Clinical trials: Fluoride
Dental Plaque, Gingivitis
A Clinical Study Investigating the Efficacy of an Experimental Toothpaste Containing Stannous Fluoride in Improving Gingival Health
The aim of this study is to evaluate the ability of an experimental toothpaste, containing 0.454 percent (%) Stannous Fluoride (SnF2) to improve gingival health and reduce plaque accumulation compared to a regular fluoride…
- Trial name
- NCT07169188
- Testing
- Test Fluoride Toothpaste, Colgate Cavity Protection Toothpaste
- Where
- Canada
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- HALEON
Dental Caries
Evaluation of Plaque Fluid Fluoride Retention From Fluoride Toothpastes
The purpose of this study is to investigate the efficacy of different sodium fluoride (NaF) containing toothpastes in prevention of dental caries.
- Trial name
- NCT00708305
- Testing
- Sodium Fluoride (NaF)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tooth; Lesion, White Spot Lesions
Remineralisation of White Spot Lesions by Elmex® gelée in Post-orthodontic Patients
The aim of this study is to monitor the effect of intraoral topical high fluoride application on the development of white spot lesions (WSL) after orthodontic treatment with multibracket appliances and to compare it to a placebo.
- Trial name
- NCT01329731
- Testing
- elmex® gelée
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- Gaba International AG
Dental Hypersensitivity
Dentin Hypersensitivity Reduction Efficacy Clinical
The objective of this study is to assess clinical efficacy of a toothpaste containing stannous fluoride (Colgate-Palmolive Company, New York, NY, USA) to provide dental hypersensitivity relief (tactile and air blast) in…
- Trial name
- NCT07738198
- Testing
- 0.454% stannous fluoride toothpaste, 5% potassium nitrate, 0.76% sodium monofluorophosphate
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Enamel Erosion
Effect of Fluoride in a Dentifrice on Remineralization of Erosive Lesions
The proposed study will evaluate the performance of fluoride delivered from a new dentifrice formulation without potassium nitrate.
- Trial name
- NCT01641237
- Testing
- sodium fluoride, no added fluoride in a silica base
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Gingivitis
Clinical Investigation of a Toothpaste Containing Stannous Fluoride as Compared to Colgate Fluoride Toothpaste
The objective of this study is to evaluate the clinical efficacy of a toothpaste containing stannous fluoride as compared to Colgate Fluoride Toothpaste in reducing plaque and gingivitis - a three- month study.
- Trial name
- CP_Total (NCT04033575)
- Testing
- Colgate Total SF, Colgate Cavity Protection toothpaste
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dentine Hypersensitivity
Meta-analysis of Stannous Fluoride Dentifrice and the Effects on Dentine Hypersensitivity
The aim of this 11 study analysis was to compare the effect of bioavailable stannous fluoride (SnF2) on dentine hypersensitivity versus a positive or negative control dentifrice.
- Trial name
- NCT04005417
- Testing
- Stannous fluoride dentifrice, Positive control dentifrice, Negative control dentifrice
- Where
- United States
- Volunteers
- 1,036 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Dental Caries
Enamel Remineralization Potential of Dentifrices in Situ
This study will use an oral in-situ caries model to study remineralization of enamel due to the action of different combinations of fluoride salts delivered from dentifrices.
- Trial name
- NCT01128946
- Testing
- NaF, SnF, NaMFP
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Caries
Assessment of Prevident Sodium Fluoride 1.1% Toothpaste Using an Intra-oral Remineralization-demineralization Model
This is a double blind, cross-over, controlled clinical trial utilizing thirty (30) adults to evaluate remineralization of early caries lesions.
- Trial name
- NCT02708160
- Testing
- Fluoride Free toothpaste, 1.1% Fluoride toothpaste, 0.243% Fluoride toothpaste
- Volunteers
- healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Plaque, Gingivitis
A Study Investigating Gingival Crevicular Fluid Biomarkers Following Use of a Commercially Available Toothpaste Containing Stannous Fluoride
The aim of this study is to evaluate the feasibility, sensitivity, and interpretability of gingival crevicular fluid (GCF) cytokine biomarkers as early indicators of tissue recovery following use of commercial dentifrice compared…
- Trial name
- NCT07842042
- Testing
- Test Toothpaste, Regular Fluoride Toothpaste
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- HALEON
Dental Plaque, Gingivitis
A Clinical Study Investigating the Effect of an Experimental Toothpaste Containing Stannous Fluoride in Improving Gingival Health
The aim of this 4-week clinical study is to evaluate the ability of an experimental toothpaste, containing 0.454 percent (%) Stannous Fluoride (SnF2), 0.3% Zinc Chloride (ZnCl2) and 1% Alumina, to improve gingival health and…
- Trial name
- NCT06602466
- Testing
- Test toothpaste, Colgate Cavity Protection Toothpaste
- Where
- United Kingdom
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- HALEON
Oral Bacteria Levels in the Mouth
Clinical Investigation to Examine Toothpaste Effect on Oral Bacteria
The primary objective was to evaluate the antibacterial effects of two toothpastes containing 0.3% triclosan, 2% copolymer and 0.234% sodium fluoride in a silica base as compared to a control regular fluoride toothpaste on…
- Trial name
- NCT02194621
- Testing
- Total Flavor option 1, Total Flavor option 2
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Caries
Salivary Fluoride Clearance
This is a single-center, four-treatment, four-period crossover study. Over the course of the study, up to thirty qualified subjects will use four (4) study treatment products, one time each according to the randomization.
- Trial name
- NCT06735235
- Testing
- 0 ppm F, 250 ppm F as MFP, 1100 ppm as MFP
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Dentin Sensitivity
A Study to Measure the Efficacy of a Toothpaste on Dentinal Hypersensitivity
Double blind parallel study to measure the efficacy of a toothpaste containing calcium-silicate/phosphate on dentinal hypersensitivity compared to a control toothpaste containing fluoride
- Trial name
- NCT03244618
- Testing
- CSSP Toothpaste, Fluoride Toothpaste
- Where
- United Kingdom
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- Unilever R&D