Clinical trials: Focus of Study, active
FSGS
A Study of the Efficacy and Safety of DMX-200 in Patients With FSGS Who Are Receiving an ARB
DMX-200 (repagermanium) is a C-C chemokine receptor type 2 (CCR2) inhibitor that, when administered concurrently with an ARB, is designed to inhibit recruitment of monocytes implicated in the inflammatory chemokine environment of…
- Trial name
- ACTION3 (NCT05183646)
- Testing
- DMX-200
- Where
- 220 sites in United States, Argentina and 19 more
- Volunteers
- 286 people
- Sponsor
- Dimerix Bioscience Pty Ltd
Metastatic Lung Small Cell Carcinoma, Metastatic Malignant Solid Neoplasm
Testing the Addition of an Anti-cancer Drug, BAY 1895344, to Usual Chemotherapy for Advanced Stage Solid Tumors, With a Specific Focus on Patients With Small Cell Lung Cancer, Poorly Differentiated Neuroendocrine Cancer, and Pancreatic Cancer
This phase I trial tests the safety, side effects and best dose of BAY 1895344 when given together with usual chemotherapy (irinotecan or topotecan) in treating patients with solid tumors that may have spread from where it first…
- Conditions
- Metastatic Lung Small Cell Carcinoma, Metastatic Malignant Solid Neoplasm, Metastatic Neuroendocrine Carcinoma, Metastatic Pancreatic Adenocarcinoma
- Trial name
- NCT04514497
- Testing
- Biopsy Procedure, Biospecimen Collection, Computed Tomography
- Where
- 23 sites in United States
- Volunteers
- 29 people
- Sponsor
- National Cancer Institute (NCI)
Bladder Cancer
Adjuvant Nivolumab Following Chemo-Radiation in Localized Muscle-Invasive Bladder Cancer
This is a phase 2, single arm, open label trial to evaluate the rate of failure free survival at 2 years after start of chemoradiation with adjuvant nivolumab in adult subjects who undergo chemoradiation for localized bladder…
- Trial name
- NEXT (NCT03171025)
- Testing
- Nivolumab
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Utah
Prostate Cancer
Anxiety in Patients Under Active Surveillance for Localized Prostate Cancer and Their Partners.
Prostate cancer (PCa) is the most common cancer and the third leading cause of cancer-related death among men in France. Active surveillance is one of the management options for low-risk prostate cancer.
- Trial name
- ANCAPRO (NCT07351461)
- Testing
- Patient on active surveillance
- Where
- France
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Localized Oesogastric Adenocarcimona, MSI and or dMMR
Pre-operative Nivolumab and Ipilimumab, Followed by Post-operative Nivolumab, for MSI/dMMR Oeso-gastric Adenocarcinoma.
This is a non-randomized study, open label phase II study. The purpose of this study is to evaluate the complete pathologic response rate (cPRR) with neoadjuvant nivolumab and ipilimumab combination in patients with MSI and/or…
- Trial name
- NEONIPIGA (NCT04006262)
- Testing
- Nivolumab 10 MG/ML, Ipilimumab 200 MG in 40 ML Injection
- Where
- 15 sites in France
- Volunteers
- 32 people
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Focal Segmental Glomerulosclerosis, Glomerulonephritis Minimal Lesion
A Study to Evaluate the Efficacy and Safety of Frexalimab, Brivekimig, or Rilzabrutinib in Participants Aged 16 to 75 Years With Primary Focal Segmental Glomerulosclerosis or Minimal Change Disease
This is a parallel, Phase 2a, double-blind, 6-arm study for the treatment of primary focal segmental glomerulosclerosis (FSGS) or minimal change disease (MCD).
- Trial name
- RESULT (NCT06500702)
- Testing
- frexalimab, brivekimig, rilzabrutinib
- Where
- 79 sites in United States, Argentina and 20 more
- Volunteers
- 84 people
- Sponsor
- Sanofi
Anterior Cruciate Ligament Injuries
A Study Of Focused Shockwave For Anterior Knee Pain Following Anterior Cruciate Ligament Reconstruction
The purpose of this study is to investigate whether Focused Shockwave (FSW) therapy reduces anterior knee pain following anterior cruciate ligament reconstruction (ACL-R) with bone-patellar tendon-bone (BTB) or quadriceps tendon…
- Trial name
- NCT07580157
- Testing
- Focused Shockwave
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Brain Tumor
MRI-Guided Focused Ultrasound Feasibility Study for Brain Tumors
The purpose of this study is to evaluate the safety of MRI-guided focused ultrasound thermal ablation of brain tumors performed through intact human skull using the ExAblate transcranial system.
- Trial name
- NCT00147056
- Testing
- ExAblate transcranial system
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- InSightec
Communication
Insights From Bereaved Parents and Oncologists
Investigators want to find better ways for doctors and families to talk about cancer and how uncertainty may affect a child's life.
- Trial name
- NCT07663539
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- St. Jude Children's Research Hospital
Childhood Obesity Prevention
Digitally Delivered Child Obesity Prevention for Parents in Home Visiting Programs
The goal of this clinical trial is to determine feasibility and acceptability of a digitally-based obesity prevention intervention for mothers of infants participating in a home visitation program.
- Trial name
- NCT07230808
- Testing
- digital intervention + home visiting curriculum, Home visiting curriculum
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Florida
Focused Acceptance and Commitment Therapy (FACT), Wailist
Focused Acceptance and Commitment Therapy (FACT) for Stress, Anxiety, and Depression
This study is an interventional study examining the feasibility and acceptability of Focused Acceptance and Commitment Therapy (FACT) as a short-term intervention.
- Trial name
- NCT07341425
- Testing
- Focused Acceptance and Commitment Therapy
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- University of Aarhus
Biliary Tract Neoplasms, Gallbladder Cancer
Neoadjuvant Gemcitabine Plus Cisplatin With or Without Durvalumab in Resectable Biliary Tract Cancer
Considering that the poor prognosis of resected biliary tract cancer and negative impact on the survival outcomes of R1/R2 resection, neoadjuvant chemotherapy may improve R0 resection rates and the survival outcomes of patients…
- Conditions
- Biliary Tract Neoplasms, Gallbladder Cancer, Cholangiocarcinoma
- Trial name
- DEBATE (NCT04308174)
- Testing
- Durvalumab + Gem/Cis, Gem/Cis
- Where
- South Korea
- Volunteers
- 45 people
- Sponsor
- Asan Medical Center
Prostate Cancer
Prospective Asian Multicenter Prostate Cancer Focal Therapy Study (ProAMFocal)
This is a multicenter observational study of patients undergoing focal therapy for prostate cancer in Asia
- Trial name
- ProAMFocal (NCT06491056)
- Testing
- Focal Therapy for Prostate Cancer
- Where
- Singapore
- Volunteers
- 500 people
- Sponsor
- Singapore General Hospital
Cesarean Delivery
IC-CS Risk: Patient Outcomes
This study is looking at the impact of the implementation of a cesarean risk calculator on cesarean delivery and maternal morbidity rates.
- Trial name
- NCT06488092
- Testing
- Cesarean Risk Calculator
- Where
- 14 sites in United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Pain
A Clinical Study on the Efficacy of Cognitive Distraction Focus Relaxation Therapy Based on MR
A prospective, single blind, randomized, parallel controlled trial was conducted to evaluate the analgesic effect and safety of MR based "cognitive distraction focus relaxation therapy" in patients clinically diagnosed with…
- Trial name
- NCT06290011
- Testing
- Pain key group
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Gingival Recession, Localized
Theravex Oral and Theravex Tissue Care Plus in the Healing Process of Mucogingival Surgery
This clinical study assesses the efficacy of two novel bioactive solutions, Theravex Oral and Theravex Tissue Care Plus, in enhancing soft tissue healing after periodontal surgery.
- Trial name
- NCT07430670
- Testing
- Modified Free Gingival Graft (M-FGG), Theravex Bioactive Solutions (Tissue Care Plus and Oral)
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad Complutense de Madrid
Seizures, Seizures, Focal
Study of the Pharmacokinetics, Safety, and Tolerability of ZONISADE in Children 1 Month to 17 Years of Age With Partial-onset Seizures
The purpose of this research is to determine the optimal dose, safety and tolerability of zonisamide oral suspension in children ages 1 month to 17 years of age who have partial-onset (focal) seizures.
- Conditions
- Seizures, Seizures, Focal, Seizure, Partial Onset, Seizure Disorder, Partial
- Trial name
- NCT06534502
- Testing
- Zonisamide Oral Product
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Azurity Pharmaceuticals
Shame, Intimate Partner Violence
How a Resilience-Focused Intervention is Perceived by Women Subjected to Domestic Violence
At Uppsala University Hospital, there is an outpatient clinic for women subjected to intimate partner violence. In order to explore how patients experience the biopsychosocial resilience-based intervention in use at the clinic…
- Conditions
- Shame, Intimate Partner Violence, Domestic Violence Exposure, Resilience, Psychological
- Trial name
- EMBER-2 (NCT07235722)
- Testing
- Qualitative interview
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Uppsala University
Focus of Study: Tailored Implementation
PIECES - Towards Large-Scale Adaptation and Tailored Implementation of Primary Cancer Prevention Programs
The PIECES project aims to evaluate the Primary Cancer Prevention Implementation Toolkit (PCP-IT), an online implementation support toolkit that aids implementation teams in improving the implementation of primary cancer…
- Trial name
- PIECES (NCT06718322)
- Testing
- Primary Cancer Prevention Implementation Toolkit (PCP-IT)
- Where
- 11 sites in Albania, Australia and 7 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hidde van der Ploeg
Focus of the Study is the Anatomy of the Soft Palate, Non-invasive Ventilation
The Inflate Study; Defining the Soft Palate in the Upper Airway Flow Pathway
The goal of this clinical trial is to understand the impact of the size and shape of the soft palate on gas airflow in the upper airway in healthy volunteers.
- Trial name
- NCT06738589
- Testing
- non-invasive ventilation
- Where
- New Zealand
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fisher and Paykel Healthcare