Clinical trials: Fractures, Spinal
Osteoporosis, Vertebral Fracture
A Trial of Vertebroplasty for Painful Acute Osteoporotic Vertebral Fractures
The standard care in patients with a painful osteoporotic vertebral compression fracture (VCF) is conservative therapy. Percutaneous vertebroplasty (PV), is a new minimally invasive technique for pain treatment in which bone…
- Trial name
- VertosIV (NCT01200277)
- Testing
- percutaneous vertebroplasty
- Where
- 4 sites in Netherlands
- Volunteers
- 80 people
- Sponsor
- Elisabeth-TweeSteden Ziekenhuis
Difference in Reduction in Visual Analogue Score at 30 Minutes
Pericapsular Nerve Block Versus Propofol During Hip Fractures Surgery
The study will compare the efficacy of Pericapsular nerve group block (PENG) versus low dose Propofol for the achievement of painless sitting position before spinal anesthesia in patients undergoing repair of Hip fractures.
- Trial name
- NCT06631118
- Testing
- pericapsular nerve group block for group A,low dose intravenous Propofol [0.7mg/kg] over 30 seconds for group B
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Hip Fractures, Anesthesia, Spinal
GA/Spinal vs. GA/Spinal/NMB for Operative Repair of Hip Fracture
Surgical repair of hip fractures may be performed with various anesthetic techniques, but are most commonly completed under general anesthesia (GA) or neuraxial anesthesia (NA).
- Conditions
- Hip Fractures, Anesthesia, Spinal, Anesthesia, General, Neuromuscular Blockade
- Trial name
- NCT03226080
- Testing
- Rocuronium, Sugammadex, Normal saline
- Where
- United States
- Sponsor
- Loyola University
Osteoporosis, Vertebral Fracture
Evaluation of Outcomes of DFine StabiliT Kyphoplasty in Vertebral Compression Fractures Due to Osteoporosis
This post-market surveillance research project consists of data collection at specified time points using standard questionnaire instruments to compare pain level, mobility and function pre and post procedure using the D-Fine…
- Trial name
- NCT01839682
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Cedars-Sinai Medical Center
Cervical Spine Fractures, Cervical Spine Injury
Study on Orthosis in Cervical Spine Fracture Treatment
Background and Purpose: Neck fractures affect over 1,100 people in Sweden each year, with the majority being frail older adults.
- Conditions
- Cervical Spine Fractures, Cervical Spine Injury, Rigid Collar
- Trial name
- SOFT (NCT06848660)
- Testing
- A rigid cervical collar
- Where
- 6 sites in Sweden
- Volunteers
- 616 people
- Sponsor
- Uppsala University Hospital
Postoperative Analgesia, Hip Surgery
PENG vs Deep Iliacus Plane Block in Intertrochanteric Femur Fractures
Intertrochanteric femur fractures are common in elderly patients and are associated with significant pain. Providing effective analgesia is clinically important both during positioning for spinal anesthesia and in the…
- Trial name
- NCT07513740
- Testing
- Intravenous Analgesia, Pericapsular nerve group (PENG) block, Deep Iliacus Plane Block (DIPB)
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Erzincan Binali Yildirim Universitesi
Scintigraphy Quantification
Absolute Quantification in Bone Scintigraphy
While absolute quantification in 18F-FDG PET (Positon Emission Tomography) is widely used in clinical routine, absolute quantification in SPECT (Single Photon Emission Computed Tomography) is under development and its clinical…
- Trial name
- QUANTOSS-3D (NCT04671238)
- Testing
- SPECT CT
- Where
- 3 sites in France
- Volunteers
- 21 people
- Sponsor
- Central Hospital, Nancy, France
Anesthesia, Spinal, Hip Fractures
Haemodynamic Effects and Complications of Continuous Versus Single-shot Spinal Anaesthesia for HIP Fracture Surgery
This research project aims to identify a safer method of spinal anaesthesia for elderly patients undergoing surgical stabilisation of proximal femoral fractures.
- Trial name
- CHIPS (NCT07358299)
- Testing
- Bupivacaine Spinal 0,5% Heavy - bolus, Bupivacaine Spinal 0,5% Heavy - titration
- Where
- 2 sites in Poland
- Volunteers
- 216 people
- Sponsor
- Centre of Postgraduate Medical Education
Fractures, Hip, Femoral Neck Fractures
Preoperative Use of Peripheral Nerve Blocks in Elderly Patients With Hip Fractures
The goal of this clinical trial is to explore the effects of different peripheral nerve blocks in older adults with hip fractures. It will also explore the safety of preoperative administration of peripheral nerve blocks.
- Conditions
- Fractures, Hip, Femoral Neck Fractures, Intertrochanteric Fractures, Subtrochanteric Fractures
- Trial name
- NCT07130006
- Testing
- PENG and LFCN peripheral nerve blocks with spinal anesthesia, FN and LFCN peripheral nerve blocks with spinal anesthesia, FIC peripheral nerve block with spinal anesthesia
- Where
- Croatia
- Volunteers
- 256 people
- Sponsor
- University Hospital of Split
Thoracolumbar Burst Fracture
Comparison of Posterior Fixation Alone and Combined With Articular Process Fusion in Thoracolumbar Burst Fractures
Nearly 90% of all spinal fractures occur in the thoracolumbar region, and burst fractures are composed of 15% of such injuries. But the treatment of thoracolumbar fractures remains controversial.
