Clinical trials: Folate
Carcinoma of Unknown Primary
Chemotherapy in Treating Patients With Cancer of Unknown Primary Origin
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003558
- Testing
- carboplatin, etoposide, fluorouracil
- Where
- 2 sites in Netherlands
- Volunteers
- 140 people
- Sponsor
- Academisch Ziekenhuis Maastricht
Metastatic Breast Cancer
Hepatic Artery Infusion With FOLFOX in Liver Metastasis From Breast Cancer
Deliver oxliplatin and 5-FU via HAI to breast cancer patients with liver-only or liver-predominant metastases who have failed at least one line of systemic chemotherapy in metastatic setting.
- Trial name
- NCT01937507
- Testing
- HAI with FOLFOX
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Western Regional Medical Center
Diabetic Foot Ulcer
Evaluation of a Folic Acid Wound Treatment (FAWT) for Chronic, Early-Stage Diabetic Foot Ulcer (DFU) Healing
This is a twelve-week single-center, randomized, double-blind, clinical study to evaluate the safety and efficacy of a folic acid wound treatment (FAWT) versus Placebo in the promotion of healing of chronic, early stage diabetic…
- Trial name
- NCT04723134
- Testing
- Folinic acid calcium salt
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Joseph Boykin, MD
Very Low Birth Weight Baby
Serum Folic Acid Levels in Preterm Infants
Therefore preterm infants must need folic acid replacement than term babies.
- Trial name
- FALIPI (NCT01360528)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Mehmet Yekta
Folic Acid Deficiency, Social Isolation
Studying the Association Between Folic Acid Deficiency and Social Isolation for Elderly Patients
Social isolation among elderly people is a frequent and major determinant for health. The risk of premature death is 2 to 5 time higher for socially isolated people, similarly for morbidity, duration of healing and complications…
- Conditions
- Folic Acid Deficiency, Social Isolation, Elderly Patients
- Trial name
- NCT04180800
- Testing
- Lubben Social Network Scale - 6
- Where
- France
- Volunteers
- 61 people
- Sponsor
- University Hospital, Strasbourg, France
Mild Cognitive Impairment, Alzheimer's Disease
Effect of Cerefolin®/CerefolinNAC® on Biomarker Measurements
In a retrospective analysis of data from 1100 patients, disease-delaying effects of Cerefolin®/CerefolinNAC® were examined in terms of cognition.
- Conditions
- Mild Cognitive Impairment, Alzheimer's Disease, Alzheimer's Disease Related Disorders
- Trial name
- NCT01745198
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Pamlab, Inc.
Ovarian Cancer
Gene Therapy and Biological Therapy in Treating Patients With Ovarian Epithelial Cancer
RATIONALE: Interleukin-2 may stimulate a person's white blood cells to kill ovarian cancer cells. Interleukin-2 combined with white blood cells that are gene-modified to recognize and kill ovarian cancer cells may be an effective…
- Trial name
- NCT00019136
- Testing
- MOv-gamma chimeric receptor gene, aldesleukin, therapeutic allogeneic lymphocytes
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Folate Deficiency
Correspondence of Folate Dietary Intake and Biomarker Data
This NHANES analysis compares self-reported dietary folate with serum and red blood cell folate status in U.S. adults.
- Trial name
- NCT03089684
- Testing
- No intervention
- Volunteers
- 4,878 people, healthy volunteers welcome
- Sponsor
- National Institute of Health and Nutrition
Stomach Cancer, Gastric Cancer
Preoperative Chemo and Chemoradiotherapy for Adenocarcinoma of the Stomach and Gastroesophageal Junction (GEJ)
The goal of this clinical research study is to learn if a combination of 5-FU, Folinic Acid and Oxaliplatin, given with radiation therapy, is effective in the treatment of gastric or gastroesophageal cancers that will be removed…
- Trial name
- NCT00525785
- Testing
- 5-Fluorouracil, Folinic Acid, Oxaliplatin
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- M.D. Anderson Cancer Center
Pregnancy, Maternal Nutrition
Effects of Maternal Folate and Folic Acid Supplementation on DNA Methylation in the Newborn Infant
An overwhelming body of evidence of the protective effect of folic acid supplementation on neural tube defect affected pregnancies led to mandatory folic acid fortification in Canada in 1998.
- Conditions
- Pregnancy, Maternal Nutrition, Fetal Health, Epigenetics
- Trial name
- NCT02244684
- Where
- Canada
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Atherosclerosis
The Effect of Coffee Consumption on the Serum Levels of Leptin, Folic Acid, and Vitamin B12
The effect of coffee and body weight during the last 3 months on the level of leptin, folic acid, and vitamin B12
- Trial name
- NCT04488731
- Testing
- Normal BMI and moderate coffee consumption, Normal BMI and heavy coffee consumption, overweight and moderate coffee consumption
- Where
- Jordan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Applied Science Private University
Kidney Failure
Vitamin Metabolism in Kidney Disease
The purpose of this study is to evaluate the urinary excretion and renal metabolism of vitamins, in particular vitamin B12 and folate, in relation to various renal conditions involving loss of renal function and/or proteinuria.
- Trial name
- NCT00257439
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Neural Tube Defects
Efficacy of Weekly Versus Daily Folic Acid Supplementation
Investigate the efficacy of weekly versus daily of folic acid supplementation on improving folate, vitamin B12,
- Trial name
- NCT00394862
- Testing
- multivitamin
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Emory University
Premature Ejaculation
Evaluation of the Clinical Efficacy and Safety of Dapoxetine, Combined Dapoxetine With Folic Acid and Combined Dapoxetine With Vitamin B12 in Treatment of Patients With Premature Ejaculation
This study will aim to assess of the clinical efficacy and safety of dapoxetine, combined dapoxetine with folic acid and combined dapoxetine with vitamin B12 in treatment of patients with premature ejaculation: A randomized…
- Trial name
- PE (NCT04085354)
- Testing
- Multi-Vitamin Tablets, Dapoxetine, Dapoxetine and folic acid.
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Sohag University
Platinum Sensitive Ovarian Cancer, Ovarian Cancer
Folate Receptor Alpha Peptide Vaccine With GM-CSF Versus GM-CSF Alone in Patients With Platinum Sensitive Ovarian Cancer
This is a double-blind, randomized, parallel groups Phase II trial. Patients with platinum-sensitive advanced ovarian cancer, defined as a lack of progression by RECIST v1.1 criteria following completion of standard-of-care…
- Trial name
- NCT02978222
- Testing
- FRα peptide plus Adjuvant (GM-CSF), Adjuvant (GM-CSF) Alone
- Where
- 18 sites in United States
- Volunteers
- 120 people
- Sponsor
- Marker Therapeutics, Inc.
Colon Cancer, Adenoma
Chemoprevention With Folic Acid
Colorectal neoplasia is the second most common cancer in the United States and other Western countries with about 140,000 newly diagnosed cases per year in the United States with a mortality rate of about 40%.
- Conditions
- Colon Cancer, Adenoma, Colonic Polyps
- Trial name
- NCT00018551
- Testing
- Folic Acid
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Osteosarcoma
A Retrospective Non-intervention Study to Characterize FOlate Rescue Treatment in Osteosarcoma Patients Treated With HDMTX
The purpose of this study is to investigate to which extend osteosarcoma patients do NOT meet the criteria for successfully advancement to next planned chemotherapy course.
- Trial name
- FORTO (NCT02383901)
- Testing
- Methotrexate
- Where
- 5 sites in Hungary, Norway and 2 more
- Volunteers
- 116 people
- Sponsor
- Isofol Medical AB
Unresectable Hepatocellular Carcinoma
Safety and Efficacy of Folic Acid Combined With Atezolizumab and Bevacizumab as First-Line Therapy for Unresectable Hepatocellular Carcinoma
This study is evaluating the safety and potential effectiveness of adding folic acid to atezolizumab plus bevacizumab as first-line treatment for adults with unresectable hepatocellular carcinoma (HCC).
- Trial name
- NCT07835737
- Testing
- Folic Acid, Atezolizumab & Bevacizumab
- Volunteers
- 78 people
- Sponsor
- West China Hospital
Neural Tube Defects (NTDs), Facial Cleft Defect
Genetic Analysis of Neural Tube and Orofacial Cleft Defects in the Irish Population
In a collaborative effort with the Health Research Board, the national organization for medical research in the Republic of Ireland, individuals with neural tube defects (NTDs) or facial cleft defects and their parents will be…
- Conditions
- Neural Tube Defects (NTDs), Facial Cleft Defect, Hereditary Oral Clefts
- Trial name
- NCT00341068
- Where
- United States
- Volunteers
- 7,451 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Ovarian Cancer
OTL38 Injection (OTL38) for Intra-Operative Imaging of Folate Receptor Positive Ovarian Cancer
The primary objective of the study is to compare the performance of different camera imaging systems in assessing the positive predictive values and sensitivity of OTL38 to detect folate positive ovarian cancer cancers using the…
- Trial name
- NCT04941378
- Testing
- OTL38, intraoperative imaging camera system
- Where
- United States
- Sponsor
- Abramson Cancer Center at Penn Medicine