Clinical trials: Fluoride
Prevention of Dental Caries
Effect of Bioactive Glass Varnish on Salivary Parameters in Children: Randomized Controlled Trial
This study is a two-arm parallel randomized controlled trial led by Principal Investigator Inas Karawia at the Faculty of Dentistry, designed to evaluate and compare the short-term (immediatly) and sustained (over 6 months)…
- Trial name
- NCT07875387
- Testing
- Bioactive glass topical varnish, Fluoride varnish
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pharos University in Alexandria
Tertiary Dentine, Indirect Pulp Capping
Silver Diamine Fluoride/ Potassium Iodide in Indirect Pulp Capping of Young Permanent Molars
The aim of this study is to evaluate and compare the clinical effectiveness of 38% silver diamine fluoride with and without potassium iodide with that of resin modified glass ionomer cement in indirect pulp capping of young…
- Trial name
- NCT04236830
- Testing
- Silver diamine fluoride/ potassium iodide, Silver diamine fluoride, Resin modified glass ionomer cement
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Nourhan M.Aly
Prostate Cancer
Sodium Fluoride (NaF) Positron Emission Tomography/Computed Tomography (PET/CT) in Patients With Metastatic Castrate-resistant Prostate Cancer (CRPC) With Microtubule Directed Chemo or AR-directed Therapy
The purpose of this research study is to evaluate a newer imaging technique, called 18F-Sodium Fluoride (NaF) positron emission tomography (PET). NaF is a tracer (dye) that is very sensitive for changes in bone.
- Trial name
- NaFl PET/CT (NCT01516866)
- Testing
- Sodium Fluoride (NaF) Positron Emission Tomography/Computed Tomography (PET/CT) imaging
- Where
- 3 sites in United States
- Volunteers
- 58 people
- Sponsor
- University of Wisconsin, Madison
Tooth Erosion
Intra Oral Kinetics of Fluoride Containing Dentifrices
The aim of this study is to assess the impact of formulation differences on fluoride retention clearance with US levels of fluoride (1150 ppm of fluoride) by evaluating and comparing between treatments the concentrations of…
- Trial name
- NCT02548156
- Testing
- Test Dentifrice, Reference Dentifrice, Comparator Dentifrice
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Caries
Fissure Caries Inhibition Study With Solea CO2-9.3μm Short-pulsed Laser
The objective of this clinical study is to evaluate whether the use of the new CO2 - 9.3μm short-pulsed laser increases the caries resistance of occlusal pit and fissure surfaces in patients in addition to fluoride therapy.
- Trial name
- LaserFissure (NCT02357979)
- Testing
- Laser, Fluoride
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Dental Caries
Fluoride Application on Preventing and Arresting Root Caries in Fluoridated and Non-fluoridated Areas
This study was a randomized clinical trial lasting for 24 months in two study sites, Hong Kong (water fluoridated) and Guangzhou (non-fluoridated area).
- Trial name
- NCT02742142
- Testing
- silver diammine fluoride
- Where
- 2 sites in China
- Volunteers
- 534 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Molar Incisor Hypomineralization, Dental Caries
Silver Diamine Fluoride and Papain-Based Gel for Management of MIH-affected Molar in Paediatric Patients
Molar incisor hypomineralization (MIH) is a developmental defect of enamel affecting the first permanent molar and frequently the incisors with a prevalence of 16-16.9% in Malaysia.
- Conditions
- Molar Incisor Hypomineralization, Dental Caries, Hypomineralization of Enamel
- Trial name
- NCT04710927
- Testing
- Silver Diamine Fluoride, Papain-Based Gel, High Viscosity Glass Ionomer Cement (HVGIC)
- Where
- Malaysia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Remineralization Effect of the Varnish on White Spot Lesions
Remineralization Potential of MI Varnish Versus Fluoride Varnish on White Spot Lesions in Maxillary Primary Incisors
Remineralization effect of CPP-ACP and Fluoride (MI varnish) versus Fluoride varnish on white spot lesions in maxillary primary incisors
- Trial name
- NCT03731403
- Testing
- MI varnish
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries
The Behaviour of Dental Nurses Applying Fluoride Varnish to Young Children
The behaviour of 12 dental nurses seeing 600 nursery school children in East Scotland will be video-taped to determine the interaction patterns adopted by the staff in the application of a fluoride varnish to the surfaces of the…
- Trial name
- BEHAVE (NCT00881790)
- Testing
- Fluoride varnish
- Where
- United Kingdom
- Volunteers
- 509 people, healthy volunteers welcome
- Sponsor
- University of St Andrews
Cavities of Teeth
Effectiveness of Silver Diamine Fluoride (SDF) in Arresting Cavitated Caries Lesions
This trial is a Phase III, multisite, randomized, placebo-controlled trial, with two parallel groups. The groups are SDF or placebo and they are applied every 6 months.
- Trial name
- NCT03649659
- Testing
- Silver Diamine Fluoride
- Where
- 3 sites in United States
- Volunteers
- 830 people
- Sponsor
- University of Michigan
Dentin Sensitivity
Effectiveness of Arginin and Potassium Nitrate Dentifrices in Dentin Hypersensitivity Therapy
Introduction: Dentin hypersensitivity (DH) could be defined as a brief and sharp pain in response to thermical, chemical, tactile and osmotic stimuli, which cannot be attributed to any dental condition or pathology.
- Trial name
- NCT02829879
- Testing
- 8% arginine/1450ppm sodium monofluorophosphate dentifrice, 5% potassium nitrate/2500ppm sodium fluoride dentifrice
- Where
- Chile
- Volunteers
- 50 people
- Sponsor
- University of Chile
White Spot Lesion
Remineralization Potential of Bioactive Varnish
This randomized controlled trial is held to investigate the effectiveness of two remineralizing agents surface pre-reacted glass-ionomer (S-PRG) filler and fluoride in management of white spot lesions.
- Trial name
- NCT07602660
- Testing
- S-PRG barrier coat, Profluorid Varnish
- Volunteers
- 60 people
- Sponsor
- Future University in Egypt
Early Childhood Caries
A Clinical Trial of Silver Diamine Fluoride to Arrest Early Childhood Caries in Young Children
Silver diamine fluoride (SDF) is an antibiotic liquid that has the potential to arrest Early Childhood Caries in young children and delay treatment until children can be seen in outpatient settings.
- Trial name
- NCT04054635
- Testing
- Silver diamine fluoride
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- University of Manitoba
Dentin Sensitivity
A Clinical Study to Evaluate a Stannous Fluoride Toothpaste for the Relief of Dentinal Hypersensitivity
The purpose of this study is to provide evidence of clinical efficacy of an experimental dentifrice containing stannous fluoride (SnF2) compared to regular fluoride dentifrice in the reduction of dentinal hypersensitivity (DH).
- Trial name
- NCT03310268
- Testing
- 0.454% Stannous fluoride (SnF2) and 0.072% sodium fluoride (NaF): 1450 ppm fluoride in total, 1400 ppm fluoride as sodium monofluorophosphate (SMFP), Stannous Chloride (SnCl2) and 0.15% NaF: 1450 ppm fluoride in total
- Where
- China
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Caries Prevention, Fissure Sealant
A Trial of Caries Prevention Effect of Fissure Sealants
The purpose of this randomized clinical trial was to compare caries prevention of a conventional resin-based sealant and a glass-ionomer sealant placed on occlusal pits and fissures over a one year period in a high caries…
- Conditions
- Caries Prevention, Fissure Sealant, Fluoride Concentration, Glass Ionomer Cement
- Trial name
- NCT02063815
- Testing
- Fissure sealant application
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Marmara University
White Spot Lesion
White Spot Lesions Treatment in Orthodontic
The study aims to investigate the effectiveness of a new treatment for demineralized white spot lesions (WSLs) after fixed appliance therapy.
- Trial name
- WSL (NCT06051981)
- Testing
- 5% sodium fluoride, Intensive 5% sodium fluoride, Casein Phosphopeptide-Amorphous Calcium Phosphate
- Volunteers
- 88 people
- Sponsor
- Riyadh Elm University
Dental Caries
Effect of Dentifrice Usage Regime on Delivery and Efficacy of Fluoride
This study will evaluate and compare the effect of the amount of toothpaste used and brushing time on enamel strengthening (percent of surface microhardness recovery, % SMHR) and enamel fluoride uptake (EFU).
- Trial name
- NCT01563172
- Testing
- Sodium fluoride / silica and carbopol, 0.5g, Sodium fluoride / silica and carbopol, 1.5g, Fluoride free dentifrice
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Caries
Effect of Water Rinsing After Topical Fluoride Application on Dental Plaque pH
The aim of this study was to determine whether rinsing with water or cleansing teeth after topical fluoride therapy affect the dental plaque pH.
- Trial name
- NCT01569165
- Testing
- cleansing teeth after topical fluoride therapy
- Where
- Iran
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mashhad University of Medical Sciences
Enamel Subsurface Lesion
Effects of a Chewing Gum Containing POs-Ca and Fluoride on Enamel
There were no differences in the degree of enamel remineralization of subsurface lesions among the chewing gums containing or not containing POs-Ca and fluoride.
- Trial name
- NCT01377493
- Testing
- chewing gum
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Tokyo Medical and Dental University
Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma
Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain Tumors
This phase I trial is studying the side effects of fluorine F18 EF5 when given during positron emission tomography to find oxygen in tumor cells of patients who are undergoing surgery or biopsy for newly diagnosed brain tumors.
- Conditions
- Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma, Adult Anaplastic Oligodendroglioma, Adult Brain Stem Glioma
- Trial name
- NCT00110032
- Testing
- EF5, conventional surgery, positron emission tomography
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- National Cancer Institute (NCI)