Clinical trials: Fragility, open to volunteers
Fragility Fracture
MyNOURISH: Hydrolysed Collagen Supplementation in Older Adults With Fragility Fractures
The goal of this clinical trial is to learn whether hydrolysed collagen supplementation (PROTÉGEN Plus) within multidisciplinary care can improve nutrition and recovery in older adults with fragility fractures.
- Trial name
- MyNOURISH (NCT07347236)
- Testing
- Hydrolysed Collagen (PROTÉGEN Plus), Standard Multidisciplinary Care
- Where
- Malaysia
- Volunteers
- 76 people
- Sponsor
- Hospital Pengajar Universiti Putra Malaysia
Sacral Fracture, Osteoporotic Fracture
Sacroplasty for Sacral Insufficiency Fractures.
This study is designed to determine whether sacroplasty, a minimally invasive procedure to stabilize sacral fractures, improves quality of life and functional recovery in adults aged 50 years or older with sacral or posterior…
- Trial name
- SACRA (NCT07493564)
- Testing
- Percutaneous Sacroplasty, Standard conservative management
- Where
- United Kingdom
- Volunteers
- 110 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Geriatric Assessment, Quality of Life
Optimized Recovery After Trauma in Geriatric Patient
Currently, there is evidence that structured care within the healthcare system increases the conditions for good care and better recovery.
- Conditions
- Geriatric Assessment, Quality of Life, Trauma, Fragility
- Trial name
- NCT04092504
- Testing
- gero-erat
- Where
- Sweden
- Volunteers
- 540 people
- Sponsor
- Vastra Gotaland Region
Fragility, Cirrhosis
Impact of Nutritional Management on the Frailty of Patients Waiting for Liver Transplantation (Via the LFI Tool)
Cirrhosis is a major public health issue responsible for about 15000 deaths each year. Liver transplantation (LT) remains the only curative treatment for decompensated cirrhosis.
- Conditions
- Fragility, Cirrhosis, Hepatic Transplantation, Undernutrition
- Trial name
- LFI-PATH (NCT06911619)
- Testing
- Dietary management, No dietary management
- Where
- France
- Volunteers
- 210 people
- Sponsor
- Hospices Civils de Lyon
Humidifier Lung, Mechanical Fragility
Evaluation of Gas Humidification Practices in Patients Under Invasive Mechanical Ventilation
When mechanical ventilation is initiated, a humidification method should be chosen. There is two methods: heat and humidity exchanger filters or heated humidity.
- Conditions
- Humidifier Lung, Mechanical Fragility, Respiratory Complication
- Trial name
- FP950 (NCT06719258)
- Testing
- MR850, FP950
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Laval University
Fragility Fractures of the Pelvis (FFP), Osteoporotic Fractures
Functional Outcomes in Older Adults With Fragility Fractures of the Pelvis: The FFP-France Study
Fragility fractures of the pelvis (FFP) are an increasingly common complication of osteoporosis in older adults and are associated with substantial morbidity, loss of independence, and mortality.
- Trial name
- NCT07871084
- Testing
- Observational Assessment of Fragility Fractures of the Pelvis
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Anesthesia, Local, Anesthesia
Prediction Models for Cardiovascular and Neurocognitive Disease Risk in the General Population
More accurate and earlier identification of people at risk of cardiovascular disease (CVD) and neurodegenerative diseases (memory, cognition, dementia) through the appropriate use of biomarkers could lead to earlier initiation of…
- Trial name
- CME (NCT05951764)
- Testing
- Non-invasive measurement of arterial stiffness by Pulse Wave Velocity (PWV)
- Where
- France
- Volunteers
- 396 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aged, Aged Subject
CREM - Clinical and Functional Outcomes in a Controlled Clinical Trial with Older Adults
To evaluate and compare the effects of different types of physical exercise on clinical and functional outcomes in the elderly. 240 community-dwelling elderly individuals of both sexes, sedentary, will be recruited for twelve…
- Trial name
- CREM (NCT06638697)
- Testing
- Free walking, Nordic walking, Dance
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Asthma, Respiratory Disease
Symptoms, Respiratory Dysfunction and Frailty Level in Allergic and Eosonophilic Asthmatics
The aim of this study is to determine the level of respiratory dysfunction, symptoms and frailty in patients with asthma according to different endophenotypes (allergic and eosonophilic asthma).
- Conditions
- Asthma, Respiratory Disease, Fragility
- Trial name
- NCT06796894
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hacettepe University
Osteoporosis Risk, Bone Loss
Comparison of Bone Microarchitecture Analysed by HRpQCT and pQCT in Pathologies With Bone Loss and/or Muscle Loss
The study aims to utilize medical devices, such as the Xtreme CT and XCT 3000, to assess bone and muscle microarchitecture for various pathologies.
- Trial name
- MICROS (NCT06541548)
- Testing
- HR-pQCT, pQCT, DEXA
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Fragility Fractures of the Pelvis (FFP)
Robot Assisted Minimally Invasive Treatment Versus Conservative Treatment for Fragility Fractures of the Pelvis Type 1-2 in Elderly Patients
This prospective randomized controlled trial aims to compare the efficacy and safety of robot assisted minimally invasive treatment versus conservative treatment in elderly patients with FFP1-2 fragility fractures of the pelvis.
