Clinical trials: Fracture of Lower Limb
Tibial Fractures, Pain
Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures: A Pragmatic, Randomized Controlled Trial
Two arm, pragmatic, randomized controlled multicenter Phase III noninferiority trial evaluating the efficacy of standard pain management without NSAIDs (Group 1) vs.
- Trial name
- NSAID (NCT07006675)
- Testing
- 600 mg Ibuprofen
- Where
- 14 sites in United States, Canada
- Volunteers
- 1,000 people
- Sponsor
- Major Extremity Trauma Research Consortium
Postoperative Cognitive Dysfunction, Orthopedic Procedures
Remimazolam vs. Midazolam for Sedation and Cognitive Outcomes in Orthopedic Surgery
This study aims to compare two medications, Remimazolam and Midazolam, used for sedation during orthopedic surgeries performed under regional anesthesia.
- Conditions
- Postoperative Cognitive Dysfunction, Orthopedic Procedures, Postoperative Pain Management, Hip Fracture
- Trial name
- REMIND-ORTHO (NCT07113483)
- Testing
- Midazolam, REMIMAZOLAM BESYLATE 2.5 Mg in 1 mL INTRAVENOUS INJECTION, POWDER, LYOPHILIZED, for SOLUTION [BYFAVO]
- Where
- Romania
- Volunteers
- 120 people
- Sponsor
- Romanian Society for Enteral and Parenteral Nutrition
Plantar Fasciitis, Flatfoot
Foot and Ankle Range of Motion (Stretching) Apparatus
Range of motion at ankle joint and subtalar joint will be assessed before and after utilization of ARM device. The changes in range of motion will be recorded and compared to literature.
- Conditions
- Plantar Fasciitis, Flatfoot, Calcaneus Fractures
- Trial name
- NCT00527748
- Testing
- Non-Measuring Ankle Exerciser
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Missouri-Columbia
Complication of Anesthesia
Effects of Bupivacaine and Levobupivacaine on Cerebral Oxygenation During Intrathecal Anesthesia in Elderly Patients
Elderly patients with hip fracture are frail due to associated comorbidity. In these situations, regional anesthesia is recommended as it is associated to less postoperative cognitive dysfunction.
- Trial name
- NCT01960543
- Testing
- fentanyl 15 microg, Bupivacaine 7 mg, Bupivacaine 9 mg
- Where
- Spain
- Volunteers
- 58 people
- Sponsor
- Corporacion Parc Tauli
Hip Fractures, Fragility Fracture
Iron Supplementation for Geriatric Hip Fractures
Geriatric hip fracture is an important disease that affects the health life of the elderly in China. Geriatric hip fracture is often complicated by a variety of comorbidities due to advanced age.
- Conditions
- Hip Fractures, Fragility Fracture, Osteoporotic Fractures
- Trial name
- NCT05489952
- Testing
- iron sucrose and ferrous lactate
- Where
- China
- Volunteers
- 444 people
- Sponsor
- He Qifei
Lower Limb Fracture
Effect of Early Versus Delayed Postoperative Feeding in Lower Limb Fracture Surgery
The treatment of lower limb fracture accounting one third of total fracture is a complex problem for the surgical and rehabilitation team.
- Trial name
- NCT05823649
- Testing
- Early feeding/intervention group
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Armed Police Force Hospital, Nepal
Tibial Fractures, Open Fractures
Safety and Performance of BonyPid-1000™ in the Treatment of Gustilo I, II, IIIA and IIIB Tibial Open Fractures
This is a prospective, multi-national, multicenter, randomized, two arms, single blind, Standard of Care (SOC) controlled, with blinded central reading center study.
- Trial name
- NCT02491047
- Testing
- BonyPid-1000, Standard of Care (SOC) treatment
- Where
- 9 sites in Israel, Philippines
- Volunteers
- 51 people
- Sponsor
- PolyPid Ltd.
Femoral Neck Fractures, Hemiarthroplasty
Uncemented Hemiarthroplasty, Radiological Features Comparing Lateral Versus Anterolateral Approach
Uncemented Hemiarthroplasty, Radiological Features Comparing Lateral Versus Anterolateral Approach. Comparing leg length discrepancy, femoral offset, valgus/varus position of the stem.
- Conditions
- Femoral Neck Fractures, Hemiarthroplasty, Heterotopic Ossification
- Trial name
- NCT03974698
- Testing
- Hemiarthroplasty
- Where
- Norway
- Volunteers
- 150 people
- Sponsor
- Sorlandet Hospital HF
Femoral Neck Fractures, Intertrochanteric Fractures
Opioid-Free Pain Treatment in Trauma Patients
Analgesic drug study that will compare pain outcomes of opioid analgesia and opioid-free analgesia in post-operative orthopedic patients.
- Conditions
- Femoral Neck Fractures, Intertrochanteric Fractures, Femoral Shaft Fracture, Distal Femur Fracture
- Trial name
- NCT06078371
- Testing
- Opioid-free pain treatment
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Kansas Medical Center
Hip Fracture
Tranexamic Acid in HIp Fracture Surgery (THIF Study)
The purpose of this study is to assess the efficacy of tranexamic acid in hip fracture surgery on the reduction of allogeneic red blood cell transfusion.
