Clinical trials: Fragility
Fragility Fractures of the Pelvis (FFP)
Robot Assisted Minimally Invasive Treatment Versus Conservative Treatment for Fragility Fractures of the Pelvis Type 1-2 in Elderly Patients
This prospective randomized controlled trial aims to compare the efficacy and safety of robot assisted minimally invasive treatment versus conservative treatment in elderly patients with FFP1-2 fragility fractures of the pelvis.
- Trial name
- FFP (NCT07636616)
- Testing
- Robot Assisted Minimally Invasive Fixation
- Volunteers
- 152 people
- Sponsor
- Junbo Liang
Hip Fracture, Femoral Neck Fracture
The Hip Fracture Surgical Approach Trial
The HIFSAT study will compare the standard direct lateral approach to hemiarthroplasty to a new muscle sparing approach (SPAIRE) in femoral neck fracture patients.
- Trial name
- HIFSAT (NCT06146205)
- Testing
- Direct lateral approach, SPAIRE
- Where
- Norway
- Volunteers
- 476 people
- Sponsor
- Diakonhjemmet Hospital
Fragility Fracture, Femur; Fracture, Pertrochanteric
Role of Strontium Ranelate in Proximal Femur Fragility Fractures.
This study is being conducted with the aim of comparing the time to bone healing after surgery for fragility fractures of proximal femur between patients receiving strontium ranelate and placebo.
- Conditions
- Fragility Fracture, Femur; Fracture, Pertrochanteric, Clinical Trial
- Trial name
- STRONG (NCT05712616)
- Testing
- Strontium Ranelate, Lacto-N-Hexaose
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Aga Khan University Hospital, Pakistan
Osteoporosis
Bone Adaptation to Impact Loading
Ageing populations have made osteoporosis and fragility fractures a major public health concern worldwide. Half of all women and 30% of all men will suffer a fracture related to osteoporosis during their lifetime.
- Trial name
- NCT00697957
- Testing
- Exercise
- Where
- Finland
- Volunteers
- 120 people
- Sponsor
- University of Oulu
Cancer, Anesthesia
Cancer Anesthesia and Frailty
Subjects undergoing cancer related surgery at the Fondazione IRCCS Istituto Nazionale dei Tumori - Milano will be consecutively recruited.
- Conditions
- Cancer, Anesthesia, Fragility
- Trial name
- NCT03575416
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Diabetic Peripheral Neuropathy
The Effect of Hand and Foot Exercises Combined With Cold Application or Virtual Reality on Diabetic Neuropathy
The study will be conducted to determine the effect of cold application and virtual reality (VR) or combined hand and foot exercises on pain intensity, kinesiophobia, and fragility levels in patients with diabetic peripheral…
- Trial name
- NCT07085130
- Testing
- Exercises and cold application, Exercises and virtual reality
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Sakarya University
Fragility, Multimorbidity
Effectiveness of Integrated Care Network
This project aims to examine the effectiveness of the community-based integrated care service model , based on a multi-domain intervention program, among community-dwelling older adults.
- Trial name
- NCT03528005
- Testing
- Multi-domain intervention
- Where
- 6 sites in Taiwan
- Volunteers
- 398 people
- Sponsor
- National Yang Ming Chiao Tung University
Frail Elderly Syndrome, Mild Cognitive Impairment
Spanish Linguistic Validation, Validity and Reliability Test of Frail´BESTest in Elderly Institutionalized Frail People
The aging of the global population presents significant social and health challenges. In Aragón, 15% of the population is between 65 and 79 years old, and the over-aging index is 16.6%, higher than the national average.
- Trial name
- NCT06438718
- Where
- Spain
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Osteoporosis
Study in Patients With Osteoporosis and Fragility Fractures to Estimate the Extent and Impact of Delayed Administration of Anti-fracture Therapy
Osteoporosis (OP) and fragility fractures are a significant problem that leads to morbidity, mortality, and high costs for the National Health System.
- Trial name
- OPGAP01 (NCT07512453)
- Where
- Italy
- Volunteers
- 8,000 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Fragility
Intervention in Frailty Versus Usual Care in Frail Patients After an Acute Myocardial Infarction
Frailty has been associated to a worse outcome in acute coronary syndromes, but the best management of frail patients after an acute coronary syndrome remains unknown.
