Clinical trials: Flap Ischemia
Donor Site Complication, Muscle; Ischemic
Change in the Lower Leg Muscle Stiffness Following Peroneal Artery-based Flap
In the field of reconstructive microsurgery, donor site morbidity after free flap harvest is one of the key factors to consider when choosing among different options of free flap.
- Trial name
- NCT04692961
- Testing
- Elastography
- Where
- Taiwan
- Volunteers
- 9 people
- Sponsor
- National Taiwan University Hospital
Mastectomy, Breast Reconstruction
Near-infrared Spectroscopy for Monitoring Tissue Oxygenation in Breast Reconstruction
The study will evaluate the use of near infrared spectrometry (NIRS)in detecting early microvascular complications in deep inferior epigastric artery perforator (DIEP)-flap(s).
- Conditions
- Mastectomy, Breast Reconstruction, Flap Ischemia
- Trial name
- NCT03757793
- Testing
- FORE-SIGHT ELITE monitor
- Where
- Belgium
- Volunteers
- 18 people
- Sponsor
- University Hospital, Antwerp
Ischemia-Reperfusion Injury, Free Flap
Non-invasive Remote Ischemic PreConditioning (RIPC) in Free Flaps for Breast Reconstruction
This prospective randomized clinical study investigates the effects of Remote Ischemic Conditioning (RIC) on tissue perfusion and ischemia-reperfusion injury in patients undergoing free flap reconstruction in reconstructive…
- Conditions
- Ischemia-Reperfusion Injury, Free Flap, Conditioning Therapy
- Trial name
- RIPC (NCT07487220)
- Testing
- Remote ischemic preconditiong
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- Ruhr University of Bochum
Breast Cancer
BENEFIT OF MECHANICAL ISCHEMIC PRECONDITIONING ON TOLERANCE OF ADIPOSE TISSUE TO ISCHEMIA REPERFUSION OF TYPE DIEP (DEEP INFERIOR EPIGASTRIC PERFORATOR) FREE FLAPS.
Breast cancer is the most common cancer amongst women in terms of frequency, with more than 50 000 newly diagnosed cases per year in France. The average 5-year survival rate for women with breast cancer is around 85%.
- Trial name
- PRIMIDIEP (NCT05373069)
- Testing
- Mechanical ischemic preconditioning of diep-type flap
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Blood Flow, Anastomotic Failure of Flap
Effects of Vasopressor on the Graft Blood Flow in TRAM
The purpose of this pilot study is to investigate whether two major vasopressors (norepinephrine vs. phenylephrine) used for treatment of hypotension during breast reconstruction with free flap transfer surgery have different…
- Conditions
- Blood Flow, Anastomotic Failure of Flap, Flap Necrosis, Flap Ischemia
- Trial name
- NCT05049278
- Testing
- Norepinephrine, Phenylephrine
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul National University Hospital
Flap Monitoring, Inflammation
Effect of Dexmedetomidine on Microsurgery Reconstruction in Cancer Patient
This double-blinded randomized controlled trial aims to investigate the effect of intraoperative dexmedetomidine administration on early flap viability and microvascular integrity in cancer patients undergoing elective…
- Conditions
- Flap Monitoring, Inflammation, Thrombosis, Oxidative Stress
- Trial name
- DEXFLAP (NCT06993740)
- Testing
- NaCl 0,9%, Dexmedetomidine
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Dharmais National Cancer Center Hospital
Air or Gas Embolism, Carbon Monoxide Poisoning
Hyperbaric Oxygen Therapy Registry
The purpose of the Hyperbaric Oxygen Therapy Registry (HBOTR) is to provide real world patient outcome and side effect information from electronic health records submitted to a specialty specific hyperbaric registry as part of…
- Conditions
- Air or Gas Embolism, Carbon Monoxide Poisoning, Clostridial Myositis and Myonecrosis (Gas Gangrene), Crush Injury, Compartment Syndrome & Other Acute Traumatic Ischemias
- Trial name
- HBOTR (NCT02483650)
- Volunteers
- 5,000 people
- Sponsor
- U.S. Wound Registry
Ischemia
Skin Flap Visible Light Spectroscopy (VLS) Oximetry for Monitoring Free-Flap Ischemia During Breast Reconstruction and Recovery
The purpose of the study is to understand the relevance of tissue oximetry measures of tissue flaps during surgery and during recovery, and to determine if T-Stat is a reliable and early method of detecting compromised flaps.
