Clinical trials: Foot Injuries
Non-healing Wound, Diabetic Foot Ulcer
Use of AC5® Advanced Wound System in the Treatment of Diabetic Foot Ulcers
The purpose of this clinical evaluation is to collect and compare outcomes data from patients with UT 1A diabetic foot ulcers treated with 510K FDA cleared, commercially available self-assembling peptide, AC5®Advanced Wound…
- Trial name
- NCT06028386
- Testing
- AC5® Advanced Wound System, Fibracol Plus Collagen Dressing
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Arch Therapeutics
Foot Fusion
Augment® Bone Graft (Formerly GEM OS™1 Bone Graft) Compared to Autologous Bone Graft in Foot and Ankle Fusions
STUDY OBJECTIVES: Demonstrate equivalent clinical and radiologic outcomes to the "gold standard" (ABG) in a representative clinical model (hindfoot and ankle fusions) STUDY HYPOTHESIS: Augment® Bone Graft is an equivalent bone…
- Trial name
- NCT00583375
- Testing
- Augment® Bone Graft, Standard of Care
- Where
- 37 sites in United States, Canada
- Volunteers
- 414 people
- Sponsor
- BioMimetic Therapeutics
Diabetes Mellitus, Diabetes Complications
Comparison of Resin Salve and Octenidine in Patients With Neuropathic Diabetic Foot Ulcers
Prevalence of diabetic foot ulcers are reported to be 15% in patients who suffer from diabetes and ulcerations are present in 84% of all diabetes-related amputations.
- Conditions
- Diabetes Mellitus, Diabetes Complications, Diabetic Neuropathies, Wound Infection
- Trial name
- NCT02169167
- Testing
- Resin salve treatment, Octenidine treatment
- Where
- Poland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Janne J. Jokinen
Other Instability, Ankle and Foot
The Effect of Strain-counterstrain on Ankle Instability
This study seeks to determine the effectiveness of Strain Counterstrain in the treatment of chronic ankle instability.
- Trial name
- NCT02025569
- Testing
- Strain Counterstrain
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Long Island University
Wounds
Positive Predictive Value of the MolecuLight i:X Imaging Device to Predict the Presence of Bacteria in Chronic Wounds
This is a non-randomized evaluation for which 50 patients will be imaged at the Southwest Regional Wound Care Center, Lubbock, Texas, who present with a chronic wound and are receiving standard treatment.
- Trial name
- NCT02682069
- Testing
- MolecuLight i:X Imaging Device
- Volunteers
- 30 people
- Sponsor
- MolecuLight Inc.
Diabetic Foot Ulcer(s)
Assessment of the Efficacy and Safety of a New Wound Dressing in the Local Treatment of Diabetic Foot Ulcers
The main purpose of this trial is to demonstrate that the new dressing is more effective than the current dressing in the local treatment of chronic foot ulcers in diabetic patients.
- Trial name
- NCT01717183
- Testing
- Urgo 310 3113
- Where
- France
- Sponsor
- Laboratoires URGO
Drop Foot
Does Blood Vessel Vasodilation, Caused by Focal Infiltration of Lidocaine Cause Temporary Nerve Functional Recovery for Patients with Common Peroneal Nerve Injury or Entrapment: Testing the 'Phoenix Sign' Effect Between Lidocaine (a Common Local Anesthetic) and Papaverine, a Know Vasodilator
The goal of this clinical trial is to compare lidocaine without epinephrine to papaverine a known vasodilatory agent, in creating improved motor strength in patients with drop foot involving an entrapment of the Common Peroneal…
- Trial name
- NCT06637046
- Testing
- Diagnostic procedures, Lidocaine HCl
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stephen Barrett
Ankle Disorders Injuries
Urdu Translation And Cross-Cultural Validation of the Foot And Ankle Disability Index
The goal of this Cross-cultural validation study is to Urdu translate and cross-cultural validation of Foot and Ankle Disability Index for the Patients with Chronic Ankle Instability.
- Trial name
- NCT05732636
- Testing
- Validation study
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Sehat Medical Complex
Wounds, Diabetes Complications
Online Wound Electronic Medical Record (OWEMR) to Decrease Amputations in Diabetics
The purpose of this study is to determine whether using the OWEMR as part of the standard of care for Diabetic Foot Ulcers reduces the rate of lower limb amputations and to quantify the relationship between glycemic control and…
- Conditions
- Wounds, Diabetes Complications, Diabetic Foot, Foot Ulcer
- Trial name
- OWEMR (NCT01371318)
- Testing
- Online Wound Electronic Medical Record
- Where
- 13 sites in United States
- Volunteers
- 1,609 people
- Sponsor
- NYU Langone Health
Wounds and Injuries, Burns
ACTICOAT™ for the Treatment of Burns and Chronic Wounds
The aim of the study is to evaluate participant reported quality of life, safety, and overall performance with ACTICOAT in a clinical setting.
- Conditions
- Wounds and Injuries, Burns, Pressure Ulcer, Foot Ulcer
- Trial name
- NCT02852148
- Testing
- ACTICOAT
- Where
- 3 sites in United Kingdom
- Volunteers
- 25 people
- Sponsor
- Smith & Nephew, Inc.
