Clinical trials: Fluid Response
Cirrhosis, Liver, Cirrhotic Cardiomyopathy
Echocardiography-guided Cirrhosis and Liver Failure-Intensive Care Protocol Sepsis
Point-of-care echocardiography is used to guide septic shock resuscitation in patients with severe sepsis in the intensive care unit (ICU), but without systematic evidence for efficacy in critically patients with Cirrhosis and…
- Conditions
- Cirrhosis, Liver, Cirrhotic Cardiomyopathy, Septic Shock
- Trial name
- ECLIPSE-I (NCT07286643)
- Testing
- POCUS, Fixed Resuscitation Strategy based on Target MAP
- Where
- India
- Volunteers
- 140 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Neonatal Sepsis
Role of Antibiotics in Preventing Infection in Babies Born Through Meconium Stained Liquor
The purpose of the study is to evaluate the role of antibiotics in preventing infection in babies born through meconium stained amniotic fluid. Normally babies do not pass meconium while in utero.
- Trial name
- AbProM (NCT01290003)
- Testing
- Piperacillin-Tazobactam and Amikacin
- Where
- India
- Volunteers
- 250 people
- Sponsor
- Lady Hardinge Medical College
Gastric Cancer
Combination of CT and Ultrasound Radiomics Combined With Liquid Biopsy to Predict Neoadjuvant Chemotherapy Response in Patients With Locally Advanced Gastric Cancer
This prospective cohort study aims to construct an artificial intelligence (AI)-derived predictive model for neoadjuvant chemotherapy response prediction in patients with locally advanced gastric cancer based on preoperative…
- Trial name
- NCT07697079
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Liu Yang
Septic Shock, Hypovolemia
Assessment of Fluid Responsiveness in Septic Shock Patients, Can End-tidal co2 Measurement Help?
Fluid therapy is important in patients with sepsis and septic shock. There are many invasive and non-invasive methods to assess fluid responsiveness in patients.
- Conditions
- Septic Shock, Hypovolemia, Sepsis
- Trial name
- NCT05557461
- Testing
- End-tifdal co2, systolic, diastolic blood pressure, ppv values and vci distensibility
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bozyaka Training and Research Hospital
Neurosurgery, Cardiovascular System
Fluid Challenge Infusion and Response
It is unclear if the rate of administration of the fluid challenge could affect the rate of fluid responsiveness. The role of this small-dose (the so called mini-FC) has been recently tested to assess if the infusion of a small…
- Conditions
- Neurosurgery, Cardiovascular System, Anesthesia, General
- Trial name
- REFILL (NCT03810118)
- Testing
- fluid challenge
- Where
- Italy
- Volunteers
- 49 people
- Sponsor
- Humanitas Clinical and Research Center
Overweight or Obese Adults
Effect of a Liquid Tonic Drink on Post-meal Glucose and Insulin Responses
A randomised, double blinded, placebo-controlled crossover design clinical trial conducted at the Mary MacKillop Institute for Health Research (MMIHR, Australian Catholic University) for individuals with overweight/ obesity.
- Trial name
- NCT07030010
- Testing
- Breakfast meal challenge with tonic drink
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Australian Catholic University
Shock, Septic
Protocolized Reduction of Non-resuscitation Fluids vs Usual Care in Septic Shock Feasibility Trial
The objectives of this feasibility trial are to assess the efficacy and feasibility of methods and procedures of a protocol purposed to compare a reduction of administration of non-resuscitation fluids to usual care in patients…
- Trial name
- NCT05249088
- Testing
- Protocolised reduction of non-resuscitation fluids, Usual care
- Where
- 8 sites in Sweden
- Volunteers
- 98 people
- Sponsor
- Region Skane
Critically Ill Patients, Septic Shock
Vexus-guided Fluid Management in Patients With Septic Shock After the Resuscitation Phase
It is well recognized the association between fluid volume administered and positive fluid balance with adverse outcomes . Active fluid removal is widely practiced in an attempt to mitigate this potential damage.
- Trial name
- VEXUS (NCT06227702)
- Testing
- Fluid management according to Venous Excess Ultrasound (VExUS) Score
- Volunteers
- 200 people
- Sponsor
- Federal University of São Paulo
Shock, Septic
Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis
The objectives of this multicenter pragmatic clinical trial are to compare the effectiveness and relative safety of balanced fluid resuscitation versus 0.9% "normal" saline in children with septic shock, including whether…
- Trial name
- PRoMPT BOLUS (NCT04102371)
- Testing
- Lactated Ringer, Normal Saline, Plasma-lyte
- Where
- 22 sites in United States
- Volunteers
- 9,041 people
- Sponsor
- Children's Hospital of Philadelphia
Influenza
Trial to Evaluate the Immune Response to OPV When Administered Concomitantly With CAIV-T to Healthy Children.
