Clinical trials: Fracture Healing
Fractures, Bone
855303-RNA Biomarker Validation
The purpose of this study is to test the accuracy of using RNA in blood as a way to forecast new fracture healing outcome.
- Trial name
- 855303-RNAVal (NCT06872775)
- Testing
- Blood draws to assess RNA expression levels
- Where
- 7 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of Pennsylvania
Fractures
The Effect of NSAID Use in the Acute Phase of Skeletally Immature Bone Healing: A Prospective Study
Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, are excellent medications for providing pain control in children with fractures or those who have surgery to correct bony deformity requiring the bone to be cut…
- Trial name
- NCT02076321
- Testing
- Acetaminophen, Ibuprofen
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Missouri-Columbia
Fracture Healing, Treatment Duration
Smart Crutch Tips for Guided Weight-Bearing in Patients Recovering From Extra-Articular Distal Tibia Fractures
The goal of this clinical trial is to learn whether personalized weight-bearing prescriptions using Smart Crutch Tips™ can improve recovery after surgery for extra-articular distal tibia fractures.
- Conditions
- Fracture Healing, Treatment Duration, Distal Tibia Fracture
- Trial name
- NCT07138066
- Testing
- Smart Crutch Tips™, Finite Element Analysis (FEA), Iterative walking
- Where
- 18 sites in Ukraine
- Volunteers
- 30 people
- Sponsor
- Comeback Mobility Inc
Bone Fracture
Fracture Healing Assessed by HR-pQCT After Administration of Calcium and Vitamin D
This study is designed as a single-blind RCT in 80 postmenopausal women to compare the effect of immediate administration of daily calcium supplementation (1000 mg calcium) or two daily dosages of calcium + vitamin D (1000 mg…
- Trial name
- NCT02889237
- Testing
- Calcium, Calcium + low dose vitamin D, Calcium + high dose vitamin D
- Where
- Netherlands
- Volunteers
- 52 people
- Sponsor
- VieCuri Medical Centre
Anterior Mandibular Fracture
Comparing Bone Healing in Jaw Fractures Fixed With Herbert Screws Versus 3D Miniplates
the goal of this clinical trial is to compare two methods of fixing fractures in the front part of the jaw (mandible): second-generation Herbert screws and 3-dimensional miniplates.
- Trial name
- herbert screw (NCT07826416)
- Testing
- headless compression screw, 3D mini plates
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Orthopaedic Trauma Infections
BBOT: Bacterial Burden in Ortho Trauma Procedures
The purpose of this research project is to improve understanding of the potential role of highly sensitive bacterial tests in diagnosing infected non-healing fractures compared to the current standard of care, microbiologic…
- Trial name
- NCT03126448
- Testing
- Highly Sensitive Assays
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Hip Fracture
A Proof-of-Concept Study Investigating the Safety and Efficacy of ZT-031 on Hip Fracture Healing in Men and Postmenopausal Women
The purpose of this research study is to test if an experimental drug called ZT-031 can help men over 30 years or post-menopausal women over 55 years of age with certain types of hip fracture to heal better or faster following…
- Trial name
- SHIFT (NCT00787358)
- Testing
- ZT-031
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Zelos Therapeutics
Surgery
Inion OTPS Biodegradable Fixation System for the Ankle
The purpose of the investigation is to compare post-operative fracture and wound healing using Inion OTPS Biodegradable Fixation System implants versus Conventional metal implants.
- Trial name
- NCT00300989
- Testing
- Inion OTPS Biodegradable Fixation System
- Where
- Finland
- Volunteers
- 43 people
- Sponsor
- Inion Oy
Fragility Fracture, Femur; Fracture, Pertrochanteric
Role of Strontium Ranelate in Proximal Femur Fragility Fractures.
This study is being conducted with the aim of comparing the time to bone healing after surgery for fragility fractures of proximal femur between patients receiving strontium ranelate and placebo.
- Conditions
- Fragility Fracture, Femur; Fracture, Pertrochanteric, Clinical Trial
- Trial name
- STRONG (NCT05712616)
- Testing
- Strontium Ranelate, Lacto-N-Hexaose
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Aga Khan University Hospital, Pakistan
Tibial Fractures
Multiregion BHA in Open Tibia Fractures
This clinical study is being conducted to demonstrate the safety and effectiveness of the Bone Healing Accelerant (BHA) product when applied to tibia (leg bone) fractures with an external wound or skin break (also called open…
- Trial name
- NCT04056429
- Testing
- BHA
- Sponsor
- Carmell Therapeutics Corporation
Tibial Fractures, Lower Extremity Fracture
Blood Flow Restriction Training in Patients With Lower Extremity Fractures
This study will look at the effect of using a blood flow restriction device during low load strengthening exercises on patients with tibial shaft fractures, compared to patients performing exercise without the device.
- Trial name
- NCT06496035
- Testing
- Blood Flow Restriction with low load exercise, Therapeutic Exercise
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Fracture Humerus of Shaft
Scandinavian Humeral Diaphyseal Fracture Trial
This pragmatic multicenter randomized controlled trial (RCT) includes adult participants with an acute humeral shaft fracture to compare surgical fixation of humeral shaft fracture to non-surgical treatment with early…
- Trial name
- SHAFT (NCT04574336)
- Testing
- Surgical treatment, Non-surgical treatment
- Where
- 22 sites in Denmark, Finland and 2 more
- Volunteers
- 287 people
- Sponsor
- Kolding Sygehus
Fractures, Bone
Biomechanical Analysis of Distal Radius (Greenstick) Fracture Healing
The study will be conducted to investigate the effects of electrical charges (flexoelectric effect) \& mechanical brachioradialis muscle bending force on the displacement and strain of fracture gap on children with Distal radius…
- Trial name
- NCT06510595
- Testing
- Active Treatment Arm, Control Treatment Arm
- Volunteers
- 2 people
- Sponsor
- Cairo University
Microcirculation, Wound Healing
Hyperbaric Oxygen Therapy in Calcaneal Intraarticular Fractures: Can it Decrease the Soft-tissue Complication Rate?
This study aims to test the hypothesis that postoperative daily hyperbaric oxygen therapy (HBOT) decreases soft-tissue complication rate during the operative handling of intra-articular calcaneal fractures. Minor motivations: 1.
- Trial name
- HOCIF (NCT01264146)
- Testing
- HBOT
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Fracture, Closed, Comminuted, Healing
Effect of Low-Magnitude, High Frequency Vibration Treatment on Femoral Shaft Fracture Healing
Diaphyseal long bone fractures are usually associated with high energy trauma in which femoral shaft fracture is one common fracture in young age group.
- Trial name
- NCT01386749
- Testing
- vibration platform provide low magnitude and high frequency vibration treatment, which is self-developed by our research team
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Healing of Fracture
Mesenchymal Stem Cells; Donor and Role in Management and Reconstruction of Nonunion Fracture
The investigators hypothesized that mesenchymal stem cells can be isolated from fracture site, iliac crest, and tibial crest, and can be expanded to be used in the management of nonunion fracture.
- Trial name
- NCT01626625
- Testing
- stem cells + hydroxy apatite, autograft taken from iliac crest
- Where
- Indonesia
- Volunteers
- 10 people
- Sponsor
- Universitas Indonesia
Osteoporotic Fractures
PTH(1-34) and Pelvic Fracture Healing - a Randomized Controlled Trial
In the proposed trial the investigators will recruit women and men >65 years of age with acute osteoporosis-related pelvic fractures and address 3 specific aims over 3 months of treatment in a placebo controlled double blind…
- Trial name
- NCT02972424
- Testing
- Teriparatide Prefilled Syringe
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Hospital for Special Surgery, New York
Ankle Fractures
Factors Influencing the Risk of Surgical Site Infections and Wound Complications in Operatively Treated Ankle Fractures in the Elderly
This study is to analyse risk factors for wound complications or surgical site infections and to analyse whether risk factors for wound complications or surgical site infections are also factors for other complications.
- Trial name
- NCT04379791
- Testing
- Data collection from routine medical records
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Distal Femur Fracture
Far Cortical Locking Versus Standard Constructs for Distal Femur Fractures
To determine if Far Cortical Locking screws increase fracture healing rates at 3 months in Closed Distal Femur Fractures in adults when compared to Standard screw constructs.
- Trial name
- FCL (NCT01766648)
- Testing
- Far Cortical locking screw fixation, Standard screw fixation
- Where
- Canada
- Volunteers
- 167 people
- Sponsor
- University of British Columbia
To Assess the Bone Healing in Fracture Mandible Defects
COMPARATIVE ANALYSIS OF INNOVATIVE BONE HEALING TECHNIQUES
the study intends to observe the outcome of interventions (concentrated growth factor with autograft and xenograft) used to expedite bone healing and adaptation with minimal side effects.
- Trial name
- NCT05480631
- Testing
- autograft, autograft with addition of concenterated growth factor, xenograft with concentrated growth factor
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences