Clinical trials: Folate
Autoimmune Disease, Lymphatic Disease
Pyrimethamine to Treat Autoimmune Lymphoproliferative Syndrome
This study will examine whether the drug pyrimethamine can shrink lymph nodes and spleen in patients with autoimmune lymphoproliferative syndrome (ALPS).
- Conditions
- Autoimmune Disease, Lymphatic Disease, Lymphoproliferative Disorder
- Trial name
- NCT00065390
- Testing
- Pyrimethamine
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Colorectal Cancer
A Study in Second Line Metastatic Colorectal Cancer
The purpose of this study is to compare overall survival in participants with metastatic colorectal cancer treated with either ramucirumab and FOLFIRI or placebo and FOLFIRI.
- Trial name
- NCT01183780
- Testing
- Ramucirumab, Irinotecan, Folinic Acid
- Where
- 213 sites in United States, Argentina and 24 more
- Volunteers
- 1,072 people
- Sponsor
- Eli Lilly and Company
Solid Tumors
A Study of MORAb-202 (Herein Referred to as Farletuzumab Ecteribulin) in Participants With Solid Tumors
The primary objective of this study is to evaluate the tolerability and safety profile of farletuzumab ecteribulin in participants with solid tumors.
- Trial name
- NCT03386942
- Testing
- Farletuzumab Ecteribulin
- Where
- 10 sites in Japan
- Volunteers
- 82 people
- Sponsor
- Eisai Inc.
Contraception
Assessment of the Pharmacodynamic Effect on Plasma Folate and Red Blood Cell Folate and Comparison of the Folate Metabolites During the 24 Weeks of Treatment (Yasmin + Metafolin Versus Yasmin + Folic Acid) Followed by a 20 Week Elimination Phase of Folate
The purpose of this study is to examine and compare the uptake of levomefolate calcium (Metafolin, a registered vitamin supplement) and folic acid in the body during 24 weeks of treatment with a following folate elimination phase…
- Trial name
- NCT01258660
- Testing
- EE 0.03 mg/DRSP 3 mg (Yasmin) + folic acid
- Where
- Germany
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Bayer
Cancer Colorectal, Metastasis
TWICE-IRI: Optimization of Second-line Therapy With Aflibercept, Irinotecan (Day 1 or Day 1,3), 5-Fluorouracile and Folinic Acid in Patients With Metastatic Colorectal Cancer. A Randomized Phase III Study.
Optimization of second-line therapy with aflibercept, irinotecan (day1 or day 1,3), 5fluorouracile and folinic acid in patients with metastatic colorectal cancer. A randomized Phase III study.
- Trial name
- TWICE-IRI (NCT04392479)
- Testing
- Aflibercept-FOLFIRI, Aflibercept-mFOLFIRI3
- Where
- France
- Volunteers
- 202 people
- Sponsor
- Hôpital Franco-Britannique-Fondation Cognacq-Jay
Resectable Breast Cancer
Intraoperative Imagery of Breast Cancer With Folate-FITC (EC17)
Breast cancer is the most common cancer and the second cause of cancer mortality in women. There are approximately 200,000 new cases of breast cancer a year.
- Trial name
- NCT01994369
- Testing
- EC17
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pennsylvania
Breast Neoplasm, Neoplastic Cells, Circulating
Circulating Tumor Cells Screen for Breast Cancer
A prospective study was used to collect patients considering breast cancer admitted to our general surgery department from 2019-6 to 2023-8, to identify the case group (breast cancer) and the control group (non-breast cancer), to…
- Trial name
- CTCSFBC (NCT05633680)
- Testing
- Peripheral blood sampling for circulating tumor cells
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Handan First Hospital
Vitamin B-12 Deficiency
THE B-BABIES STUDY: An Observational Study of Group B Vitamins in Preterm Infants
Infancy may be associated with a risk of micronutrient depletion due to the high demands of rapid growth. This is particularly true when preterm birth occurs, as the period before term exhibits the highest rate of bodily growth…
- Trial name
- B-BABIES (NCT07163962)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
High Grade Ovarian Cancer, Primary Peritoneal Cancer
Mirvetuximab Soravtansine (MIRV) With Carboplatin in Second-line Treatment of Folate Receptor Alpha (FRα) Expressing, Platinum-sensitive Epithelial Ovarian Cancer
IMGN853-0420 is a multicenter, open-label, phase 2 study of carboplatin plus mirvetuximab soravtansine followed by mirvetuximab soravtansine continuation in folate receptor-alpha positive, recurrent platinum sensitive, high-grade…
- Conditions
- High Grade Ovarian Cancer, Primary Peritoneal Cancer, Fallopian Tube Cancer
- Trial name
- NCT05456685
- Testing
- Mirvetuximab soravtansine, Carboplatin
- Where
- 69 sites in United States, Belgium and 4 more
- Volunteers
- 125 people
- Sponsor
- AbbVie
Advanced Ovarian Cancer, Platinum-resistant Ovarian Cancer
A Study of MOv18 IgE in Patients With Solid Tumours That Express Folate Receptor Alpha
EPS101-10-02 is a Phase Ib open label, multicentre clinical trial comprising of a Dose Escalation phase (Part 1) followed by a Dose Expansion phase (Part 2) of MOv18 IgE in patients with folate receptor alpha-expressing (5% or…
- Conditions
- Advanced Ovarian Cancer, Platinum-resistant Ovarian Cancer, Triple Negative Breast Cancer (TNBC), Triple -Negative Breast Cancer
- Trial name
- NCT06547840
- Testing
- MOv18 IgE
- Where
- 7 sites in United Kingdom
- Volunteers
- 45 people
- Sponsor
- Epsilogen Ltd
Gingival Overgrowth
Folic Acid Supplementation in Phenytoin Induced Gingival Overgrowth
Phenytoin, a common anti-seizure drug, leads to cosmetically unacceptable side effect of gingival overgrowth in a significant number of patients.
- Trial name
- PIGO (NCT00781196)
- Testing
- folic acid
- Where
- India
- Volunteers
- 120 people
- Sponsor
- All India Institute of Medical Sciences
Type 2 Diabetic Peripheral Neuropathy (DPN)
Study of Metanx® in Subjects With Type 2 Diabetic Peripheral Neuropathy (DPN)
The purpose of this research study is to determine if Metanx improves sensory neuropathy in persons with Type 2 diabetes. Metanx is a medical food available with a prescription from a physician.
- Trial name
- NCT00726713
- Testing
- Metanx (a medical food)
- Where
- 6 sites in United States
- Volunteers
- 214 people
- Sponsor
- Pamlab, Inc.
Rheumatoid Arthritis
Study to Investigate the Efficacy, Safety, and Tolerability of FBL-MTX in Patients With Rheumatoid Arthritis
The goal of this clinical trial is to evaluate the efficacy of FBL-MTX administered by subcutaneous route in Rheumatoid Arthritis patients.
- Trial name
- NCT06565273
- Testing
- FBL-MTX
- Where
- 8 sites in Portugal
- Volunteers
- 40 people
- Sponsor
- SOLFARCOS - Pharmaceutical and Cosmetic Solutions Ltd
Autistic Disorder
Treating Oxidative Stress in Children With Autism
An open label trial was undertaken in 40 autistic children to determine whether treatment with metabolic precursors methylcobalamin and folinic acid would improve plasma biomarkers of oxidative stress and measures of core…
- Trial name
- NCT00692315
- Testing
- Methylcobalamin (methylB12)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Extreme Prematurity, Anemia of Prematurity
Folic Acid Supplementation to Reduce Anemia in Extremely Preterm Infants
Anemia of Prematurity (AOP) is very common in extremely preterm infants and often leads to blood transfusions. Folic acid, essential for growth and DNA synthesis, is deficient in premature infants.
- Trial name
- FASCINATE (NCT06220461)
- Testing
- Folic acid
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- University of Calgary
Breast Cancer, Head & Neck Cancer
A Master Regulator of Lipid-Associated Macrophage Function in Cancer
Cancer progression is shaped not only by genetic alterations but also by systemic and local metabolic changes that influence the tumor microenvironment (TME).
- Trial name
- FoMe-LAM (NCT07848061)
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Mitochondrial DNA Deletion, Macrocytosis
Vitamin B12 and Folinic Acid Supplementation in Mitochondrial DNA Deletion Syndromes
The purpose of this single center study is to evaluate whether there is a concordant improvement in macrocytosis in patient with mtDNA deletions with established macrocytosis following a trial of Vitamin B12 and Folinic acid…
- Trial name
- NCT06186154
- Testing
- Folinic acid (oral); Cyanocobalamin sublingual
- Volunteers
- 25 people
- Sponsor
- University of British Columbia
Anemia
Evaluating of the Impact of Micronutrient Interventions Among Adolescents in Mozambique
This purpose of this study is to assess effects of iron and folic acid supplementation and multiple micronutrient supplementation on anemia status and the impact of a nutrition curriculum on diet diversity and anemia knowledge…
- Trial name
- NCT06815315
- Testing
- Multiple micronutrient supplementation, Iron Folic Acid Supplementation, Adolescent Nutrition Curriculum
- Where
- Mozambique
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- World Vision US
Ovarian Cancer, Peritoneal Cancer
Gemzar (Gemcitabine) and Alimta (Pemetrexed) in the Treatment of Patients With Recurrent Platinum-Sensitive and Platinum-Resistant Ovarian or Peritoneal Cancer
This study hopes to evaluate whether the combination of Gemzar plus Alimta will have any beneficial effects for patients with recurrent platinum-sensitive or platinum-resistant ovarian or peritoneal cancer.
- Trial name
- NCT00055432
- Testing
- Gemzar and Alimta
- Where
- United States
- Sponsor
- Eli Lilly and Company
Colorectal Cancer
Fluorouracil and Irinotecan With or Without Leucovorin Compared With Observation in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer
RATIONALE: Drugs used in chemotherapy, such as irinotecan, leucovorin, and fluorouracil, work in different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00091312
- Testing
- FOLFIRI regimen, fluorouracil, irinotecan hydrochloride
- Where
- 9 sites in Egypt, France and 4 more
- Volunteers
- 1,976 people
- Sponsor
- Federation Francophone de Cancerologie Digestive