Clinical trials: Fluorides, Dental Caries
Dental Caries
2-year Caries Clinical Study: Arginine Fluoride-Free Toothpastes vs. NaF Toothpaste
The objective of this study is to evaluate the anticaries efficacy for three dentifrices (1.5% arginine in a calcium base, 8.0% arginine in a calcium base, and 0.32% sodium fluoride in a silica base) in a two-year caries clinical…
- Trial name
- NCT05560945
- Testing
- 0.32% Sodium Fluoride Dentifrice Toothpaste, 1.5% Arginine Dentifrice, 8.0% Arginine Dentifrice
- Where
- 3 sites in China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Early Childhood Caries (ECC), Color Stability of Restoration
Evaluation of Silver Diamine Fluoride, Sodium Fluoride With Casein Phosphopeptide-Amorphous Calcium Phosphate(MI Varnish) and Dycal to Arrest Caries When Used in Indirect Pulp Capping Procedures in Children
Early childhood caries is a serious public health issue often neglected and goes untreated having detrimental effects on the child and their family. Hence, multiple teeth are affected with dental caries approaching close to pulp.
- Conditions
- Early Childhood Caries (ECC), Color Stability of Restoration, Caries Arrested, Caries,Dental
- Trial name
- SDF (NCT07893756)
- Testing
- Silver Diamine Fluoride (SDF, 38%) gel, Sodium Fluoride with CPP-ACP (MI varnish), Calcium Hydroxide (CH)
- Where
- Saudi Arabia
- Volunteers
- 90 people
- Sponsor
- University of Jazan
Incipient Caries
Clinical and Cost-Effectiveness of Silver Diamine Fluoride and Silver Fluoride, With or Without Application of LED, in Arresting Incipient Permament Molar Caries
The study aims to compare the effect of international brand ammonia based 38% SDF, water based silver fluoride solution (AgF), an aqueous silver fluoride solution, and local brand ammonia based SDF with and without LED light…
- Trial name
- SDF and AgF (NCT07366645)
- Testing
- International Sliver Diamine Fluoride, Local brand Egyptian Silver Diamine Fluoride, Silver Fluoride
- Volunteers
- 366 people
- Sponsor
- Cairo University
Dental Caries
Silver Diamine Fluoride Pilot Study (SDF)
This pilot trial is randomized, double-blind, and placebo-controlled trial with two parallel arms: an intervention group using silver diamine fluoride (SDF) and a placebo group (control).
- Trial name
- SDF (NCT02591147)
- Testing
- Silver Diamine Fluoride 38%
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Justine Kolker
Dental Caries, Tooth Demineralization
"Comparison of the Effects of Resin Infiltrant, Fluoride Varnish, and the Combined Application of Resin Infiltrant and Fluoride Varnish on Primary Molars in the Treatment of Proximal Non-Cavitated Carious Lesions in Children."
Purpose: This randomized controlled clinical trial aimed to compare the effectiveness of fluoride varnish, resin infiltrant, and their combination in treating superficial proximal carious lesions in primary molars of children…
- Conditions
- Dental Caries, Tooth Demineralization, Pediatric Dentistry, Molar, Deciduous
- Trial name
- NCT07112963
- Testing
- Fluoride Varnish
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Sacide Duman
Dental Caries
A Study to Evaluate the Cariostatic Efficacy of Nano Silver Fluoride (NSF) vs. Silver Diamine Fluoride (SDF) in Children
This study, titled "A Randomized Controlled Trial to Evaluate the Cariostatic Efficacy of Nano Silver Fluoride (NSF) vs. Silver Diamine Fluoride (SDF) in Children" (Study Number: ATSU-YI-NSF 2025), is sponsored by Young…
- Trial name
- NCT07861321
- Testing
- Nano Silver Fluoride / NSF
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- A.T. Still University of Health Sciences
Dental Caries in Children
Cost Effectiveness of Sodium Fluoride Varnish in Prevention of Dental Caries in School Children
Fluoride varnish application is universally accepted as a dental caries prevention method. This study was aimed in assessment of clinical outcome and cost effectiveness in using that method in Sri Lankan school children
- Trial name
- NCT03571815
- Testing
- 5% sodium fluoride varnish, WATER ON TEETH
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- University of Peradeniya
Dental Caries
Evaluation Of Fluoride Uptake By Dentine Following Silver Diamine Fluoride Under Resin Modified Glass Ionomer Restoration In Carious Primary Molars
Dental caries is one of the most common oral diseases of childhood and is considered as a major public health problem especially in areas with poor access to dental care.
