Clinical trials: Fluid Response
Periodontitis, Acute-Phase Response
Relationship Between LRG and Periodontal Disease
This study aimed to investigate gingival crevicular fluid (GCF) and serum levels of LRG, interleukin (IL)-6 and tumor necrosis factor (TNF)-α in patients with periodontitis before and after non-surgical periodontal treatment.
- Conditions
- Periodontitis, Acute-Phase Response, Inflammation
- Trial name
- NCT04383561
- Testing
- Non-surgical periodontal treatment, Oral hygiene instructions
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Septic Shock
Non Invasive Evaluation of Fluid Responsiveness in Septic Patient
The study aims to evaluate the accuracy of fluid responsiveness assessment with non-invasive cardiometry compared to ultrasound guided inferior vena cava (IVC) collapsibility for management of critically ill septic patients with…
- Trial name
- NCT05310942
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Benha University
Breast Neoplasms
Sweden Cancerome Analysis Network - Breast : Genomic Profiling of Breast Cancer
This study evaluates the genomic profiles of breast cancer in a prospective and population-based manner. In the first phase, breast tumors are analyzed by whole transcriptome RNA-sequencing.
- Trial name
- SCAN-B (NCT02306096)
- Where
- 10 sites in Sweden
- Volunteers
- 20,000 people
- Sponsor
- Lund University
Breast Cancer
Liquid Biopsies and Imaging in Breast Cancer
The aim of the study is to show proof of concept for combining multi-parametric MRI with liquid biopsies in addition to conventional clinical and pathologic information, to accurately predict response to neoadjuvant treatment for…
- Trial name
- LIMA (NCT04223492)
- Testing
- Liquid biopsy, Multi-parametric MRI
- Where
- Netherlands
- Volunteers
- 61 people
- Sponsor
- UMC Utrecht
Acute Kidney Injury, Acute Kidney Injury Due to Sepsis
Use of NGAL for Fluid Dosing and CRRT Initiation in Pediatric and Neonatal AKI
This study will follow patients admitted to the PICU with sepsis, NICU with sepsis or after abdominal surgery, or CICU who are identified as being at risk for developing acute kidney injury.
- Conditions
- Acute Kidney Injury, Acute Kidney Injury Due to Sepsis, Neonatal Sepsis
- Trial name
- Taking Focus 2 (NCT05114057)
- Testing
- Renal Angina Index (RAI)
- Where
- United States
- Sponsor
- Children's Hospital Medical Center, Cincinnati
HIV, ICL
Tissue Biopsy and Imaging Studies in HIV-Infected Patients
This study will examine tissue from the tonsils, lymph nodes and large bowel of HIV-infected patients to investigate changes in viral load and certain white blood cells during treatment.
- Conditions
- HIV, ICL, Healthy Volunteers
- Trial name
- NCT00001471
- Where
- United States
- Volunteers
- 386 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sepsis
Controlled Fluid Resuscitation in Sepsis
To evaluate two different strategy of fluid resuscitation in sepsis patients
- Trial name
- NCT03214913
- Testing
- Early Goal Directed Therapy, Ruijin Strategy
- Volunteers
- 550 people
- Sponsor
- Ruijin Hospital
Septic Shock
Microcirculatory Guided Goal Directed Fluid Therapy in Septic Shock; a Feasibility Study
Prospective single centre study to assess the feasibility of fluid resuscitation guided by macrocirculatory and microcirculation parameters in patients in the early stages of septic shock.
- Trial name
- MICRORESUS (NCT03898674)
- Testing
- Intra venous fluid
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- King's College London
Stress, Psychological, Autonomic Nervous System
Feldenkrais Method and Stress-Related Responses in Adult Women
This pilot study aimed to explore whether the Feldenkrais Method, a gentle movement and awareness practice, could help reduce stress and improve well-being in sedentary adult women.
- Conditions
- Stress, Psychological, Autonomic Nervous System, Hydration, Healthy Volunteers
- Trial name
- NCT07175974
- Testing
- Feldenkrais Method - Awareness Through Movement (ATM)
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Intraoperative Hemodyamic Monitoring
Arterial dP/dt Dependency on Loading Conditions
In the present study the investigators aim to assess the changes of the arterial dP/dtmax induced by fluids and vasoactive drugs during abdominal surgery
- Trial name
- REABILITY (NCT06164405)
- Testing
- arterial dp/dtmax
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Septic Shock
Carotid Doppler and EEOT for Fluid Responsiveness Prediction
Fluid responsiveness prediction prior to fluid challenge administration is a topic of interest, which has been extensively investigated, but remains challenging.