- Trial name
- FFP (NCT07636616)
- Testing
- Robot Assisted Minimally Invasive Fixation
- Volunteers
- 152 people
- Sponsor
- Junbo Liang
Depression in Old Age, Fragility Fracture
Serotonin-norepinephrine Reuptake Inhibitor in Prophylaxis of Depression Following Fragility Fractures
The goal of this pilot study is to learn about the feasibility about prescribing anti-depressants at discharge in patients aged 50 years and older with a lower extremity fragility fracture.
- Trial name
- SNRI (NCT05851898)
- Testing
- Duloxetine 30 mg
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University Health Sciences
Fragility Fractures of the Pelvis (FFP), Osteoporosis
Robot Assisted Minimally Invasive Treatment Versus Conventional Surgery for FFP3-4 Fragility Fractures of the Pelvis in Elderly Patients
This prospective randomized controlled trial aims to compare the efficacy and safety of robot assisted minimally invasive treatment versus conventional surgery in elderly patients with FFP3-4 fragility fractures of the pelvis.
- Trial name
- NCT07639619
- Testing
- Robot Assisted Minimally Invasive Fixation, Conventional Open Fixation
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Junbo Liang
Preventive Cardiology, Respiration Disorders
"ADEN Platform: Pilot Clinical Validation for Chronic Disease Risk Stratification in Colombia"
This protocol describes a 90-day prospective pilot study designed to validate the capacity of the ADEN clinical intelligence platform to stratify early chronic disease risk across six priority public health profiles in Colombia.
- Conditions
- Preventive Cardiology, Respiration Disorders, Oncologic Disease, Autoimmune
- Trial name
- VALIDATES (NCT07727915)
- Testing
- Molecular Target
- Where
- Colombia
- Volunteers
- 120 people
- Sponsor
- Unidad de Investigación Genética Molecular
Fracture; Pelvic, Insufficiency Fractures
Real World Evidence of SI-BONE's iFuse TORQ TNT Advancing Treatment of Pelvic Ring Fractures
The purpose of this study is to evaluate outcomes in patients treated with iFuse TORQ TNT for pelvic fragility fractures.
- Conditions
- Fracture; Pelvic, Insufficiency Fractures, Fragility Fracture, Sacroiliac; Fusion
- Trial name
- REBAR (NCT07530497)
- Testing
- iFuse TORQ TNT Implant System
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- SI-BONE, Inc.
Lower Extremity Fractures, Pelvis
PROactive HEALing in High-Risk Pelvic and Non-hip Lower Extremity Fragility Fractures (PRO HEAL Pilot)
Fragility fractures are common in older adults with weakened bone. At least 1 in 3 females and 1 in 5 males will sustain a fragility fracture in their lifetime, and over 80% of fractures in Canadians aged 50 years and older are…
- Conditions
- Lower Extremity Fractures, Pelvis, Acetabulum
- Trial name
- PRO HEAL Pilot (NCT06303284)
- Testing
- subcutaneous Teriparatide injection
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- University of Calgary
Pelvis; Fracture
Surgical Treatment of Pelvis in Fragility Fracture in Germany: a Prospective, National, Multicenter, Observational, Comparative Cohort Study Comparing Isolated Posterior Versus Combined Anterior-posterior Surgical Fracture Stabilization
Over a period of approximately two years, patients above the age of 65 who have suffered from an FFP equal to or higher than type IIc FFP, according to Rommens and Hofmann, will be eligible for inclusion.
- Trial name
- AO TOP (NCT06550934)
- Testing
- Fracture stabilization
- Volunteers
- 420 people
- Sponsor
- AO Innovation Translation Center
Chronic Obstructive Pulmonary Disease (COPD), Acute Coronary Syndrome
Feasibility Study of a Digital Interactive Life-style Platform for Individuals After Rehabilitation
The goal of this clinical trial is to evaluate the feasibility and usability of a digital lifestyle platform designed to support patients after discharge from inpatient rehabilitation.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Acute Coronary Syndrome, Fragility Fracture, Minor Stroke
- Trial name
- Feas Platf (NCT07597031)
- Testing
- Digital Lifestyle Platform, Usual Care (Standard Post-Rehabilitation Care)
- Where
- 2 sites in Switzerland
- Volunteers
- 240 people
- Sponsor
- Matthias Wilhelm, MD
Frailty, Frailty Syndrome
Prevalence, Determinants and Natural History of Frailty and Pre-frailty in Elderly People
Frailty syndrome (i.e. frailty) is a geriatric syndrome which relies on the reduction of multisystem reserve capacity. Frail people have a lower potential to respond to external stressors and various life incidents as well as…
- Conditions
- Frailty, Frailty Syndrome, Frail Elderly Syndrome, Fragility
- Trial name
- FRAILPOL (NCT04518423)
- Where
- Poland
- Volunteers
- 1,093 people, healthy volunteers welcome
- Sponsor
- The Opole University of Technology
Ankle Fractures, Pilon Fracture
FRAME Study (Frailty-Related Ankle Fracture Management and Evaluation)
This will be a multi-centre randomized controlled trial, with London Health Sciences Centre (LHSC) as the lead site. Elderly patients with complex ankle fractures who meet the inclusion criteria and provide consent will be…
- Trial name
- FRAME (NCT05131321)
- Testing
- Primary ankle arthrodesis (fusion), ORIF (open reduction and internal fixation), Intramedullary Fibular Nailing (IMFN)
- Where
- Canada
- Volunteers
- 172 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's