Clinical trials: Fluid Response
Shock, Sepsis
The Effects of Sedative on the Fluid Responsiveness in Critically Ill Patients
Hypotension and bradycardia are often observed following induction of dexmedetomidine or propofol sedation.Cardiac preload decrease by sedative agents was often considered as one of main causes for this hypotension.The…
- Trial name
- NCT01447875
- Testing
- Passive Leg Raising, propofol or mexmedetomidine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Southeast University, China
Locally Advanced Rectal Carcinoma, Neoadjuvant Treatment
Longitudinal Multimodal Response Assessment During Neoadjuvant Treatment of Rectal Cancer
This pilot study aims to trial multimodal early response assessment to enable therapy adaptions in the context of non-operative therapy strategies of locally advanced rectal cancer (LARC) for development of a non-invasive…
- Conditions
- Locally Advanced Rectal Carcinoma, Neoadjuvant Treatment, Radiotherapy, Adaptive Treatment
- Trial name
- PRIMO (NCT05524012)
- Testing
- Blood sample, MRI scan
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Jena University Hospital
Septic Shock, Critically Ill
Resuscitation Strategies in Septic Shock
The purpose of this study, in mechanically ventilated septic shock patients, is to determine whether a fluid loading strategy based on parameters derived from the transpulmonary thermodilution technique may lead to more…
- Trial name
- ReSSeS (NCT02150512)
- Testing
- Transpulmonary Thermodilution, Surviving Sepsis Guidelines (SSG)
- Where
- Netherlands
- Volunteers
- 170 people
- Sponsor
- Medisch Spectrum Twente
Pleth Variability Index
Evaluation of the Fluid Response of SARS-CoV-2 (COVID-19) Patients in Intensive Care; Pleth Variability Index
In this study; We aimed to investigate the role of pleth variability index, which is a noninvasive method, in showing fluid response in SARS-CoV-2 (COVID-19) patients, which we know is appropriate fluid management.
- Trial name
- NCT04373213
- Testing
- Pleth variability index
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Erzincan University
Septic Shock
Does the Time Between the End of Vascular Filling and Evaluation of Its Effectiveness Modify Fluid Challenge Results in Septic Shock?
The main objective of this study is to evaluate in a population of patients with septic shock receiving 500 ml crystalloid over 10 minutes, the proportion of patients classified as "responders" to the fluid challenge (increase of…
- Trial name
- FC-Rev (NCT02116413)
- Testing
- Fluid challenge, Cardiac ultrasound
- Where
- 9 sites in France
- Volunteers
- 145 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Sepsis
Bioimpedance Analysis in Septic Intensive Care Unit (ICU) Patients
Patients with severe infections initially require large amounts of fluid as part of resuscitation. Later on however, problems may arise from excess fluid such as increased time on a ventilator and kidney damage.
- Trial name
- BIOVISION (NCT01379404)
- Testing
- Bioelectric Impedance Analysis
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Acute Lung Injury (ALI), Acure Respiratory Distress Syndrome (ARDS)
Effect of Intraoperative Fluid Restriction on Postoperative Outcomes in Video-assisted Thoracic Surgery (VATS)
The objective of this study is to compare the effects of two intraoperative fluid regimens - restrictive versus liberal (standard)- on postoperative outcomes (e.g.
- Conditions
- Acute Lung Injury (ALI), Acure Respiratory Distress Syndrome (ARDS), Sepsis
- Trial name
- NCT00854386
- Testing
- liberal fluid administration, restrictive fluid administration
- Where
- 2 sites in Israel
- Volunteers
- 200 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Sepsis
Predictive Value of Sublingual Microcirculation and Peripheral Tissue Oxygen Monitoring
Change and predictive Value of Sublingual Microcirculation and Peripheral Tissue Oxygen Monitoring in Sepsis Patients With Successful Fluid Resuscitation
- Trial name
- NCT03859726
- Testing
- NIRS, Sublingual microcirculation
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Xiangya Hospital of Central South University
Septic Shock
The Effect of Restrictive Fluid Management on Cardiac Function and Glycocalyx Degradation
The study aims to compare the effects of restrictive fluid management on cardiac dysfunction and vascular integrity in septic shock patients.
- Trial name
- NCT04282252
- Testing
- I.V. SOLUTIONS
- Where
- Sweden
- Volunteers
- 54 people
- Sponsor
- Karolinska Institutet
Anesthesia
Can Peripheral NIRS Predict the Response to a Fluid Challenge in Pediatric Patients: An Interventional Study
This study will be conducted on pediatric patients up to 14 years of age. The effect of two fluid challenge regimes on cerebral and peripheral NIRS will be assessed, in a randomized double blinded controlled trial.