Leg Ulcer, Diabetic Foot Ulcer
Proof of Concept (Design Validation) in Patient With Hard to Heal Wounds Such as Pressure Ulcer, Diabetic Foot Ulcer and Leg Ulcer, Leia
The purpose of this reseach study is to determine Mölnlycke Health Care´s Leia dressing performance properties is fulfilled and that the dressing is safe when used on wound types such as pressure ulcer, leg ulcer, and diabetic…
- Conditions
- Leg Ulcer, Diabetic Foot Ulcer, Pressure Ulcer
- Trial name
- NCT01966380
- Testing
- Leia
- Where
- Sweden
- Volunteers
- 6 people
- Sponsor
- Molnlycke Health Care AB
Infection, Soft Tissue, Infection, Wound
Direct Antibiotic Delivery of Cefazolin Into Soft Tissue Infections Using Subcutaneous Injection and Ultrasonic Dispersion
This study focuses on a new drug delivery system (Direct Antibiotic Delivery) to treat soft tissue infections. In this study, cefazolin is delivered directly to the target tissues using subcutaneous injection of antibiotic…
- Conditions
- Infection, Soft Tissue, Infection, Wound, Cellulitis, Diabetic Foot Ulcer
- Trial name
- DAD (NCT01238276)
- Testing
- Cefazolin, Silberg Tissue Preparation System
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sonescence, Inc.
Hallux Limitus
Contracture Reduction Following Bunionectomy: a Longitudinal, Controlled Trial
To determine the efficacy of Metatarsal Dynasplint Sytem (MTP) in reducing contracture of hallux limitus secondary to Bunionectomy, in a longitudinal, controlled trial.
- Trial name
- Bunionectomy (NCT01589679)
- Testing
- standard of care, Metarsal Dynasplint
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Dynasplint Systems, Inc.
Pes Planus, Running Related Injuries
Comparing Effects of Custom Foot Orthotic Intervention to Foot-Core Training Protocol on Lower Extremity Kinematics in Runners With Pes Planus
Running is a full body movement that requires the feet to support the body and absorb forces greater than the individual's body weight in a repeated fashion.
- Trial name
- CFO (NCT07723573)
- Testing
- Custom foot orthoses, Intrinsic foot muscle strengthening exercises
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Dalhousie University
Diabetic Foot Ulcer, Pressure Ulcer
A Prospective, Open Label, Multicenter Trial for Evaluating the Efficacy of Treating and Managing Wounds in Elderly Population in Specialized Nursing Facilities Using RD1
The study is a prospective, single arm, multicenter efficacy study, consisting of 60 subjects who will complete the study (note: if any patients are lost to follow-up or withdrawn, enrollment will increase to compensate for loss…
- Conditions
- Diabetic Foot Ulcer, Pressure Ulcer, Venous Leg Ulcer, Trauma Injury
- Trial name
- NCT04577183
- Testing
- RD1 System
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- RedDress Ltd.
Diabetic Foot Ulcer, Foot Ulcer
A Study to Evaluate ENERGI-F703 GEL in Diabetic Foot Ulcer
This Phase 3 study is a randomized, double-blind, vehicle-controlled, multiple-center, parallel study to evaluate efficacy and safety of ENERGI-F703 GEL compared with vehicle control in subjects with Wagner Grade 1 to Grade 2…
- Conditions
- Diabetic Foot Ulcer, Foot Ulcer, Diabetes Mellitus, Wound
- Trial name
- NCT05930210
- Testing
- ENERGI-F703 GEL, ENERGI-F703 matched vehicle
- Where
- 24 sites in United States, Taiwan
- Volunteers
- 230 people
- Sponsor
- Energenesis Biomedical Co., Ltd.
Spinal Cord Injuries, Spastic Gait
Neuromodulation of Ankle Muscles in Persons With SCI
The ability to voluntarily move the ankles is important for walking. After spinal cord injury (SCI), this ability is impaired because of changes in the communication between the brain, spinal cord, and body.
- Conditions
- Spinal Cord Injuries, Spastic Gait, Foot Drop
- Trial name
- NCT04238013
- Testing
- Whole Body Vibration (WBV), Electrical Stimulation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Shepherd Center, Atlanta GA
Diabetic Foot Ulcer, Diabetic Foot
Ulcer Location and Debridement Frequency: Weekly vs. Biweekly Sharp Debridement in Diabetic Foot Ulcers
The goal of this clinical trial is to determine the optimal frequency for sharp debridement in promoting the healing of diabetic foot ulcers (DFUs). The main questions it aims to answer are: 1.
- Conditions
- Diabetic Foot Ulcer, Diabetic Foot, Wound Heal
- Trial name
- NCT06160817
- Testing
- Conservative sharp debridement
- Where
- Spain
- Volunteers
- 16 people
- Sponsor
- Universidad Complutense de Madrid
Ankle Injuries, Foot Injuries and Disorders
Weight Change With Controlled Ankle Movement (CAM) Boot Use
The purpose of the study is to determine if patients wearing a CAM boot have a change in weight compared to patients who wear a CAM boot and are provided nutritional guidelines and perform upper body exercises.
- Conditions
- Ankle Injuries, Foot Injuries and Disorders, Body Weight Changes
- Trial name
- CAM (NCT05692401)
- Testing
- Nutrition and Exercise Instruction
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Nell Blake, DPM
Diabetic Foot
Negative Pressure Wound Therapy in Diabetic Wounds
Topical Negative Pressure Wound Therapy (TNPW) is an established tool in the management of Diabetic foot ulcer in many countries. This treatment option is under utilized in the public sector of Mauritius.
- Trial name
- NCT05041244
- Testing
- Negative pressure wound therapy delivered through VAC, Standard of care
- Where
- Mauritius
- Volunteers
- 80 people
- Sponsor
- University of Mauritius