Clinical trials: Folate
Plasma Total Homocysteine Level, Blood Pressure
Effect of Enalapril Plus Folic Acid on Blood Pressure and Glycometabolism
Combinded therapy with folic acid and enalapril may significantly decrease plasma total homocysteine level and had beneficial effect on blood pressure reduction and glycometabolism.
- Trial name
- NCT00520247
- Testing
- enalapril plus folic acid
- Where
- China
- Volunteers
- 443 people
- Sponsor
- Anhui Medical University
Healthy
Increasing Folate Status of a General Population(FOLSUPP STUDY)
The aim of this study is to determine the best source of folate to raise the folate status of a general population over a 16 week intervention period.
- Trial name
- NCT00372645
- Testing
- Folic acid (supplement), Metafolin (supplement), Folate rich foods
- Where
- 2 sites in United Kingdom
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Quadram Institute Bioscience
Folate, Folate Bioavailability
PREconception Folic Acid Clinical Efficacy (PREFACE) Trial
A study to help understand what forms of folic acid are most effective to increase folate status during pregnancy for the best protection against neural tube defects
- Conditions
- Folate, Folate Bioavailability, Clinical Trials, Pregnancy
- Trial name
- PREFACE (NCT06641245)
- Testing
- Folic Acid, 5-MTHF (5-methyltetrahydrofolate)
- Volunteers
- 272 people
- Sponsor
- University of British Columbia
Contraception
Trial Evaluating Folic Acid Supplementation by Concomitant Administration of Ethinyl Estradiol + Levonorgestrel
This trial evaluated folic acid supplementation after oral administration of the ethinyl estradiol + levonorgestrel + folic acid (0.02 mg + 0.10 mg + 0.4 mg) coated tablet (Level-Fol® Biolab Sanus Farmacêutica, São Paulo, Brazil)…
- Trial name
- NCT03359057
- Testing
- ethinyl estradiol + levonorgestrel + folic acid, Folic Acid
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Galeno Desenvolvimento de Pesquisas Clínicas
Systemic Lupus Erythematosus
Study of Methotrexate in Lupus Erythematosus
The treatment of systemic lupus erythematosus (SLE) has been aimed at decreasing mortality and morbidity because the etiology of the disease is unknown.
- Trial name
- SMILE (NCT00470522)
- Testing
- Methotrexate and folic acid
- Where
- Canada
- Volunteers
- 86 people
- Sponsor
- University Health Network, Toronto
Chronic Kidney Disease, Cardiovascular Disease
Folic Acid for Vascular Outcome Reduction In Transplantation (FAVORIT)
The purpose of this randomized clinical trial is to determine if lowering homocysteine levels in renal transplant recipients with a multivitamin will reduce the occurrence of cardiovascular disease outcomes.
- Conditions
- Chronic Kidney Disease, Cardiovascular Disease, Death
- Trial name
- FAVORIT (NCT00064753)
- Testing
- High Dose Multivitamin, Low Dose Multivitamin
- Where
- 30 sites in United States, Brazil and 1 more
- Volunteers
- 4,110 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diarrhoea;Acute
Effectiveness of Folic Acid Supplementation in Acute Watery Diarrhea Among Children Under 5 Years of Age
Folic acid is a palatable and easily available drug with no serious adverse effects. L-methylfolate is its biologically activated form and is preferred because of its direct availability for certain metabolic processes.
- Trial name
- NCT04782037
- Testing
- L-Methylfolate Calcium
- Where
- Pakistan
- Volunteers
- 324 people
- Sponsor
- King Edward Medical University
Advanced High-Grade Epithelial Ovarian Cancer, Primary Peritoneal Cancer
A Study to Assess Adverse Events and Change in Disease Activity in Participants With Platinum-Resistant Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha Expression Treated With Intravenously (IV) Infused Mirvetuximab Soravtansine
Cancer is a condition where cells in a specific part of body grow and reproduce uncontrollably. The purpose of this study is to assess the safety and efficacy of for Mirvetuximab Soravtansine in participants with…
- Conditions
- Advanced High-Grade Epithelial Ovarian Cancer, Primary Peritoneal Cancer, Fallopian Tube Cancers
- Trial name
- NCT06682988
- Testing
- Mirvetuximab Soravtansine
- Where
- 52 sites in United States, Australia and 6 more
- Volunteers
- 110 people
- Sponsor
- AbbVie
Lung Cancer
Intraoperative Imaging of Pulmonary Adenocarcinoma
The goal is to improve surgery by preventing tumor cells from being left behind at the time of surgery. This includes finding residual tumor cells in the wound after surgery.
- Trial name
- NCT02653612
- Testing
- EC17 imaging contrast agent
- Where
- United States
- Sponsor
- VA Office of Research and Development
Pregnancy, Autistic Disorder
Screening for Metabolic Problems in Mothers of Children With Autism and Typically Developing Children
The purpose of this research study is to screen for metabolic abnormalities that are maternal risk factors for having a child with autism.
- Conditions
- Pregnancy, Autistic Disorder, Folic Acid Deficiency
- Trial name
- NCT02674022
- Testing
- Prenatal supplement
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Pancreatic Cancer, Metastasis
Chemotherapy and Surgical Resection in Patients With Hepatic Oligometastatic Adenocarcinoma of the Pancreas
This is an interventional, open-label, non-randomised, multicentre, single-arm phase II clinical trial. Eligible patients with hepatic oligometastatic adenocarcinoma of the pancreas will receive neoadjuvant combination…
- Conditions
- Pancreatic Cancer, Metastasis, Surgery, Oligometastatic Disease
- Trial name
- HOLIPANC (NCT04617457)
- Testing
- nal-irinotecan (nal-iri) (Onyvide), oxaliplatin (ox), 5-fluouracil (5-FU), folinic acid (FA)
- Where
- 11 sites in Germany
- Volunteers
- 150 people
- Sponsor
- University of Cologne
Pregnant Women
Comparison of The Effect of 5-MTHF and Folic Acid Supplementation in Increasing Red Blood Cell Folate in Pregnant Women
This randomized controlled trial aims to compare the efficacy of 5-methyltetrahydrofolate (5-MTHF) and folic acid supplementation in increasing red blood cell (RBC) folate levels in pregnant women.
- Trial name
- NCT06935630
- Testing
- Folic Acid, 5-MTHF (5-methyltetrahydrofolate)
- Where
- Indonesia
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Dr. Soetomo General Hospital
High Grade Glioma
Pilot Study of Pembrolizumab Combined With Pemetrexed or Abemaciclib for High Grade Glioma
The purpose of this study is to evaluate any preliminary evidence of anticancer activity of pembrolizumab combined with either pemetrexed or abemaciclib when used following surgery and before standard therapy with radiation and…
- Trial name
- NCT04220892
- Testing
- Pembrolizumab, Pemetrexed, Abemaciclib
- Where
- United States
- Sponsor
- Jose Carrillo
Obesity and Overweight, Anemia, Iron-Deficiency
Different Efficacy of IFA Supplementation Among Obese and Non-obese Women
This clinical trial aims to learn if there is a relationship between OWT/OB and IDA in nonpregnant women of reproductive age and its impact on iron supplementation.
- Trial name
- NCT06622551
- Testing
- Iron-folic acid supplement
- Where
- Indonesia
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Griffith University
Anemia
Treatment and Prevention of Anemia With Ferrous Sulfate Plus Folic Acid in Children in Goiania - Goias, Brazil
Iron deficiency anemia is the most common nutritional problem in the world. The objectives of this study are: to evaluate the prevalence of anemia in children from 6 to 24 months of age and the therapeutic and prophylactic…
- Trial name
- NCT00701246
- Testing
- ferrous sulfate, folic acid
- Where
- Brazil
- Volunteers
- 196 people
- Sponsor
- Universidade Federal de Goias
Tumors
First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Mirvetuximab Soravtansine in Adults With Ovarian Cancer and Other Folate Receptor 1 (FOLR1)-Positive Solid Tumors
The purpose of this study is to test mirvetuximab soravtansine (IMGN853) in participants with ovarian cancer and other FOLR-1 positive tumors.
- Trial name
- IMGN853-0401 (NCT01609556)
- Testing
- Mirvetuximab soravtansine
- Where
- 12 sites in United States, Canada
- Volunteers
- 206 people
- Sponsor
- ImmunoGen, Inc.
Hypertension, Hyperhomocysteinemia
CSPPT- Chronic Kidney Diseases Study
The purpose of this trial is to confirm that enalapril maleate and folic acid tablets is more effective in preventing renal function decline among the patients with primary hypertension when compared to enalapril maleate.
- Trial name
- CSPPT-CKD (NCT01871740)
- Testing
- Enalapril maleate and folic acid tablets, Enalapril maleate
- Where
- 2 sites in China
- Sponsor
- Shenzhen Ausa Pharmed Co.,Ltd
One-carbon Metabolism in Healthy Individuals
Impact of High-dose Folic Acid Supplementation on Pathways Linked to DNA Formation
Periconceptional supplementation with folic acid - the synthetic form of the B-vitamin folate - reduces the occurrence of adverse pregnancy outcomes such as spina bifida.
- Trial name
- NCT01687127
- Testing
- Folic acid, 5-methyltetrahydrofolate, calcium salt
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of British Columbia