Clinical trials: Fluoride
Orthodontic Appliance Complication
Efficacy of a Novel Fluoride Varnish in Preventing WSL During/After Treatment With Fixed Orthodontic Appliances
The aim of the present study is to evaluate the efficacy of a novel fluoride varnish (NFV) in preventing white spot lesion development in adolescents during and after treatment with fixed orthodontic appliances.
- Trial name
- NCT03725020
- Testing
- Fluoride varnish
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Malmö University
Early Childhood Caries
The Anticariogenic Effect of Silver Diamine Fluoride and Sodium Fluoride Varnish
Sodium Fluoride (NAF) varnish was considered as the treatment of Early Childhood Caries (ECC). However, the emergence of Silver Diamine Fluoride (SDF) has become more popular to tackle dental caries among children.
- Trial name
- NCT06316323
- Testing
- Silver diamine fluoride, Sodium fluoride
- Where
- Malaysia
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Universiti Teknologi Mara
Hypersensitivity Dentin, Tooth Hypersensitivity
Effectiveness of Bioactiveglass Air Abrasion Versus Fluoride Varnish in Management of Dentin Hypersensitivity
Will the use of Bioactive glass with air abrasion technology (Sylc) compared to Fluoride Varnish (Biflourid 10) affects the degree of pain in patients complaining from hypersensitivity due to non-carious lesions?
- Trial name
- NCT03285360
- Testing
- Sylc, fluoride varnish (Bifluorid 10)
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Deep Caries
Silver Diamine Fluoride After Minimal Caries Removal Technique in Asymptomatic Young Permanent Teeth With Deep Caries
This study is comparing between the Silver Diamine Fluoride after minimal caries removal versus glass ionomer in permanent teeth with open apex
- Trial name
- NCT03568474
- Testing
- Silver Diamine Fluoride, Glass Ionomer
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Disease
Anti-Plaque and Anti-Gingivitis Effects of Moringa Plant Extract and Fluoride Toothpastes
The present study aims to assess and compare the anti-plaque and anti-gingivitis effects of Moringa plant extract and Fluoride toothpastes among a group of Egyptian Children.
- Trial name
- NCT05390099
- Testing
- Moringa oleifera leaf
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Tooth Stain
A Clinical Trial to Test the Effect of a Marketed Mouth Rinse on Stain Removal
The whitening action of an investigative hydrogen peroxide/sodium fluoride containing mouth rinse will be evaluated through stain removal using mean Lobene Stain Index over 14 days compared to a currently marketed hydrogen…
- Trial name
- NCT02151058
- Testing
- Colgate® Regular Cavity Protection, Experimental Mouth Rinse, Crest® 3D White Multi-Care Whitening Rinse, Glamorous White, Fresh Mint
- Where
- United States
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Dental Caries in Children
Cost Effectiveness of Sodium Fluoride Varnish in Prevention of Dental Caries in School Children
Fluoride varnish application is universally accepted as a dental caries prevention method. This study was aimed in assessment of clinical outcome and cost effectiveness in using that method in Sri Lankan school children
- Trial name
- NCT03571815
- Testing
- 5% sodium fluoride varnish, WATER ON TEETH
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- University of Peradeniya
Dental Caries
Stopping Cavities Study: Diammine Silver Fluoride
This study is being conducted to test whether the use of diammine silver fluoride (also called silver diamine fluoride) hardens the cavity sufficiently so that it arrests.
- Trial name
- NCT02536040
- Testing
- 38% diammine silver fluoride, Water
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Advantage Dental Services, LLC
Fluorosis, Dental
Nails and Teeth as Biomarkers of Fluoride Exposure
To determine fluoride concentration in fingernails and estimate if there is a correlation between fluoride concentration in fingernails and fluoride concentration in toothpaste used.
- Trial name
- NCT05442320
- Testing
- Biodent Toothpaste (Ilirija d.d., Ljubljana, Slovenia)
- Volunteers
- 342 people
- Sponsor
- University of Ljubljana
Demineralization, Tooth, Caries,Dental
Prospective Randomized Controlled Trial for Prevention of Demineralization During Fixed Orthodontic Treatment
Treatment with fixed orthodontic appliances is often associated with pain, which poses great challenges in the efficient brushing of the teeth thus making the teeth more vulnerable to plaque formation.
