Clinical trials: Flow-mediated Dilation
Type 2 Diabetes
Evaluation of the Effect of Pulsatile Cuts Stendo3 on Vascular Function Patients With Diabetes Type 2
The purpose of the study is to demonstrate an improvement of vascular function, and particularly dependent vasodilation flow and micro-vasculature, by STENDO for diabetic patients compared to a control period in crossover.
- Trial name
- STENDO3 (NCT02359461)
- Testing
- Combination pulsatile Stendo3
- Where
- France
- Volunteers
- 46 people
- Sponsor
- University Hospital, Clermont-Ferrand
Unspecified Injury of Brachial Artery, Left Side, Initial Encounter
Vascular Effect of Estrogens Versus Placebo Evaluated by Flow-mediated Dilatation of Brachial Artery
The aim of this study is to evaluate the vascular effects of estrogens on climacteric women measured by flow-mediated evaluation of the brachial artery using high resolution ultrasound and compare to placebo.
- Trial name
- EDILA (NCT01482416)
- Testing
- Estrogens, Conjugated (USP)
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Systolic Hypertension, Brachial Artery Flow-mediated Dilation
Dose-Response Effects of Inspiratory Muscle Strength Training on Blood Pressure and Vascular Function
This study will assess the dose-response effects of Inspiratory Muscle Strength Training (IMST) in adults with above-normal systolic blood pressure over a 6-week period.
- Trial name
- NCT07109739
- Testing
- POWERbreathe K5
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of Minnesota
Health Subjects With Cardiovascular Risk Factors
Sublingual L-GSH Supplementation in Male Subjects With Smoking Habit and/or Hypertension
Background. The antioxidant systems are the main endogenous defense against free radicals, and glutathione seems to play an important role in this mechanism.
- Trial name
- NCT02125045
- Testing
- L-GSH
- Where
- Italy
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Niguarda Hospital
Cardiovascular Diseases, Smoking
Effect of Switching From Cigarette Smoking to THS on Systemic Endothelial Function in Subjects With Established Atherosclerotic Disease
The purpose of this study is to demonstrate improvement in flow mediated dilation (FMD), a functional endpoint associated with the progression of atherosclerosis, when switching from cigarettes to the Tobacco Heating System (THS)…
- Conditions
- Cardiovascular Diseases, Smoking, Tobacco Use, Peripheral Arterial Disease
- Trial name
- NCT05566678
- Testing
- Cigarette, THS, Smoking Abstinence
- Sponsor
- Philip Morris Products S.A.
Pulmonary Disease, Chronic Obstructive
Improvement of Cardiovascular Function After Bronchoscopic Lung Volume Reduction Using Endobronchial Valves
There is increasing evidence showing an association between COPD and cardiovascular disease which is independent from smoking. Recently, it has been shown that FMD of the brachial artery, a surrogate marker of endothelial…
- Trial name
- NCT04556942
- Testing
- Flow Mediated Dilation (FMD) measurement, Blood pressure, pulse and blood oxygen saturation measurement, ST George Respiratory Questionnaire
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Daniel Franzen
Coronary Artery Disease
Effect of BNP (Brain Natriuretic Peptides) on Endothelial Dysfunction Induced by Coronary Angioplasty
Patients receiving BNP or nitroglycerin (IV) during the angioplasty procedure. 24 h after the procedure, vascular reactivity will be re-examined using the brachial artery flow-mediated dilatation study.
- Trial name
- NCT00262574
- Testing
- Nesiritide,
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- The Baruch Padeh Medical Center, Poriya
Cardiooncology, Myeloma
Vascular Functions in Myeloma Patients During Anti-tumor Therapy
Treatment options for multiple myeloma have increased significantly over the last years with the approval of immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs).
- Conditions
- Cardiooncology, Myeloma, Endothelial Dysfunction
- Trial name
- NCT03776331
- Testing
- Flow mediated dilation
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University Hospital, Essen
Dyslipidemia
Study of Trilipix Effects on Lipids and Arteries
Fibrates reduce atherosclerosis and cardiovascular disease events. A major mechanism of this benefit appears to be their ability to raise plasma high density lipoprotein cholesterol (HDL-C), especially in patients with high…
- Trial name
- NCT01025492
- Testing
- Trilipix
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Utah
Coronary Artery Disease, Dyslipidemia
The Impact of Tredaptive on Flow-Mediated Dilation in Cardiac Patients
Laropiprant (LRP; Merck \& Co., Inc, Whitehouse Station, NJ, USA) is a potent, once-daily, highly selective PGD2-receptor (DP1) antagonist.
- Trial name
- NCT01052311
- Testing
- Tredaptive (1 g extended release niacin+ 20 mg laropiprant), Tredaptive
- Where
- Israel
- Volunteers
- 8 people
- Sponsor
- Sheba Medical Center
Peripheral Artery Disease
Evaluation of Concomitant Administration of Cilostazol and Probucol on Biomarkers, Endothelial Function and Safety
Based upon evidence of efficacy and safety of both cilostazol and probucol administration in independent randomized controlled trials in PAD and CAD, the present trial seeks to investigate the effect of concomitant administration…
- Trial name
- NCT01142284
- Testing
- Cilostazol, Probucol
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Korea Otsuka Pharmaceutical Co., Ltd.
Periodontal Disease (PD), Cardio Vascular Disease
PMPR and Chlorhexidine on Periodontal Disease and Vascular Function
Gum inflammation is called gingivitis. Gum disease, known as periodontal disease, is a long-term inflammation of the gums and bone around teeth, leading to tooth loss.
- Conditions
- Periodontal Disease (PD), Cardio Vascular Disease, Oral-Systemic Link, Vascular Dysfunction
- Trial name
- CHX-PMPR-PERIV (NCT07311512)
- Testing
- Chlorhexidine (0.2%) mouthwash
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Mahdi Mutahar
Ischaemia Reperfusion Injury
Effect of Tea on Endothelial Function and Ischaemia-reperfusion Injury
Tea consumption may impact upon the decrease in endothelial function after IR-injury. However, no previous study directly examined the potential of tea to impact upon the change in endothelial function after IR-injury.
- Trial name
- NCT01660516
- Where
- Netherlands
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Blood Pressure, Albuminuria
Effect of NWT-03 on Blood Pressure
Part 2 of the study will assess the effect of 2g of NWT-03 (an egg-white protein hydrolysate) on systolic and diastolic blood pressure and flow-mediated dilation in a crossover designed study in healthy adults with mild…
- Trial name
- NCT02144740
- Testing
- NWT-03, an egg-white protein hydrolysate
- Where
- Ireland
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Newtricious R&D BV
Pregnancy
Pregnancy, Nitrate, Endothelial Function and Tissue Oxygen Saturation
Adequate macro and microvascular endothelial function during pregnancy is essential for the normal placental development and growing fetus.
- Trial name
- NCT03315806
- Testing
- Beetroot juice
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Chronic Renal Failure
Evaluation of Endothelial Dysfunction Using the "Flow Mediated Dilation" Test in a Population of Chronic Renal Failure Patients at Different Stages, and Evaluation of the Role of Antiphospholipid Antibodies
The vascular endothelium is an organ in its own right, playing, among other things, a primordial role in the control of vascular tone.
- Trial name
- NCT06347029
- Testing
- Urine sampling, Blood sampling, Flow mediated dilatation test
- Where
- Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Brugmann University Hospital