Clinical trials: Fractures, Bone
Orbital Fractures
The Use of 3D Printing in Orbital Fractures
The study is a prospective randomized longitudinal clinical study to compare pre-adapted patient-specific orbital implants utilizing an office-based 3-D printer versus standard non-adapted orbital implants (the latter being the…
- Trial name
- NCT03673865
- Testing
- office-based 3-dimensional printers (OB3DP), standard stock orbital plate
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Emory University
Femoral Neck Fractures
Fixation Using Alternative Implants for the Treatment of Hip Fractures (FAITH-2)
The purpose of this study is to determine the impact of surgical fixation (cancellous screws versus sliding hip screws) and biologic intervention (Vitamin D versus placebo) on patient important outcomes.
- Trial name
- FAITH-2 (NCT01908751)
- Testing
- Sliding Hip Screw, Cancellous Screws, Vitamin D
- Where
- 20 sites in United States, Australia and 1 more
- Volunteers
- 91 people
- Sponsor
- McMaster University
Arthralgia, Trouble Balancing
Even-Up to Minimize Secondary Site Pain For Ankle Fracture
Evaluating impact of use of Even-Up shoe wear device for patients treated in CAM boot walker for an ankle fracture. Randomized controlled trial, randomizing patients into control group with boot treatment only versus boot…
- Trial name
- NCT04164563
- Testing
- Even-Up
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Cancer, Spinal Disease
Anderson Circulating Tumor Cell Burden (CTCB) Study
Phase 1 - Optimization Phase: Primary Objective: The primary objective of Phase 1 of this study is to determine the time point at which maximal Circulating Tumor Cell Burden (CTCB) occurs following standard vertebroplasty and…
- Conditions
- Cancer, Spinal Disease, Vertebral Compression Fractures
- Trial name
- NCT00819832
- Testing
- Kyphoplasty, Vertebroplasty, Cavity SpineWand
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Pseudoarthrosis
Humeral Shaft Pseudoarthrosis Treated With Bone Autograft Versus Platelet Rich Plasma
Patients with humeral shaft pseudoarthrosis is going to be treated with a standard protocol with a locking compression plate and bone autograft, and other group of patients treated with platelet rich plasma.
- Trial name
- NCT02520089
- Testing
- bone autograft of iliac crest, Platelet Rich Plasma plus bone autograft
- Where
- Mexico
- Volunteers
- 23 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Subchondral Cysts, Subchondral Bone Edema
SCP Hip Outcomes Study
Post-market clinical outcomes study to collect data on the short- and long-term outcomes for subjects who are undergoing or have undergone the Subchondroplasty® (SCP®) Procedure in the hip in a standard clinical setting.
- Conditions
- Subchondral Cysts, Subchondral Bone Edema, Bone Marrow Edema, Insufficiency Fractures
- Trial name
- NCT03494660
- Testing
- Subchondroplasty Procedure with AccuFill
- Where
- 6 sites in United States
- Volunteers
- 77 people
- Sponsor
- Zimmer Biomet
Postmenopausal Osteoporosis
VERtebral Fracture Treatment Comparisons in Osteoporotic Women
The primary purpose of participation in this study is to answer whether teriparatide is superior to risedronate in reducing the occurrence of new vertebral fractures during 24 months of therapy.
- Trial name
- VERO (NCT01709110)
- Testing
- Teriparatide, Risedronate, Calcium
- Where
- 103 sites in United States, Argentina and 13 more
- Volunteers
- 1,366 people
- Sponsor
- Eli Lilly and Company
Physical Frailty, Hip Fracture
Exercise and Testosterone Therapy in Elderly Men With Physical Frailty
The primary aim of this study is to determine, in hypogonadal older men with physical frailty, whether exercise training combined with testosterone replacement therapy can improve skeletal muscle strength, and lean mass, to a…
- Conditions
- Physical Frailty, Hip Fracture, Elective Hip Replacement, Hypogonadism
- Trial name
- NCT00345969
- Testing
- Transdermal Testosterone gel (1%), Supervised exercise training
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Washington University School of Medicine
Femur Fracture
Intramedullary Nailing of the Femur:Trochanteric vs Piriformis Starting Portals
This project is designed to determine whether or not the trochanteric insertion portal will show any difference when compared with the piriformis fossa portal in terms of pain and strength of the hip abductor muscles, while…
- Trial name
- TROCHNAIL (NCT00593333)
- Testing
- Antegrade Intramedullary Nail, Trigen Trochanteric Femoral Nail
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Alabama at Birmingham
Blunt Injury of Thorax, Multiple Rib Fractures, Involving Three Ribs
Low Dose Ketamine for Blunt Thoracic Trauma
The goal of this Randomized controlled double-blinded trial is to compare the addition of a ketamine infusion to placebo, when added to standard care in adult blunt trauma patients with multiple rib fractures.
- Trial name
- NCT06236113
- Testing
- Ketamine 1 Mg/mL-NaCl 0.9% Intravenous Solution
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- North Memorial Health Care
Fusion of Spine (Disease), Fractures, Ununited
A Clinical Registry to Collect Patient Outcome Date for the BIOMET® Stimulator Systems
The purpose of this clinical registry is to capture data on an ongoing basis from a population of patients who will use Biomet's BHS, OrthoPak and SpinalPak devices.
- Trial name
- NCT01750840
- Testing
- Biomet® EBI Bone Healing System, Biomet Orthopak® Non-Invasive Bone Growth Stimulator System, Biomet SpinalPak® Non-Invasive Spine Fusion Stimulator
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Zimmer Biomet
Fracture Healing
Study To Assess FRacTure Healing With SclerosTin Antibody - Hip
This is an international, multi-center study to determine the efficacy, safety, and tolerability of romosozumab (AMG 785) in adults with a fresh unilateral hip fracture, status post surgical fixation.
- Trial name
- STARTT-Hip (NCT01081678)
- Testing
- Romosozumab
- Where
- 99 sites in United States, Argentina and 22 more
- Volunteers
- 332 people
- Sponsor
- Amgen
Rib Fractures, Pain, Acute
Dexmedotomidine for Acute Pain Control in Patients With Multiple Rib FracturesRandomized Controlled Trial
Blunt chest trauma is the second most common form of unintentional trauma in the US and is associated with significant morbidity and mortality. Thoracic injuries are the third most common cause of death in trauma patients.
- Trial name
- NCT05321121
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of California, Irvine
Rib Fractures, Pain, Acute
A Retrospective Review of Rib Fracture Pain Management at a London Major Trauma Centre
Thoracic epidural analgesia (TEA) is widely considered to be the current gold standard treatment for rib fracture pain and is used in the Imperial invasive treatment pathway for rib fractures.
- Trial name
- NCT04863807
- Testing
- Regional Anaesthesia
- Where
- United Kingdom
- Volunteers
- 389 people
- Sponsor
- Imperial College Healthcare NHS Trust
Tibial Delayed Healing
Tibial Delayed Healing Pivotal Clinical Trial
Evaluate the INFUSE/MASTERGRAFT™ Delayed Healing Device as an alternative/replacement to autograft in the treatment of tibial delayed healing.
- Trial name
- NCT01016067
- Testing
- INFUSE/MASTERGRAFT, Autograft bone
- Where
- 16 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Medtronic Spinal and Biologics
Radiation Exposure
Novel Use of an Enhanced Fluoroscopic Imaging Device to Reduce Radiation Exposure and Operative Time During Intramedullary Nailing of Hip Fractures
The purpose of this study is to evaluate the effectiveness of a novel digital image enhancement (DIE) technology in reducing the radiation exposure to both the patient and surgical staff during standard intramedullary nail…
- Trial name
- NCT02856828
- Testing
- DIE
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Duke University
Surgical Site Infection, Unplanned Fracture-Related Reoperation
Pre-operative Alcohol Skin Solutions in Fractured Extremities
The prevention of infection is an important goal influencing peri-operative care of extremity fracture patients. Standard practice in the operative management of extremity fractures includes sterile technique and pre-operative…
- Conditions
- Surgical Site Infection, Unplanned Fracture-Related Reoperation, Open Appendicular Fracture, Closed Lower Extremity Fracture
- Trial name
- PREPARE (NCT03523962)
- Testing
- DuraPrep, ChloraPrep
- Where
- 27 sites in United States, Canada
- Volunteers
- 8,485 people
- Sponsor
- University of Maryland, Baltimore
Hip Fractures, Femoral Neck Fractures
Comparing Total Hip Arthroplasty and Hemi-Arthroplasty on Secondary Procedures and Quality of Life in Adults With Displaced Hip Fractures
Each year, hip fracture, an injury that can impair independence and quality of life, occurs in about 280,000 Americans and 36,000 Canadians.
- Trial name
- HEALTH (NCT00556842)
- Testing
- Total hip arthroplasty, Hemi-arthroplasty
- Where
- 2 sites in United States, Canada
- Volunteers
- 1,495 people
- Sponsor
- McMaster University
Bone Metastases
Study of Denosumab vs. Zoledronic Acid to Treat Bone Metastases in Subjects With Advanced Cancer or Multiple Myeloma.
The purpose of this study is to determine if denosumab is non-inferior to zoledronic acid (Zometa®) in the treatment of bone metastases (lytic bone lesions from multiple myeloma) in subjects with advanced cancer and multiple…
- Trial name
- NCT00330759
- Testing
- Denosumab, Zoledronic Acid
- Volunteers
- 1,779 people
- Sponsor
- Amgen
Trauma, Fractures, Closed
Intranasal Versus Intravenous Ketamine for Procedural Sedation in Children With Non-operative Fractures
This a randomized clinical trial involving children with non-operative fractures presenting the emergency department randomized either to intranasal or intravenous ketamine.
- Conditions
- Trauma, Fractures, Closed, Children, Only, Deep Sedation
- Trial name
- NCT03781817
- Testing
- Intravenous Ketamine, Intranasal Ketamine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham