Clinical trials: Fluorescence Imaging
Head and Neck Neoplasms
Sentinel Lymph Node Mapping of Oral Cancer Using Near-Infrared Fluorescence Imaging
Cervical lymph node involvement, in head and cancer neck patients, is one of the most important prognostic factors. Currently patients undergo neck dissection removing some or all nodes and neck involvement is retrospectively…
- Trial name
- SLN Mapping (NCT02478138)
- Testing
- Sentinel lymph node mapping, Indocyanine Green (ICG), near-infrared fluorescence (NIR) imaging (Pinpoint, Novadaq, Waterloo)
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University Health Network, Toronto
Psoriasis, Crohn Disease
Quantitative Fluorescence Molecular Imaging of Ustekinumab-800CW to Elucidate the Drug Distribution Throughout Inflamed Tissue in Crohn's Disease and Psoriasis.
Crohn's Disease (CD) and psoriasis are chronic inflammatory diseases. Ustekinumab is a humanized monoclonal antibody. Ustekinumab is expensive and primary non-response is high in both CD and psoriasis.
- Trial name
- VIDEO (NCT05725876)
- Testing
- Ustekinumab
- Where
- Netherlands
- Volunteers
- 56 people
- Sponsor
- University Medical Center Groningen
Head and Neck Cancer (H&N), Free Tissue Flaps
Comparing Intraoperative Indocyanine Green Fluorescence Imaging With Standard Clinical Assessment for Flap Perfusion in Head and Neck Reconstruction (VISION Trial)
This is a prospective multicentre randomised controlled trial evaluating whether intraoperative indocyanine green (ICG) fluorescence angiography improves outcomes in head and neck free flap reconstruction compared with standard…
- Conditions
- Head and Neck Cancer (H&N), Free Tissue Flaps, Free Flap, Free Flap Evaluation
- Trial name
- VISION (NCT07635420)
- Testing
- Indocyanine Green, Standard clinical perfusion assessment
- Where
- Sweden
- Volunteers
- 244 people
- Sponsor
- Region Skane
Prostate Cancer, Neoplasm, Residual
Feasibility of the LUM Imaging System for Detection of Prostate Cancer
The primary objective of this feasibility study is to determine if administration of LUM015 will result in positive fluorescence of tumor tissue from ex vivo specimen imaging with the LUM Imaging device from patients undergoing…
- Trial name
- NCT03441464
- Testing
- LUM Imaging System
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Lumicell, Inc.
Total Thyroidectomy, Bilateral Neck Exploration for Primary Hyperparathyroidism
Intra-operative Infra-red Fluorescent Imaging in Thyroid and Parathyroid Surgery
Reliable identification of parathyroid glands is critical to the success of thyroid and parathyroid surgery. In thyroid surgery, inadvertent injury to parathyroid glands may cause temporary or permanent hypoparathyroidism (low…
- Trial name
- NCT02089542
- Testing
- MB and fluorescent imaging
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Prostate Cancer
Multispectral Fluorescence as a Tool to Separate Healthy and Disease Related Lymphatic Anatomies in Prostate Cancer.
Multispectral imaging of the lymphatic draining pattern of the tumor and the abdominall wall/lower limb to evaluate technical feasibility to differentiate these patterns and in the future reduce the amount of complications that…
- Trial name
- SPLIT (NCT05120973)
- Testing
- multispectral imaging, fluorescence for lymphatic mapping
- Where
- Netherlands
- Volunteers
- 26 people
- Sponsor
- The Netherlands Cancer Institute
Tenosynovial Giant Cell Tumor
Accuracy of Indocyanine Green (ICG) Fluorescence Imaging in Tenosynovial Giant Cell Tumor Surgery
This study evaluates the diagnostic accuracy of Indocyanine Green (ICG) fluorescence imaging in visualizing Tenosynovial Giant Cell Tumor (TGCT) lesions during surgery.
- Trial name
- ICG-TGCT (NCT07315841)
- Testing
- Indocyanine Green
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Colorectal Cancer
Endoscopic Optical Imaging for Precision Oncology Treatment Applied to Colorectal Tumours (Elios-Color-on-Specimen)
The Institute of Image-Guided Surgery (IHU) of Strasbourg is a translational research Institute aiming to develop hybrid surgery techniques.
- Trial name
- NCT04101292
- Testing
- Characterization of tumor tissue by fluorescence
- Sponsor
- IHU Strasbourg
Liver Resection
Real-time Navigation for Laparoscope Liver Resections Using Fusion 3D Imaging and Indocyanine Green Fluorescence Imaging
The aim of this study was to evaluate the feasibility and efficacy of a novel real-time navigation way for laparoscope liver resection, which was fused images comprising 3D imaging and indocyanine green Fluorescence imaging…
- Trial name
- NCT03811704
- Testing
- Laparoscopic surgical navigation system, Indocyanine Green
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhujiang Hospital
Barrett's Esophagus, Intraepithelial Neoplasia
Endoscopic Multispectral Imaging for the Early Detection of Barrett's Neoplasia
The overall objective of this pilot study is to determine whether multispectral imaging increases the diagnostic accuracy of the current standard of high-definition white-light endoscopy for the detection of Barrett's-associated…
- Trial name
- NCT01384864
- Testing
- proflavine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Anandasabapathy, Sharmila, M.D.
Giant Cell Tumor of Bone
Accuracy of Indocyanine Green (ICG) Fluorescence Imaging in Giant Cell Tumor of Bone Surgery
This study evaluates the diagnostic accuracy of Indocyanine Green (ICG) fluorescence imaging in visualizing residual lesions of Giant Cell Tumor of Bone (GCTB) in the tumor cavity during surgery.
- Trial name
- ICG-GCTB (NCT07315828)
- Testing
- Indocyanine Green
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Endometrial Cancer, Near Infrared Fluorescence Imaging
CYTALUX for Intraoperative Imaging of Patients With Endometrial Cancer
The research study is being done to assess the safety and ability of an investigational drug called CYTALUX (pafolacianine) and a special camera system for the detection of cancer in patients undergoing surgical resection for…
- Conditions
- Endometrial Cancer, Near Infrared Fluorescence Imaging, CYTALUX (Pafolacianine) Injection, Planned Diagnostic Laparoscopies
- Trial name
- CYTALUX ISS (NCT07278986)
- Testing
- CYTALUX™ (pafolacianine), 1788 4K Camera System with Advanced Imaging Modality
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Endometrial Cancer
Lymph Node Mapping in Patients With Endometrial Cancer
This clinical trial studies lymph node mapping in patients with endometrial cancer. Lymph node mapping may allow for limited removal of lymph nodes in as part of endometrial cancer staging and treatment.
- Trial name
- NCT01818739
- Testing
- sentinel lymph node detection, indocyanine green solution, isosulfan blue
- Where
- 2 sites in United States
- Volunteers
- 204 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Gliomas, Malignant, Metastases to Brain
Intraoperative Sonographically Versus Fluorescence-guided Resection of Contrast-enhancing Gliomas and Brain Metastases
Objective of the study is to determine whether intraoperative ultrasound guided resection of gliomas with contrast enhancement in magnetic resonance imaging and brain metastases can achieve as high rate of gross total resection…
- Trial name
- SONOFLUO (NCT05475522)
- Testing
- Ultrasound guided brain tumor resection, 5-aminolevulinic acid fluorescence-guided brain tumor resection
- Where
- Russia
- Volunteers
- 134 people
- Sponsor
- Sklifosovsky Institute of Emergency Care
Cholangiocarcinoma
Fluorescence QRH-882260 Peptide Imaging in the Bile Duct
Patients undergoing ERCP procedure with biliary stricture will have epithelial mucosa labeled with QRH-882260 fluorescence peptide that binds to EGFR.
- Trial name
- NCT03438435
- Testing
- QRH-882260 Heptapeptide
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- D. Kim Turgeon, MD
Malignant Brain Tumors, Glioma
Fluorescence-Guided Imaging of Brain Tumors: A Safety Study Using SBK2-ICG
Participants in this research study are people who are likely to have, or have been diagnosed with a brain tumor, for which surgical removal (or "resection") is the standard of care treatment.
- Trial name
- NCT07438860
- Testing
- SBK2-ICG, Craniotomy (Standard of Care)
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Tiffany Hodges
Adrenalectomy
Robotic Adrenalectomy With Versus Without Indocyanine Green Fluorescence Imaging
This is a prospective randomized study comparing robotic adrenalectomy with versus without intraoperative indocyanine green imaging.
- Trial name
- NCT07813247
- Testing
- indocyanine green imaging
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- The Cleveland Clinic
Sentinel Lymph Node, Breast Cancer
Sentinel Lymph Node Biopsy in Breast Cancer Surgery Using ICG
This clinical trial is a prospective, multicenter, self-controlled clinical study. In order to meet the requirements of this plan, 130 breast cancer patients need the sentinel lymph node biopsy with novel near-infarred…
- Trial name
- NCT03579979
- Testing
- Methylene Blue, Indocyanine Green
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Chinese Academy of Sciences
Thyroid Carcinoma, Surgery
Thyroid Cancer and Central Lymph Node Metastases Detection Using Bevacizumab-IRDye800CW
Background: Papillary thyroid cancer (PTC) patients often develop central lymph node metastases (CLNM), which pose a high risk of disease recurrence.
- Trial name
- TARGET-beva (NCT06095362)
- Testing
- Bevacizumab-IRDye800CW
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Head and Neck Cancer, Unknown Primary Cancer
A Phase 2a, Single-dose, Open-label Study to Evaluate Diagnostic Performance and Safety of Pegsitacianine, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer, in Patients With Unknown Primary Head and Neck Cancer (ILLUMINATE STUDY)
This is a non-randomized, open-label, single-center, safety and imaging feasibility study of Pegsitacianine, an intraoperative fluorescence imaging agent.
- Conditions
- Head and Neck Cancer, Unknown Primary Cancer, Head and Neck Squamous Cell Carcinoma
- Trial name
- NCT05576974
- Testing
- Pegsitacianine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Texas Southwestern Medical Center