- Trial name
- FRAMIP (NCT02715453)
- Testing
- Intervention on frailty
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- University of Valencia
Hip Fractures
Effects of Music on Acute Postoperative Pain Intensity and Mobility After Fragility Hip Fracture
Music has been proven to be beneficial in postoperative care by reducing pain. The effects of music listening to reduce pain postoperatively are well studied among cases undergoing elective orthopaedic surgery.
- Trial name
- NCT06277102
- Testing
- music listening
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Hospital Authority, Hong Kong
Type1diabetes
Skeletal Fragility in Type 1 Diabetes: Glycemic Control and Bone Strength
The purpose of this research study is to find out how bones are affected in children and adolescents with type 1 diabetes (T1D) as compared to children and adolescents without type 1 diabetes.
- Trial name
- NCT04289727
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Columbia University
Atrial Fibrillation, Fragility
EdOxaban in fRagIle Patients With Percutaneous Endoscopic GAstrostoMy and atrIal fIbrIllation
The goal of this interventional study is to describe the use of Edoxaban via PEG in patients with an indication to anticoagulation therapy.
- Trial name
- ORIGAMI II (NCT06285942)
- Testing
- Edoxaban, No Edoxaban
- Where
- 3 sites in Italy
- Volunteers
- 168 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Bone Loss, Age-related
Microbiota and Bone Fragility:Study of the Relation Between Gut Microbiota and Bone Microarchitecture
Gut microbiota regulate metabolism of their human host. Some diseases are associated with variations in gut microbiota diversity and higher fracture risk.
- Trial name
- MICROBONE (NCT04265742)
- Testing
- bone densitometry, High resolution peripheral QCT, Collection of biological samples
- Where
- France
- Volunteers
- 440 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Severe Fragility Fracture
Outcomes of Severe Osteoporotic Fractures Hospitalized in France: the CROSS Cohort
The purpose of this study is to determine the outcomes of severe osteoporotic fractures hospitalized in France, the risk of incident severe fracture at 2 years and 5 years and the risk of mortality over 2 and 5 years.
- Trial name
- CROSS (NCT02606162)
- Where
- France
- Volunteers
- 912 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Living Kidney Donor, Living Kidney Donation
Fracture Risk in Living Kidney Donors
This study will be a population-based, matched retrospective cohort study using linked administrative healthcare databases from Ontario, Alberta, and British Columbia to evaluate the long-term risk of fractures among living…
- Conditions
- Living Kidney Donor, Living Kidney Donation, Fractures, Nephrectomy,Kidney Donation
- Trial name
- NCT07401953
- Testing
- Nephrectomy
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Depression in Old Age, Fragility Fracture
Serotonin-norepinephrine Reuptake Inhibitor in Prophylaxis of Depression Following Fragility Fractures
The goal of this pilot study is to learn about the feasibility about prescribing anti-depressants at discharge in patients aged 50 years and older with a lower extremity fragility fracture.
- Trial name
- SNRI (NCT05851898)
- Testing
- Duloxetine 30 mg
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University Health Sciences
Osteoporosis, Hyperkyphosis
Relationship Between Thoracic Hyperkyphosis and Fall Risk in Women with Fragility Vertebral Fractures
Multiple vertebral fragility fractures, one of the main complications of osteoporosis, are frequently associated with thoracic hyperkyphosis, which in turn leads to significant postural alterations.
- Conditions
- Osteoporosis, Hyperkyphosis, Vertebral Body Fracture
- Trial name
- NCT06842758
- Testing
- Rehabilitation Treatment, None Treatment
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Palermo
Vertebral Fracture, Osteoporotic Fractures
CCEF in the Treatment of Acute VFFs: Randomized Controlled Trial
in recent years the search for therapeutic protocols that could enhance the VFFs healing, thus reducing bed rest-related complications and improving the quality of life of osteoporotic patients.
- Trial name
- NCT05803681
- Testing
- Capacitive Coupled Electric Fields (CCEF), Calssic clinical protocol
- Volunteers
- 70 people
- Sponsor
- University of Bari Aldo Moro
Fragility
Exercise Intervention to Reverse Frailty
The objective of this study is to evaluate a multi-component exercise intervention as an effective therapy to reverse pre-frailty phenotype in females age 65 or older.
- Trial name
- ERF (NCT02952443)
- Testing
- Exercise, Control
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia