Clinical trials: Fractures, Spinal
Osteoporosis Fracture, Osteoporosis Vertebral
Development and Validation of a Postoperative Re-fracture Risk Model for Osteoporotic Spinal Fractures
In this project, IDEAL-IQ technology and PDFF and R2* image-based imaging methods are used to analyze the intrinsic relationship between preoperative vertebral bone marrow fat content, magnetic susceptibility properties of bone…
- Conditions
- Osteoporosis Fracture, Osteoporosis Vertebral, Compression Fracture, Perform PVP / PKP Treatment
- Trial name
- NCT06379243
- Testing
- PVP/PKP
- Where
- China
- Volunteers
- 560 people
- Sponsor
- The Seventh Affiliated Hospital of Sun Yat-sen University
Osteoporosis Fracture, Spinal Cord Injuries
Evaluation of Romosozumab vs. Zoledronic Acid Effect in Patients With Spinal Cord Injury and Low Bone Mineral Density
This is a randomized study to determine the effects of monthly romosozumab for one year or one-time zoledronic acid on bone mineral density (BMD) and biochemical markers of bone formation and resorption, in patients with spinal…
- Trial name
- NCT04597931
- Testing
- Romosozumab, Zoledronic Acid
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Osteoporotic Fracture
Prevention of Residual Low Back Pain After Percutaneous Kyphosis(PKP) Using Posterior Branch Block of Spinal Nerve
The purpose of this study was to block the posterior branch of lumbar spinal nerve during PKP operation and compare it with the patients without spinal nerve block, so as to verify the effect of posterior branch block of spinal…
- Trial name
- NCT04108507
- Testing
- posterior branch block of spinal nerve
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Osteoporotic Fractures
Vertebroplasty Compared With a Sham-procedure for Painful Acute Osteoporotic Vertebral Fractures
The main purpose of this study: to determine whether vertebroplasty has a pain palliating effect superior to a sham-procedure for acute painful osteoporotic vertebral fractures of the thoracic and lumbar spine.
- Trial name
- VOPE (NCT01537770)
- Testing
- Percutaneous vertebroplasty, Lidocaine injection
- Where
- Denmark
- Volunteers
- 52 people
- Sponsor
- Spine Centre of Southern Denmark
Open Fractures, Degenerative Osteoarthritis and Degenerative Spinal Diseases
A Prospective Randomized Controlled Study on the Clinical Efficacy of a New Surface Modified Composite Coating Orthopedic Implant Device
This study is a prospective, randomized, controlled, double-arm, non-inferiority study that will be carried out in China. It aims to compare two implant systems (the research group uses surface-modified composite coated…
- Trial name
- NCT04481269
- Testing
- Surface-modified composite coated orthopedic implants, conventional orthopedic implants
- Volunteers
- 240 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Osteoporosis, Vertebral Fracture
Effectiveness of Physiotherapy for Osteoporotic Spinal Fracture
The aim of this pilot study was to determine the effect of physiotherapy on impairments and health-related quality of life in people with a painful osteoporotic spinal fracture.
- Trial name
- NCT00638768
- Testing
- Physiotherapy
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- University of Melbourne
Osteoporosis, Rheumatoid Arthritis
Performance of CT Parameters Compared to Bone Mineral Density to Detect Bone Fragility in Rheumatoid Arthritis
Objective: To evaluate the performance of CT parameters (SBAC-L1 and fractal analysis) compared to BMD (gold standard) to detect vertebral fractures in rheumatoid arthritis
- Conditions
- Osteoporosis, Rheumatoid Arthritis, Vertebral Fracture
- Trial name
- NCT04413448
- Where
- France
- Volunteers
- 260 people
- Sponsor
- Central Hospital, Nancy, France
Degenerative Lumbar Spinal Stenosis, Degenerative Spondylolisthesis
Clinical Evaluation of Orion Lamina Cover in Patients Undergoing Lumbar Laminectomy With Instrumented Fusion
Laminectomy with internal fixation and osseofusion is a common surgery for treating degenerative spinal diseases. It removes excessive bone spurs and removes the lamina for decompression to relieve nerve compression, and then…
- Conditions
- Degenerative Lumbar Spinal Stenosis, Degenerative Spondylolisthesis, Spinal Stenosis, Scoliosis
- Trial name
- NCT06532968
- Testing
- ORION spinal lamina cover
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Orion Biotech Inc.
Osteoporosis, Vertebral Fracture
Chiropractor Delivered Virtual Intervention After Vertebral frActure
This study will determine feasibility of a chiropractor delivered virtual intervention for individuals following osteoporotic vertebral fracture. This pilot trial will have two parallel groups with a 1:1 ratio.
- Trial name
- VIVA (NCT07288684)
- Testing
- VIVA
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of Waterloo
Hip Fractures, Arthroplasty, Replacement, Hip
PENG Block + LIA For Endoprosthesis Surgery
The goal of this clinical trial is to learn if a new local anesthesia technique can control pain as well as the standard spinal anesthesia for adults having hip endoprosthesis surgery.
