Clinical trials: Folate
Pregnancy
Néevo®/NéevoDHA® P.L.U.S. Program (Progress Through Learning, Understand & Support)
This is an observational study in which patients who have been prescribed Néevo®/NéevoDHA® are invited to participate in surveys about their pregnancy and experiences with Néevo®/NéevoDHA®.
- Trial name
- NCT01358552
- Testing
- Néevo®/ NéevoDHA®
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Pamlab, Inc.
Hepatocellular Carcinoma (HCC)
Efcacy and Safety of Postoperative Adjuvant Hepatic Arterial Infusion Chemotherapy With mFOLFOX in Hepatocellular Carcinoma With High-risk Recurrence Factors
This is a single-center, single-arm, prospective trial to explore the efficacy and safety of postoperative adjuvant hepatic arterial infusion chemotherapy(HAIC) with mFOLFOX in hepatocellular carcinoma with high-risk recurrence…
- Trial name
- NCT07337421
- Testing
- mFOLFOX ：Oxaliplatin,leucovorin calcium,5-fluorouracil
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Northern Jiangsu People's Hospital
Epithelial Ovarian Cancer, Fallopian Tube Cancer
A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.
Cancer is a condition where cells in a specific part of body grow and reproduce uncontrollably. The purpose of this study is to assess the safety and efficacy of neoadjuvant carboplatin and mirvetuximab soravtansine in…
- Conditions
- Epithelial Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer, Neoadjuvant
- Trial name
- NCT06890338
- Testing
- Carboplatin, Mirvetuximab Soravtansine, Bevacizumab
- Where
- 73 sites in United States
- Volunteers
- 140 people
- Sponsor
- AbbVie
Maternal Micronutrient Status, Pregnancy
Multiple Micronutrient Versus Iron-Folic Acid Supplementation in Pregnant Women in Indonesia
Micronutrient deficiencies during pregnancy may affect the mother's nutritional status and the baby's growth. This study compared two types of daily supplements for pregnant women: a multiple micronutrient supplement and an iron…
- Conditions
- Maternal Micronutrient Status, Pregnancy, Low Birth Weight, Maternal Anemia
- Trial name
- NCT07725549
- Testing
- Multiple micronutrient supplementation, Iron and Folic Acid Supplementation
- Where
- Indonesia
- Volunteers
- 66 people
- Sponsor
- Indonesia Timur University
Lung Neoplasms, Lung Cancer
OTL38 Injection for Intraoperative Imaging of Folate Receptor Positive Lung Nodules
This is a phase 2, multi-center, single dose, open-label, exploratory study in suspected lung cancer patients scheduled to undergo endoscopic or thoracic surgery per CT/positron emission tomography imaging based on standard of…
- Trial name
- NCT02872701
- Testing
- OTL38 for Injection, Near infrared camera imaging system, Endoscopic or Thoracic Surgery
- Where
- 6 sites in United States, Netherlands
- Volunteers
- 100 people
- Sponsor
- On Target Laboratories, LLC
Type 1 Diabetes
D-chiro-Inositol in Overweight Type 1 Diabetes Patients
The purpose of this pilot study was to evaluate the effect of D-chiro-Inositol (DCI) oral supplementation in addiction to folic acid compared to folic acid alone on glycaemic control as assessed by HbA1c in overweight or obese…
- Trial name
- NCT02730949
- Testing
- D-chiro-inositol, Folic Acid
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Campus Bio-Medico University
Rheumatoid Arthritis
Natrunix Versus Methotrexate in Rheumatoid Arthritis
Phase II Double-Blinded, Placebo-Controlled Randomized Study Examining the Safety and Efficacy of Natrunix versus MTX (+folate) for the Treatment of Rheumatoid Arthritis
- Trial name
- NCT05363917
- Volunteers
- 150 people
- Sponsor
- XBiotech, Inc.
Cerebral Small Vessel Diseases, Stroke
Folic Acid and Intensive Antihypertensive Therapy for Hypertension With CSVD
The primary objectives of this trial are: 1. Efficacy evaluation of amlodipine folic acid tablets: To assess the effects of amlodipine folic acid tablets 5.8 mg (5 mg amlodipine + 0.8 mg folic acid)versus amlodipine tablets 5 mg…
- Trial name
- FAITH (NCT05169021)
- Testing
- Amlodipine folic acid 5.8mg+intensive antihypertensive therapy, Amlodipine folic acid 5.8mg+standard antihypertensive therapy, Amlodipine+intensive antihypertensive therapy
- Where
- China
- Volunteers
- 15,000 people
- Sponsor
- Beijing Tiantan Hospital
Blood Pressure
Blood Pressure Lowering Effect of B-vitamins in Adults With a Genetic Pre-disposition to Elevated Blood Pressure.
Approximately 12% of the world's population have a have a common C677T polymorphism in the gene encoding the folate metabolising enzyme, methylenetetrahydrofolate reductase (MTHFR).
- Trial name
- RAFA (NCT04278378)
- Testing
- Riboflavin, Folic acid
- Where
- United Kingdom
- Volunteers
- 2,564 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Muscle Strength, Vitamin B 12 Deficiency
Study of the Association of Muscle Strength, Balance and Other Factors With Vitamin Levels Among Elderly Diabetics
Vitamin B12 deficiency can cause severe problems with the blood, nerves, brain and psychological well-being. Ironically, our modern methods for the control of diabetes mellitus can actually contribute to vitamin B12 deficiency.
- Conditions
- Muscle Strength, Vitamin B 12 Deficiency, Folate Deficiency, Vitamin D Deficiency
- Trial name
- NCT03376490
- Where
- Singapore
- Volunteers
- 56 people
- Sponsor
- SingHealth Polyclinics
Pancreatic Adenocarcinoma
Alternative Neoadjuvant Chemotherapy in Resectable and Borderline Resectable Pancreatic Cancer
Using alternative neoadjuvant gemcitabine-nab-paclitaxel and nal-IRI with 5-Fluorouracil (5FU) and folinic acid (Leucovorin) regimens of localized cancer, we hope to ensure exposure of the cancer to a broader array of potentially…
- Trial name
- NCT03703063
- Testing
- Gemcitabine, nab paclitaxel, Onivyde
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Benaroya Research Institute
Liver Cancer
Diagnostic Accuracy of Folate-Targeted NIR-II Carbon Dots for Ex Vivo HCC Detection
This prospective, single-center observational study evaluates the diagnostic accuracy of a novel Folate-targeted Near-Infrared II Carbon Dot (FA-CDots) probe for the ex vivo assessment of Hepatocellular Carcinoma (HCC).
- Trial name
- NCT07295340
- Testing
- Ex Vivo FA-CDots Staining
- Where
- China
- Volunteers
- 20 people
- Sponsor
- West China Hospital
Acute Myeloid Leukemia, AML, Childhood
ELU001 in Pediatric Subjects Who Have Relapsed and/or Refractory CBFA2T3-GLIS2-positive AML
This research study was planned to focus on a rare type of acute myeloid leukemia (with the subtype CBFA2T3::GLIS2 that overexpresses folate receptor alpha (FRα) (a protein on the surface of leukemia cells)) that has relapsed or…
- Conditions
- Acute Myeloid Leukemia, AML, Childhood, Relapsed Pediatric AML, Refractory Pediatric AML
- Trial name
- Pediatric AML (NCT05622591)
- Testing
- ELU001
- Sponsor
- Elucida Oncology
HPV Infection, HPV Integration
Effect of EGCG, Folic Acid, Vitamin B12 and Hyaluronic Acid on HPV DNA Integration
This interventional, single-center, open-label randomized clinical study evaluates the efficacy of an oral dietary supplement (Pervistop®) in women with persistent Human Papillomavirus (HPV) infection.
- Conditions
- HPV Infection, HPV Integration, HPV Disease, HPV Genital Infection
- Trial name
- NCT07697196
- Testing
- Epigallocatechin gallate (EGCG), Folic Acid (FA), Vitamin B12 (B12), and Hyaluronic Acid (HA)
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- IRCCS San Raffaele
Ovarian Cancer, Ovarian Carcinoma
A Study of STRO-002, an Anti-Folate Receptor Alpha Antibody Drug Conjugate, in Combination With Bevacizumab in Epithelial Ovarian Cancer
Phase 1 trial to study the safety, pharmacokinetic and Preliminary Efficacy of STRO-002 in combination with Bevacizumab.
- Conditions
- Ovarian Cancer, Ovarian Carcinoma, Ovary Cancer, Fallopian Tube Cancer
- Trial name
- NCT05200364
- Testing
- STRO-002, Bevacizumab
- Where
- 6 sites in United States
- Volunteers
- 58 people
- Sponsor
- Sutro Biopharma, Inc.
Colorectal Cancer
A Randomized Trial of Avastin + Gemcitabine + 5-Fluorouracil (5FU)/Folinic Acid Versus Avastin + Oxaliplatin + 5FU/Folinic Acid in Metastatic Colorectal Cancer
The purpose of the study is to describe the tumor response rates for the two regimens being studied, and to determine how long patients live after receiving the treatment, how long patients are without return of their disease…
- Trial name
- NCT00192075
- Testing
- Gemcitabine, avastin, 5FU/folinic acid
- Where
- 15 sites in United States
- Volunteers
- 84 people
- Sponsor
- Eli Lilly and Company
Depression
The Effect of Methylated Vitamin B Complex on Depression
The proposed study is a 60-day, randomized, double-blind, placebo-controlled trial to evaluate the efficacy of a methylated vitamin B complex nutritional supplement (Max Stress B™) for improving depressive and anxiety symptoms…
- Trial name
- NCT01672372
- Testing
- Max Stress B
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Miami
Neoplasm Metastasis, Colorectal Cancer
5-FU, Folinic Acid and Irinotecan (FOLFIRI) Plus Cetuximab Versus FOLFIRI Plus Bevacizumab in First Line Treatment Colorectal Cancer (CRC)
The FIRE-3 trial is a multicenter randomized phase III trial investigating 5-FU, folinic acid and irinotecan (FOLFIRI) plus cetuximab versus FOLFIRI plus bevacizumab in first line treatment of metastatic colorectal cancer.
- Trial name
- NCT00433927
- Testing
- 5-FU, folinic acid, irinotecan
- Where
- Germany
- Volunteers
- 568 people
- Sponsor
- PD Dr. med. Volker Heinemann
Endometrial Cancer
Evaluation of Mirvetuximab Soravtansine (IMGN853) in Women With Folate Receptor-α Positive Endometrial Cancer
The purpose of this study is to evaluate the activity and safety profile of mirvetuximab soravtansine (IMGN853) in patients with type II endometrial cancers that overexpress folate receptor alpha (FRα).
- Trial name
- NCT03832361
- Testing
- IMGN853
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Alessandro Santin
Stomach Neoplasms
Oxaliplatin in Gastric Cancer
To determine the objective response to oxaliplatin/5FU/leucovorin combination chemotherapy in patients with advanced unresectable or metastatic gastric cancer.
- Trial name
- NCT00263354
- Testing
- Oxaliplatin
- Volunteers
- 20 people
- Sponsor
- Sanofi