- Conditions
- Demineralization, Tooth, Caries,Dental, White Spot Lesion
- Trial name
- NCT04342858
- Testing
- Fluoride Varnish, Fluoride Varnish with tricalcium phosphate, Oral health education
- Where
- Hong Kong
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Dentin Sensitivity
Clinical Study to Investigate the Ability of a Stannous Fluoride Toothpaste to Protect From Dentine Hypersensitivity
The purpose of this study is to investigate and characterize the Dentine Hypersensitivity (DH) protection profiles of a 0.454 percent (%) Stannous Fluoride (SnF2) toothpaste and a regular fluoride toothpaste, in response to…
- Trial name
- NCT06733285
- Testing
- Sensodyne Rapid Relief, Colgate Cavity Protection
- Where
- United Kingdom
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- HALEON
Fungal Infection
Assessment of Voriconazole Penetration Into the Brain by Fluorine-Magnetic Resonance Spectroscopy
The purpose of this study is to determine the amount of voriconazole in the brain by fluorine-magnetic resonance spectroscopy (MRS) and to compare brain levels to plasma levels.
- Trial name
- NCT00136968
- Testing
- Voriconazole
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Heart; Complications, Valve, Prosthesis
18F-Fluoride Assessment of Aortic Bioprosthesis Durability and Outcome
This study will evaluate the two main types of replacement tissue heart valve used in current practice, comparing outcomes from surgical aortic valve replacement (AVR) with that of the more recently introduced "key-hole"…
- Trial name
- 18F-FAABULOUS (NCT02304276)
- Testing
- 18F-Fluoride PET-CT, CT calcium score of aortic valve
- Volunteers
- 105 people
- Sponsor
- University of Edinburgh
Caries, Dental, Health Behavior
Interactive Parent-Targeted Text Messaging in Pediatric Clinics to Reduce Caries Among Urban Children
This is a randomized clinical trial to test the efficacy of a parent-targeted text message-based intervention program on caries incidence and oral health behaviors (child and parent).
- Trial name
- iSmile (NCT03294590)
- Testing
- OHT Parent targeted text messages, CWT Parent targeted text messages
- Where
- United States
- Volunteers
- 754 people, healthy volunteers welcome
- Sponsor
- Boston University
White Spot Lesion of Tooth, Demineralization
Remineralization Potential of PRG Barrier Coat Versus Fluoride Varnish in White Spot Lesions in Permanent Anterior Teeth of Children
To evaluate the remineralization potential of PRG Barrier Coat versus fluoride varnish in white spot lesions in permanent anterior teeth of children.
- Trial name
- PRG Barrier (NCT06986551)
- Testing
- 5% NaF fluoride varnish, PRG Barrier coat
- Where
- Egypt
- Volunteers
- 78 people
- Sponsor
- Cairo University
Dental Caries in Children
Silver Diamine Fluoride in Preventing Occlusal Caries in Primary Teeth
In Hong Kong, approximately half of the kindergarten children have dental caries (tooth decay) and the majority (>90%) of the decayed teeth were left untreated.
- Trial name
- NCT05084001
- Testing
- silver diamine fluoride, sodium fluoride varnish, tonic water
- Where
- China
- Volunteers
- 769 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Stroke, Carotid Stenosis
PET-MRI Imaging in Patients With Symptomatic Carotid Artery Stenosis
Ischaemic stroke is a major cause of death and disability worldwide. In patients with recent stroke, the 18F-fluoride positron emission tomography-computed tomography highlights high-risk culprit carotid plaque and is more…
- Trial name
- NCT03215550
- Testing
- CEA, 18F PET-MRI, Transcranial Doppler
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Edinburgh
Gingivitis, Plaque, Dental
Gingivitis Reduction After Use of 0.45% Stannous Fluoride Toothpaste
The 6-month clinical study was designed to investigate clinical efficacy on plaque and gingivitis for the stannous fluoride containing toothpaste (SNAP) compared to Colgate Cavity Protection Toothpaste after 3 and 6 months of…
- Trial name
- NCT06300866
- Testing
- Test, Control
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Early Childhood Caries
Effect of Three Types of Fluoride Varnish in Preventing Early Childhood Caries
This study evaluates and compares the effect of two types of calcium- and phosphate-containing fluoride varnishes to conventional fluoride varnishes in preventing early childhood caries.
- Trial name
- NCT04274569
- Testing
- NaF vanish, NaF-TCP, NaF-CPP-ACP
- Where
- Hong Kong
- Volunteers
- 570 people
- Sponsor
- The University of Hong Kong
Dental Devices, Home Care
Comparative Efficacy of Dental Flossing Before or After Tooth Brushing on Interproximal Plaque Reduction and Fluoride Retention in That Area
This randomized controlled crossover trial conducted on 25 dental students. in the preliminary session each volunteer was given a toothbrush(Trisa, soft, Switzerland) and toothpaste(Pooneh, Iran) and Dental Floss( Mina, Iran)to…
- Trial name
- NCT02971514
- Testing
- Flossing before Brushing, Brushing before Flossing
- Where
- Iran
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mashhad University of Medical Sciences