Clinical trials: Fluorescence Imaging
Peritoneal Carcinomatosis, Colorectal Cancer
Multi-modality Imaging in Peritoneal Carcinomatosis of Colorectal Origin
Intraoperative tumor localization and resection can be enhanced using intraoperative fluorescence imaging and radiodetection. Labetuzumab specifically recognizes CEA which is is expressed on > 95% of colorectal cancers..
- Conditions
- Peritoneal Carcinomatosis, Colorectal Cancer, Carcinoma, Neoplasms
- Trial name
- MMIPC (NCT03699332)
- Testing
- Indium-111-DOTA-Labetuzumab-IRDye800CW injection, SPECT/CT scan, CRS extended with dual-modality imaging
- Where
- Netherlands
- Volunteers
- 29 people
- Sponsor
- Radboud University Medical Center
Diffuse Parenchymal Lung Diseases
Prospective Data Collection of Patients With Diffuse Parenchymal Lung Diseases
The purpose of this study is to generate a prospective database of all patients evaluated for diffuse parenchymal lung diseases to provide much needed data on the various disease aetiologies, incidence and prevalence rates…
- Trial name
- NCT01600378
- Where
- Singapore
- Volunteers
- 500 people
- Sponsor
- Singapore General Hospital
Esophageal Cancer
Quantitative Fluorescence Endoscopy Using Durvalumab-680LT in Esophageal Cancer
Treatment of patients with locally advanced esophageal cancer (EC) is multidisciplinary and consists of neoadjuvant therapy followed by surgical removal of the esophageal tumor and potentially tumor positive lymph nodes.
- Trial name
- OPTIC (NCT05450484)
- Testing
- Fluorescence endoscopy using durvalumab-680LT
- Where
- Netherlands
- Volunteers
- 21 people
- Sponsor
- University Medical Center Groningen
Cranial Nerve Injuries
Phase I/II Clinical Trial of NP41 for Cranial Nerve Fluorescence Imaging
Preclinical evidence has shown that NP41 is a novel nerve-binding peptide with safe pharmacokinetics. Fluorescently labeled NP41 is effective for the intraoperative visualization of cranial nerves during neurosurgery.
- Trial name
- NCT05043519
- Testing
- FAM-NP41
- Volunteers
- 40 people
- Sponsor
- Peking University Third Hospital
Breast Cancer, Lymph Node Mapping
A Study Assessing the Safety and Effectiveness of IC2000 and SPY Fluorescence Imaging Systems (SPY-PHI) in the Visualization of Lymphatic Vessels and Identification of Lymph Nodes During Sentinel Lymph Node Biopsy in Subjects With Breast Cancer
This is a prospective, open label, multicenter, non-inferiority within-patient study to determine the effectiveness of IC2000 (Indocyanine Green (ICG) for Injection) and the SPY Portable Handheld Imaging System (SPY-PHI) as an…
- Conditions
- Breast Cancer, Lymph Node Mapping, Sentinel Lymph Node Biopsy
- Trial name
- FILM-B (NCT03200704)
- Testing
- IC2000 and SPY-PHI, Tc-99m radioactive colloid and Gamma Probe
- Where
- 7 sites in United States, Canada
- Volunteers
- 152 people
- Sponsor
- Novadaq Technologies ULC, now a part of Stryker
Bladder Cancer, Muscle-Invasive Bladder Carcinoma
Clinical Trial to Evaluate Post-Operative Outcomes of Ureteral Stent vs Ureteral Stent Free Radical Cystectomy
Subjects will be randomized into 2 groups (stent or no stent) prior to radical cystectomy with ileal conduit urinary diversion (RCIC). They will follow the standard of care and be enrolled in the study for 12 months post-op.
- Conditions
- Bladder Cancer, Muscle-Invasive Bladder Carcinoma, Urothelial Carcinoma, Pelvic Malignancy
- Trial name
- NCT07234968
- Testing
- Ureteral Stent Placement, No Ureteral Stent, Indocyanine Green with Fluorescence Imaging
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Thomas Jefferson University
Sentinel Lymph Node, Breast Cancer
Sentinel Lymph Node Biopsy in Breast Cancer Surgery Using ICG
This clinical trial is a prospective, multicenter, self-controlled clinical study. In order to meet the requirements of this plan, 130 breast cancer patients need the sentinel lymph node biopsy with novel near-infarred…
- Trial name
- NCT03579979
- Testing
- Methylene Blue, Indocyanine Green
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Chinese Academy of Sciences
Intraoperative Ureter Visualization, Abdominolpelvic Surgery
A Study to Find Out if ASP5354 Can Clearly Help Show the Ureter During Surgery
The ureter was the tube that carries urine from the kidneys to the bladder. It was difficult for surgeons to see the ureter during abdominal surgery. This could lead to injuring the ureter which, although rare, could be serious.
- Trial name
- NCT05754333
- Testing
- pudexacianinium chloride
- Where
- 6 sites in United States
- Volunteers
- 107 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Non-Small-Cell Lung Carcinoma, Head and Neck Squamous Cell Cancer
LIFE-Lung Bronchoscopy in Patients at Risk for Developing Lung Cancer
The purpose of the study is to evaluate the usefulness and accuracy of the "LIFE-Lung Bronchoscopy" to identify early changes in lung tissues that show precancerous, cancer in situ (just beginning and not spread) and microscopic…
- Conditions
- Non-Small-Cell Lung Carcinoma, Head and Neck Squamous Cell Cancer, Pulmonary Disease, Chronic Obstructive
- Trial name
- NCT00260598
- Testing
- LIFE Bronchoscopy
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- University of Pittsburgh
Resectable Pancreatic Adenocarcinoma
Fluorescent Navigation Technology in Radical Resection of Pancreatic Cancer
This study intends to design the prospective, exploratory, single center clinical study, using targeted EGFR fluorescence imaging agent (anti-EGFR-IR800CW) and fluorescent navigation technology, in its lymph node tracing…
- Trial name
- CISPD-6 (NCT06168552)
- Testing
- Injection of fluorescent developer (anti-EGFR-IR800CW)
- Volunteers
- 20 people
- Sponsor
- Zhejiang University
Breast Cancer
Intraoperative Imaging of Lymph Nodes
One-third of the global population battles cancer, with surgery being the primary treatment for localized forms. Successful treatment often hinges on the thorough removal of primary tumors and pinpointing cancerous sentinel lymph…
- Trial name
- NCT06276439
- Testing
- Surgical removal of breast cancer and lymph nodes
- Where
- North Macedonia
- Volunteers
- 48 people
- Sponsor
- University of Illinois at Urbana-Champaign
Trauma Injury
ICG Fluorescence Imaging in Lower Extremity Amputation Patients
This is a non-randomized prospective study of 30 patients scheduled to undergo lower extremity amputation (below the knee, through the knee or above the knee) evaluating bone perfusion and viability using indocyanine green (ICG)…
- Trial name
- NCT04250558
- Testing
- Lower Extremity Amputation
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Surgical Procedure, Unspecified
Safety and Feasibility of ActivSight(tm) in the Identification of The Ureter Via Riboflavin Fluorescence
The main Objective of this study is to determine the safety and feasibility of a prototype ActivSightTM in identifying the ureter in real-time during elective laparoscopic abdominopelvic surgery after pre-surgical administration…
- Trial name
- NCT06535555
- Testing
- Investigational Safety and Feasibility
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Activ Surgical
Cholecystolithiasis, Cholecystitis
FALCON: a Multicenter Randomized Controlled Trial
Rationale: Several clinical feasibility studies have shown the potential benefit of near-infrared fluorescence (NIRF) imaging using indocyanine green (ICG) for enhanced and earlier biliary anatomy visualization during…
- Trial name
- NCT02558556
- Testing
- Laparoscopic Fluorescence Imaging System (Karl Storz), Indocyanine Green
- Where
- Netherlands
- Volunteers
- 308 people
- Sponsor
- Maastricht University Medical Center
Basal Cell Carcinoma of Skin, Squamous Cell Carcinoma (Skin)
Machine Learning Analysis of Two-photon Fluorescence Microscopy of Dermatologic Biopsies
The goal of this study is to investigate the ability of a machine learning model to evaluate two-photon fluorescence microscopy images of dermatologic biopsies at point of care.
- Trial name
- NCT07682831
- Testing
- Two photon microscopy imaging
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of Rochester
GIST
NIR Fluorescence Imaging With ICG for the Intraoperative Identification of Gastrointestinal Stromal Cell Tumours
This is an open-label pilot study including 10 GIST patients scheduled for an elective open or laparoscopic resection at Leiden University Medical Center (LUMC) and Erasmus Medical Center (EMC), Rotterdam.
- Trial name
- NCT04761172
- Testing
- Intraoperative near-infrared fluorescence imaging using indocyaninegreen
- Where
- 2 sites in Netherlands
- Volunteers
- 10 people
- Sponsor
- Leiden University Medical Center
Atherosclerosis Coronary Artery With Angina Pectoris, Atheroscleroses, Coronary
First-In-Human Intracoronary OCT-FLIm In Patients Undergoing PCI
Patients will undergo intracoronary imaging using combined optical coherence tomography-fluorescence lifetime imaging (OCT-FLIm) during percutaneous coronary intervention, and the obtained imaging data will be used to assess the…
- Conditions
- Atherosclerosis Coronary Artery With Angina Pectoris, Atheroscleroses, Coronary, Atherosclerotic Plaque, Thin-cap fIbroatheroma
- Trial name
- NCT04835467
- Testing
- Dual-modal OCT-FLIm
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Korea University Guro Hospital
Head and Neck Cancer (H&N), Free Tissue Flaps
Comparing Intraoperative Indocyanine Green Fluorescence Imaging With Standard Clinical Assessment for Flap Perfusion in Head and Neck Reconstruction (VISION Trial)
This is a prospective multicentre randomised controlled trial evaluating whether intraoperative indocyanine green (ICG) fluorescence angiography improves outcomes in head and neck free flap reconstruction compared with standard…
- Conditions
- Head and Neck Cancer (H&N), Free Tissue Flaps, Free Flap, Free Flap Evaluation
- Trial name
- VISION (NCT07635420)
- Testing
- Indocyanine Green, Standard clinical perfusion assessment
- Where
- Sweden
- Volunteers
- 244 people
- Sponsor
- Region Skane
Surgery, Fluorescence
ICG Indocyanine Green in Reconstructive Surgery
The success or failure of a reconstruction is largely related to the vascularization of the operated area. Near infrared fluorescence (also near infrared fluorescence angiography, NIR FA) with ICG administration is an innovative…
- Trial name
- ICG-R (NCT06129669)
- Testing
- Indocyanine green
- Where
- Netherlands
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Primary Soft-tissue Sarcoma
A Microdose Evaluation Study of ABY-029 in Primary Sarcoma
The primary study objective is to determine if microdoses of ABY-029 (up to 6X) lead to detectable signals (defined as signal-to-noise ratio, SNR ≥10, with the Odyssey NIR scanner in sampled tissues with an EGFR pathology score ≥…
- Trial name
- NCT03154411
- Testing
- ABY-029
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Dartmouth-Hitchcock Medical Center