- Conditions
- Hip Fractures, Arthroplasty, Replacement, Hip, Pain, Postoperative, Anesthesia and Analgesia
- Trial name
- PENG 360° (NCT07239817)
- Testing
- Pericapsular Nerve Group Blocks with Local Infiltration Analgesia, spinal anesthesia
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- ASST Gaetano Pini-CTO
Spine Fracture
Three Dimensional Gait Analysis and Electromyography After Stabilisation of Thoracolumbar Spine Fractures Focusing on Possible Temporal Diferences in Physiological Gait Recovery Through Comparison of Open and Minimally Invasive Approaches.
We prospectively enrolled patients with a thoracic or lumbar spine fracture indicated for instrumented posterior stabilization. We consequently randomized the patient for either a conventional open approach procedure or minimally…
- Trial name
- NCT07516834
- Testing
- spine stabilization
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.
Acute Spinal Cord Injury, Acute Spinal Paralysis
Canadian-American Spinal Cord Perfusion Pressure and Biomarker Study
This multicenter study will enroll 100 patients with acute traumatic cervical and thoracic SCI who have a lumbar intrathecal catheter inserted within 24 hours of their injury.
- Conditions
- Acute Spinal Cord Injury, Acute Spinal Paralysis, Spinal Cord Injuries, SPINAL Fracture
- Trial name
- CASPER (NCT03911492)
- Testing
- SCPP Management => 65 mmHg
- Where
- 8 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- University of British Columbia
Osteoporosis, Multiple Myeloma
Investigation of Bone Defects and Microcirculation With Computed Tomography and Magnetic Resonance Imaging
Subject of the proposed study is the non-invasive in vivo imaging of bone, bone marrow and localized microcirculation in test animals with osteoporosis, fractures and after placement of bone substitute material with volume…
- Conditions
- Osteoporosis, Multiple Myeloma, Vertebral Fracture
- Trial name
- NCT01374412
- Where
- Germany
- Volunteers
- 144 people
- Sponsor
- German Cancer Research Center
Obesity, Bariatric Surgery Candidate
Bone Fragility Evaluation in Obese Patients
This research will study the bone fragility in obese patients, on DXA and CT-scan, in a transversal study. The investigators want also to study the specific risk factors of bone fragility in these obese patients (relationship…
- Trial name
- NCT04174495
- Testing
- DXA and CT-scan
- Where
- France
- Volunteers
- 1,500 people
- Sponsor
- Central Hospital, Nancy, France
Spinal Cord Injury
The Relationship Between Irisin and Bone Health in Individuals With Spinal Cord Injury
This study will examine the relationship between circulating irisin and bone health individuals with spinal cord injury. Additionally, this study seeks to examine the influence of muscle fiber type on circulating irisin and…
- Trial name
- IBSCI (NCT05319522)
- Testing
- Acute Exercise
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Depressed Lateral Condyle Fracture, Benign Bone Tumour Cavity
Bioactive Glass as Bone Graft Substitute in Operative Treatment of Bone - a 10 Years Follow-up Study
The main aim is to evaluate the long-term safety and bone healing in the operated area and to compare bioactive glass granules with autogenous bone as a filler material.
- Conditions
- Depressed Lateral Condyle Fracture, Benign Bone Tumour Cavity, Spinal Fusion
- Trial name
- NCT00935870
- Testing
- Bioactive glass and/or autogenous bone
- Where
- Finland
- Volunteers
- 63 people
- Sponsor
- Vivoxid Ltd
Vertebral Fracture
Prevalence of Subclinical Vertebral Fractures in Rheumatoid Arthritis and Ankylosing Spondylitis
Study of prevalence of subclinical vertebral fractures in Rheumatoid Arthritis and Ankylosing spondylitis
- Trial name
- NCT06092775
- Testing
- DEXA scan,X_ray
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Assiut University
Multiple Myeloma, Compression Fracture of Vertebral Column
Evaluation of Vertebral Compression Fracture Fixation With RF Kyphoplasty in Patients With Multiple Myeloma
The objective of this post market clinical study is to collect prospective clinical data to confirm the efficacy of RF Kyphoplasty for the treatment of pathological fractures of the spine caused by multiple myeloma.
- Trial name
- MM (NCT01410929)
- Testing
- Kyphoplasty/Vertebral Augmentation (Device-StabiliT)
- Sponsor
- DFINE Inc.
Hip Fracture, Hypotension
Continuous Spinal Anesthesia With Hypobaric Bupivacaine to Preserve Hemodynamics in Elderly
The study evaluates the potential beneficial effects on hemodynamics when hypobaric bupivacaine is used instead of isobaric bupivacaine in continuous spinal anesthesia for surgical repair of hip fracture in elderly patients.
- Trial name
- NCT02428257
- Testing
- continuous spinal anesthesia, hypobaric bupivacaine, isobaric bupivacaine
- Where
- Tunisia
- Volunteers
- 120 people
- Sponsor
- Institut Kassab d'Orthopédie
Lumbar Spinal Stenosis, Lumbar Disc Herniation
In Turkish Version Lumbar Spine Surgery Expectation Survey
The aim of this study was to determine the Turkish validity and reliability of Lumbar Spine Surgery Expectations Survey developed by Mancuso.
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Radiculopathy, Lumbar Fracture
- Trial name
- NCT04547075
- Testing
- Turkish validity and reliability
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Kutahya Health Sciences University