Clinical trials: Fluoride
Enamel Erosion
Meta-analysis of Stannous Fluoride and the Effects on Enamel Erosion
The aim of this 5 study analysis was to compare the effect of bioavailable stannous fluoride (SnF2) dentifrices to assess enamel erosion protection in-situ using surface profilometry.
- Trial name
- NCT04006470
- Testing
- Stannous fluoride dentifrice, Positive control dentifrice, Negative control dentifrice
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Dental Erosion
Experimental Dentifrice Remineralization/Fluoride Uptake in an in Situ Model
The purpose of this study is to determine whether an experimental fluoridated dentifrice is effective in the treatment of dental caries
- Trial name
- NCT00752089
- Testing
- NaF/ KNO3/isopentane Dentifrice, NaF/KNO3 Dentifrice, NaF Dentifrice
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Plaque, Gingivitis
A Pilot Study to Evaluate a Method for Plaque When Comparing Stannous Fluoride Toothpaste to a Regular Dentifrice
This study will evaluate the sensitivity of an assay and its ability to split a marketed stannous fluoride toothpaste versus a negative control.
- Trial name
- NCT02543060
- Testing
- stannous fluoride toothpaste, cavity protection toothpaste
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Caries, Dental, Calcium Hypophosphite
Comparative Study of Caries-Preventive Effects: 2% Calcium Hypophosphite Toothpaste vs. Sodium Fluoride Toothpaste (1450ppm F)
The aim of the study is to compare the caries-preventive effect of the test and control toothpaste in order to proof the non-inferiority of the test toothpaste compared to the control.
- Conditions
- Caries, Dental, Calcium Hypophosphite, Fluoridation
- Trial name
- NCT07068204
- Testing
- 2% Calcium Hypophosphite Toothpaste, Sodium Fluoride Toothpaste (1450 ppm F)
- Where
- 2 sites in Poland
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Dr. Joachim Enax
Dental Caries in Children
Silver Diamine Fluoride Gel: Single Group Observational Study
A single group observational study to determine the clinical response of dental caries lesions in primary teeth where 38% silver diamine fluoride gel is applied and cover with 2.5% sodium fluoride varnish.
- Trial name
- KiruPoderoso (NCT05395065)
- Testing
- Silver Diamine Fluoride/Sodium Fluoride Varnish
- Where
- 5 sites in Peru
- Volunteers
- 237 people
- Sponsor
- Advantage Silver Dental Arrest, LLC
Oral Health
A Study to Evaluate the Effect of a Stannous Fluoride Toothpaste on the Oral Microbiome
The aim of this study is to evaluate the effect of a toothpaste containing stannous fluoride (SnF2) over time on the oral bacterial composition and activity and to explore its effect in comparison to a regular fluoride toothpaste.
- Trial name
- NCT06048809
- Testing
- Stannous Fluoride Toothpaste (Sensodyne Repair and Protect), Regular Fluoride Toothpaste (Colgate Cavity Protection)
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- HALEON
Plaque, Gingivitis
The Clinical of Stannous Fluoride Toothpaste and a Newly Designed Toothbrush Compared to Colgate Cavity Protection Toothpaste and a Regular Toothbrush in Reducing Plaque and Gingivitis.
Qualified subjects will be enrolled and randomly assigned to either of the two study groups based on their initial Plaque and Gingivitis scores.
- Trial name
- NCT06427499
- Testing
- Stannous fluoride toothpaste, Colgate Cavity Protection Toothpaste
- Where
- Thailand
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Caries
Evaluation of the Fluoride Dose Response Using In Situ Caries Model
The purpose of this study is to evaluate the fluoride dose response of different dentifrice fluoride concentrations - 0, 250, 1100 and 2800 ppm fluoride as sodium monofluorophosphate (MFP) and a fifth leg of 1100 ppm Stannous…
- Trial name
- NCT04763044
- Testing
- 0 ppm F, 250 ppm F as MFP, 1100 ppm as MFP
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Bone Metastases
F18PET/CT Versus TC-MDP Scanning to Detect Bone Mets
The primary objective is to compare the diagnostic performance of 18F- Fluoride PET/CT scanning to that of conventional bone scanning for detecting cancer that has spread to the bone (bone metastasis).
- Trial name
- NCT00882609
- Testing
- Bone Scan: F18-Fluoride PET/CT or TC-MDP
- Where
- 19 sites in United States, Australia and 3 more
- Volunteers
- 550 people
- Sponsor
- American College of Radiology - Image Metrix
Glioma (Any Grade) in the Brain
18F-Floretyrosine Expanded Access Program
The aim of this Expanded Access Program (EAP) is to enable the use of 18F-Floretyrosine with positron emission tomography/computed tomography (PET/CT) or positron emission tomography/magnetic resonance (PET/MR) imaging to…
- Trial name
- NCT06743100
- Testing
- 18F-Floretyrosine
- Where
- 10 sites in United States
- Sponsor
- Telix Pharmaceuticals (Innovations) Pty Limited
Subgingival Plaque, GCF
Analysis of Stannous Fluoride in GCF and Subgingival Plaque
The amount of stannous fluoride in GCF and subgingival plaque samples will be analyzed.