- Trial name
- NCT01173133
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Spectros Corporation
Critical Limb Ischemia, Peripheral Artery Disease
Safety & Feasibility Study of Tack-It Device for Vessel Dissection Repair
The study is intended to evaluate the safety and feasibility of using the Intact Vascular (Innovasc) Tack-It Endovascular Dissection Repair System (Tack Intravascular Staple System) in patients with vascular flaps in the…
- Trial name
- NCT02044003
- Testing
- Innovasc Tack Intravascular Staple System (Tack)
- Where
- 2 sites in Paraguay
- Volunteers
- 11 people
- Sponsor
- Philips Clinical & Medical Affairs Global
Microsurgical Free Flaps
Sevoflurane Protective Effect on Ischemia-reperfusion Injury. Multicenter, Randomized Controlled Trial
This study aimed to evaluate the possible protective effect of anesthetic technique balanced(with sevoflurane) compared with total intravenous anesthetic technique (propofol,remifentanil).
- Trial name
- NCT01905501
- Testing
- Balanced anesthesia, Total intravenous anesthesia
- Where
- Italy
- Volunteers
- 132 people
- Sponsor
- Regina Elena Cancer Institute
Gluteal Tissue Ischemia Risk, Foreign-Body Reaction
Prospective Agreement Study of Magnetic Resonance Imaging Measurements and Intraoperative Dimensions During Gluteal Permanent Synthetic Filler Removal
This prospective agreement study will compare preoperative MRI measurements with direct surgical measurements in adults undergoing removal of gluteal tissue affected by permanent synthetic fillers.
- Conditions
- Gluteal Tissue Ischemia Risk, Foreign-Body Reaction, Soft Tissue Filler Complication
- Trial name
- NCT07808996
- Testing
- Preoperative MRI Morphometric Mapping, Standardized Intraoperative and Fresh-Specimen Measurement
- Volunteers
- 220 people
- Sponsor
- Research Inc
Head and Neck Neoplasms
Remote Ischemic Preconditioning in Head and Neck Cancer Reconstruction - A Randomized Controlled Trial
The purpose of the trial is to investigate, if remote ischemic preconditioning reduces the risk of complications in patients undergoing resection of head and neck cancer and immediate reconstruction with autologous free tissue…
- Trial name
- RIPC-HNC (NCT02548377)
- Testing
- Remote ischemic preconditioning
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Aarhus University Hospital Skejby
Surgical Wound Infection, Neck Infection
Antibiotic Tissue Penetration and Tissue Response in Head and Neck Infection and Reconstructive Surgery
The goal of this study is to measure how well commonly used antibiotics reach the tissue in the head and neck region in adults with a postoperative neck infection or undergoing reconstructive nasal surgery with an inferior…
- Conditions
- Surgical Wound Infection, Neck Infection, Nasal Reconstruction
- Trial name
- ANTIBIOTIKA (NCT07896239)
- Testing
- Cefuroxime, Dicloxacillin, Cloxacillin
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Tejs Ehlers Klug
Soft Tissue Filler Complication, Surgical Flap Ischemia
Randomized Evaluation of Indocyanine Green Fluorescence Angiography-Guided Versus Standard Clinical Perfusion Assessment During Gluteal Permanent Synthetic Filler Removal
This randomized clinical trial will compare indocyanine green fluorescence angiography-guided assessment with standard clinical assessment of gluteal flap perfusion during removal of permanent synthetic fillers.
- Conditions
- Soft Tissue Filler Complication, Surgical Flap Ischemia, Tissue Necrosis
- Trial name
- NCT07808957
- Testing
- Indocyanine Green, Standard Clinical Perfusion Assessment
- Where
- Colombia
- Volunteers
- 300 people
- Sponsor
- Research Inc
Flap Ischemia, Hypoxia
Spectroscopic Assessment of Tissue Oxygenation Changes in Plastic Surgical Flap Reconstructions
This study is a single-center, observational study designed to collect tissue spectrometric data.
- Trial name
- NCT07786610
- Volunteers
- 30 people
- Sponsor
- Spectrocor
Complication,Postoperative
Heparin Alone vs. Heparin-Aspirin Combo in Free Flap Survival
This randomized clinical trial aims to compare the effectiveness of heparin alone versus combination therapy of Heparin- Aspirin in improving free flap survival in patients undergoing reconstructive surgery.
- Trial name
- NCT06512233
- Testing
- LMW Heparin 5000 U/ML-Aspirin 75 MG, LMW Heparin 5000 U/ML
- Where
- Pakistan
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Aga Khan University