- Trial name
- NCT04470856
- Testing
- End-expiratory occlusion test (EEOT)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Renal Resistive Index, Acute Kidney Injury
Renal Resistive Index as a Predictor of Acute Kidney Injury and Evaluation of Fluid Administration in Sepsis
We aim from this study to investigate the role of renal resistance index (RRI) in evaluation of Acute kidney injury development and fluid administration in sepsis patients considering the change in RRI values over 7 days from…
- Conditions
- Renal Resistive Index, Acute Kidney Injury, Sepsis
- Trial name
- NCT06009445
- Testing
- Renal resistive index
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Tanta University
Satiety, Appetite
Effect of Liquid Volume and the Amount of Incorporated Gas Into a Carbohydrate/Protein Beverage on Satiety
Liquid foams can be formed by trapping pockets of gas in a beverage. The primary objective of this study is to test the individual contribution, and possible interaction, of the liquid volume and gas to liquid volume ratio (i.e.
- Trial name
- NCT02405494
- Testing
- Beverage 1, Beverage 2, Beverage 3
- Where
- United Kingdom
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Biomarkers, Acute Kidney Injury
Vancomycin Exposure and Biomarker Tracking Using Real-time Monitoring of Interstitial Fluid
The goal of this observational study is to understand whether a wearable sensor (the Nutromics Sensor Device) can accurately measure drug and biomarker levels in the fluid just under the skin (interstitial fluid), instead of…
- Conditions
- Biomarkers, Acute Kidney Injury, Sepsis
- Trial name
- VENTURE (NCT07893223)
- Where
- 5 sites in United States
- Volunteers
- 200 people
- Sponsor
- Nutromics
Sepsis, Acute Respiratory Distress Syndrome
Study of Biomarkers in Patients of Sepsis Complicated With Acute Respiratory Distress Syndrome (ARDS)
1. Title: Study of Biomarkers in Blood and Alveolar Lavage Fluid Samples of Sepsis Patients Complicated With Acute Respiratory Distress Syndrome (ARDS) 2. Research center: Single-center study. 3.
- Trial name
- NCT04552821
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Tianjin Nankai Hospital
Primary CNS Lymphoma
Diagnosis; Objective RespOnse; THErApy
Thi is a prospective and low-intervention clinical trial. We propose to design a panel of "core" genetic alterations by sequencing Cerebral Spinal Fluid (CSF) DNA in patients with confirmed or suspicious Primary Central Neurvous…
- Trial name
- DOROTHEA (NCT05036564)
- Testing
- Lumbar puncture
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- IRCCS San Raffaele
Septic Shock, Fluid Resuscitation
Evolution of Tissue Perfusion and Venous Congestion Markers in Fluid-Responsive Septic Shock Patients
Septic shock remains a leading cause of mortality in intensive care, and while fluid resuscitation (FR) is a cornerstone of early management, its benefit-risk balance is highly variable.
- Conditions
- Septic Shock, Fluid Resuscitation, Congestion, Venous
- Trial name
- FLUID-IMPACT (NCT06958809)
- Testing
- Echography
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hospital Ambroise Paré Paris
Septic Shock, Fluid Responsiveness
Timing of Preload Responsiveness in Sepsis
During acute circulatory failure, volume expansion does not always lead to a significant increase in cardiac output (fluid responsiveness).
- Trial name
- TIPRES (NCT05627817)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Bicetre Hospital
Other Complications of Esophagostomy
Outcome Study of Restrictive vs. Liberal Intraoperative Fluid Management Guided by PPV in Esophagectomy
The purpose of this study is to determine whether intraoperative restrictive fluid management guided by pulse pressure variation produces a better effect on the postoperative lung function, kidney function, inflammatory response…
- Trial name
- PPV (NCT01933451)
- Testing
- Intraoperative fluid therapy
- Where
- Taiwan
- Volunteers
- 7 people
- Sponsor
- National Taiwan University Hospital
Oropharyngeal Squamous Cell Carcinoma, Oropharyngeal HPV Squamous Cell Carcinoma
Tumor Mutational Burden, Liquid Biopsy, Angiogenic Factors and DCE-MRI Perfusion in HPV-Negative Oropharyngeal Cancer
This prospective interventional study evaluates the predictive value of tumor mutational burden, liquid biopsy biomarkers (including circulating tumor DNA), angiogenic factors, and dynamic contrast-enhanced magnetic resonance…
- Trial name
- NCT07407205
- Testing
- Concurrent Chemoradiotherapy, Dynamic Contrast-Enhanced MRI Perfusion (DCE-MRI)
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- Institute of Oncology Ljubljana