Clinical trials: Foot Injuries
Diabetic Foot Ulcer
Matrix Metalloproteinase-1/Tissue Inhibitor of Metalloproteinase-1 (MMP-1/TIMP-1) Ratio and Diabetic Foot Ulcers
The primary objective of this study is to assess the sensitivity and specificity of a MMP-1/TIMP-1 ratio equal to 0.24 at study entry to predict wound healing at 12 weeks' follow up visit.
- Trial name
- DIAB-MMP2 (NCT00935051)
- Testing
- Picture + MMPs and TIMP1 at week 0 and week 4
- Where
- 2 sites in France
- Volunteers
- 59 people
- Sponsor
- University Hospital, Grenoble
Foot and Ankle Surgeries, Bunion
Efficacy of Tranexamic Acid in Foot and Ankle Surgeries
Epidemiology of foot and ankle surgeries that present to the hospitals in the US are often underestimated. However there has been growing emphasis on identification of these injuries and practice patterns.
- Trial name
- NCT03653429
- Testing
- Tranexamic Acid, Normal saline
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Diabetic Foot Ulcer, Non-healing Wound
An Observational Clinical Trial Examining the Effect of Topical Oxygen Therapy (NATROX™) on the Rates of Healing of Chronic Diabetic Foot Ulcers
This study aims to evaluate the effectiveness of NATROX™ Topical Oxygen Wound Therapy for subjects with non-healing foot ulceration. Subjects will be treated with standard care for 4 weeks.
- Trial name
- NCT03863054
- Testing
- NATROX™ Topical Oxygen Therapy System
- Where
- Singapore
- Volunteers
- 20 people
- Sponsor
- Singapore General Hospital
Foot Fracture, Ankle Fractures
Use of Sterile HemaClear Tourniquet Below Calf Versus Pneumatic Tourniquet at the Thigh for Ankle and Foot Surgery
This is a Randomized controlled trial evaluating the effects of the use of Sterile HemaClear Tourniquet Below Calf Versus Pneumatic Tourniquet at the Thigh for Ankle and Foot Surgery The trial will randomize 60 patients into an…
- Conditions
- Foot Fracture, Ankle Fractures, Ankle Injuries, Foot Injuries and Disorders
- Trial name
- HemaClear (NCT04818775)
- Testing
- HemaClear, Pneumatic Tourniquet
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital do Coracao
Diabetic Foot Ulcers (DFU), Venous Stasis Ulcers (VSU)
OASIS Wound Matrix (Oasis) Mechanism of Action
OASIS Wound Matrix (Oasis) will be applied to wounds, with sequential biopsy of healing wounds to explore the mechanism of action.
- Trial name
- NCT00570141
- Testing
- OASIS Wound Matrix
- Where
- 3 sites in United States
- Volunteers
- 13 people
- Sponsor
- Healthpoint
Charcot Joint of Foot, Osteoarthropathy
Factors Associated With an Evolution in the Quality of Life of Diabetic Patients With Chronic, Wound-free Charcot Foot
Charcot foot, characterized by progressive destructive damage to bone, soft tissue and tendons, involving joint dislocation in the ankle and foot, is a complication of diabetes that is still poorly understood by patients and…
- Trial name
- CHARQUAM (NCT05491577)
- Testing
- Filling in the SF-36, FAAM-F, PHQ-9, PHQ-2 and the simplified version of the EPICES score questionnaire
- Where
- 17 sites in France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Foot Ulcer, Diabetic Foot
EZCast-DFU Study With Portal for Application of Topical Medications
This study is designed to evaluate the ability to modify a contact cast system so that topical medications can be applied daily to an underlying wound in patients with diabetic plantar ulcers.
- Trial name
- EZCast-DFU (NCT02131961)
- Testing
- Collagenase ointment, Modified Contact Cast System
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Miami
Foot Ulcer, Varicose Ulcer
Skin Ulcers Treatment With an Handicraft Topical Device
The aim of this study was to evaluate the efficacy of a handicraft topical device of negative pressure versus traditional healing treatment for skin ulcers in lower limbs; in patients with diabetes mellitus, venous stasis and…
- Trial name
- NCT02512159
- Testing
- drenovac handcrafted, Healing
- Volunteers
- 144 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Diabetic Ulcer
Evaluation of Topical Wound Oxygen (two2) Therapy
The purpose of this study is to evaluate the efficacy of the Topical Wound Oxygen (two2) therapy system on the healing of diabetic lower extremity ulcers.
- Trial name
- NCT00871312
- Testing
- Topical wound oxygen therapy
- Where
- 3 sites in United States, Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- AOTI Ltd.
Perfusion; Complications, Wound; Foot
Avazzia-University of Texas Southwestern Medical Center-Tennant Biomodulator® PRO Perfusion Study
This study is an open label trial designed to test the effectiveness of the Tennant Biomodulator® PRO electrical stimulation device (Avazzia), which uses BEST™ (Bio-Electric Stimulation Technology), on hospital in-patients to…
- Trial name
- NCT03843307
- Testing
- Avazzia Tennant Biomodulator® PRO
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Avazzia, Inc
Lower Leg Wound
A Pilot Study of the WoundWand™ Debridement Device on Infection Prevention
A Pilot Study of the WoundWand™ Debridement Device on Infection Prevention
- Trial name
- WoundWand (NCT01924806)
- Testing
- WoundWand™ Debridement Device, Standard of Care sharp debridement
- Where
- 2 sites in France, United Kingdom
- Volunteers
- 11 people
- Sponsor
- Smith & Nephew, Inc.
Hallux Limitus, Movement, Abnormal
Foot Posture Index, Hallux Limitus in Patients With Chronic Low Back Pain. Gait With Optogait Sensor
Foot disorders have been recognized as being linked to chronic low back pain
- Conditions
- Hallux Limitus, Movement, Abnormal, Back Pain Lower Back Chronic
- Trial name
- NCT04607863
- Testing
- Case control
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Seville
Diabetic Foot Ulcers, Diabetic Foot Wounds
Wound Edge Changes Following Treatment With Santyl
The goal of this study is to evaluate changes in the healing tissue of diabetic foot wounds following 14 days of treatment with Santyl or its vehicle base.
- Trial name
- NCT01197898
- Testing
- Collagenase Santyl Ointment
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Healthpoint
Wound Heal, Diabetic Foot Ulcer
Acellular Dermal Allograft for Chronic Diabetic Wounds
The purpose of this study is to determine the efficacy of a novel decellularized dermal matrix (DDM) DermGEN™ for the treatment of diabetic foot ulcers (DFU).
- Trial name
- NCT06227520
- Testing
- decellularized dermal matrix
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Fasciitis, Plantar
Efficacy of Focused Shock Waves Combined With Adjuvant Therapy With Tendon Supplement
Physical treatment with focused shock waves is effective in the treatment of tendonitis. Food supplements could facilitate the healing of tendinopathies when combined with shock wave therapy.
- Trial name
- NCT04664712
- Testing
- Tendisulfur Pro, Focused shock wave
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Foot Ulcer, Diabetic
Treatment Study of Negative Pressure Wound Therapy for Diabetic Foot Wounds
On behalf of a consortium of 19 health insurance companies the Institute for Research in Operative Medicine as part of the University of Witten / Herdecke gGmbH is planning and conducting a clinical study evaluating the efficacy…
- Trial name
- DiaFu (NCT01480362)
- Testing
- Negative Pressure Wound Therapy, Standard Wound Therapy
- Where
- 42 sites in Germany
- Volunteers
- 360 people
- Sponsor
- University of Witten/Herdecke
Diabetic Foot Ulcer of Neuropathic Origin
The TRAfermin in Neuropathic Diabetic Foot Ulcer Study - Northern Europe The TRANS-North Study
Trafermin is a recombinant human basic fibroblast growth factor (bFGF; original development code, KCB-1), which is manufactured by genetic engineering using Escherichia coli by Kaken Pharmaceutical Co., Ltd. (Tokyo, Japan).
- Trial name
- TRANS-North (NCT01217476)
- Testing
- Trafermin 0.01% spray
- Where
- 37 sites in Belgium, Bulgaria and 8 more
- Volunteers
- 207 people
- Sponsor
- Olympus Biotech Corporation
Strain of Muscle and/or Tendon of Lower Leg, Fracture of Lower Leg
Onset Time of Nerve Block: A Comparison of Two Injection Locations in Patients Having Lower Leg/ Foot Surgery
The purpose of this study is to compare injecting local anesthetic (numbing medication) in different patterns around a major nerve in the leg.
- Conditions
- Strain of Muscle and/or Tendon of Lower Leg, Fracture of Lower Leg, Crushing Injury of Lower Leg, Fracture Malunion - Ankle and/or Foot
- Trial name
- NCT01542840
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Diabetic Polyneuropathy, Foot Injuries
Spatio-Temporal Gait Parameters and Gait Symmetry In Diabetic Lower Extremity Burn Injury.
This study evaluated the spatio-temporal gait parameters and gait symmetry in individuals with lower extremity burn injury due to diabetic polyneuropathy.
- Trial name
- NCT03687840
- Testing
- gait analysis
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Diabetic Foot Ulcer, Infection
Topical PluroGel N for the Treatment of Mildly Infected Diabetic Foot Ulcers
This will be a randomized, double-blind (evaluator-blind), vehicle-controlled study of 50 enrolled subjects. Adult subjects (greater than 18 years old) who present with a mildly infected diabetic foot ulcer (IDSA criteria) having…
- Trial name
- NCT02091596
- Testing
- PluroGel N, PluroGel
- Where
- 15 sites in United States
- Volunteers
- 42 people
- Sponsor
- PluroGen Therapeutics, Inc