Clinical trials: Fluency Disorder
Stuttering, Adult, Childhood-onset Fluency Disorder
Efficacy and Tolerability of Ecopipam in Adults With Childhood Onset Fluency Disorder (Stuttering).
The primary objective of this study is to evaluate the efficacy and tolerability of ecopipam in reducing stuttering symptoms. It is hypothesized that ecopipam effectively reduces stuttering symptoms as measured on the SSI-IV…
- Conditions
- Stuttering, Adult, Childhood-onset Fluency Disorder, Speech Disorders, Language Disorders
- Trial name
- NCT02909088
- Testing
- Ecopipam 50mg, Ecopipam 100mg
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Gerald Maguire, MD
Parkinson's Disease
Evaluation of Intensive Language Therapy
Due to Parkinson's Disease (PD) speech and language (SL) deficits may occur. Further, the literature reports that PD patients, who have not undergone deep brain stimulation (DBS), have deficits regarding voice quality (e.g.
- Trial name
- EILT (NCT02935842)
- Testing
- Specific SL-therapy, Rhythmic Balance-Movement Training (rBMT)
- Where
- Switzerland
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Aphasia, Apraxia of Speech
Investigating the Effects of Rhythm and Entrainment on Fluency in People With Aphasia
Speaking in unison with another person is included as a part of many treatment approaches for aphasia. It is not well understood why and how this technique works.
- Trial name
- NCT05248295
- Testing
- Unison speech (vs. solo), Metrical timing (vs. conversational)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- MGH Institute of Health Professions
Stuttering
Effects of Psilocybin on Speech Fluency, Struggle, and Brain Activity in People Who Stutter
This Phase 2a clinical trial is an open-label, single-group, within-subjects pilot study designed to evaluate the safety, feasibility, and preliminary efficacy of psilocybin as a therapeutic intervention for adults with…
- Trial name
- NCT07296328
- Testing
- Psilocybin, Speech therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- NYU Langone Health
Major Depressive Disorder Remission, Major Depressive Disorder
Vulnerability Markers for Depression
The current study is a pilot for the GRF project entitled "Predicting illness trajectories in fully remitted major depression using concurrent TBS/fNIRS".
- Conditions
- Major Depressive Disorder Remission, Major Depressive Disorder, Healthy
- Trial name
- NCT06402422
- Testing
- Theta-burst stimulation
- Where
- Hong Kong
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Stuttering, Adult
Effects of Altered Auditory Feedback on Speech Fluency
The purpose of the study is to use altered auditory vocal feedback to increase fluency in people who stutter and to examine changes in this effect over the course of a one month period occurring outside the laboratory setting.
- Trial name
- NCT06011837
- Testing
- Altered Auditory Feedback
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts Institute of Technology
Apraxia of Speech, Aphasia
Auditory Masking Effects on Speech Fluency in Aphasia and Apraxia of Speech
Impaired speech production is a major obstacle to full participation in life roles by stroke survivors with aphasia and apraxia of speech.
- Conditions
- Apraxia of Speech, Aphasia, Cerebrovascular Accident
- Trial name
- NCT02094014
- Testing
- Normal Auditory Feedback, Masked Auditory Feedback, Altered Auditory Feedback
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Dyslexia, Reading Disability
Brain Stimulation Paired With Structured Reading Instruction in Children With Dyslexia
This study investigates whether transcranial electrical stimulation (tES) delivered during structured reading instruction affects reading proficiency in children with developmental dyslexia and related reading disabilities.
- Trial name
- NCT07762365
- Testing
- Active transcranial electrical stimulation (tES)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- General Neuro Inc.
Post-stroke Aphasia
Effects of Neuromodulation on Verbal Fluency in Post-stroke Aphasia
This is a single site, open label study with a single arm designed to assess the feasibility of use of caloric vestibular stimulation (CVS) in patients with post-stroke aphasia.
- Trial name
- NCT02270866
- Testing
- TNM Device
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Scion NeuroStim
Dyslexia
Working Memory Training for Children With Dyslexia
The main aim of this interventional study is to investigate whether the effects of computerized working memory training improves reading abilities for children, i.e. ages 9 - 16 years, diagnosed with dyslexia.
- Trial name
- NCT02429739
- Testing
- Working memory Training
- Where
- Norway
- Volunteers
- 32 people
- Sponsor
- Sorlandet Hospital HF
Stuttering
Shaping Motor Neural Functioning of Developmental Stuttering to Improve Fluency
Developmental stuttering (DS) is a motor/speech disorder, characterized by specific alterations in the functioning of brain circuits.
- Trial name
- NCT05306782
- Testing
- transcranial Electrical Stimulation, Speech Therapy
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Normal Non-fluency, Cataract
Comparative Study of the Optical Biometer for Measurements of the Eye
The primary purpose of this comparative clinical study is to collect clinical data to demonstrate the equivalence of the investigational device to the predicate device for measurements of the eye.
- Conditions
- Normal Non-fluency, Cataract, Aphakic Eye, Eyes With Corneal Abnormality
- Trial name
- NCT01729962
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Nidek Co. LTD.
Developmental Stuttering
Dopamine Function in Developmental Stuttering
This study will use positron emission tomography (PET) to examine the role of the chemical messenger dopamine in stuttering. It will measure and compare the number of dopamine receptors and the amount of dopamine released in the…
- Trial name
- NCT00024960
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Persistent Developmental Stutter, Childhood-Onset Fluency Disorder (Stuttering)
Stimulation of the Thalamus to Ameliorate Persistent Disfluency
Persistent developmental stutter / childhood onset fluency disorder is a disabling condition leading to significant communication and psychological disability.
- Trial name
- SToPeD (NCT05641701)
- Testing
- System On, System off
- Volunteers
- 3 people
- Sponsor
- University of British Columbia
Stroke
Dextroamphetamine and tDCS to Improve the Fluency
The proposed study aims to evaluate safety and efficacy of combined dextroamphetamine (Dexedrine) and transcranial direct current stimulation (tDCS) with melodic intonation therapy (MIT) for treatment of aphasia after stroke.
- Trial name
- NCT02514044
- Testing
- Dexedrine, Active tDCS, Speech Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas Health Science Center, Houston
Stuttering, Fluency Disorders
Enhancing Speech Fluency With Non-invasive Brain Stimulation in Developmental Stuttering
This study aims to test whether the addition of transcranial direct current stimulation (TDCS) to speech fluency training results in improvements in speech fluency in adults with developmental stuttering.
- Conditions
- Stuttering, Fluency Disorders, Speech Disorders
- Trial name
- NCT02288598
- Testing
- Anodal TDCS, Fluency Training
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Oxford
Childhood-Onset Fluency Disorder
A 10-week Efficacy Study of NOE-105 in Childhood Onset Fluency Disorder (Orpheus)
This study is designed to evaluate the effectiveness of NOE-105 on speech fluency without the known antipsychotic-induced side effects of commonly used treatments for childhood onset fluency disorder (COFD).
- Trial name
- NCT05583955
- Testing
- NOE-105
- Where
- 9 sites in United States, Australia
- Volunteers
- 75 people
- Sponsor
- Noema Pharma AG
Vascular Diseases, Peripheral
FLUENCY® PLUS in the Treatment of Peripheral Artery Disease
This is a retrospective, multi-center study to assess the safety and performance by proactively reviewing pre-existing medical records and imaging of patients who had previous placement of FLUENCY® PLUS Vascular Stent Graft in…
- Trial name
- NCT04765566
- Testing
- Endovascular revascularization of peripheral arteries
- Where
- 6 sites in Germany, Poland
- Volunteers
- 146 people
- Sponsor
- C. R. Bard