Clinical trials: Fluoride
Dental Caries in Children
Silver Diamine Fluoride Gel: Single Group Observational Study
A single group observational study to determine the clinical response of dental caries lesions in primary teeth where 38% silver diamine fluoride gel is applied and cover with 2.5% sodium fluoride varnish.
- Trial name
- KiruPoderoso (NCT05395065)
- Testing
- Silver Diamine Fluoride/Sodium Fluoride Varnish
- Where
- 5 sites in Peru
- Volunteers
- 237 people
- Sponsor
- Advantage Silver Dental Arrest, LLC
Oral Health
A Study to Evaluate the Effect of a Stannous Fluoride Toothpaste on the Oral Microbiome
The aim of this study is to evaluate the effect of a toothpaste containing stannous fluoride (SnF2) over time on the oral bacterial composition and activity and to explore its effect in comparison to a regular fluoride toothpaste.
- Trial name
- NCT06048809
- Testing
- Stannous Fluoride Toothpaste (Sensodyne Repair and Protect), Regular Fluoride Toothpaste (Colgate Cavity Protection)
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- HALEON
Caries
In Situ Comparison of the Remineralization Potential of Optimized Fluoride Dentifrice With Control Fluoride Dentifrice
The purpose of this study is to compare the remineralization potential of an optimized fluoride dentifrice to a control fluoride dentifrice in an in situ caries model.
- Trial name
- NCT06010732
- Testing
- 1100 ppm F as sodium fluoride (positive control), 1100 ppm F as sodium fluoride Test Product
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Indiana University
Plaque, Gingivitis
The Clinical of Stannous Fluoride Toothpaste and a Newly Designed Toothbrush Compared to Colgate Cavity Protection Toothpaste and a Regular Toothbrush in Reducing Plaque and Gingivitis.
Qualified subjects will be enrolled and randomly assigned to either of the two study groups based on their initial Plaque and Gingivitis scores.
- Trial name
- NCT06427499
- Testing
- Stannous fluoride toothpaste, Colgate Cavity Protection Toothpaste
- Where
- Thailand
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Root Caries
Silver Diamine Fluoride Treatment of Active Root Caries Lesions in Older Adults: A Case Series
The authors conducted a case series to determine the outcomes of treatment of root surface caries lesions when the teeth were treated topically with 38% silver diamine fluoride.
- Trial name
- NCT04370080
- Testing
- Silver Diamine Fluoride 38%
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Roseman University of Health Sciences
Deep Caries
Treatment of Primary Molars With Deep Caries Using Silver Diamine Fluoride
Untreated dental caries is a worldwide pandemic (Edelstein, 2006). Due to limited financial resources, poor access to basic oral care, and the high cost of restorative treatment, children of low-income nations have their general…
- Trial name
- NCT03563534
- Testing
- Silver Diamine Fluoride, Glass Ionomer
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries
Elmex Gel Efficacy in Preventing White Spot Lesions
the objective of this phase IV study: to establish the efficacy of elmex gel with a fluoride concentration of 1.25% compared with placebo by determining prevention of white spot lesions in patients wearing fixed orthodontic…
- Trial name
- NCT00268138
- Testing
- elmex gel
- Where
- 2 sites in Germany, Israel
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
White Spot Lesions [Initial Caries] on Smooth Surface of Tooth
Clinical Evaluation of the Efficacy of SPR-G Barrier Coat Versus Fluoride Varnish Versus MI Paste in the Treatment of Early White Spot Lesions in Pediatric Patients
In-Vivo randomized clinical trial to compare between the clinical performance of fluoride varnish versus MI paste (CPP_ACP) and the PRG- Barrier coat material concerning enamel remineralization, arrest of active early lesions…
- Trial name
- NCT05202821
- Testing
- PRG Barrier Coat, Fluoride varnish, MI paste
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Plaque, Dental, Dental Plaque Induced Gingivitis
The Effect of Photodynamic Therapy on Plaque in Orthodontic Patients
This randomized controlled trial will be conducted on 40 orthodontic patients at the Department of Orthodontics, University Hospital Centre Zagreb, Croatia. Respondents will be randomly allocated into 4 groups (n=10).
- Conditions
- Plaque, Dental, Dental Plaque Induced Gingivitis, White Spot Lesion
- Trial name
- NCT06331442
- Testing
- Photodynamic therapy, Tricalcium phosphate (TCP) varnish with 5% NaF, Chlorhexidine varnish
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Dental Caries, Quality of Life
Silver Diamine Fluoride: A Randomized Controlled Trial on Its Effectiveness As A Caries Arresting Agent
The aim of the study is to assess the effectiveness of 38% Silver Diamine Fluoride (SDF) solution and to determine if it is superior to 5% NaF varnish in arresting carious lesions in the primary teeth of young children attending…
- Trial name
- NCT05008718
- Testing
- 38% SDF group, 5% NaF group
- Where
- Malaysia
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Universiti Teknologi Mara
White Spot Lesions on Smooth Surface of Tooth
The Effectiveness of the Self-Assembling Peptide P11-4 in the Remineralization of Enamel Carious White Spot Lesions
This is three-arm Randomized Controlled Trial. The main goal is to evaluate the effectiveness of self-assembling peptide P11-4 (SAP P11-4) in the remineralization of enamel carious white spot lesions.