- Trial name
- NCT01864785
- Testing
- Fixation Combined With Fusion, Fixation Alone
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jinling Hospital, China
Bone Diseases, Infectious, Disease of Bone
Spinal Infection Management With Structural Allograft
Background. Bone infections can involve the vertebral column, intervertebral disc space, spinal canal and soft tissues, can generate neurological deficit in addition to the destruction of the bone that causes functional…
- Conditions
- Bone Diseases, Infectious, Disease of Bone, Syndrome, Spine Infection
- Trial name
- NCT03265561
- Testing
- Bone allograft, Bone auto and allograft group
- Where
- Mexico
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Nuevo Leon
Neck Injuries
A Pragmatic Evaluation of the Canadian C-Spine Rule by Paramedics
Each year, half a million patients with a potential neck (c-spine) injury are transported to Ontario emergency departments (ED). Less than 1% of all these patients actually have a neck bone fracture.
- Trial name
- NCT02786966
- Testing
- Canadian C-Spine Rule
- Where
- Canada
- Volunteers
- 3,646 people
- Sponsor
- Ottawa Hospital Research Institute
SPINAL Fracture
Minimally Invasive Surgical Management of Traumatic Spinopelvic Instability
the main aim of this study is to evaluate the results of performing minimally invasive surgical management for cases with traumatic spinopelvic instability and spinopelvic dissociation.
- Trial name
- NCT05321186
- Testing
- minimally invasive spinopelvic fixation
- Volunteers
- 20 people
- Sponsor
- Assiut University
Osteoporosis, Hyperkyphosis
Nordic Walking for Individuals With Osteoporosis, Vertebral Fracture or Hyperkyphosis
Nordic walking is currently offered by a number of health care practitioners as a form of exercise therapy for older adults at risk of fracture.
- Conditions
- Osteoporosis, Hyperkyphosis, Vertebral Fracture
- Trial name
- NCT03885466
- Testing
- Nordic Walking exercise
- Where
- Canada
- Volunteers
- 117 people
- Sponsor
- University of Saskatchewan
Postoperative Delirium, Hip Fractures
Intrathecal Dexmedetomidine and Postoperative Delirium in Elderly Hip Fracture Surgery
Postoperative delirium (POD) is a common and serious complication in elderly patients undergoing surgical repair for hip fractures, often triggered by acute pain, surgical stress, neuroinflammation, and opioid consumption.
- Trial name
- NCT07810556
- Testing
- Dexmedetomidine, Hyperbaric Bupivacaine with Normal Saline
- Volunteers
- 130 people
- Sponsor
- Assiut University
Hip Fractures, COVID-19
Anesthesia Technique in COVID-19 Positive Hip Fracture Patients
Patients with COVID undergoing hip fracture repair have high mortality rates. If spinal anesthesia is associated with decreased rates of mortality, this study could provide hypothesis generating data for prospective studies.
- Conditions
- Hip Fractures, COVID-19, General Anesthesia, Spinal Anesthesia
- Trial name
- NCT05133648
- Testing
- Hip Fracture Surgery, COVID-19 infection
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Type 2 Diabetes
Comparison of Bone Quality in Type 2 Diabetic Patients With a Non-diabetic Control Population
Patients with type 2 diabetes have many complications in different organs. These complications are extremely frequent and severe: cardiovascular and renal disease, visual impairment, and, more recently, complications affecting…
- Trial name
- DIABONE (NCT02797314)
- Testing
- Bone biopsies
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Neck Injuries, Spinal Injuries
Treatment of Type II Odontoid Fractures Among the Elderly
The purpose of this study is to compare the safety and effectiveness of surgical versus conservative management of type II odontoid fractures among patients > 64 years of age.
- Trial name
- NCT00266929
- Testing
- surgical, conservative treatment
- Where
- 15 sites in United States, Canada
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- AOSpine North America Research Network
Ankylosing Spondylitis
Clinical Trial of Osteoporosis in Ankylosing Spondylitis
This is an observational study aiming to study the prevalence and risk factors for osteoporosis and vertebral fractures in patients with ankylosing spondylitis attending three Rheumatology clinics in Western Sweden.
- Trial name
- NCT00858819
- Where
- Sweden
- Volunteers
- 250 people
- Sponsor
- Göteborg University
Spine Degeneration, Spine Spondylosis Thoracic
Clariance ErYs Registry
International, prospective, single arm, multicenter and observational Post-Market Clinical Follow-up (PMCF). The overall objective of this study is to collect preoperative, intraoperative and postoperative (at 9 weeks, 6 months…
- Conditions
- Spine Degeneration, Spine Spondylosis Thoracic, Spinal Deformity, Spinal Tumor
- Trial name
- ErYs (NCT05170815)
- Testing
- Spine surgery
- Where
- France
- Volunteers
- 760 people
- Sponsor
- Clariance