Clinical trials: Fracture Non Union
Tibia Fracture Non Union Bone
Study to Analyze the Effects of EBI OsteoGen™ on the Surgical Reconstruction of Tibia Non-unions
The purpose of this clinical outcomes collection study is to analyze the effect of the EBI OsteoGen™ Direct Current Stimulator upon surgical reconstruction of tibia nonunion (no visible progressive signs of healing) fracture in a…
- Trial name
- NCT00726193
- Testing
- OsteoGen
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Zimmer Biomet
Congenital Pseudarthrosis of Tibia
NVD-003 in the Treatment of Congenital Pseudarthrosis of the Tibia
A single arm, multi-country, multi-center study in pediatric patients, suffering from congenital pseudarthrosis of the tibia (CPT), treated during the primary surgical intervention with NVD-003, an autologous 3D scaffold free…
- Trial name
- NCT05693558
- Testing
- NVD-003, an autologous 3D scaffold free osteogenic graft
- Where
- 2 sites in United States, Belgium
- Volunteers
- 4 people
- Sponsor
- Novadip Biosciences
Femur Fracture, Tibial Fractures
Distal Targeter vs Free-hand
This study is a randomized controlled trial comparing the use of two different surgical techniques--free-hand versus distal targeting jig-based for distal interlock screw--placement and their effects on total operative time and…
- Conditions
- Femur Fracture, Tibial Fractures, Nonunion of Fracture, Nonunion of Fracture of Tibia
- Trial name
- NCT05613257
- Testing
- Distal targeting jig, Free-hand/perfect circles technique
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Cedars-Sinai Medical Center
Nonunion Fracture, Delayed Bone Healing
Using the Boneflo System During Orthopedic and Trauma Surgery: A Prospective Multicenter Study
Critical bone defects, non-unions, and delayed bone healing remain major challenges in orthopedic and trauma surgery and often require bone grafting.
- Conditions
- Nonunion Fracture, Delayed Bone Healing, Critical Bone Defects
- Trial name
- BoneFlo (NCT07562165)
- Testing
- Intraoperative bioactivation of bone substitute materials using the Boneflo® Tissue Collector System.
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Universität Duisburg-Essen
Fractures, Bone, Nonunion of Fracture
Safety, Efficacy, & Use of ViviGen Cellular Bone Matrix Allograft in Orthopaedic Fracture Care
Prospective registry and retrospective data collection study to assess the efficacy and safety of Vivigen Cellular Bone Matrix (Vivigen) in orthopaedic trauma patients who require bone grafting in the acute, delayed, non-union…
- Conditions
- Fractures, Bone, Nonunion of Fracture, Fractures, Open, Fractures, Ununited
- Trial name
- NCT04299022
- Testing
- Vivigen Cellular Bone Matrix
- Where
- 4 sites in United States
- Volunteers
- 250 people
- Sponsor
- LifeNet Health
Fracture, Ununited, Pseudarthrosis
Feasibility Study of Aastrom Tissue Repair Cells to Treat Non-Union Fractures.
The purpose of this multi-center study is to obtain clinical data to substantiate that Aastrom TRC autologous bone marrow cells will regenerate bone in patients with established (appendicular skeletal) non union fractures, when…
- Trial name
- NCT00424567
- Testing
- Fracture surgery, Cultured Bone Marrow Tissue
- Where
- 4 sites in United States
- Volunteers
- 36 people
- Sponsor
- Vericel Corporation
Fracture Nonunion, Infection
Smoking Cessation in Nonunion, Malunion, Osseous Infection
The Study Investigators have seen high rates of tobacco cessation success combining Chantix with the risk of no surgery, should tobacco use continue.
- Trial name
- nicotine (NCT00754299)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Fracture Non Union, Fracture Healing
Prospective Validation Study of the CD8+TEMRA Cells As a Prognostic Biomarker of Healing Outcome After Fracture
In approx. 10-15% of all fracture patients, there is a prolonged healing time or even a complete absence of fracture healing (non-union).
- Conditions
- Fracture Non Union, Fracture Healing, Long Bone Delayed-Union Fracture, Humerus Shaft Fracture
- Trial name
- BioBone (NCT06658379)
- Testing
- CD8+TEMRA
- Where
- 7 sites in Germany
- Volunteers
- 640 people
- Sponsor
- Charite University, Berlin, Germany
Pseudoarthrosis of Bone, Pseudarthrosis
Treatment of Nonunion Fractures With Mesenchymal Stromal Cells (MSCs)
The goal of this study is to evaluate the bone regeneration capacity of BM-MSC (Bone marrow mesenchymal stromal cells), in patients with nonunion.
- Conditions
- Pseudoarthrosis of Bone, Pseudarthrosis, Non Union Fracture, Nonunion Bone Fracture
- Trial name
- MSC (NCT06103396)
- Testing
- Transplantation of autologous MSCs in nonunion fracture, Transplantation of allogeneic MSCs in nonunion fracture
- Where
- Venezuela
- Volunteers
- 30 people
- Sponsor
- Instituto Venezolano de Investigaciones Cientificas
Bone Metastases, Fracture Nonunion
Ankle Arthrodesis Nail for 2-level Pathologic Tibial Fracture
Tibial pseudarthrosis in 83 year old patient suffering from pathologic fractures
- Conditions
- Bone Metastases, Fracture Nonunion, Bone Lesion
- Trial name
- NCT04940754
- Testing
- osteosynthesis
- Where
- Switzerland
- Volunteers
- 1 people
- Sponsor
- Orthopaedie Zentrum Zuerich
Osteoarthritis, Hip, Rheumatoid Arthritis
G7 Freedom Constrained Vivacit-E Liners
The main objectives of this study are to confirm the long-term safety, performance, and clinical benefits of the G7 Freedom Constrained Vivacit-E Acetabular Liners in primary and revision total hip arthroplasty.
