Clinical trials: Folate
Preterm Labor, Small for Gestational Age at Delivery
Calcium Aspirin Multiple Micronutrients (CAMMS) to Reduce Preterm Birth
This trial will evaluate the impact of an integrated intervention of daily maternal calcium, aspirin, and multiple micronutrients (CAMMS) compared to iron-folic acid (IFA) during pregnancy on preterm birth and other adverse birth…
- Conditions
- Preterm Labor, Small for Gestational Age at Delivery, Hypertensive Disorder of Pregnancy, Low Birth Weight
- Trial name
- CAMMS (NCT05612984)
- Testing
- Calcium aspirin multiple micronutrients, Iron-folic Acid
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Dyslipidemias
Effect of Adding Folic Acid on Lipid Parameters in Population With Dyslipidemias
Background: Homocysteinemia is associated with increased risk of stroke, dyslipidemias, dementia, peripheral vascular disease and coronary artery disease. folic acid is involved in the metabolism of homocysteine.
- Trial name
- NCT03674333
- Testing
- Folic Acid
- Where
- Pakistan
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Ovarian Cancer
The Development of Human Immunologic Assays Specific to Folate Receptor Antigen
Ovarian cancer has the highest mortality rate of gynecologic malignancies and the overall 5-year survival rate of ovarian cancer is only 20-30%.
- Trial name
- NCT00155935
- Testing
- venous puncture
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Stroke, Transient Ischemic Attack
China Stroke Secondary Prevention Trial
The CSSPT study is a multi-center, randomized, double blinded, placebo-controlled secondary stroke prevention trial in China to determine whether the addition of folic acid and vitamin supplements will reduce recurrent stroke…
- Trial name
- CSSPT (NCT01317849)
- Testing
- Folic Acid, Vitamin B6, Vitamin B12
- Where
- China
- Sponsor
- Xijing Hospital
Rheumatoid Arthritis
Study of Different Doses of Folic Acid in Combination With Methotrexate in Rheumatoid Arthritis
Introduction: Methotrexate is the sheet anchor for the treatment of rheumatoid arthritis. Folic acid supplementation is usually given at a dose of 5-30 mg per week to ameliorate adverse effects.
- Trial name
- FOLVARI (NCT01583959)
- Testing
- Folic Acid
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Female Infertility
Myo-inositol and Vitamin D3 During IVF
Administration of a multicomponent dietary supplement (myo-inositol, vitamin D3, folic acid and melatonin) to women undergoing IVF procedures.
- Trial name
- NCT04019899
- Testing
- control group, study group
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Lo.Li.Pharma s.r.l
Metastatic Colorectal Cancer
Masitinib in Combination With FOLFIRI for Second-line Treatment of Patients With Metastatic Colorectal Cancer
The objective is to compare the efficacy and safety of masitinib in combination with FOLFIRI ( irinotecan, 5-fluorouracil and folinic acid) to placebo in combination with FOLFIRI in second line treatment of patients.
- Trial name
- NCT02605044
- Testing
- Masitinib (AB1010), FOLFIRI
- Where
- 3 sites in France, Singapore and 1 more
- Volunteers
- 123 people
- Sponsor
- AB Science
High Grade Serous Ovarian Cancer
Investigating Idetrexed and Olaparib in Patients With Ovarian Cancer
Two drugs called Idetrexed and olaparib are being evaluated. Idetrexed is a type of drug called an "aFR-targeted thymidylate synthase inhibitor".
- Trial name
- IDOL (NCT06976892)
- Testing
- Dose Level 2 (starting dose), Dose Level 1, Dose Level -1
- Where
- 3 sites in United Kingdom
- Volunteers
- 33 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Depression, Bipolar Disorder
Prevention of Mood Disorders by Folic Acid Supplementation
The purpose of this study is to determine whether daily folic acid supplements can prevent new episodes of mood disorder in young people (aged 14-24 years) of biological parents with current or past history of depression or…
- Trial name
- PRE-EMPT (NCT00459264)
- Testing
- Folic Acid
- Where
- United Kingdom
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Stomach Neoplasms
A Phase II Study of Oxaliplatin in Association With 5FU and Folinic Acid in the Treatment of Subjects With Non-Surgical or Advanced Metastatic Gastric Cancer
This phase II trial will evaluate, in first line advanced or metastatic gastric cancer, the efficacy and tolerance of another oxaliplatin, 5FU bolus combination already tested in advanced colorectal cancer
- Trial name
- NCT00611507
- Testing
- Oxaliplatin, 5-Fluorouracil
- Where
- Colombia
- Volunteers
- 21 people
- Sponsor
- Sanofi
Hypertension
H-Type Hypertension Precision Medicine Trial
This is a multicenter, randomized, double-blind, controlled clinical trial. It aims to investigate the effects of different doses of folic acid on lowering homocysteine (Hcy) in patients with hypertension with different genotypes…
- Trial name
- NCT03472508
- Testing
- Folic Acid, Enalapril Maleate and Folic Acid Tablets (Yiye), Enalapril
- Where
- 5 sites in China
- Volunteers
- 3,600 people
- Sponsor
- Shenzhen Ausa Pharmed Co.,Ltd
Advanced Solid Tumor, Advanced Cancer
AMT-151 in Patients With Selected Advanced Solid Tumours
This first-in-human study will evaluate the Maximum Tolerated Dose (MTD) / the Recommended Phase 2 Dose (RP2D), safety, tolerability, anti-tumor activity, pharmacokinetics, pharmacodynamics and immunogenicity of AMT-151, a novel…
- Conditions
- Advanced Solid Tumor, Advanced Cancer, Advanced Carcinoma, Ovarian Cancer
- Trial name
- NCT05498597
- Testing
- AMT-151
- Where
- 9 sites in Australia, China
- Volunteers
- 30 people
- Sponsor
- Multitude Therapeutics Inc.
Schizophrenia
Potential Intervention Strategy With Folic Acid and Vitamin B12 in Patients With Schizophrenia
The investigators study aims are: 1. To investigate folate, vitamin B12, and homocysteine levels in patients with schizophrenia. 2.
- Trial name
- NCT02916121
- Testing
- folic acid 5 mg/cap
- Where
- Taiwan
- Volunteers
- 88 people
- Sponsor
- Taipei Medical University WanFang Hospital
Colorectal Cancer
Phase I/II CT 2106 and 5-FU/FA in Colorectal Cancer
CT-2106, a camptothecin (CPT) conjugate, is a new generation of topoisomerase I inhibitors designed to deliver higher, more effective chemotherapy to tumor tissue with less toxicity to normal tissues.
- Trial name
- NCT00291785
- Testing
- CT-2106, Folinic acid, 5-FU (fluorouracil)
- Where
- 2 sites in Italy
- Volunteers
- 48 people
- Sponsor
- CTI BioPharma
Autism Spectrum Disorder
Folinic Acid as a Treatment for Autism Spectrum Disorder in Children
Autism spectrum disorder (ASD) is a neurodevelopmental condition that affects communication, behavior, and social interaction in children. Current treatments are limited and mainly focus on managing symptoms.
- Trial name
- FOLIN-A (NCT07630506)
- Testing
- Folinic Acid
- Where
- Singapore
- Volunteers
- 184 people
- Sponsor
- KK Women's and Children's Hospital
Calcification of Aortic Valve, Aortic Valve Stenosis
Folic Acid Supplementation in Calcific Aortic Valve Disease
This is a prospective, randomized, comparative, clinical trial conducted by Wuhan Union Hospital that aims to evaluate the efficacy and safety of folic acid compared to placebo in patients with calcific aortic valve disease with…
- Trial name
- NCT05861648
- Testing
- Folic Acid Oral Tablet
- Volunteers
- 100 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Epithelial Ovarian Cancer, Non-small Cell Lung Cancer
ITIL-306 in Advanced Solid Tumors
ITIL-306-201 is a phase 1a/1b, multicenter, clinical trial evaluating the safety and feasibility of ITIL-306 in adult participants with advanced solid tumors whose disease has progressed after standard therapy.
- Conditions
- Epithelial Ovarian Cancer, Non-small Cell Lung Cancer, Renal Cell Carcinoma
- Trial name
- NCT05397093
- Testing
- ITIL-306
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Instil Bio
Ovarian Cancer
OTL38 for Intra-operative Imaging of Folate Receptor Positive Ovarian Cancer
This is a phase 3, randomized, multi-center, single dose, open label, pivotal study in patients diagnosed with, or with high clinical suspicion of, ovarian cancer scheduled to undergo primary surgical cytoreduction, interval…
- Trial name
- NCT03180307
- Testing
- OTL38, near infrared camera imaging system, laparotomy
- Where
- 11 sites in United States, Netherlands
- Volunteers
- 140 people
- Sponsor
- On Target Laboratories, LLC
Gestational Diabetes
MTHFR Mutation and Concentration of B12,Folic Acid,Homocysteine and HS CRP in the Blood of Pregnant Women With GDM.
Research hypothesis: pregnant women with gestational diabetes have elevated serum CRP values and homocysteine compared to pregnant women with normal glucose metabolism Elevated CRP and homocysteine values are associated with…
- Trial name
- NCT04952324
- Testing
- Blood sampling and determination of MTHFR mutation,vitamin B12, folic acid, homocystein and HS CRP
- Where
- 2 sites in Bosnia and Herzegovina
- Volunteers
- 100 people
- Sponsor
- University of Mostar
Supplementation
Maternal Adherence to MMS in Nepal
Although clinical studies highlight the value of MMS for pregnant and lactating women, implementation research studies are necessary to understand adherence and acceptability to the product and to uncover potential obstacles to…
- Trial name
- NAMASTE MMS (NCT06327646)
- Testing
- Multiple Micronutrient Supplement Blister, Multiple Micronutrient Supplement Bottle, Iron Folic Acid Blister
- Where
- 119 sites in Nepal
- Volunteers
- 2,640 people, healthy volunteers welcome
- Sponsor
- Helen Keller International