- Trial name
- THIF (NCT00327106)
- Testing
- Tranexamic acid (Exacyl)
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Hip Fractures
InterTAN IM Nail Versus Sliding Hip Screw in Geriatric Fractures
Elderly patients with an intertrochanteric hip fracture will be randomized to receive either a sliding hip screw (SHS) (control group) or InterTAN intermedullary nail (IMN) (experimental group) for surgical fixation of their hip…
- Trial name
- NCT00664950
- Testing
- sliding hip screw, IntertAn IM nail
- Where
- 3 sites in Canada
- Volunteers
- 240 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Proximal Femur Fracture
Postoperative Pain Relieve for Patients Undergoing Surgical Treatment of Femoral Fracture
The aim of the study is to investigate postoperative pain relief for patients undergoing surgical treatment of proximal femoral fracture using intrathecal administration of morphine.
- Trial name
- NCT05920642
- Testing
- Intrathecal morphine administration, Parenteral administration of analgesics
- Where
- Czechia
- Volunteers
- 82 people
- Sponsor
- University Hospital Ostrava
Neoplasms, Bone Tissue, Pain, Intractable
Study of the Impact of the Femoral Implant "Y-strut" on Lytic Bone Metastases of the Femoral Neck (WAZA-ARY)
Bone metastases appear in many cancers. They are associated with severe pain that is refractory to standard treatment. Improving the quality of life and better pain relief is therefore an essential goal of the treatment of…
- Conditions
- Neoplasms, Bone Tissue, Pain, Intractable, Hip Fractures
- Trial name
- WAZA-ARY (NCT03887494)
- Testing
- Implantation
- Volunteers
- 15 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pelvic Fracture, Urethra Tear
Primary Urethral Realignment Versus Suprapubic Cystostomy After Pelvic Fracture Urethral Injury
Pelvic fracture urethral injuries (PFUI) occur in up to 10% of pelvic fractures. It remains controversial whether initial urethral realignment after PFUI decreases rates of urethral obstruction and the need for subsequent…
- Conditions
- Pelvic Fracture, Urethra Tear, Urethra Injury Male, Trauma
- Trial name
- NCT03195179
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Utah
Foot Ankle Injuries, Anticoagulants and Bleeding Disorders
A Prospective Study in Chinese Patients With Lower Extremity Ankle Fracture of Oral Anticoagulants to Prevent Venous Thromboembolism (VTE)
Deep vein Thrombosis (Deep Venous Thrombosis, DVT) and Pulmonary Embolism, Pulmonary Embolism, PE) both collectively known as Venous thromboembolism (VTE) (Venous Thrombus Embolism, VTE), is a common clinical disease, and…
- Conditions
- Foot Ankle Injuries, Anticoagulants and Bleeding Disorders, Venous Thromboembolism
- Trial name
- NCT04128254
- Testing
- Apixaban Oral Tablet
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hip Fractures, Pain, Postoperative
Effects of Pericapsular Nerve Group Block Applied in Patients Undergoing Hip Fracture Surgery.
In this study, it was aimed to compare the multimodal analgesia application or the pericapsular nerve group (PENG) block methods in patients undergoing hip surgery.
- Trial name
- NCT06183541
- Testing
- Pericapsular Nerve Group (PENG) Block
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Umraniye Education and Research Hospital
Femoral Fractures, Fracture Fixation, Internal
Interest of Navigation for the Treatment of Pertrochanteric Fractures With the Gamma 3 Nail
The aim of the study is to compare Tip-Apex Distance values in two groups of patients after intramedullary nailing of proximal femur.
- Conditions
- Femoral Fractures, Fracture Fixation, Internal, Trochanteric Fractures
- Trial name
- INOPEG (NCT02672696)
- Testing
- FluoroMap 3D
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Hôpital du Valais
Femoral Neck Fractures
FNS (FEMORAL NECK SYSTEM) Study
A post-market, prospective study to evaluate the reoperation rate of displaced and nondisplaced femoral neck fractures treated with the Femoral Neck System (FNS)™
- Trial name
- FNS (NCT04577261)
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Wake Forest University Health Sciences
Osteoporosis, Arthroplasty Complications
Surgeon-Initiated Bone Health Referral Pathway in Patients Undergoing Lower Extremity Arthroplasty
The goal of this clinical trial is to observe the impact of a surgeon-driven bone health referral pathway following lower extremity arthroplasty.
- Conditions
- Osteoporosis, Arthroplasty Complications, Fragility Fracture
- Trial name
- NCT05845021
- Testing
- Surgeon-Initiated Bone Health Referral Pathway
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Hip Fractures
Deep Neuromuscular Block on Cytokines Release and Postoperative Delirium
The purpose of the study is to determine the relationship between the degree of neuromuscular block, the release of cytokines and clinical outcomes in elderly patients undergoing orthopedic surgery.
- Trial name
- NCT02507609
- Testing
- Moderate neuromuscular blockade, Deep neuromuscular blockade
- Where
- South Korea
- Volunteers
- 82 people
- Sponsor
- Konkuk University Medical Center
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