- Trial name
- WSL-Curodont (NCT07664046)
- Testing
- Self-assembling peptide P11-4, Fluoride varnish
- Where
- Poland
- Volunteers
- 75 people
- Sponsor
- Medical University of Warsaw
Dental Caries
Traditional vs. Minimally Invasive Decay Treatments in Primary Molars: An 18-month Split-mouth Randomized Study
The goal of this clinical trial is to compare the 18-month clinical success rates of three caries management approaches in primary molars of 60 healthy children aged 4-8 years attending the Department of Pediatric Dentistry at…
- Trial name
- MiCRO-PM (NCT07447583)
- Testing
- Hall Technique, Silver diamine Fluoride 38%, Compomer Restoration
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Dental Caries
Use of Fissure Sealants on Primary Molars
Sealants have been shown to be the most effective caries preventive measure in permanent dentition. Sealants of the primary molars soon after they erupt would reduce the total caries experience of the primary teeth of the…
- Trial name
- NCT01438866
- Testing
- Fissure sealant, Fissure sealants and fluoride varnish
- Where
- Kuwait
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Kuwait University
Adverse Reaction to Diagnostic Agents and Kits Nos
Tracking Peripheral Blood Mononuclear Cells With Fluorine MRI
Cell-based therapies in the form of stem cell-based or immune cell-based therapies are becoming important treatment options that are either approved for clinical use or are showing promise in clinical trials.
- Trial name
- TRACK (NCT02921373)
- Testing
- 19F Cell Sense-labeled PBMC, MRI
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Gregory A. Dekaban
Dentin Hypersensitivity
Evaluation of Biomimetic Mineralization Plus Soft Laser Irradiation in Dentin Hypersensitivity Management
Randomized clinical trial to investigate the efficacy of diode laser , Biomimetic mineralization desensitizing agents Curodont D'Senz (CS) gel both in combination and alone, and the efficacy of bifluoride 10 (5 % sodium fluoride)…
- Trial name
- Rct (NCT06829277)
- Testing
- Sodium fluoride varnish, Curodont De Senz, Curodont De Senz plus laser irradiation
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- MTI University
Pit and Fissure Caries
Investigation of the Incidence of Caries in Pits and Fissures Sealed With Bioactive Sealant Compared to Fluoride Releasing Resin Based Pit and Fissure Sealant
This study will be conducted to investigate the incidence of caries in pits and fissures sealed with a bioactive sealant compared to a fluoride releasing resin based pits and fissures sealant in preventive treatment procedures in…
- Trial name
- NCT03628729
- Testing
- Embrace™ WetBond™ Pit & Fissure Sealant, Seal-Rite™ Pit & Fissure Sealant, Pulpdent Corportation, USA
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries
Nanosilver Fluoride to Prevent Dental Biofilms Growth
This study aims to evaluate the effectiveness of nanosilver fluoride for controlling the growth of S. mutans present in dental plaque of children.
- Trial name
- NSFCT (NCT01950546)
- Testing
- nanosilver fluoride
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pernambuco
Dental Caries
In Situ Remineralisation Response of Different Artificial Caries-like Enamel Lesions to Home-care and Professional Fluoride Treatments
This study mainly compared the response of the artificial carious enamel lesions to remineralisation in situ. The tested in vitro demineralising protocols were: MC gel, PA gel, MHDP and Buffer solutions.
- Trial name
- NCT02637830
- Testing
- Application of fluoride varnish (22600 ppm F, Duraphat) at the begining of the study, Application of fluoride toothpaste (1500 ppm F, Crest) twice a day for 3 days of the study
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Caries
Evaluation of the Fluoride Dose Response Using In Situ Caries Model
The purpose of this study is to evaluate the fluoride dose response of different dentifrice fluoride concentrations - 0, 250, 1100 and 2800 ppm fluoride as sodium monofluorophosphate (MFP) and a fifth leg of 1100 ppm Stannous…
- Trial name
- NCT04763044
- Testing
- 0 ppm F, 250 ppm F as MFP, 1100 ppm as MFP
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Dental Caries
Fluoride Release,Compressive Strength and Clinical Performance of a Bioactive Restorative Material in ART
The study will be two parallel group, triple blinded randomized controlled clinical trial that based on CONSORT (consolidated standards of reporting trials) guideline .The selected participants according to inclusion and…
- Trial name
- NCT03788616
- Testing
- Fuji IX EXTRA, ACTIVA KIDS bioactive restorative material
- Where
- Egypt
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Marina F Fahmy, MD