Clinical trials: Folate
Neuropathic Pain
Evaluation of an ATP-Containing Parenteral Vitamin B Complex in Patients With Symptomatic Diabetic Polyneuropathy
Epinosine B Forte ampoule is an intramuscular injectable supplement containing adenosine triphosphate (ATP), Cocarboxylase (vitamin B1 derivative), vitamin B12, and nicotinamide (vitamin B3).
- Trial name
- NCT07296354
- Testing
- adenosine triphosphate, Vitamin B Complex
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Egyptian International Pharmaceutical Industries Co
Chronic Kidney Diseases
Effect of Folic Acid and/or Pentoxifylline on Patients With Chronic Kidney Disease
The aim of this study is to evaluate the effect of administration of folic acid and /or pentoxifylline on patients with chronic kidney disease (CKD).
- Trial name
- NCT05284656
- Testing
- combination of Pentoxifylline 400 MG and Folic Acid, folic acid, Pentoxifylline 400 MG
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Al-Azhar University
Cervical Cancer, Precancerous Condition
Folic Acid Clinical Trial for the Prevention of Cervical Cancer
RATIONALE: Supplements, such as folic acid, may stop or delay the development of cervical cancer in women infected with human papillomavirus.
- Trial name
- NCT00703196
- Testing
- folic acid
- Where
- United States
- Volunteers
- 368 people
- Sponsor
- University of Alabama at Birmingham
Adnexal Mass, Borderline Ovarian Epithelial Tumor
Folate Receptor in Diagnosing Ovarian Cancer Using Serum Samples From Patients With Newly Diagnosed Pelvic Mass or Previously Diagnosed Ovarian Cancer
This pilot research trial studies folate receptor in diagnosing ovarian cancer using serum samples from patients with a newly diagnosed pelvic mass or previously diagnosed ovarian cancer.
- Conditions
- Adnexal Mass, Borderline Ovarian Epithelial Tumor, Ovarian Clear Cell Tumor, Ovarian Endometrioid Tumor
- Trial name
- NCT02520115
- Testing
- Dexamethasone, Laboratory Biomarker Analysis, Valproic Acid
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Healthy
Measurement of the Folate Receptor in Blood
The folate receptor (FR) is a cell marker that is over expressed on the cell surface of certain cancers, this occurs most frequently in ovarian cancers.
- Trial name
- NCT00838747
- Where
- United Kingdom
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Ovarian Cancer
TPIV200/huFR-1 (A Multi-Epitope Anti-Folate Receptor Vaccine) Plus Anti-PD-L1 MEDI4736 (Durvalumab) in Patients With Platinum Resistant Ovarian Cancer
This is a Phase 2 clinical trial, which tests two investigational drugs: TPIV200/huFR-1 (also called TPIV200), which is a vaccine consisting of proteins from the folate receptor alpha mixed with GM-CSF, and durvalumab (MEDI4736)…
- Trial name
- NCT02764333
- Testing
- TPIV200, Durvalumab
- Where
- 5 sites in United States
- Volunteers
- 29 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Maternal Dietary Diversity, Iron-Folic Acid Supplementation
A Feasibility Study of Integrating Maternal Nutrition Interventions Into Antenatal Care Services in Ethiopia
Alive \& Thrive (A\&T) is an initiative that supports the scaling up of nutrition interventions to save lives, prevent illnesses, and contribute to healthy growth and development through improved maternal nutrition, breastfeeding…
- Conditions
- Maternal Dietary Diversity, Iron-Folic Acid Supplementation, Early Initiation of Breastfeeding
- Trial name
- NCT04125368
- Testing
- Health Facility Interventions, Community Interventions, Health System Interventions
- Where
- United States
- Volunteers
- 4,256 people, healthy volunteers welcome
- Sponsor
- International Food Policy Research Institute
Pancreatic Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
Safety of Combining Irinotecan With 5-FU, Leucovorin/Folinic Acid, Oxaliplatin, and Docetaxel Chemotherapies
The purpose of the proposed study is to establish the safety of combining irinotecan chemotherapy with 5-FU, leucovorin/folinic acid, oxaliplatin, and docetaxel (abbreviated as the I-FLOAT study of gFOLFOXIRITAX) chemotherapies…
- Conditions
- Pancreatic Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Adenocarcinoma
- Trial name
- I-FLOAT (NCT04361708)
- Testing
- Oxaliplatin, Docetaxel, Leucovorin
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Chicago
Neurodevelopmental Disorders, Autism Spectrum Disorder
Patterns of Neurodevelopmental Disorders
The purpose of this study is to systematically evaluate the results of medical investigations to identify symptom and biological patterns and common etiologies of neurodevelopmental disorders.
- Conditions
- Neurodevelopmental Disorders, Autism Spectrum Disorder, Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infection, Pediatric Acute-Onset Neuropsychiatric Syndrome
- Trial name
- NCT06213090
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Richard Frye
Colorectal Cancer
A Safety Study of Pentamidine in Patients With Metastatic Colon Cancer Undergoing Standard Chemotherapy as Second-line and/or Third-line Treatment
The purpose of this study is to investigate the safety and possible efficacy of the use of pentamidine in the treatment of colon cancer metastasis in subjects receiving standard therapy.
- Trial name
- NCT00809796
- Testing
- pentamidine
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Oncozyme Pharma Inc.
Colorectal Cancer
Patients Preference for Oral or i.v. Therapy
Until recently, bolus 5-flourouracil (FU) + folinic acid (FA) has been considered the standard chemotherapy for patients with colorectal cancer. Several studies have shown that Capecitabine is as effective as Mayo regimen.
- Trial name
- NCT00212589
- Testing
- Capecitabine, Fluorouracil + folinic acid
- Where
- 4 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- Odense University Hospital
Deep-Vein Thrombosis, Pulmonary Embolism
VITRO-Trial. B Vitamins and the Secondary Prevention of Venous Thrombosis
The VITRO (Vitamins and Thrombosis) study investigated the effect of homocysteine lowering by daily supplementation of B-vitamins on the risk reduction of deep-vein thrombosis and pulmonary embolism.
- Trial name
- NCT00314990
- Testing
- 5 mg folic acid, 50 mg pyridoxine and 0.4 mg cyanocobalamin
- Where
- Netherlands
- Volunteers
- 620 people
- Sponsor
- Radboud University Medical Center
Epithelial Ovarian Cancer
Torvutatug Samrotecan Plus Bevacizumab as First-line Maintenance in Homologous Recombination Deficiency (HRD) Negative Advanced Epithelial Ovarian Cancer
This study will evaluate the efficacy, safety and tolerability of Torvutatug samrotecan (torvu-sam) in combination with bevacizumab compared with bevacizumab monotherapy as first line maintenance treatment in patients with…
- Trial name
- TREVI-OC-02 (NCT07851025)
- Testing
- Torvutatug samrotecan, Bevacizumab
- Where
- 186 sites in United States, Argentina and 22 more
- Volunteers
- 950 people
- Sponsor
- AstraZeneca
Malaria
Long-term Iron Supplements and Malaria Risk in Early Pregnancy: a Randomized Controlled Trial
A randomized double-blind controlled trial will be carried out in which young, nulliparous (having never given birth) women will be randomly assigned to receive weekly supplementation with either iron and folic acid or folic acid…
- Trial name
- PALUFER (NCT01210040)
- Testing
- Folic Acid, Folic Acid and Iron
- Where
- Burkina Faso
- Volunteers
- 1,959 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Obesity
Dietary Intervention and Assessment of Obesity-related Gene Methylation Levels in Overweight Women
The clinical study aimed to study the effect of an intervention with foods containing folate and hazelnut oil to assess whether this diet could modulate the methylation levels of two obesity-related genes, LEP and POMC, in…
- Trial name
- NCT04523532
- Testing
- Dietary folate and hazelnut oil
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Thamires Ribeiro Chaves
Iron Deficiency, Vitamin A Deficiency
Nutritional Status and Bouillon Use in Northern Ghana
This pilot aims to generate data that are critical for informing the design of a planned, more detailed study to evaluate the effect of multiple micronutrient (MN)-fortified bouillon cube on biomarkers of nutrient status of women…
- Conditions
- Iron Deficiency, Vitamin A Deficiency, Vitamin B 12 Deficiency, Folate Deficiency
- Trial name
- NCT04632771
- Testing
- N/A (observational study)
- Where
- Ghana
- Volunteers
- 995 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Schizophrenia
Effectiveness of Vitamin Supplementation in Treating People With Residual Symptoms of Schizophrenia
This study will evaluate the effectiveness of folate and B12 supplementation in reducing negative symptoms in people with schizophrenia.
- Trial name
- NCT00611806
- Testing
- Folic Acid, B12
- Where
- 3 sites in United States
- Volunteers
- 140 people
- Sponsor
- Massachusetts General Hospital
Esophageal Cancer
Twice Weekly TP-HDFL for Recurrent or Metastatic Esophageal Cancer
The primary objective of this study is to find out the response rate of twice weekly paclitaxel and cisplatin and weekly HDFL in recurrent or metastatic esophageal carcinoma patients who need palliative Chemotherapy.
- Trial name
- NCT00154700
- Testing
- Paclitaxel,Cisplatin,5-Fu,Folic Acid
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Folic Acid Deficiency
Folate-Rich Foods Improve Folate Status
This study evaluates the effects of folate-rich foods regarding improvement of folate status compared with folic acid supplement.
- Trial name
- Folatefood (NCT02373033)
- Testing
- Natural food folate, Folic acid, Apple juice
- Where
- Egypt
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Renal Cell Carcinoma
Intraoperative Imagery of Renal Nodules With Folate-fluorescein Conjugate(EC17)
According to the National Cancer Institute, an estimated 64,770 men and women will be diagnosed with kidney cancer in 2012. Of this number, an estimated 13,570 will die of this disease.
- Trial name
- NCT01778933
- Testing
- EC17
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pennsylvania