- Trial name
- NCT04777968
- Testing
- Silver diamine fluoride
- Where
- 2 sites in Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Early Childhood Caries, Dental Caries in Children
Treatment of Early Childhood Caries Using Silver Diammine Fluoride and Sodium Fluoride Tricalciumphosphate and the Effects on Oral Health Related Quality of Life
There is still a need for the assessment of different minimal intervention strategies and treatments focusing on the prevention and arrest of carious lesions of primary molars The evidence-based clinical practice guideline on…
- Conditions
- Early Childhood Caries, Dental Caries in Children, Dental Caries Extending Into Dentin, Dental Caries
- Trial name
- NCT05772039
- Testing
- Topical application of 38% Silver Diammine Fluoride Solution, Topical application of 5% Sodium Fluoride with functional Tricalcium phosphate Varnish
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- Universiti Sains Malaysia
Dental Caries
Effectiveness of Fluoride Varnish in Prevention of Dental Caries in School Children
Despite the availability of free health dental service in Sri Lanka, the prevalence and severity of dental caries among 6year old school children stand at a very high level according to the results of national oral health survey…
- Trial name
- NCT02877888
- Testing
- fluoride varnish 22600ppm
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- University of Peradeniya
Dental Caries
Nanosilver Fluoride to Prevent Dental Biofilms Growth
This study aims to evaluate the effectiveness of nanosilver fluoride for controlling the growth of S. mutans present in dental plaque of children.
- Trial name
- NSFCT (NCT01950546)
- Testing
- nanosilver fluoride
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pernambuco
Dental Caries
Effectiveness of SDF With Different Post-treatment Protocols in Arresting Dental Caries
To compare the effectiveness of the semi-annual application of 38% SDF with two post-treatment protocols in arresting dental caries in preschool children
- Trial name
- NCT05655286
- Testing
- 38% SDF treatment, not to rinse for at least 30 minutes after SDF treatment, rinse mouth immediately after SDF treatment
- Where
- China
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Dental Caries, Dental Caries in Children
The Effects of Sodium Fluoride and Chlorhexidine Use on Salivary IL-6 and Matrix Metalloproteinase Levels in Children With Active Caries
This study aims to compare salivary IL-6, MMP-8, MMP-9, and TIMP-1 levels between healthy children and caries-active children, and to evaluate the effects of 5% sodium fluoride (NaF) varnish and 2% chlorhexidine (CHX) used in…
- Trial name
- DentalCaries (NCT07609797)
- Testing
- 5% Sodium Fluoride Varnish, 2% Chlorhexidine Pre-Treatment + 5% NaF Varnish, Standard Oral Hygiene Education
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Gül Keskin
Caries, Dental, Remineralization
Remineralizing Efficacy of Giomer Varnish vs. Fluoride Varnish in Management of White Spot Lesions in Adult Patients
To evaluate the remineralizing capability of biosmart S-PRG barrier coat varnish and its employment in clinical practice
- Conditions
- Caries, Dental, Remineralization, White Spot Lesion
- Trial name
- NCT05306691
- Testing
- Bio-smart Light Cured Protective Shield with bioactive S-PRG (Surface Pre- Reacted Glass ionomer) filler technology (PRG Barrier Coat) by (By SHOFU Inc., Japan).
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries
Efficacy of Dentifrices Containing Arginine Versus Fluoride on Microbial Acid
This study will be conducted to evaluate the effect of arginine versus fluoride containing toothpaste on neutralization of microbial acid produced by Cariogenic bacteria in adult population using chair side assessment method.
- Trial name
- NCT03143023
- Testing
- arginine toothpaste, fluoride toothpaste
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries
Fluoride Availability in Saliva After Use of Sodium Fluoride or Monofluorophosphate Toothpastes
Considering the widespread use of sodium fluoride (NaF) and monofluorophosphate (MFP) based toothpastes, the present study aim to evaluate F availability in saliva after use of the top-selling Brazilian toothpastes.
- Trial name
- NCT01589458
- Testing
- Toothpaste
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Dental Caries
Effect of Silver Diamine Fluoride and LED Activation on Residual Caries Activity in Class II Cavities
This observational clinical study investigates the effect of silver diamine fluoride (SDF) and its activation with light-emitting diode (LED) on residual caries activity after caries excavation in Class II primary molar cavities.
- Trial name
- NCT07250009
- Testing
- DIAGNOdent measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Dental Caries
Fluoride Varnish Randomized Clinical Trial
The purpose of this study is to compare the efficacy of fluoride varnish (FV) applied once or twice a year with counseling to counseling alone in preventing early childhood caries (ECC) (tooth decay in children under the age of…
- Trial name
- NCT00066963
- Testing
- Fluoride Varnish
- Where
- United States
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Primary Teeth, Microbial Colonization
The Antibacterial Effect of Nanosilver Fluoride on Primary Teeth
To assess the antibacterial effect of Nanosilver Fluoride (NSF) in relation to caries activity in dentin caries lesions of primary teeth in comparison to Silver Diamine Fluoride (SDF).
- Conditions
- Primary Teeth, Microbial Colonization, Caries, Dental Caries in Children
- Trial name
- NCT05221749
- Testing
- Nanosilver Fluoride (NSF), Silver diamine fluoride
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nour Ammar, BDS
Caries, Dental, Health Behavior
Interactive Parent-Targeted Text Messaging in Pediatric Clinics to Reduce Caries Among Urban Children
This is a randomized clinical trial to test the efficacy of a parent-targeted text message-based intervention program on caries incidence and oral health behaviors (child and parent).
- Trial name
- iSmile (NCT03294590)
- Testing
- OHT Parent targeted text messages, CWT Parent targeted text messages
- Where
- United States
- Volunteers
- 754 people, healthy volunteers welcome
- Sponsor
- Boston University