Clinical trials: Fluorescence Imaging
Age-Related Macular Degeneration, NAMD
Targeted Fluorescence Imaging in AMD
Rationale: To track performance of intravitreal distribution of anti-VEGF-A (Bevazicumab-800CW) and provide information about neovascularization and inflammation in Age-Related Macular Degeneration (AMD), thereby predicting…
- Trial name
- LEAF (NCT05262244)
- Testing
- Bevacizumab-IRDye800CW
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- University Medical Center Groningen
Surgery, Fluorescence
ICG Indocyanine Green in Reconstructive Surgery
The success or failure of a reconstruction is largely related to the vascularization of the operated area. Near infrared fluorescence (also near infrared fluorescence angiography, NIR FA) with ICG administration is an innovative…
- Trial name
- ICG-R (NCT06129669)
- Testing
- Indocyanine green
- Where
- Netherlands
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Stage I Breast Cancer, Stage II Breast Cancer
Comparison of Use of Indocyanine Green and 99mTc-labeled Radiotracer for Axillary Lymphatic Mapping in Patients With Breast Cancer
This clinical trial will enroll up to 130 adult women with a confirmed diagnosis of clinical stage 1 or 2 breast cancer who are undergoing breast cancer surgery with lumpectomy or mastectomy and planned axillary sentinel node…
- Trial name
- NCT02419807
- Testing
- Indocyanine Green Solution, Technetium Tc-99m Sulfur Colloid, Lymphoscintigraphy
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Case Comprehensive Cancer Center
Head and Neck Cancer, Cancer of the Head and Neck
Fluorescence Imaging in Head and Neck Cancer
Fluorescent technology continues to advance in the detection of sentinel lymph nodes (SLNs). Currently, this requires switching from near-infrared light to white light to be able to identify the fluorescent tissue contrasting…
- Trial name
- NCT03297957
- Testing
- Hands-free goggle system
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Washington University School of Medicine
Solitary Pulmonary Nodules
Near Infrared Fluorescence Imaging With Indocyanine Green
This research study will evaluate how Near Infrared Fluorescence imaging (NIFI) with indocyanine green (ICG) contrast dye can assist in the identification and diagnosis of lung nodules during surgery.
- Trial name
- NIFI-ICG (NCT02851368)
- Testing
- near infrared fluorescence imaging (NIFI), Indocyanine Green
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Pittsburgh
Colorectal Cancer, Colorectal Neoplasms
Indocyanine Green Fluorescence Imaging in Prevention of Colorectal Anastomotic Leakage
This is a randomized, controlled, parallel, multicenter trial to determine the difference in post-operative anastomotic leakages in colorectal surgery, where anastomosis perfusion is evaluated using indocyanine green fluorescence…
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Gastrointestinal Cancer, Gastrointestinal Neoplasms
- Trial name
- ICG-COLORAL (NCT03602677)
- Testing
- ICG fluorescence imaging
- Where
- 2 sites in Finland
- Volunteers
- 1,062 people
- Sponsor
- Oulu University Hospital
Wounds, Diabetic Foot Ulcers
Evaluation of a 'Hand-held' Fluorescence Digital Imaging Device for Real-Time Advanced Wound Care Monitoring (JDRTC/UHN)
We have developed an innovative optical molecular imaging platform (called PRODIGI) based on high-resolution fluorescence and white-light technologies in a hand-held, real-time, high-resolution, non-invasive format.
- Trial name
- JDRTC/UHN (NCT01651845)
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University Health Network, Toronto
Ulcerative Colitis (UC), Crohn Disease (CD)
Fluorescence Imaging of Risankizumab-800CW in Inflammatory Bowel Disease
Crohn\'s Disease (CD) and Ulcerative Colitis (UC) are chronic inflammatory bowel diseases (IBD). Risankizumab is a human monoclonal antibody against IL23 p19, part of a pro-inflammatory cytokine that mediates the inflammatory…
- Trial name
- NAVIGATE (NCT06606808)
- Testing
- Risankizumab-800CW 4.5 mg, Risankizumab-800CW 15 mg, Risankizumab-800CW 25 mg
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- University Medical Center Groningen
Esophageal Cancer, Recurrent Laryngeal Nerve
The Value of Near-Infrared Fluorescence Imaging in the Protection of the Recurrent Laryngeal Nerve During Minimally Invasive Esophagectomy
The goal of this clinical trial is to learn whether the application of indocyanine green near-infrared imaging system can accurately locate the recurrent laryngeal nerve (RLN) during lymph node dissection in esophageal cancer…
- Conditions
- Esophageal Cancer, Recurrent Laryngeal Nerve, ICG (Indocyanine Green), Lymph Node Dissection
- Trial name
- NCT07406815
- Testing
- ICG (Indocyanine Green)
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Fujian Medical University Union Hospital
Stomach Neoplasm
Real-time Identification of the Aberrant Left Hepatic Arterial Territory in the Liver Using Near-infrared Fluorescence Imaging
" Hepatic artery variants are occasionally seen, especially 20-30% of aberrant left hepatic artery. In radical gastrectomy, decision for aberrant left hepatic artery(ALHA) ligation should consider the oncologic safety and…
- Trial name
- NCT05971069
- Testing
- Group1, Group2, Group3
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Gangnam Severance Hospital
Frozen Sections, Indocyanine Green
Multi-center Study on CCeLL-In Vivo's Clinical Efficacy for Intraoperative Brain Tumor Diagnosis.
