Clinical trials: Fluid Challenge, open to volunteers
Fluid Responsiveness
Fluid Responsiveness in Prone Patients
To assess fluid responsiveness in prone patient
- Trial name
- NCT06254456
- Testing
- End expiratory occlusion test
- Volunteers
- 84 people
- Sponsor
- Bhumibol Adulyadej Hospital
Fluid Responsiveness Predictability
Hemodynamic Response to the End-expiratory Occlusion Test to Titrate Fluid Challenge in Operating Room.
Personalzing intraoperative anesthetic fluid management may help in preventing fluid accumulation and related complications. Fluids are gine as boluses in operating room (the so-called FC).
- Trial name
- FC_EEOT (NCT06627907)
- Testing
- fluid challenge, end-expiratory occlusion test
- Volunteers
- 300 people
- Sponsor
- Humanitas Clinical and Research Center
To Assess the Ability of PI to Detect Preload Responsiveness
Changes in Pulse-Oximetry Perfusion Index Induced by Tidal Volume Challenge Versus Fluid Volume Challenge to Detect Preload Responsiveness in Mechanically Ventilated Patients With Low Tidal Volume
The primary goal of this study was to assess the ability of PI changes induced by a Vt challenge or fluid challenge test to detect preload responsiveness in critically ill adult patients on mechanical ventilation with low-tidal…
- Trial name
- NCT06673862
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Benha University
Hemodynamic, Fluid Responsiveness
Fluid Responsiveness and Venous Congestion Evolution During Volume Expansion
Fluid responsiveness is a critical determinant guiding fluid therapy in critically ill patients. However, excessive fluid administration can result in fluid overload, leading to venous congestion and worse clinical outcomes.
- Conditions
- Hemodynamic, Fluid Responsiveness, Venous Congestion, Fluid Challenge
- Trial name
- FREVO (NCT06772038)
- Where
- 3 sites in China, France
- Volunteers
- 64 people
- Sponsor
- Bicetre Hospital
Hemodynamic Instability
Respiratory Variation of Carotid Doppler Peak Velocity (CDPV) for Non-invasive Prediction of Fluid Responsiveness
The purpose of this study is to assess respiratory variation of carotid doppler peak velocity (∆CDPV) for prediction of fluid responsiveness during major abdominal surgery.
- Trial name
- NCT05185141
- Where
- Germany
- Volunteers
- 84 people
- Sponsor
- Johannes Gutenberg University Mainz
Acute Circulatory Failure
Peripheral Tissue Perfusion in Intensive Care
Tissue perfusion has been identified as an early prognosis factor in patients admitted to intensive care. However, little is known about the effects of different hemodynamic interventions performed in clinical routine on…
- Trial name
- INPPEREA (NCT06384287)
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Circulatory Failure, Critical Illness
Role of End-Tidal CO2 During Passive Leg Raising to Predict Fluid Responsiveness in ICU
This prospective observational study evaluates whether monitoring changes in exhaled carbon dioxide (End-Tidal CO2 or EtCO2) during a "Passive Leg Raising" (PLR) test can reliably predict fluid responsiveness in critically ill…
- Conditions
- Circulatory Failure, Critical Illness, Hypovolemia
- Trial name
- NCT07304648
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Izmir Katip Celebi University
Critically Ill Patients, Circulatory Shock
Capillary Refill Time Variation to Predict Oxygen Comsumption Variation After FLuid Challenge (CARTOFL)
Circulatory shock is characterized by tissue hypoxia. Although fluid resuscitation is an essential treatment in many forms of circulatory shock, its benefits are variable, and its administration carries a risk of potentially…
- Conditions
- Critically Ill Patients, Circulatory Shock, Ventilated Patients
- Trial name
- CARTOFL (NCT07837843)
- Testing
- Indirect calorimetry measurement
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Hospices Civils de Lyon
Venous Congestion
Changes in Portal Vein Pulsatility Variability During a Tidal Volume Challenge Can Predict Fluid Tolerance
In critically ill patients, appropriate fluid administration is one of the cornerstones of hemodynamic management, as both hypovolemia and fluid overload can negatively impact clinical outcomes.
- Trial name
- SERLU (NCT07131228)
- Volunteers
- 60 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
Portal Hypertension
Non-Invasive Portal and Hepatic Vein Pressure Estimation
Background Portal hypertension (PH) is a spectrum of complications of end-stage liver disease (ESLD) and cirrhosis, with severe manifestations including ascites and gastroesophageal varices.
- Trial name
- NONEEDLES (NCT06210178)
- Testing
- Magnetic Resonance Imaging
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Leiden University Medical Center
Celiac Disease
Gluten Challenge in Celiac Disease - Which Formulation of Gluten Gives the Best Response?
The goal of this clinical trial is to evaluate the immune response to gluten in patients with celiac disease (CeD) by comparing different forms of gluten administration.
- Trial name
- SHAKE (NCT07039773)
- Testing
- Vital wheat gluten
- Where
- 2 sites in Norway
- Volunteers
- 30 people
- Sponsor
- Oslo University Hospital
Velocity-time Integral Measurement, Critically Ill Patients
Reliability of Minimally Trained Operator's Velocity-Time Integral Measurement Guided by Artificial Intelligence VTI
Stroke volume is a major determinant of tissue perfusion and therefore a key parameter to monitor in patients with hemodynamic instability and hypoperfusion.
- Conditions
- Velocity-time Integral Measurement, Critically Ill Patients, Tissue Hypoperfusion
- Trial name
- MiniTrainedVTI (NCT06486467)
- Testing
- Fluid challenge (cristalloids) OR passive leg raising
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Colorectal Cancer, Urologic Cancer
Fluid Challenge and Plasma Volume, During Surgery
A short bolus infusion of fluid, called "fluid challenge" is commonly recommended for fluid treatment during longer surgery. However a prolonged increase of the blood volume is a prerequisite to recommend the technique.
- Conditions
- Colorectal Cancer, Urologic Cancer, Gynecologic Cancer, Colorectal Disorders
- Trial name
- FC-VE (NCT05726136)
- Testing
- acetated Ringers, albumin 5%, albumin 20%
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Joachim Zdolsek
Sepsis, Shock, Septic
"Mini Fluid Challenge Assessment: a Comparison Among Three Hemodynamic Tools"
The mini fluid challenge (mini_FC) is a functional hemodynamic test which has been used in different clinical contexts to assess fluid responsiveness.
- Conditions
- Sepsis, Shock, Septic, Critically Ill
- Trial name
- MINI3 (NCT04934943)
- Testing
- mini_FC
- Where
- 2 sites in Italy
- Volunteers
- 45 people
- Sponsor
- Humanitas Clinical and Research Center