Perianal Fistula
Comparison Of Surgical Outcomes Between Ligation Of Intersphincteric Fistula Tract And Fistulotomy With Seton In Perianal Fistula
This study aims to compare two commonly used surgical techniques for the treatment of perianal fistula: Ligation of the Intersphincteric Fistula Tract (LIFT) and fistulotomy with seton.
- Conditions
- Anal Fistula, Perianal Fistula, Fistula-in-ano
- Trial name
- LIFT-SETON (NCT07579715)
- Testing
- Ligation of Intersphincteric Fistula Tract (LIFT), Fistulotomy with Seton Placement
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Islamabad Medical and Dental College
Anal Fistula
Treatment of Complex Anal Fistulas Using Centrifuged Adipose Tissue Containing Progenitor Cells
In the treatment of complex anal fistulas transplant of freshly collected autologous adipose tissue mechanically fragmented or centrifuged adipose tissue (CAT) might be an alternative to in vitro expanded autologous or allogeneic…
- Trial name
- CAT (NCT04326907)
- Testing
- Autologous centrifuged adipose tissue (CAT) injection after anal fistulectomy
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital of Ferrara
Anal Cancer
Drainage Seton With Flap Versus EAS Preserving Seton in Treatment of Transsphincteric Anal Fistula
Patients with high trans-sphincteric anal fistula will be randomized to one of two equal group: group 1 will have drainage seton with mucosal advancement flap and group 2 will undergo external anal sphincter sparing seton
- Trial name
- NCT03983174
- Testing
- Drainage seton with flap, EAS sparing seton
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Hemorrhoids, Fissure in Ano
Multi-Drug Analgesia vs. Standard Solution for Anal Surgery
The primary aim is to test the magnitude and duration of analgesia provided by single dose multi-drug analgesia administered for perianal block, and compare with standard solution (Marcaine \& Lidocaine in 1:1 mixture - Total 60…
- Conditions
- Hemorrhoids, Fissure in Ano, Fistula;Rectal
- Trial name
- NCT03105674
- Testing
- Multi-drug local anesthetics (Combination), Standard local anesthetics (Combination)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Columbia University
Anal Fistula
Do Antibiotics Prevent Anal Fistulae Formation?
Purpose: This randomized study assesses the effects of antibiotics on the formation of fistulae after drainage of anorectal abscesses.
- Trial name
- NCT01012843
- Testing
- Amoxicillin-Clavulanate
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 151 people
- Sponsor
- Ankara University