The primary objective of this study is to demonstrate the non-inferiority of cCeLL compared to frozen section analysis. The investigational device is intended for use with indocyanine green (ICG) for fluorescence imaging as an…
- Conditions
- Frozen Sections, Indocyanine Green, Brain Tumor
- Trial name
- PRECISION (NCT06867978)
- Testing
- cCeLL In vivo, Indocyanine Green
- Volunteers
- 100 people
- Sponsor
- VPIX Medical
Uterine Cancer
High-Resolution Microendoscopy to Guide Hysteroscopic Tumor Resection
The goal of this clinical research study is to learn if imaging (called a hysteroscopy) can be used to help guide tumor removal during a hysterectomy.
- Trial name
- NCT02095847
- Testing
- High-Resolution Microendoscopy Imaging, Proflavine
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer
Sentinel Lymph Node Mapping With Near Infrared Fluorescent Markers
Surgery is the primary curative option for patients with cancer, with the overall objective of complete resection of all cancerous tissue while avoiding damage to healthy tissue.
- Trial name
- NCT03619967
- Testing
- Multispectral imager
- Where
- North Macedonia
- Volunteers
- 31 people
- Sponsor
- University of Illinois at Urbana-Champaign
Breast Neoplasms
Study Assessing The Interest of Indocyanine Green Fluorescence Imaging With Radioisotope Method For Sentinel Lymph Node Biopsy in Patients With Breast Cancer
The sentinel node has a fundamental role in the management of early breast cancer. Currently, the double detection of blue and radioisotope is recommended.
- Trial name
- FLUOTECH (NCT02279108)
- Testing
- indocyanine green, isotope
- Where
- France
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Surgical Procedure, Unspecified
Safety and Feasibility of ActivSight(tm) in the Identification of The Ureter Via Riboflavin Fluorescence
The main Objective of this study is to determine the safety and feasibility of a prototype ActivSightTM in identifying the ureter in real-time during elective laparoscopic abdominopelvic surgery after pre-surgical administration…
- Trial name
- NCT06535555
- Testing
- Investigational Safety and Feasibility
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Activ Surgical
Diabetic Cardiomyopathies
Single-center Clinical Study of Early Diagnosis of Diabetic Cardiomyopathy With FLIM
Diabetic Cardiomyopathy (DCM) is disease of myocardial structure and function which is independent of hypertension, coronary heart disease, heart valve abnormalities, and other types of heart disease.
- Trial name
- NCT04534894
- Testing
- fluorescence lifetime imaging microscopy
- Volunteers
- 243 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Cranial Nerve Injuries
Phase I/II Clinical Trial of NP41 for Cranial Nerve Fluorescence Imaging
Preclinical evidence has shown that NP41 is a novel nerve-binding peptide with safe pharmacokinetics. Fluorescently labeled NP41 is effective for the intraoperative visualization of cranial nerves during neurosurgery.
- Trial name
- NCT05043519
- Testing
- FAM-NP41
- Volunteers
- 40 people
- Sponsor
- Peking University Third Hospital
Perfusion, Fluorescence Imaging
Micro-dosing Indocyanine Green (ICG) in Children
The goal of this cohort study is to identify the lowest dose of Indocyanine Green (ICG) that achieves satisfactory intra-operative fluorescence for the assessment of gastrointestinal or genitourinary tract perfusion in children.
- Conditions
- Perfusion, Fluorescence Imaging, Gastrointestinal Tract Disorders, Genitourinary Disease
- Trial name
- NCT06421103
- Testing
- Indocyanine Green (ICG)
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Colorectal Surgery, Colorectal Resection
AUGUR-AI - Indocyanine Green Fluorescence Angiography Representer
Surgery can effectively treat colorectal cancer, but it is a complex procedure with risks and complications. Surgeons often rely on cameras to visually guide their instruments during operations, especially in minimally invasive…
- Conditions
- Colorectal Surgery, Colorectal Resection, Anastomosis, Surgical, Fluorescence Guided Surgery
- Trial name
- AUGUR-AI (NCT06708819)
- Where
- Ireland
- Volunteers
- 300 people
- Sponsor
- Mater Misericordiae University Hospital
Meniscus Rupture
NIR Arthroscopic Fluorescence Angiography of Menisci
This trial is an explorative single center, single-arm study to assess whether vascularization of the meniscus can be visualized intraoperatively using arthroscopic near-infrared (NIR) fluorescence using ICG during standard of…
- Trial name
- FLUORarth (NCT05420974)
- Testing
- NIR fluorescence imaging of the vascular perfusion of the meniscus using ICG
- Volunteers
- 20 people
- Sponsor
- Isala