- Trial name
- NCT03296657
- Testing
- stannous fluoride
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Caries
In Situ Caries Model of Fluoride Toothpastes
This study is to evaluate the effect of fluoride dentrifrices on enamel with artificial caries lesions in an in situ model
- Trial name
- NCT01005966
- Testing
- Sodium Fluoride Toothpaste, Amine Fluoride Toothpaste, Sodium monofluorophosphate/Sodium Fluoride Toothpaste
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Calculus, Dental
Efficacy of Toothpaste Containing 0.454% Stannous Fluoride as Compared to a Regular Fluoride Toothpaste Containing 0.76% Sodium Monofluorophosphate in Controlling Supragingival Calculus Formation Over a 12-week Period.
To evaluate the comparative clinical efficacy of a test toothpaste containing 0.454% stannous fluoride as compared to a regular fluoride toothpaste containing 0.76% sodium monofluorophosphate in controlling supragingival calculus…
- Trial name
- NCT07223060
- Testing
- 0.454% stannous fluoride, 0.76% sodium monofluorophosphate
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Plaque
Dental Plaque Prevention Efficacy of a Stannous Fluoride Toothpaste
This randomized, stratified, double-blind, two-cell parallel clinical study evaluated the dental plaque prevention efficacy of a stannous fluoride toothpaste compared to a sodium fluoride control toothpaste following a…
- Trial name
- NCT07419737
- Testing
- Stannous Fluoride Toothpaste (SnF), Sodium Fluoride Dentifrice
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Church & Dwight Company, Inc.
Tooth Erosion
Investigate a Varnish to Protect From Erosive Toothwear
This in-situ study will investigate on extracted teeth the protection of a re-formulated varnish containing fluoride in the same concentration as an existing approved varnish used to treat caries and erosion.
- Trial name
- NCT06136754
- Testing
- Varnishes, Fluoride
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Caries
A Clinical Trial to Assess the Safety and the Anti-caries Efficacy of COL 101 (Arginine) Non-fluoride Dentifrices in Comparison With 0.24% Sodium Fluoride (1100 Ppm F) Dentifrice Control in 10 to 14-year-old Children
The objective of this study is to assess the safety and to evaluate the anti-caries efficacy of COL101 (arginine) non-fluoride dentifrices compared to a 0.24% sodium fluoride dentifrice in 10-14 year-old children over a one year…
- Trial name
- NCT04750902
- Testing
- 0.24% Sodium Fluoride Dentifrice, 1.5% Arginine Dentifrice, 4.0% Arginine Dentifrice
- Where
- 9 sites in United States, Puerto Rico
- Volunteers
- 2,025 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Caries
Pharmacokinetics of Advantage Arrest in Children
The purpose of this study is to characterize basic PK parameters (Cmax, t1/2, AUC) in healthy children to contribute to evidence for the safety of Advantage Arrest, consistent with Guidance for Industry--Exposure--Response…
- Trial name
- NCT04186663
- Testing
- Silver Diamine Fluoride
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Advantage Silver Dental Arrest, LLC
Dental Caries
Sequential PVP-I and FV
This prospective cohort study in children will determine if: topical povidone iodine 10% followed by topical fluoride varnish is superior to placebo iodine followed two different varnishes alone to prevent tooth decay (dental…
- Trial name
- NCT07683910
- Testing
- fluoride varnish, 2.5%, topical fluoride, 2.1%, Povidone Iodine Topical
- Volunteers
- 393 people, healthy volunteers welcome
- Sponsor
- Advantage Silver Dental Arrest, LLC
White Spot Lesions
Fluoride Varnish for Treatment of White Spot Lesions
Study will look at ability of fluoride varnish to remineralize white spot enamel lesions that can occur around the edge of fixed orthodontic brackets.
- Trial name
- NCT01500187
- Testing
- Vanish Varnish, Pediagel
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Solventum US LLC
Gingivitis
A Clinical Study to Assess the Effects of a Stannous Fluoride Dentifrice on Plaque and Gingivitis
The objective of this clinical study is to assess the effects of a 0.454% stannous fluoride dentifrice on gingivitis and plaque after 3 months when compared to a negative control.
- Trial name
- NCT03936556
- Testing
- Marketed toothpaste, Marketed Cavity Protection Toothpaste
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble