Clinical trials: Folate
Mutation
C677T Methylenetetrahydrofolate Reductase Mutation
To investigate the effect of anticoagulant treatment on pregnancy outcomes in patients with previous recurrent miscarriages (RM) who carry a methylenetetrahydrofolate reductase (MTHFR) gene mutation.
- Trial name
- C677T (NCT05864937)
- Testing
- infertily evaluation
- Where
- France
- Volunteers
- 363 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Rectal Cancer
Modulation of Adjuvant 5-FU by Folinic Acid and Interferon-alpha in Colon Cancer
The primary objective was to improve adjuvant 5-FU chemoradiotherapy in resectable rectal cancer. The investigators hypothesis was that modulation of 5-FU by addition of either FA or INF-alpha may increase overall survival.
- Trial name
- FOGT1 (NCT01060501)
- Testing
- Folinic Acid, interferon-alpha
- Where
- Germany
- Volunteers
- 796 people
- Sponsor
- University of Ulm
Uremia, Chronic Renal Failure
Uremic Hyperhomocysteinemia -A Folate Trial for Possible Prevention of Cardiovascular Events
Homocysteine recently gained access to the category of risk factor for the development of atherosclerotic cardiovascular disease in the general population.
- Conditions
- Uremia, Chronic Renal Failure, Hemodialysis, Hyperhomocysteinemia
- Trial name
- NCT00317005
- Testing
- folate treatment
- Where
- 2 sites in Brazil
- Volunteers
- 186 people
- Sponsor
- Universidade Estadual de Londrina
Cancer, Myocardial Infarction
NORVIT and WENBIT - Long-term Follow-up
Two large homocysteine-lowering B-vitamin intervention trials have been performed in Norway during the period 1998 to 2005, NORVIT and WENBIT.
- Conditions
- Cancer, Myocardial Infarction, Cerebrovascular Stroke
- Trial name
- NORVITWENBIT (NCT00671346)
- Where
- 2 sites in Norway
- Volunteers
- 6,839 people
- Sponsor
- Haukeland University Hospital
Ovarian Cancer, Ovarian Carcinoma
Study of STRO-002, an Anti-Folate Receptor Alpha (FolRα) Antibody Drug Conjugate in Ovarian & Endometrial Cancers
Phase 1 trial to study the safety, pharmacokinetics and preliminary efficacy of STRO-002 given intravenously every 3 weeks.
- Conditions
- Ovarian Cancer, Ovarian Carcinoma, Ovary Cancer, Endometrial Cancer
- Trial name
- NCT03748186
- Testing
- STRO-002
- Where
- 27 sites in United States, Spain
- Volunteers
- 136 people
- Sponsor
- Sutro Biopharma, Inc.
Morbidity, Mortality
Impact of Zinc Supplementation on Mortality and Hospitalizations in Children Aged 1 Months to 23 Months
Children, aged 1 months to 23 months, in the intervention households received zinc, iron and folic acid and those in the control households were administered iron and folic acid (IFA) alone for a period of one year.
- Conditions
- Morbidity, Mortality, Diarrhea, Pneumonia
- Trial name
- NCT00269542
- Testing
- Zinc and iron folic acid - Intervention
- Volunteers
- 94,359 people, healthy volunteers welcome
- Sponsor
- Society for Applied Studies
Epilepsy, Psychiatric or Mood Diseases or Conditions
Does Valproate Increase Levels of Folate Receptor Autoantibodies in Women?
Women who take folate (folic acid) before getting pregnant can lower the risk of giving birth to infant with certain birth defects. However, some medications may affect the action of folate.
- Trial name
- NCT01231646
- Testing
- No intervention
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Northwell Health
Lung Cancer
Folic Acid Interferes With Radiation Esophagitis
This randomized study compared the incidence and severity of radiation esophagitis with folic acid and with conventional symptomatic treatment.
- Trial name
- NCT05296369
- Testing
- Folic acid
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Guizhou Medical University
Human Cancers
Phase I Study of MOv18 IgE
This first in human study of the new therapeutic antibody MOv18 immunoglobulin (Ig) E, which targets a protein called folate receptor alpha (FRa), in patients with advanced cancer seeks to demonstrate the potential for the use of…
- Trial name
- NCT02546921
- Testing
- MOv18 IgE
- Where
- 4 sites in United Kingdom
- Volunteers
- 26 people
- Sponsor
- Cancer Research UK
Obesity
Folic Acid Supplementation in Women of Child Bearing Age
The objective of this study is to identify genes whose expression is potentially modifiable due to changes in folate intake and help delineate mechanisms accounting for the variability in individual response to folic acid…
- Trial name
- FASUPP (NCT01841658)
- Testing
- Folic acid
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Colorectal Cancer, Metastatic Cancer
Liver Resection and Floxuridine Plus Fluorouracil and Leucovorin in Treating Patients With Liver Metastases From Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and giving drugs in different ways may kill more tumor cells.
- Trial name
- NCT00002842
- Testing
- floxuridine, fluorouracil, leucovorin calcium
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- City of Hope Medical Center
Ovarian Cancer, Fallopian Tube Cancer
MOv19-BBz CAR T Cells in aFR Expressing Recurrent High Grade Serous Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Phase I study to establish safety and feasibility of intraperitoneally administered lentiviral transduced MOv19-BBz CAR T cells with or without cyclophosphamide + fludarabine as lymphodepleting chemotherapy
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Carcinoma
- Trial name
- NCT03585764
- Testing
- MOv19-BBz CAR T cells, Alpha Folate Receptor expression test
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Pennsylvania
Rectal Cancer
Preoperative Radiotherapy and Chemotherapy in Patients With Locally Advanced Rectal Cancer
The aims of the trial are (1) to determine the tolerability rate in the setting of a multi-centre study and (2) to determine secondary tolerability endpoints, toxicity rates and complete pathologic response rate in patients with…
- Trial name
- PROArCT (NCT01013805)
- Testing
- External Beam Radiotherapy, Oxaliplatin, Fluorouracil
- Where
- Australia
- Volunteers
- 41 people
- Sponsor
- Trans Tasman Radiation Oncology Group
Papilloma-induced Cervical Lesions
Epigallocatechin Gallate and Other Antural Compounds in HPV Infections
The investigators enroll patients with a PAP-test cytology reporting LSIL or ASCUS. Pateitns undergo HPV-DNA test for screening.
- Trial name
- EGCGHPV (NCT06098456)
- Testing
- EGCG, FA, HA, B12
- Where
- Italy
- Volunteers
- 178 people
- Sponsor
- Centro di Ricerca Clinica Salentino
Essential Hypertension
Efficacy of Amlodipine-Folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine
To evaluate the efficacy of Amlodipine-Folic Acid Tablets on reduction of blood pressure and plasma total homocysteine.
- Trial name
- NCT01956786
- Testing
- Amlodipine-FA tablet,low dose group, Amlodipine-FA tablet,high dose group, Amlodipine
- Where
- 3 sites in China
- Volunteers
- 540 people
- Sponsor
- Shenzhen Ausa Pharmed Co.,Ltd
Dementia
Can Oral Vitamin B12 and Folate Supplementation Preserve Cognitive Function of Patients With Early Dementia?
Background: Vitamin B12 and folate are essential to brain health. Sub optimal status of vitamin B12 and folate leads to elevation of plasma homocysteine concentration, which is associated with Dementia.
- Trial name
- NCT00164970
- Testing
- Vitamin B12, folate
- Where
- China
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Dyslipidemia
Effect of Compound (Cardiol Forte) on Lipid And Glycemic Parameters in Low Cardiovascular Risk Individuals
This study will evaluate the effects of a combination dietary supplement, Cardiol Forte, on lipid and glycemic parameters in adults at low cardiovascular risk with suboptimal cholesterol levels.
- Trial name
- CLARISKI (NCT07515573)
- Testing
- Cardiol Forte
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- U.G.A. Nutraceuticals
Congenital Malformations
Folic Acid Dosage and Malformations Reduction
In 1991 the Medical Research Council Vitamin Study Group and in 1992 the Hungarian randomised clinical trial have shown conclusively that the risk of neural tube defects can be reduced substantially by taking folic acid during…
- Trial name
- NCT01244347
- Testing
- folic acid
- Where
- 34 sites in Italy
- Volunteers
- 5,000 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Plasma Homocysteine, HbA1c Level
Vitamin B Complex and Diabetic Nephropathy in Type 1 Diabetes
Homocysteine levels have been found elevated in T1DM patients with Diabetic nephropathy (DN) due to several causes, including dietary deficiencies.
- Trial name
- NCT03594240
- Testing
- Vitamin B complex tablets (Neurorubine TM -Forte Lactab TM)
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Hepatitis C
A Pilot Study to Assess the Efficacy and Safety of Folic Acid and/or Vitamin B Complex on Hepatitis C Infected Patients Treated With Pegylated Interferon and Ribavirin.
Since success of the combination therapy with PEG-IFN and RBV is contingent on maintaining adequate doses of both drugs throughout the treatment period, the emergence of hematological side effects is expected and requires…
- Trial name
- NCT02150291
- Testing
- Folic acid, Neurobion
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- British University In Egypt