Clinical trials: Foot Pathology
Metatarsalgia
Randomized Controlled Trial of Custom Foot Orthoses for Chronic Forefoot Pain
Background Chronic metatarsalgia (CM) causes significant pain and disability, affecting quality of life. Foot orthoses (FOs) including medially wedged designs with a metatarsal pad decrease excessive plantar pressure under the…
- Trial name
- NCT06962475
- Testing
- Podiatric advice, Customized foot orthoses
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Université du Québec à Trois-Rivières
Diabetic Polyneuropathy
Combined Effects of Foot-Ankle Therapeutic Exercises and Mindful Walking in Patients With Diabetic Polyneuropathy
The aim of this study is to investigate the combined effects of foot ankle therapeutic exercises and mindful walking on pain, foot and ankle disability, and quality of life in patients with diabetic polyneuropathy.
- Trial name
- NCT07248631
- Testing
- Foot-Ankle therapeutic exercises and Mindful Walking., Standard care with Mindful walking.
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Pressure Ulcers, Venous Ulcers
Use of Fish Skin Extracellular Matrix (ECM) to Facilitate Chronic Wound Healing
The clinical study is designed to assess the effectiveness, safety and non-immunogenicity of fish skin wound dressing extracellular matrix (ECM) in treating chronic wounds.
- Conditions
- Pressure Ulcers, Venous Ulcers, Diabetic Ulcers, Chronic Ulcer of Foot
- Trial name
- NCT01348581
- Testing
- Marigen Wound Dressing
- Where
- Iceland
- Volunteers
- 37 people
- Sponsor
- Kerecis Ltd.
Morton Neuroma, Radriofrequency
Radiofrequency Before to Surgical Removal of a Recalcitrant Morton´s Neuroma
The purpose of this study is to perform a radiofrequency procedure prior to the removal of morton's neuroma. This procedure would be performed to check in which percentage of the nerve ablation has been performed, and whether the…
- Trial name
- REQUIEM (NCT05550831)
- Testing
- Radiofrequency
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- Universidad de Extremadura
Peripheral Vascular Disease, Ischemia
A Clinical Study Using Adipose-derived Stem Cells for Diabetic Foot
Stem cell therapy has been a new and effective therapy in recent years for diabetic foot.This study intends to establish an optimal clinical research program, and attempts to break the technical bottleneck in the stem cell…
- Conditions
- Peripheral Vascular Disease, Ischemia, Diabetic Foot
- Trial name
- NCT02831075
- Testing
- Adipose-derived stem cell, saline
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Jie Shen
Painful Intermetatarsal Neuroma (Morton's Neuroma)
A Study to Evaluate the Efficacy and Safety of CNTX-4975 in Subjects With Painful Intermetatarsal Neuroma (Morton's Neuroma)
Study 4975-MN-202 is a double-blind, placebo-controlled, parallel group, single-injection study in which subjects will be randomized to receive three doses of CNTX-4975 or placebo injected into the intermetatarsal space around a…
- Trial name
- NCT02283957
- Testing
- CNTX-4975
- Where
- 16 sites in United States
- Volunteers
- 119 people
- Sponsor
- Centrexion Therapeutics
Xerosis Cutis, Neuropathic Pain Associated With Diabetic Peripheral Neuropathy
Effectiveness of CBD for Neuropathic Pain in Diabetic Foot Neuropathy
Evaluation of cannabidiol and urea 10%.
- Trial name
- NCT07162454
- Testing
- Group 1. Complete formula, Group 2. Cannabidiol and Urea 10% formula.
- Where
- Spain
- Volunteers
- 23 people
- Sponsor
- Universidad Complutense de Madrid
Bunions, Postoperative Pain
Dose-Escalation Study of HTX-034 Following Bunionectomy
This was a Phase 1b/2, randomized, blinded, active-controlled study. Phase 1b evaluated escalating doses of HTX-034 compared with bupivacaine HCl.
- Trial name
- NCT04398329
- Testing
- HTX-034 low dose, HTX-034 high dose, Luer lock applicator
- Where
- 4 sites in United States
- Volunteers
- 78 people
- Sponsor
- Heron Therapeutics
Plantar Fasciitis
Efficacy of Manual Therapy in Plantar Fasciitis
Plantar fasciitis is characterized by localized pain at the insertion site of the plantar fascia on the calcaneus. The pain worsens in the morning with the first step of the foot, after resting or at the beginning of a workout…
- Trial name
- MTPlantarF (NCT04758572)
- Testing
- Manual Therapy, Massage muscle chain
- Where
- 2 sites in Spain
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Diabetes Mellitus
Pain and Comfort in Diabetic Foot Ulcer Care
The purpose of this study is to reveal the effect of cold application of 0.9% NaCl solution used during diabetic foot ulcer (DFU) care on the pain and comfort levels of patients.
- Trial name
- NCT06644235
- Testing
- Cold Application
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Mardin Artuklu University
Hallux Valgus, Bunionectomy
Sciatic Nerve Block With ALX006 in Subjects Undergoing Bunionectomy
This is a Phase 2, randomized, double-blind, active-controlled, dose-escalation study evaluating the safety, pharmacokinetics, efficacy, and pharmacodynamics of ALX006, an extended-release bupivacaine formulation, administered as…
- Trial name
- NCT07574385
- Testing
- ALX006 (bupivacaine extended-release injection), Bupivacaine Hcl 0.25% Inj, Sciatic Nerve Block
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Rebel Medicine Inc
Strain of Muscle and/or Tendon of Lower Leg, Fracture of Lower Leg
Onset Time of Nerve Block: A Comparison of Two Injection Locations in Patients Having Lower Leg/ Foot Surgery
The purpose of this study is to compare injecting local anesthetic (numbing medication) in different patterns around a major nerve in the leg.
- Conditions
- Strain of Muscle and/or Tendon of Lower Leg, Fracture of Lower Leg, Crushing Injury of Lower Leg, Fracture Malunion - Ankle and/or Foot
- Trial name
- NCT01542840
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Metatarsalgia
Physiotherapy for Chronic Metatarsalgia
The pilot study was conducted in the form of an open prospective single-arm observational study with 28 patients who received physiotherapy at the Spiraldynamik® Med Center in Zurich.
- Trial name
- NCT02578615
- Testing
- physiotherapy
- Volunteers
- 28 people
- Sponsor
- Spiraldynamik AG
Chronic Obstructive Pulmonary Disease
The Effects on Sleep qualıty and fatıgue Level of Foot Bath
Aims and objectives: To determine the effect of foot bath on sleep quality and fatigue level in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT05668247
- Testing
- FOOT BATH
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Sevil Şahin
Diabetes, Ulceration
Shear and Pressure Reducing Insoles for the Diabetic Foot
We evaluated the feasibility of the GlideSoft™ novel insole to reduce pressure and shear forces on the foot. No commercially available insoles are designed to reduce shear.
- Conditions
- Diabetes, Ulceration, Amputation, Foot Deformity
- Trial name
- GlideSoft (NCT00499356)
- Testing
- pressure reducing insole, GlideSoft®
- Where
- United States
- Volunteers
- 299 people
- Sponsor
- Diabetica Solutions Inc.
Low Back Pain
Lumbopelvic Stabilization Versus Pilates Exercises On Gait Phases And Peak Pressure On Foot In Low Back Pain
the purpose of this trial is to investigate and compare between lumbopelvic stabilization and pilates exercises on gait cycle phases and maximum peak pressure on the foot in chronic nonspecific low back pain?
- Trial name
- LBP (NCT04942782)
- Testing
- lumbopelvic stabilization exercises, pilates exercise, conventional therapy
- Volunteers
- 100 people
- Sponsor
- Cairo University
Wound Heal, Ulcer
IDEAL: Efficacy of Porcine Placental Extracellular Matrix Augmented Plus Standard of Care (SOC) Versus SOC Alone for the Management of Diabetic Foot Ulcers
A multi-center, prospective, observer-blinded, randomized controlled clinical trial to evaluate the efficacy of PPECM augmented standard of care versus standard of care alone in the management of hard-to-heal diabetic foot ulcers.
- Trial name
- IDEAL (NCT06616844)
- Testing
- InnovaMatrix® AC
- Where
- 21 sites in United States
- Volunteers
- 235 people
- Sponsor
- ConvaTec Inc.
Tinea Pedis, Tinea Cruris
Pharmacokinetic Study of Pediatric Subjects With Tinea Cruris and Tinea Pedis
This study is being done to see how the body is affected when a study drug is applied to both feet if the subject has athlete's foot or to both feet and the groin area if the subject has both athlete's foot and jock itch.
- Trial name
- NCT01712360
- Testing
- NAFT500 (pediatric), NAFT600 (pediatric), NAFT500 (adult)
- Where
- 4 sites in United States, Dominican Republic and 1 more
- Volunteers
- 56 people
- Sponsor
- Merz North America, Inc.
Diabetic Foot Ulcer
The Effect of Breathing Exercise and Pressurized Cold Application on Pain and Anxiety During Sharp Debridement
In our planned study, it is envisaged that patients who receive breathing exercises and pressurized cold application will experience a decrease in the level of pain they feel during the debridement process, a decrease in their…
- Trial name
- NCT06886633
- Testing
- Breathing exercise, Experimental: Pressurized Cold Application Group
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Harran University
Foot Pain
Orthofeet: A Prospective Proof of Concept Trial to Evaluate an Innovative Pain Relief Footwear
The purpose of this prospective randomized crossover study is to evaluate the effectiveness of a new pain relief footwear, Orthofeet, in reducing foot pain and improving daily physical activity.
- Trial name
- NCT05434078
- Testing
- Orthofeet Shoes
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bijan Najafi, PhD