- Trial name
- NCT05111132
- Testing
- Fluid challenge (cristalloïd, NaCl 0,9%)
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Acute Kidney Injury, Hypoperfusion
The Predictive Performance of Renal Ultrasound on Changes in Renal Clearance
The study will examine the ability of renal ultrasound (Doppler and Contrast Enhanced Ultrasound (CEUS)) in distinguishing ICU patients who exhibit increases in glomerular filtration rate (GFR) in response to fluid loading, from…
- Conditions
- Acute Kidney Injury, Hypoperfusion, Fluid Overload
- Trial name
- NCT04198168
- Testing
- IV crystalloid fluid bolus
- Where
- Denmark
- Volunteers
- 2 people
- Sponsor
- Aarhus University Hospital
Metastatic Lung Cancer
LIquid Biopsy to prEdict Responses To First-line immunotherapY in Metastatic Non-small Cell LUNG Cancer. LIBERTY LUNG
Patient with histologically proven NSCLC in a metastatic stage, treatment naïve and eligible for first-line treatment with immune checkpoint inhibitor. Combination with chemotherapy is possible.
- Trial name
- LIBERTYLUNG (NCT04790682)
- Testing
- assessment of the predictive value of ctDNA level of the prominent mutant allele variation between baseline and week 6, on response to treatment according to RECIST 1.1 criteria.
- Where
- 3 sites in France
- Volunteers
- 300 people
- Sponsor
- Institut Curie
Cancer, Septic Shock
Evaluation of Fluid Resuscitation in Children With Cancer With Severe Sepsis / Septic Shock
Retrospective study to evaluate the characteristics of patients and of fluid resuscitation during intensive care unit hospitalization of patients under septic chock.
- Conditions
- Cancer, Septic Shock, Other Fluid Overload
- Trial name
- NCT01304680
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Grupo de Apoio ao Adolescente e a Crianca com Cancer
Poor Ovarian Response
SIRT3 Expression in Granulosa Cells and the Levels of Follicular Fluid Metabolites Among POR Subgroups
The goal of this prospective, observational study is to learn about the pathogenesis and biological target of the subtypes of poor ovarian response (POR) during In vitro fertilization and embryo transfer (IVF-ET).
- Trial name
- POR SIRT3 (NCT06617988)
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shandong University of Traditional Chinese Medicine
Lung Neoplasms, Neoadjuvant Therapy
MRD-Guided Postoperative Surveillance and Adaptive Treatment for Resectable Lung Cancer
This study is a prospective single-arm clinical trial targeting patients with stage IB-IIIA non-small cell lung cancer (NSCLC) who have received neoadjuvant immunotherapy.
- Conditions
- Lung Neoplasms, Neoadjuvant Therapy, Immunotherapy, Minimal Residual Disease
- Trial name
- NCT07894458
- Testing
- Adaptive therapy of de-escalation and escalation based on MRD testing and pathological response
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University People's Hospital
Ventricular Dysfunction
Hemodynamic Indices Predictive of a Beneficial Response to Fluid Expansion in Case of Hemodynamic Failure After Cardiac Surgery With Altered Preoperative Ejection Fraction (LVEF≤45%)
Low Cardiac Output Syndrome occurs frequently after cardiac surgery, especially when pre-operative LVEF is altered (LVEF≤45%). The correction of hemodynamic failure requires adapted treatments: fluid expansion and/or inotropic or…
- Trial name
- ALTERVOL (NCT01673230)
- Testing
- cardiac surgery for ventricular dysfunction
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Rennes University Hospital
Vegetable Signature Documentation With Metabolomic Technique
Vegetable Signature From Human Metabolomics Responses
The purpose of this study is to perform dietary intervention studies on a variety of vegetables.
- Trial name
- NCT03483558
- Testing
- Control, Spinach, Celery
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Sepsis
Precision Resuscitation With Crystalloids in Sepsis
Fluids are one of the most common treatments given to patients in the hospital. Fluids are especially important in treating patients with sepsis.
- Trial name
- PRECISE (NCT06253585)
- Testing
- Algorithm Alarm- Crystalloids, Standard of Care
- Where
- 7 sites in United States
- Volunteers
- 2,012 people
- Sponsor
- Emory University
Critically Ill, Acute Kidney Injury
Renal Resistive Index and Cardiac Output Changes During Resuscitation Predict the Occurrence of Acute Kidney Injury in Septic Shock Patients
Record the renal resistive index and hemodynamic parameters ( record the cardiac output and stroke volume if the patient's next to kin agree to undertake a PiCCO monitoring ) before and after resuscitation for severe sepsis or…
- Conditions
- Critically Ill, Acute Kidney Injury, Septic Shock
- Trial name
- CORRI (NCT01862588)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhongda Hospital
Muscle-Invasive Bladder Cancer (MIBC), Upper Tract Urothelial Carcinoma
Validation of a Circulating Tumor DNA Blood Test in Muscle-Invasive Bladder and Upper Tract Urothelial Cancer
This prospective observational study evaluates a blood-based circulating tumor DNA (ctDNA) test in patients with muscle-invasive bladder cancer or upper tract urothelial cancer.
- Conditions
- Muscle-Invasive Bladder Cancer (MIBC), Upper Tract Urothelial Carcinoma, Urothelial Carcinoma (UC)
- Trial name
- BLUT-DNA (NCT07756437)
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- AZ Sint-Lucas Gent