Clinical trials: Foot Injuries, open to volunteers
Diabetic Foot Ulcer
Treating Diabetic Foot Ulcers, Comparing Two Topical Antimicrobial Agents, Dakin´s and Prontosan
202 Diabetic foot ulcers will be cleaned with either Hypochlorous Acid, HClO or Polyhexamethylene biguanide, PHMB twice a week until healed or 24 weeks.
- Trial name
- NCT05132179
- Testing
- Dakins Full Strength Solution, 0.5% Topical Solution, HOCl solution
- Where
- Sweden
- Volunteers
- 202 people
- Sponsor
- Vastra Gotaland Region
Diabetic Foot Ulcers (DFUs), Diabetic Foot
Miro3D Wound Matrix for Treatment of Diabetic Foot Ulcers
This study is designed to evaluate whether the Miro3D Wound Matrix, when used in addition to standard of care, improves healing outcomes in patients with chronic diabetic foot ulcers.
- Conditions
- Diabetic Foot Ulcers (DFUs), Diabetic Foot, Chronic Wounds
- Trial name
- FOCUS 3D (NCT07632001)
- Testing
- Miro3D Wound Matrix, Standard of Care
- Where
- 14 sites in United States
- Volunteers
- 180 people
- Sponsor
- Reprise Biomedical, Inc.
Chronic Wounds, Venous Leg Ulcers (VLUs)
Efficacy of Carbonlife Amniotic Tissue Product in the Treatment of Chronic Wounds
Chronic wounds constitute a significant global health burden, affecting millions of individuals and contributing to increased morbidity, diminished quality of life, and rising healthcare costs.
- Conditions
- Chronic Wounds, Venous Leg Ulcers (VLUs), Diabetic Foot Ulcers (DFUs), Arterial Ulcers
- Trial name
- NCT07223892
- Testing
- Amniotic Tissue Allograft
- Volunteers
- 600 people
- Sponsor
- Bardia Anvar
Diabetic Foot Ulcers (DFUs)
PREPUP: A Randomized Trial of Bonvadis® Versus Collagenase Ointment in Diabetic Foot Ulcers
This study is designed to evaluate topical wound products for DFUs using a hybrid design that combines prospectively randomized treatment arms with external control cohorts.
- Trial name
- NCT07779239
- Testing
- Bonvadis® (NWBOT), Clostridial Collagenase Ointment
- Where
- 10 sites in United States
- Volunteers
- 100 people
- Sponsor
- Oneness Biotech Co., Ltd.
Lower Limb Injury, Ankle Foot Orthosis (AFO)
IM ABLE 2: Injuries Managed With Advanced Bracing for Lower Extremities
The purpose of the study is to test different categories of ankle foot orthoses (AFOs) with patients who have had lower limb salvage, reconstruction or other problems impacting limb function.
- Conditions
- Lower Limb Injury, Ankle Foot Orthosis (AFO), Lower Limb Trauma
- Trial name
- IM ABLE 2 (NCT07721792)
- Testing
- Advanced Ankle Foot Orthosis (AFO), Conventional Ankle Foot Orthosis (AFO)
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- University of South Florida
Neuropathic Foot Ulcer
Efficacy of Photobiomodulation on Wound Healing and Il-6 in Neuropathic Foot Ulcer
The aim of this study is to detect the effect of Laser Photobiomodualation on the wound healing and Il-6 in neuropathic foot ulcer.
- Trial name
- NCT06703762
- Testing
- He-Ne low level laser (LLL), Conventional traditional treatment
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Cairo University
Diabetic Foot Infections, Chronic Venous Insufficiency
Clinical Study in Adult Patients With Purulent-inflammatory Processes of the Skin and Soft Tissues, Phase I-II of the Wound Process
The purpose of this study is to estimate efficiency, tolerance, safety of "Foscelantan, medicinal plate 4.0x5.0 cm in package No.
