Clinical trials: Food Reward
Esophageal Cancer, Weight Gain
Resection of the Esophagus and Subsequent Weight Loss
The investigators aim to ascertain how food reward signals and eating behaviour relates to the gut-brain pathway in weight-losing patients after curative surgery for oesophageal cancer, and how this pathway responds to clinical…
- Conditions
- Esophageal Cancer, Weight Gain, Eating Behavior, Food Reward
- Trial name
- REWARD (NCT03377660)
- Testing
- Clinical treatment
- Where
- Ireland
- Volunteers
- 30 people
- Sponsor
- Imperial College London
Binge Eating Behaviour, Binge Eating/Loss of Control Eating
Impact of the EXOMIND (BTL-699-2) on the Brain Reward Pathway
The goal of this clinical trial is to thoroughly explore and ascertain the mechanism of action of the therapy with the EXOMIND (BTL-699-2) device in the treatment of food cravings (serving as an important precipitant to binge…
- Conditions
- Binge Eating Behaviour, Binge Eating/Loss of Control Eating, Food Craving
- Trial name
- NCT07024550
- Testing
- Treatment with BTL-699-2 device, Treatment with BTL-699-2 device with intensity below therapeutic threshold
- Where
- Czechia
- Volunteers
- 8 people
- Sponsor
- BTL Industries Ltd.
Binge Eating
Food and the Brain
The proposed study will examine the role of reward and emotion in women with and without a history of binge eating. It is important to understand how the brain responds to reward and emotion in binge eating in order to identify…
- Trial name
- NCT02743000
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Stanford University
Adiposity
Reward System Responses to Food Aromas
Food aromas are a part of foods' flavor, and can promote overeating. Alcohol consumption also stimulates appetite, and contributes to overeating while under alcohol's acute effects.
- Trial name
- NCT02041039
- Where
- United States
- Volunteers
- 332 people, healthy volunteers welcome
- Sponsor
- Robert Considine
Roux-en-Y Bariatric Surgery
Investigation of the Effects of Obesity Surgery on Appetitive Behaviour
Among all the existing ways to treat obesity (lifestyle, pharmacological), Roux-en-Y gastric bypass (RYGB) surgery is currently the most effective.
- Trial name
- NCT02010385
- Testing
- Octreotide, Saline
- Where
- Ireland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Eating Behavior, Eating Habit
Young Adult Eating Habits
Most individuals with obesity become so before age 35 and adolescent's unhealthy dietary patterns, specifically high intake of ultra-processed foods and poor overall diet quality, may contribute to energy overconsumption and…
- Trial name
- YAEH (NCT05550818)
- Testing
- High Ultra Processed Food Diet, No Ultra Processed Food Diet
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Obesity
Reward Mechanisms in Obesity
The study aims to investigate the effects of 3.0 mg of liraglutide on reward brain circuits in human obesity and to better understand its effects on weight loss (in patients without diabetes).
- Trial name
- LIRAOB (NCT03347890)
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Zoltan Pataky
Eating Disorders, Eating Behavior
Food Reward Circuit Change by Orthodontics
It has been described in obese individuals in which decreased basal metabolism as well as dopaminergic changes in the prefrontal cortex and striatum parallels the increased activation of reward brain regions in response to…
- Conditions
- Eating Disorders, Eating Behavior, Eating Habit, Orthodontic Appliance Complication
- Trial name
- DTI (NCT05026411)
- Testing
- T 0 Diffusion Tensor MR, T 1 Diffusion Tensor MR, T 2 Diffusion Tensor MR
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Children's Nutrition Intake
The Nutritional Effect of Parental Use of Food as a Reward
Control rules are common parental practices that use food as reward to encourage children to conduct parents' preferred behaviors.
- Trial name
- NCT02354157
- Testing
- no intervention
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- McGill University
Behavior, Eating
Effect of High-fat/High-sugar Diet on Food Reward Signaling
In this randomized, single-blinded basic research study, healthy normal-weight human participants are exposed to a high-fat/high-sugar (HF/HS) snack or a low-fat/low-sugar (LF/LS) snack twice a day for eight weeks in addition to…
- Trial name
- NCT05574660
- Testing
- High-Fat/High-Sugar (HF/HS) Diet, Low-Fat/Low-Sugar (LF/LS) Diet
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Max Planck Institute for Metabolism Research
Healthy
Food Intake Decisions
Functional Magnetic resonance study on the effect of cognitive context variables on the perception and valuation of food odorants and flavor.
- Trial name
- NCT03095833
- Testing
- Odors, Visual stimulation, Experimental Task
- Where
- France
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Opioid Dependence, Obesity
The Impact of Methadone Maintenance Therapy on Food Reward Processing in Opioid Dependence
Methadone maintenance therapy (MMT) has shown clear efficacy for relieving opioid withdrawal symptoms and reducing the morbidity and mortality of opioid dependence.
- Trial name
- NCT03575273
- Testing
- Sniffin' Sticks Odor Identification and Hedonic Scale, Sucrose Taste Preference Assessment, Food Preferences Task
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Eating Behavior, Food Reward
Effects of Exercise on Energy Intake-Prescription of Resistance Exercise
Healthy young males will complete five trials in a randomized crossover counter-balanced order, including three different inter-set rest of resistance exercise in equal training volume, one repeated until failure and sedentary…
- Trial name
- NCT06223282
- Testing
- short inter-set rest resistance exercise, medium inter-set rest, long inter-set rest
- Where
- Taiwan
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Normal Weight Adults, Adults With Obesity
Validation of a French-version of the Leeds Food Preference Questionnaire in Normal Weight and Patients With Obesity
While Food reward is an important component of the appetite control to consider, there is actually no tool that has been developed in French to perform its evaluation.
- Trial name
- LFPQ-F (NCT04041830)
- Testing
- Visit 1, Visit 2
- Where
- France
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Obesity
Multi-level Communications and Access Strategies to Improve the Food Environment
The overarching goal of B'More Healthy Retail Rewards (BHRR) is to develop, implement, and evaluate a pilot multi-level communications and pricing intervention to improve access to and consumption of healthy foods in low-income…
- Trial name
- BHRR (NCT02279849)
- Testing
- Communications, Pricing, Combined (Communications & Pricing)
- Where
- United States
- Volunteers
- 444 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Adiposity, Weight Loss
Dopaminergic Function and Food Reward
The broad aim of the study is to obtain a better understanding of alterations in mesolimbic reward pathways in adiposity based on the hypothesis of a hypofunctioning reward system in obesity.
- Trial name
- NCT01906411
- Testing
- Dopamine depletion vs. Balanced aminoacid drink
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Impulsivity, Alcohol Consumption
The Gut-brain Axis in Food Reward and Alcohol Consumption
The aims of this project are to: 1. Determine if 3-weeks dietary supplementation with NOPE-EGCG (PhosphoLEANtm, 85mg NOPE+50mg EGCG per capsule) versus a placebo will improve performance on impulsivity, go/no-go tasks and…
- Trial name
- NCT01902069
- Testing
- Phospholean
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Yale University
Obesity
Crave Crush Neuroimaging Study
The purpose of the research is to test whether a gymnemic acids (GA) lozenge will reduce reward region response to intake of high-sugar food and ad lib candy intake and whether the GA lozenge reduced reward region response to…
- Trial name
- NCT02949102
- Testing
- Crave Crush
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Obesity, Childhood, Eating Behavior
Study of Brain, Reward, and Kids' Eating
Children from rural communities are at greater risk for obesity than children from more urban communities. However, some children are resilient to obesity despite greater exposure to obesogenic influences in rural communities…
- Trial name
- BRAKE (NCT05456516)
- Testing
- Food Rating
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Penn State University
Bulimia Nervosa, Food Reward
Dopamine Release to Food Reward in Bulimia Nervosa
This study will assess the role of dopamine responses to food reward in Bulimia Nervosa patients, by performing simultaneous Positron Emission Tomography (PET) and Magnetic Resonance (MR) scanning.
- Trial name
- NCT03471806
- Testing
- Food reward at baseline, Food reward after treatment
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven