Clinical trials: Fluoride
Dental Erosion
Experimental Dentifrice Remineralization/Fluoride Uptake in an in Situ Model
The purpose of this study is to determine whether an experimental fluoridated dentifrice is effective in the treatment of dental caries
- Trial name
- NCT00752089
- Testing
- NaF/ KNO3/isopentane Dentifrice, NaF/KNO3 Dentifrice, NaF Dentifrice
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Caries
Caries-preventive Effect of a Dentifrice Containing 5,000 Ppm Fluoride in Orthodontic Patients
AIM: To evaluate the efficacy of daily tooth brushing with high concentrated fluoride dentifrice on white spot lesion (WSL) formation in adolescents during treatment with fixed orthodontic appliances (FOA).
- Trial name
- NCT01768390
- Testing
- toothpaste containing 5,000 ppm fluoride, 1450 GCP
- Where
- Sweden
- Volunteers
- 500 people
- Sponsor
- University of Copenhagen
Root Caries
Comparison of Silver Diamine Fluoride and Sodium Fluoride Varnish to Prevent and Arrest Root Caries in Older Adults
Dental caries (coronal and root) is highly prevalent in older adults. It is important to identify and implement the most effective methods that prevent the formation of root caries lesions and inhibit existing lesions at the…
- Trial name
- NCT04432415
- Testing
- Silver Diamine Fluoride, Soduim Fluoride Varnish
- Where
- Mexico
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Mexico
Dentin Sensitivity
Clinical Study to Evaluate the Anti-sensitivity Efficacy of a Stannous Fluoride Toothpaste in a Population of Dentin Hypersensitivity Sufferers
The aim of this study is to confirm the clinical Dentin Hypersensitivity (DH) efficacy of a 0.454 percent (%) Stannous Fluoride (SnF2) toothpaste.
- Trial name
- NCT06359028
- Testing
- Stannous fluoride toothpaste, Crest cavity protection toothpaste
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- HALEON
Caries, Dental, Caries Class I
Caries Sealing Using Giomer and Glass Ionomer Cement With or Without Silver Diamine Fluoride
The purpose of this study is to evaluate and compare the clinical performance of Giomer and GIC restorations with and without SDF on caries sealing of primary molar teeth
- Trial name
- NCT03872986
- Testing
- SDF, Giomer, GIC
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Dental Caries, Fluor
Efficacy of Fluor Protector S in the Prevention in Adolescents
Purpose of the study is to evaluate the effectiveness of Fluor Protector S in preventing tooth decay in adolescents and to isolate factors that reduce its effectiveness.
- Trial name
- NCT03720379
- Testing
- Fluor Protector S
- Where
- Poland
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Teeth Color, Teeth Staining
A Clinical Study to Evaluate the Stain Reduction Efficacy of a Non-Fluoride Tooth Whitening Dentifrice Containing Nano-Hydroxyapatite (nHAP) and a High Cleaning Silica Abrasive System Compared to a Commercial Fluoride Non-Whitening Dentifrice as a Negative Control
To determine whether brushing with a non-fluoride tooth whitening dentifrice containing nHAP and a high cleaning silica system produces a greater level of stain reduction as indicated by the Modified Lobene Stain Index (MLSI) for…
- Trial name
- NCT07214038
- Testing
- toothpaste
- Where
- India
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Boka LLC
Dental Caries
Remineralization of Dentine Caries Using Two Remineralizing Agents Which Are Nanosilver Fluoride and Casein phosphopeptides_amorphous Calcium Phosphate
The study is randomized controlled trial ...The null hypothesis suggests that there is no significant difference between nanosilver fluoride and sodium fluoride with Casein phosphopeptides_amorphous calcium phosphate in the…
- Trial name
- NCT04930458
- Testing
- Nanosilver fluoride, Sodium fluoride with casein phosphopeptides amorphous calcium phosphate, Sodium fluoride varnish
- Where
- Iraq
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Molar Incisor Hypomineralization
Comparative Evaluation of Giomer Varnish vs Fluoride Varnish as Desensitizing Agents in Teeth With MIH
this clinical trial's aim is to compare two desensitizing agents available in the market to prove which one is more efficient in children with molar incisor hypomineralization complaining from hypersensitivity
- Trial name
- NCT05542667
- Testing
- Giomer varnish, Fluoride varnish
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Primary Teeth, Microbial Colonization
The Antibacterial Effect of Nanosilver Fluoride on Primary Teeth
To assess the antibacterial effect of Nanosilver Fluoride (NSF) in relation to caries activity in dentin caries lesions of primary teeth in comparison to Silver Diamine Fluoride (SDF).