- Trial name
- OLENKRON-01 (NCT06232421)
- Testing
- Foscelantan, Povidon-iodine
- Where
- 2 sites in Belarus
- Volunteers
- 224 people
- Sponsor
- Research Institute for Physical Chemical Problems of the Belarusian State University
Diabetic Foot Ulcer, Venous Leg Ulcer
Cold atmOspheric plaSMa Therapy Versus standArd Wound Care in Diabetic Foot and Venous Leg ulcerS
Chronic wounds such as diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs) pose a major health burden to the patients but also to the healthcare system because of their distorted healing capacity.
- Trial name
- COSMAS (NCT07251426)
- Testing
- COLD ATMOSPHERIC PLASMA
- Volunteers
- 494 people
- Sponsor
- Olaf Bakker
Chronic Wounds, Biofilm Infection
Diabetic Foot Ulcer (DFU) Biofilm Infection and Recurrence
This work is based on DFU patients, seeks to conduct a fully powered clinical study testing i) If DFU with a history of biofilm infection closes with deficient barrier function.
- Conditions
- Chronic Wounds, Biofilm Infection, Trans-epidermal Water Loss (TEWL), Diabetic Foot
- Trial name
- DFUBiofilm (NCT05172089)
- Where
- 2 sites in United States
- Volunteers
- 405 people
- Sponsor
- University of Pittsburgh
Diabetic Foot Ulcer (DFU)
A Study Comparing an Investigational Wound Gel With Standard Treatment for Mild to Moderate Diabetic Foot Ulcers
The goal of this clinical investigation is to evaluate if VES-0-D (an investigational wound gel) works to treat mild to moderate Diabetic Foot Ulcers.
- Trial name
- AIM-DFU (NCT07783087)
- Testing
- VES-0-D wound gel, Standard of Care (Investigator Choice)
- Where
- 8 sites in Belgium
- Volunteers
- 64 people
- Sponsor
- Flen Health
Diabetic Foot Ulcer, Wagner Grade 1 - 2
Evaluation of ELU42 Topical Spray for the Treatment of Diabetic Foot Ulcers
ELU42 01 01 (SuperHealer42) is a Phase I/IIA open label study sponsored by Eluciderm, Inc. that evaluates the safety and preliminary effectiveness of ELU42, a topical small molecule designed to modulate Wnt signaling, for the…
- Conditions
- Diabetic Foot Ulcer, Wagner Grade 1 - 2, Chronic Wound, Open Wound
- Trial name
- NCT07396376
- Testing
- ELU42 Topical Spray
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- Eluciderm Inc
Diabetic Foot Ulcer, Venous Leg Ulcer
Post-Marketing Surveillance of Dehydrated Human Amnion/Chorion Membrane (DHACM) in Non-Ischemic Chronic Wounds
The purpose of this survey is to observe the efficacy and safety of EPIFIX® dehydrated human amnion/chorion membrane (DHACM) for the treatment of intractable diabetic foot ulcers or venous leg ulcers.
- Trial name
- NCT06236750
- Testing
- EPIFIX
- Where
- 5 sites in Japan
- Volunteers
- 75 people
- Sponsor
- MiMedx Group, Inc.
Diabetic Foot Ulcer, Venous Leg Ulcer
Real World Evidence with the Debritom+ TM Novel Micro Water Jet Technology At a Single Wound Center
Prospective, single-blinded, single-center, parallel group, randomized controlled trial (RCT) to assess rate and frequency of wound healing and associated financial savings, when using Medaxis debritom+ versus standard of care as…
- Conditions
- Diabetic Foot Ulcer, Venous Leg Ulcer, Surgical Wound Dehiscence, Traumatic Wounds
- Trial name
- EVIDENT (NCT04920253)
- Testing
- Study Device Debridement, SOC Debridement
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Medaxis, LLC
Femur Fracture, Tibia Fracture
Outpatient Floor Pedal Bike Utilization
The goals of this clinical trial are: to test the feasibility of identifying patients and getting patients the floor pedal bikes, to test how well floor pedal bikes help patients with lower body injuries heal, and to test methods…
- Conditions
- Femur Fracture, Tibia Fracture, Ankle Injuries
- Trial name
- NCT06586190
- Testing
- Floor Pedal Bike with Guided Instructions for Home
- Volunteers
- 20 people
- Sponsor
- Wake Forest University Health Sciences
Diabetic Foot Ulcer (DFU), Diabetic Symmetrical Polyneuropathy
Comparative Study of Combination Treatment of Bionerv E+ Versus Vitamin B Complex in Treatment of Diabetic Polyneuropathy in Type 2 Diabetic Patients and Its Effect on Wound Healing
Diabetic symmetrical polyneuropathy (DSPN) is a common complication of diabetes that affects the nerves, especially in the legs and feet. It can cause pain, numbness, tingling, weakness, and loss of sensation.
- Trial name
- NCT07877948
- Testing
- Alpha-Lipoic Acid, Vitamin B1, Vitamin B6, Vitamin B12, Vitamin E, Vitamin B1, Vitamin B6, Vitamin B12
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- BREGO Life Sciences
Foot Ulcer
Photoacoustic Imaging of Foot Wound
This pilot device trial aims to test the feasibility of using photoacoustic images to monitor tissue perfusion and to guide post-surgical wound treatment.
- Trial name
- NCT07216599
- Testing
- Photoacoustic imaging and multispectral imaging
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- State University of New York at Buffalo
Foot Ankle Injuries
Is 6 Weeks Immobilization for a Chopart Injury Still State of the Art? Comparison Between Cast Immobilization Versus Functional Treatment
Treatment Arms for Randomization 1. Restrictive treatment: Immobilization in a cast or VACOped boot (lower leg boot with ankle immobilzation) for 6 weeks. Advantage: Provides stable conditions for fracture healing.
- Trial name
- NCT07477327
- Testing
- 6 weeks cast immobilization, Rigide sole
- Volunteers
- 70 people
- Sponsor
- Hôpital Fribourgeois
Diabetic Foot Ulcer
Diabetic Foot Ulcers: Shorter Treatment Period Using Custom Felt Relief?
The Surgical Outpatient Clinic at Molde Hospital has since 2015 offered specialized treatment for patients with diabetic foot ulcers. This treatment is given by an interdisciplinary diabetic foot ulcer team.
- Trial name
- NCT04058639
- Testing
- "custom felt relief", standard relief treatment
- Where
- Norway
- Volunteers
- 74 people
- Sponsor
- Helse Møre og Romsdal HF
Patellar Tendinopathy, Achilles Tendinopathy (AT)
Evaluation of Platelet-Rich Plasma (PRP) Treatment in Tendinopathies
This multicenter, prospective, observational study, based on real-world evidence (RWE), aims to evaluate the efficacy and safety of Platelet-Rich Plasma (PRP) treatment across four types of tendinopathies: patellar, Achilles…
- Conditions
- Patellar Tendinopathy, Achilles Tendinopathy (AT), Epicondylitis, Lateral, Plantar Fasciitis, Chronic
- Trial name
- RWE-TDP-PRP (NCT07558564)
- Testing
- Platelet rich plasma (PRP)
- Where
- 5 sites in Spain
- Volunteers
- 2,000 people
- Sponsor
- ReSport Clinic
Chronic Wound of the Lower Limb (Leg Ulcer or Foot Ulcer), Chronic Wound Care
Clinical Performance of ComBatic™ Antimicrobial Wound Care Products in Hard-to-Heal Wounds
The goal of this clinical trial is To assess the feasibility of delivering the study protocol in adults with chronic, hard-to-heal lower leg wounds.
- Trial name
- COMBAT-H (NCT07872930)
- Testing
- Irrigation Solution for wounds, Hydrogel for wound care
- Volunteers
- 96 people
- Sponsor
- University of Calgary