Phase III trial to evaluate the immune response to oral poliovirus vaccine (OPV) when administered concomitantly with CAIV-T to healthy children.
- Trial name
- NCT00192426
- Testing
- CAIV-T
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- MedImmune LLC
Septic Shock, Electrolyte and Fluid Balance Conditions
OPTImized Restrictive Strategy Targeting Non-Resuscitative FLUIDs in Septic Shock: Pilot Study.
Intravenous fluids are one of the keystones in the initial management of patients with septic shock, but they inevitably lead to a fluid overload, which is associated with poor outcome.
- Trial name
- OPTIFLUID (NCT04947904)
- Testing
- Reduction of the patient's fluid intake during the first 7 days
- Where
- 4 sites in France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Allergic Rhinitis, Asthma
Development of Human Nasal Challenge Models With Microbial Constituents and Grass Pollen
The investigators propose the development of a range of nasal spray challenge models to study the way the nose can respond to different types of nasal challenge that elicit different forms of inflammation.
- Conditions
- Allergic Rhinitis, Asthma, Latent Tuberculosis
- Trial name
- NCT02090374
- Testing
- Poly ICLC, Poly I:C, R848
- Where
- United Kingdom
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Locally Advanced Rectal Cancer
Observational Study on Rectal Cancer to Verify if Response After Chemo-radiotherapy Can be Predicted With a Particular Blood Test.
Research project for patients with locally advanced rectal cancer in which biological material and health-related personal data are collected.
- Trial name
- LiBReCa (NCT03699410)
- Testing
- Neoadjuvant radiotherapy, Neoadjuvant chemotherapy, Radical surgery
- Where
- 2 sites in Switzerland
- Volunteers
- 25 people
- Sponsor
- Dimitri Christoforidis
Primary CNS Lymphoma
Diagnosis; Objective RespOnse; THErApy
Thi is a prospective and low-intervention clinical trial. We propose to design a panel of "core" genetic alterations by sequencing Cerebral Spinal Fluid (CSF) DNA in patients with confirmed or suspicious Primary Central Neurvous…
- Trial name
- DOROTHEA (NCT05036564)
- Testing
- Lumbar puncture
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- IRCCS San Raffaele
Septic Shock, Sepsis
The Effect of Early Norepinephrine on Stroke Volume Index, Cardiac Index, Lactate, and Arterial Elastance in Pediatric Septic Shock
The complexity of pediatric septic shock arise from its varied pathophysiology, which includes systemic inflammation, cardiovascular collapse, and multiple organ dysfunction.
- Trial name
- NCT06461390
- Testing
- Norepinephrine, Ringer's Lactate
- Where
- Indonesia
- Volunteers
- 42 people
- Sponsor
- Universitas Indonesia
Sepsis
Controlled Fluid Resuscitation in Sepsis
To evaluate two different strategy of fluid resuscitation in sepsis patients
- Trial name
- NCT03214913
- Testing
- Early Goal Directed Therapy, Ruijin Strategy
- Volunteers
- 550 people
- Sponsor
- Ruijin Hospital
Septic Shock
Non Invasive Evaluation of Fluid Responsiveness in Septic Patient
The study aims to evaluate the accuracy of fluid responsiveness assessment with non-invasive cardiometry compared to ultrasound guided inferior vena cava (IVC) collapsibility for management of critically ill septic patients with…
- Trial name
- NCT05310942
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Benha University
Hepatocellular Carcinoma Non-resectable
Evaluation of Treatment Predictors Reflecting Beta-catenin Activation in Hepatocellular Carcinoma
This prospective clinical trial will evaluate PET/CT and genomic liquid biopsy based biomarkers as predictors of clinical therapeutic response to immune-checkpoint inhibitor (ICI) therapy for patients with inoperable…
- Trial name
- ExTRACT-HCC (NCT04965454)
- Testing
- Fluorine-18 fluorocholine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Queen's Medical Center
Septic Shock, Fluid Resuscitation
Restricted or Liberal Fluid for Haemodynamic Resuscitation in Sepsis
A prospective, individual patient data meta-analysis (IPDMA) of four multicentre, open-label, randomised clinical trials of initial haemodynamic resuscitation in patients with septic shock.
- Trial name
- FRESHLY (NCT05453565)
- Testing
- Vasopressors, Fluids
- Volunteers
- 7,838 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Septic Shock, Hemodynamic Instability
Whether a Minimal Volume Could Predict Fluid Responsiveness Using Thermodilution by PAC in Septic Shock Patients
Assessment of fluid responsiveness (FR) is to detect whether patient could benefit from fluid therapy. Mini fluid challenge has been widely used in clinical practice to prevent patients from volume overload.
- Conditions
- Septic Shock, Hemodynamic Instability, Fluid Therapy
- Trial name
- NCT04515511
- Testing
- 4% gelatin
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College Hospital