- Conditions
- Primary Teeth, Microbial Colonization, Caries, Dental Caries in Children
- Trial name
- NCT05221749
- Testing
- Nanosilver Fluoride (NSF), Silver diamine fluoride
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nour Ammar, BDS
White Spot Lesion
Self-assembling Peptide With Sodium Fluoride in Treating White Spot Lesionss in Primary Teeth
Regenerative medicine-based approaches for caries treatment focus on biomimetic remineralization of initial carious lesions as a minimally invasive therapy using Self-Assembling Peptide P11-4 (CURODONTTM REPAIR) which enhances…
- Trial name
- NCT05721586
- Testing
- Self Assembling Peptide P11-4 (CURODONTTM REPAIR) + Fluoride varnish (DURAFLOR, Fluoride varnish (DURAFLOR
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Hams Hamed Abdelrahman
Pregnant Women
Streptococcus Mutans Reduction Early Mother-infant Transmission
Evidence exists on the vertical transmission of Streptococcus mutans from the mother to her children. This transmission can be prevented by maintaining maternal oral health during pregnancy.
- Trial name
- NCT04868513
- Testing
- Pregnant women to whom applied silane fluoride, Pregnant women to whom applied silane fluoride + 1% chlorhexidine
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Biochemical and Microbiology Laboratory, Faculty of Dentistry, Autonomous University of San Luis Pot
Dental Caries
The Use of Antimicrobial Agents in the Inhibition of Mutans Streptococci in Children With Dental Caries
The aim of the present study was to compare salivary MS levels in four different groups of children with caries, that have been submitted to intraoral topical treatment with either 1,23% sodium fluoride, 1% chlorhexidine, 3% or…
- Trial name
- NCT00612469
- Testing
- Sodium Fluoride, vancomycin hydrochloride, chlorhexidine digluconate
- Where
- Brazil
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Ceara
Dental Plaque, Gingivitis
The Clinical Investigation of a New Toothpaste Containing Stannous Fluoride as Compared to a Commercially Available Fluoride Toothpaste in Reducing Plaque and Gingivitis
The objective of this study is to evaluate the clinical efficacy of a new toothpaste containing stannous fluoride (SnF) as compared to Colgate Fluoride Toothpaste in reducing gingivitis and dental plaque.
- Trial name
- NCT03852056
- Testing
- MFP Fluoride toothpaste, Stannous fluoride toothpaste
- Where
- China
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Healthy Volunteers - Male and Female
Development of an Improved Method of Measuring Total Body Bone Perfusion Using Total-body PET/CT
Broken bones (fractures) are a common problem in several serious health conditions, such as osteoporosis, kidney failure, and sickle cell disease.
- Trial name
- NCT07860346
- Testing
- 1-hour Total Body PET/CT scan using the tracer [18F]-sodium fluoride
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- King's College London
Dental Caries
Preventing and Arresting Dental Root Surface Caries in Community-dwelling Older Adults
This study is a randomized clinical trial lasting for 30 months. A total of 300 subjects will be recruited from social centres for elders located in different districts in Hong Kong.
- Trial name
- NCT02360124
- Testing
- silver diammine fluoride, saturated potassium iodide solution
- Where
- China
- Volunteers
- 323 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Gingivitis, Plaque, Dental
Gingivitis Reduction After Use of 0.45% Stannous Fluoride Toothpaste
The 6-month clinical study was designed to investigate clinical efficacy on plaque and gingivitis for the stannous fluoride containing toothpaste (SNAP) compared to Colgate Cavity Protection Toothpaste after 3 and 6 months of…
- Trial name
- NCT06300866
- Testing
- Test, Control
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dentin Sensitivity
A Clinical Study to Evaluate the Anti-Sensitivity Efficacy of a Stannous Fluoride Toothpaste in a Population of Dentin Hypersensitivity Sufferers
The aim of this study is to confirm the clinical Dentin Hypersensitivity (DH) efficacy of a 0.454 percent (%) Stannous Fluoride (SnF2) toothpaste.
- Trial name
- NCT06354270
- Testing
- Stannous fluoride toothpaste, Regular fluoride toothpaste (Crest Cavity Protection)
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- HALEON
Dental Plaque and Gingivitis
The Clinical Investigation of a Zinc Based Toothpaste in Reducing Plaque and Gingivitis
This is a six (6) month, double-blind, parallel, controlled clinical trial utilizing one hundred and sixty (160) adults to evaluate the reduction of dental plaque and gingivitis.
- Trial name
- NCT02243046
- Testing
- Control toothpaste, Experimental toothpaste, Active Comparator
- Where
- Dominican Republic
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Plaque, Gingivitis
Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash)
The objective of this clinical research study is to assess the efficacy of a commercially available triclosan/copolymer toothpaste compared to a commercially available oral hygiene multi-component regimen encompassing the use of…
- Trial name
- NCT02366689
- Testing
- Triclosan/fluoride toothpaste, stannous fluoride toothpaste, fluoride only toothpaste
- Where
- United States
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive