Clinical trials: Fracture Nonunion
Orthopaedic Trauma Infections
BBOT: Bacterial Burden in Ortho Trauma Procedures
The purpose of this research project is to improve understanding of the potential role of highly sensitive bacterial tests in diagnosing infected non-healing fractures compared to the current standard of care, microbiologic…
- Trial name
- NCT03126448
- Testing
- Highly Sensitive Assays
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Bone Fracture
Autologous BM-MSC Transplantation in Combination With Platelet Lysate (PL) for Nonunion Treatment
Nonunion of long bones would occur in almost 10% of fractures and because of its long term and complicated treatment, is known as a therapeutic challenge for both of the surgeons and patients.
- Trial name
- NCT02448849
- Testing
- Percutaneous injection
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Royan Institute
Tibia Fracture
Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures
The proposed study is a two arm, pragmatic, randomized controlled multicenter Phase III noninferiority trial. 1,000 patients with tibia fractures treated with intramedullary (IM) nail will be randomized into two treatment arms.
- Trial name
- NCT05000281
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Major Extremity Trauma Research Consortium
Femoral Shaft Fracture
IMN Diameter to Femoral Canal Diameter and Union
To Detect the Relation Between the Intramedullary Nail Diameter to Canal Ratio and the Incidence of Non-union
- Trial name
- NCT04195334
- Testing
- internal fixation by IMN
- Volunteers
- 100 people
- Sponsor
- Assiut University
Rheumatoid Arthritis, Osteoarthritis
A Two Centre Study to Assess the Stability and Long-term Performance of the C-Stem™ AMT in a Total Primary Hip Replacement
The purpose of this study is to monitor the stability of the C-Stem™ AMT hip within the thigh bone when used in the treatment of patients with hip joint disease requiring a total hip replacement.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Post-traumatic Arthritis, Collagen Disorders
- Trial name
- NCT00872573
- Testing
- C-Stem™ AMT Femoral Component (standard and high off-set variants)
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- DePuy International
Healing of Fracture
Mesenchymal Stem Cells; Donor and Role in Management and Reconstruction of Nonunion Fracture
The investigators hypothesized that mesenchymal stem cells can be isolated from fracture site, iliac crest, and tibial crest, and can be expanded to be used in the management of nonunion fracture.
- Trial name
- NCT01626625
- Testing
- stem cells + hydroxy apatite, autograft taken from iliac crest
- Where
- Indonesia
- Volunteers
- 10 people
- Sponsor
- Universitas Indonesia
Nonunion of Fracture of Scaphoid Bone, Fractures, Ununited
Scaphoid Non-union and Low-intensity Pulsed Ultrasound Trial
This is a prospective, double-blind, multicentered, randomized controlled trial to determine the effectiveness of low-intensity pulsed ultrasound in decreasing the time to union of scaphoid non-unions after operative fixation as…
- Trial name
- SNAPU (NCT02383160)
- Testing
- Bioventus Exogen 4000: Low-intensity pulsed ultrasound
- Where
- 6 sites in Canada
- Volunteers
- 154 people
- Sponsor
- University of Calgary
Nonunion of Fracture of Fifth Metatarsal
A Double-Blind Study on Adjunctive Use of PEMF in the Treatment of 5th Metatarsal Non-Union Fractures
The purpose of this study is to analyze the effect of PEMF in surgical reconstruction of 5th metatarsal non-union fractures.
- Trial name
- NCT00586170
- Testing
- EBI Bone Healing System, Surgery
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Zimmer Biomet
Scaphoid Fracture
Vascularized Bone Grafts for Treatment of Scaphoid Nonunion
To assess the effect of vascularized bone grafting on the functional, clinical and radiological outcomes of the scaphoid nonunion
- Trial name
- NCT05358015
- Testing
- vascularized bone graft for scaphois nonunion
- Volunteers
- 25 people
- Sponsor
- Assiut University
Pseudarthrosis, Clavicle Fracture
Descriptive Single-center Retrospective Study of a Series of Cases of Clavicle Pseudarthrosis: Epidemiology, Surgical Management, and Functional Outcomes
1. Study identification Study title: PSEUDO-CLAV - Single-center retrospective descriptive study of clavicle nonunion (pseudarthrosis): epidemiology, surgical management, and functional outcomes PSEUDO-clav_Notice non oppositi……
- Conditions
- Pseudarthrosis, Clavicle Fracture, Clavicle Fracture, Non Union/Malunion
- Trial name
- PSEUDO-CLAV (NCT07414654)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Brest
Pseudarthrosis, Ununited Fracture
Tuebingen Register of Union Failure After Fractures of the Upper and Lower Extremities
TRUFFLE is a register of clinical patient data of failed bone healing and bone non-union after fracture. All patients suffering from a long bone delayed or non-union after fracture and undergoing revision surgery are registered…
- Trial name
- TRUFFLE (NCT06098157)
- Where
- Germany
- Volunteers
- 850 people
- Sponsor
- Department of Trauma and Reconstructive Surgery at Eberhard Karls University Tuebingen, BG Klinik Tu
Nonunion Fracture
Treatment of Atrophic Nonunion Fractures by Autologous Mesenchymal Stem Cell Percutaneous Grafting
Bone fractures heal most of the time particularly well and without complications. The solidification takes rarely more than two to three months. The wound healing depends greatly on a good blood supply and needs several steps.
- Trial name
- NCT01429012
- Testing
- Mesenchymal Stem Cells, Culture medium without MSC.
- Where
- Belgium
- Sponsor
- University of Liege
Femur Fracture, Tibial Fractures
Distal Targeter vs Free-hand
This study is a randomized controlled trial comparing the use of two different surgical techniques--free-hand versus distal targeting jig-based for distal interlock screw--placement and their effects on total operative time and…
- Conditions
- Femur Fracture, Tibial Fractures, Nonunion of Fracture, Nonunion of Fracture of Tibia
- Trial name
- NCT05613257
- Testing
- Distal targeting jig, Free-hand/perfect circles technique
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Cedars-Sinai Medical Center
Humerus Fractures
Serum-Protein-Based Indices for the Progression of Fracture Healing and Nonunion
To define a serum protein-based diagnostic for the progression and failure of fracture healing, through the identification of a set of serum proteins that appear at early times of biological healing and show a specific…
- Trial name
- UNION (NCT05143476)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Major Extremity Trauma Research Consortium
Tibial Delayed Healing
Tibial Delayed Healing Pivotal Clinical Trial
Evaluate the INFUSE/MASTERGRAFT™ Delayed Healing Device as an alternative/replacement to autograft in the treatment of tibial delayed healing.
- Trial name
- NCT01016067
- Testing
- INFUSE/MASTERGRAFT, Autograft bone
- Where
- 16 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Medtronic Spinal and Biologics
Tibial Fractures, Nonunion of Fracture
Intramedullary Bone Grafting for Open Tibial Shaft Fractures
This study will examine if there is a difference between the time to full union between the control group and the study group. Each group will be composed of patients who have an open fracture in the mid tibia.
- Conditions
- Tibial Fractures, Nonunion of Fracture, Delayed Union of Fracture
- Trial name
- NCT03891888
- Testing
- Intramedullary Bone Graft
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of Louisville
Atrophic Nonunion of Fracture
Mesenchymal Stromal Cells for the Treatment of Non-union Fractures of Long Bones
The present study evaluates the effect of XCEL-MT-OSTEO-ALPHA in non-union fractures (pseudoarthrosis) of long bones in comparison to the standard treatment of autologous iliac crest.
- Trial name
- NCT02230514
- Testing
- XCEL-MT-OSTEO-ALPHA, autologous iliac crest, Surgery
- Where
- Spain
- Volunteers
- 19 people
- Sponsor
- Banc de Sang i Teixits
Fracture Non Union, Fracture Healing
Prospective Validation Study of the CD8+TEMRA Cells As a Prognostic Biomarker of Healing Outcome After Fracture
In approx. 10-15% of all fracture patients, there is a prolonged healing time or even a complete absence of fracture healing (non-union).
- Conditions
- Fracture Non Union, Fracture Healing, Long Bone Delayed-Union Fracture, Humerus Shaft Fracture
- Trial name
- BioBone (NCT06658379)
- Testing
- CD8+TEMRA
- Where
- 7 sites in Germany
- Volunteers
- 640 people
- Sponsor
- Charite University, Berlin, Germany
Femoral Neck Fractures, Avascular Necrosis
Femoral Neck Fracture in Adult and Avascular Necrosis and Nonunion
One of the most serious sequelae of femoral neck fractures (FNFs) is avascular necrosis (AVN) and nonunion, and this translates to a significant morbidity and mortality.
- Trial name
- NCT03666637
- Testing
- dynamic hip screw (DHS) and cannulated screw (CS)
- Where
- Saudi Arabia
- Volunteers
- 69 people
- Sponsor
- Security Forces Hospital
Scaphoid Fracture, Scaphoid Nonunion
Arthroscopic vs. Open Bone Grafting for Scaphoid Delayed/Nonunion
Single site, prospective, observer-blinded randomized controlled trial. Eighty-eight patients aged 18-68 years with scaphoid delayed/non-union, will be randomized, 1:1, to either open iliac crest cancellous graft reconstruction…
- Trial name
- NCT05574582
- Testing
- Graft reconstruction and internal fixation with compression screw
- Where
- Denmark
- Volunteers
- 88 people
- Sponsor
- Herlev and Gentofte Hospital