- Conditions
- Osteoarthritis, Hip, Rheumatoid Arthritis, Non-Union Fracture, Trochanteric Fractures
- Trial name
- NCT05587244
- Testing
- Total Hip Arthroplasty with G7 Freedom Constrained Vivacit-E Liners
- Where
- 10 sites in United States
- Volunteers
- 202 people
- Sponsor
- Zimmer Biomet
Mitigation of Fracture Non-union in Patients at Risk
Observational, Non-interventional Use of LIPUS to Mitigate Fracture Non-union in Patients at Risk
This study is one of three separate studies of the Bioventus Observational Non-interventional EXOGEN Studies (BONES) program. Eligibility for each study is determined by fractured bone.
- Trial name
- BONES (NCT03382483)
- Testing
- Low intensity pulsed ultrasound
- Where
- United States
- Volunteers
- 12,387 people
- Sponsor
- Bioventus LLC
Pseudarthrosis
rhBMP-2 vs Autologous Bone Grafting for the Treatment of Non-union of the Docking Site in Tibial Bone Transport
When there is a bone defect, bone transport is used to bridge the defect. Frequently, the bone in the docking site (where the transported bone comes together) doesn't heal.
- Trial name
- NCT01756144
- Testing
- rhBMP-2
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Wound Infection, Fractures, Open
Tobramycin Injection to Prevent Infection in Open Fractures
The goal of open extremity fracture (OEF) treatment is to promote fracture healing and restore function while preventing the development of infection.
- Conditions
- Wound Infection, Fractures, Open, Surgical Site Infection
- Trial name
- NCT04964947
- Testing
- Tobramycin Injection
- Where
- 3 sites in United States
- Volunteers
- 600 people
- Sponsor
- Massachusetts General Hospital
Fracture Non Union
Results of the Staged Surgical Approach for Management of Infected Un-united Femoral Shaft Fractures in Adults
Assessment of the efficacy of the multistage technique in the eradication of infection and achieving the union of traumatic infected femoral un-united shaft fractures in adult patients for one year follow up.
- Trial name
- NCT04681846
- Testing
- Staged approach using antibiotic-cement impregnated PMMA spacer
- Volunteers
- 40 people
- Sponsor
- Assiut University
Tibial Fractures
Pulsed Electromagnetic Field (PEMF) Stimulation for Tibia Fractures
Fractures of the tibial shaft (diaphysis) are some of the most common long bone fractures. They most frequently occur in males less than 40 years of age.
- Trial name
- NCT00127725
- Testing
- Pulsed electromagnetic field stimulation
- Where
- 5 sites in Australia
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Sydney South West Area Health Service
Atrophic Nonunion of Fracture
Mesenchymal Stromal Cells for the Treatment of Non-union Fractures of Long Bones
The present study evaluates the effect of XCEL-MT-OSTEO-ALPHA in non-union fractures (pseudoarthrosis) of long bones in comparison to the standard treatment of autologous iliac crest.
- Trial name
- NCT02230514
- Testing
- XCEL-MT-OSTEO-ALPHA, autologous iliac crest, Surgery
- Where
- Spain
- Volunteers
- 19 people
- Sponsor
- Banc de Sang i Teixits
Clavicle Fracture, Non Union/Malunion
Plating Clavicle Fractures
The anterior-inferior clavicle plate position will have a lower rate of soft tissue irritation that limits activity and/or requires hardware removal compared to superior plate position.
- Trial name
- NCT00871468
- Testing
- superior plate, anterior-inferior plate
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- United States Army Institute of Surgical Research
Forearm Injuries, Radius Fractures
Time to Healing in Displaced Pediatric Diaphyseal Forearm Fractures Treated With Bioabsorbable Compared to Titanium Intramedullary Nails
This study looks at children with forearm fractures that need surgery. The standard treatment uses titanium nails, which usually need to be removed in a second operation later.
- Conditions
- Forearm Injuries, Radius Fractures, Ulna Fractures, Fractures, Bone
- Trial name
- FOREST (NCT07536581)
- Testing
- Bioabsorbable intramedullary nail, Titanium elastic intramedullary nail
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Children's Fractures Interest Group, Denmark
Non Union Fracture, Non-Union of Ankle Joint Without Infection
Comparative Study of Gene-activated Bone Substitute and Autobone in Treatment of Long Bone Nonunions
The study is aimed to compare the effectiveness of "Histograft" bone substitute (gene-activated bone substitute based on octacalcium phosphate and plasmid DNA encoding VEGFA gene) mixed with shredded autobone and pure shredded…
- Trial name
- NCT04705857
- Testing
- "Histograft", a bone substitute based on octacalcium phosphate (OCP) and plasmid DNA encoding VEGFA gene
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Histograft Co., Ltd.